May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YHJX - Uncharacterized MFS-type transporter YhjX
UniProt: P37662 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12268
Length: 402 (381)
Sequences: 67381
Seq/Len: 176.85
YHJX
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
97_D 101_M 4.108 1.00
85_L 113_A 3.426 1.00
92_L 105_S 3.406 1.00
94_A 169_V 3.216 1.00
58_G 108_V 2.986 1.00
100_M 104_L 2.859 1.00
66_A 116_A 2.823 1.00
89_G 105_S 2.817 1.00
98_N 101_M 2.687 1.00
75_V 127_K 2.682 1.00
333_F 341_N 2.616 1.00
99_L 103_W 2.575 1.00
82_S 116_A 2.496 1.00
129_F 136_I 2.486 1.00
134_G 275_D 2.486 1.00
248_D 251_S 2.485 1.00
44_P 47_Q 2.465 1.00
87_G 175_A 2.456 1.00
132_R 135_L 2.324 1.00
89_G 109_L 2.312 1.00
89_G 113_A 2.268 1.00
71_E 339_A 2.227 1.00
62_S 112_L 2.213 1.00
262_A 312_A 2.212 1.00
289_I 317_N 2.153 1.00
266_G 316_F 2.138 1.00
224_L 352_G 2.115 1.00
296_A 310_A 2.06 1.00
162_V 166_K 2.037 1.00
228_M 356_G 2.03 1.00
76_K 80_M 2.028 1.00
279_R 331_E 2.024 1.00
96_S 101_M 1.984 1.00
334_G 337_N 1.926 1.00
208_A 212_R 1.926 1.00
47_Q 99_L 1.871 1.00
293_G 310_A 1.831 1.00
96_S 105_S 1.829 1.00
62_S 115_G 1.822 1.00
43_A 99_L 1.8 1.00
70_Q 120_L 1.771 1.00
89_G 110_V 1.767 1.00
68_K 72_R 1.758 1.00
91_F 172_G 1.746 1.00
371_Y 375_A 1.74 1.00
54_L 103_W 1.722 1.00
54_L 108_V 1.716 1.00
58_G 62_S 1.709 1.00
278_A 281_R 1.697 1.00
51_S 102_L 1.688 1.00
305_V 309_A 1.688 1.00
93_T 105_S 1.665 1.00
80_M 183_A 1.66 1.00
293_G 317_N 1.635 1.00
74_G 77_R 1.627 1.00
220_A 348_G 1.606 1.00
272_I 276_K 1.557 1.00
180_V 184_T 1.556 1.00
291_L 381_L 1.549 1.00
232_Y 360_A 1.536 1.00
259_I 315_A 1.505 1.00
286_G 320_G 1.496 1.00
43_A 47_Q 1.485 1.00
181_F 185_L 1.484 1.00
262_A 266_G 1.472 1.00
69_L 78_V 1.46 1.00
93_T 102_L 1.459 1.00
77_R 81_A 1.45 1.00
67_G 71_E 1.445 1.00
271_G 275_D 1.442 1.00
87_G 176_L 1.438 1.00
94_A 172_G 1.43 1.00
209_E 212_R 1.426 1.00
80_M 179_I 1.426 1.00
247_L 251_S 1.411 1.00
101_M 105_S 1.404 0.99
135_L 275_D 1.404 0.99
163_G 166_K 1.397 0.99
69_L 73_F 1.397 0.99
92_L 95_H 1.397 0.99
36_A 39_A 1.39 0.99
87_G 179_I 1.382 0.99
169_V 173_A 1.376 0.99
291_L 378_I 1.372 0.99
81_A 85_L 1.358 0.99
73_F 78_V 1.357 0.99
91_F 95_H 1.35 0.99
209_E 337_N 1.34 0.99
251_S 254_N 1.335 0.99
85_L 89_G 1.332 0.99
84_I 179_I 1.325 0.99
273_L 277_I 1.317 0.99
125_C 140_A 1.315 0.99
62_S 65_V 1.314 0.99
280_I 284_T 1.299 0.99
269_V 272_I 1.294 0.