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OPENSEQ.org
GUDP - Probable glucarate transporter
UniProt: Q46916 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13169
Length: 450 (411)
Sequences: 63994
Seq/Len: 155.70
GUDP
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
106_D 116_A 4.239 1.00
94_I 127_A 3.623 1.00
101_L 120_L 3.48 1.00
103_G 184_F 3.192 1.00
110_G 115_V 3.162 1.00
98_F 120_L 3.019 1.00
67_A 122_F 2.971 1.00
96_S 190_G 2.955 1.00
115_V 119_T 2.944 1.00
84_S 141_A 2.912 1.00
75_G 130_P 2.775 1.00
149_G 313_D 2.772 1.00
110_G 116_A 2.74 1.00
143_F 151_A 2.552 1.00
111_F 118_F 2.538 1.00
377_A 385_S 2.521 1.00
91_S 130_P 2.509 1.00
262_Y 396_S 2.487 1.00
286_S 289_K 2.442 1.00
98_F 127_A 2.402 1.00
53_D 56_G 2.388 1.00
80_D 383_G 2.38 1.00
147_E 150_T 2.356 1.00
98_F 123_L 2.324 1.00
266_A 400_T 2.31 1.00
71_G 126_L 2.31 1.00
246_K 250_G 2.164 1.00
144_P 147_E 2.082 1.00
106_D 110_G 2.029 1.00
105_V 116_A 2.015 1.00
378_P 381_I 2.014 1.00
105_V 120_L 1.994 1.00
177_V 181_H 1.981 1.00
100_L 187_G 1.955 1.00
209_G 212_K 1.919 1.00
71_G 129_A 1.916 1.00
85_K 89_F 1.898 1.00
111_F 115_V 1.857 1.00
63_A 122_F 1.851 1.00
56_G 111_F 1.835 1.00
419_I 423_V 1.834 1.00
89_F 194_S 1.821 1.00
79_L 134_G 1.818 1.00
98_F 124_V 1.805 1.00
60_V 117_L 1.805 1.00
63_A 118_F 1.792 1.00
317_R 375_D 1.769 1.00
197_W 201_I 1.761 1.00
89_F 198_L 1.756 1.00
216_E 219_A 1.75 1.00
195_F 199_K 1.736 1.00
270_F 404_I 1.721 1.00
96_S 194_S 1.712 1.00
102_Q 120_L 1.7 1.00
67_A 71_G 1.696 1.00
52_L 111_F 1.684 1.00
304_G 361_F 1.671 1.00
93_F 194_S 1.67 1.00
26_F 158_A 1.664 1.00
300_C 357_A 1.663 1.00
77_W 81_R 1.662 1.00
83_G 86_R 1.619 1.00
247_Q 250_G 1.603 1.00
310_I 314_W 1.591 1.00
76_G 80_D 1.557 1.00
309_G 313_D 1.54 1.00
52_L 56_G 1.524 1.00
258_Y 392_F 1.515 1.00
18_R 147_E 1.505 1.00
116_A 120_L 1.505 1.00
102_Q 117_L 1.503 1.00
101_L 104_F 1.496 1.00
350_W 354_G 1.468 1.00
247_Q 381_I 1.466 1.00
86_R 90_W 1.465 1.00
78_L 87_V 1.462 1.00
145_A 148_R 1.453 1.00
82_F 87_V 1.439 1.00
285_M 289_K 1.439 1.00
90_W 94_I 1.433 1.00
300_C 304_G 1.432 1.00
316_M 319_T 1.43 1.00
96_S 187_G 1.426 1.00
211_N 214_E 1.425 1.00
184_F 188_G 1.41 1.00
150_T 313_D 1.403 0.99
269_Y 397_G 1.401 0.99
100_L 104_F 1.397 0.99
71_G 74_P 1.395 0.99
78_L 82_F 1.389 0.99
103_G 187_G 1.386 0.99
178_G 181_H 1.374 0.99
94_I 98_F 1.359 0.99
45_E 48_K 1.359 0.99
91_S 127_A 1.354 0.99
342_F 355_F 1.35 0.99
289_K 292_F 1.342 0.99
406_Y 410_T 1.332 0.99
66_W 398_I 1.327 0.99
119_T 123_L 1.319 0.99
140_A 148_R 1.311 0.99
311_I 315_L 1.31 0.99
307_L 310_I 1.285 0.99
103_G 180_S 1.28 0.99
139_V 155_F 1.277 0.99
115_V 118_F 1.277 0.99
28_V 131_S 1.272 0.99
86_R 89_F 1.265 0.99
280_V 290_A 1.264 0.99
141_A 382_S 1.259 0.99
280_V 287_I 1.25 0.99
82_F 86_R 1.24 0.98
396_S 400_T 1.233 0.98
33_Y 159_Q 1.232 0.98
168_P 295_S 1.232 0.98
173_L 181_H 1.23 0.98
80_D 384_L 1.229 0.98
267_L 425_A 1.224 0.98
278_Y 283_R 1.222 0.98
96_S 191_I 1.213 0.98
79_L 84_S 1.211 0.98
42_A 174_T 1.208 0.98
62_S 398_I 1.205 0.98
67_A 125_G 1.199 0.98
254_M 258_Y 1.186 0.98
196_I 200_V 1.184 0.98
405_G 409_G 1.183 0.98
74_P 77_W 1.179 0.98
54_P 409_G 1.179 0.98
80_D 84_S 1.174 0.98
337_S 429_V 1.169 0.97
304_G 307_L 1.168 0.97
76_G 383_G 1.167 0.97
30_S 162_A 1.164 0.97
191_I 195_F 1.161 0.97
181_H 184_F 1.16 0.97
339_V 355_F 1.16 0.97
69_V 391_M 1.157 0.97
188_G 192_V 1.154 0.97
97_M 101_L 1.149 0.97
64_F 68_Y 1.149 0.97
175_H 288_L 1.14 0.97
87_V 90_W 1.138 0.97
64_F 128_E 1.131 0.97
350_W 353_I 1.122 0.97
299_V 303_I 1.12 0.96
341_V 422_G 1.118 0.96
211_N 216_E 1.118 0.96
423_V 427_I 1.117 0.96
337_S 426_L 1.117 0.96
24_M 196_I 1.116 0.96
255_I 259_I 1.116 0.96
83_G 87_V 1.115 0.96
148_R 375_D 1.115 0.96
116_A 119_T 1.112 0.96
28_V 88_Y 1.112 0.96
55_V 409_G 1.111 0.96
92_I 194_S 1.111 0.96
101_L 116_A 1.109 0.96
415_N 419_I 1.103 0.96
34_G 166_F 1.103 0.96
49_D 180_S 1.1 0.96
373_M 389_F 1.098 0.96
47_A 57_M 1.097 0.96
150_T 154_I 1.093 0.96
46_M 179_W 1.083 0.96
407_I 411_T 1.082 0.96
86_R 203_E 1.08 0.95
59_Y 402_I 1.079 0.95
106_D 180_S 1.073 0.95
279_L 285_M 1.066 0.95
416_G 419_I 1.061 0.95
171_G 291_G 1.056 0.95
104_F 184_F 1.051 0.94
45_E 49_D 1.049 0.94
168_P 172_W 1.047 0.94
163_T 298_A 1.036 0.94
244_Q 247_Q 1.036 0.94
59_Y 63_A 1.036 0.94
261_Q 389_F 1.035 0.94
34_G 186_M 1.031 0.94
310_I 313_D 1.031 0.94
105_V 110_G 1.031 0.94
89_F 197_W 1.025 0.93
62_S 402_I 1.02 0.93
43_G 57_M 1.019 0.93
64_F 125_G 1.017 0.93
359_A 362_G 1.015 0.93
292_F 296_V 1.014 0.93
416_G 420_Y 1.014 0.93
69_V 398_I 1.012 0.93
426_L 430_L 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.94441000.222Contact Map0.488
4j05A20.95781000.235Contact Map0.622
3wdoA10.881000.253Contact Map0.647
3o7qA10.89111000.258Contact Map0.624
4gc0A10.94671000.277Contact Map0.733
2cfqA10.88891000.277Contact Map0.472
2gfpA20.82441000.281Contact Map0.188
4ldsA20.92891000.285Contact Map0.641
2xutA30.961000.303Contact Map0.521
4apsA20.961000.319Contact Map0.552
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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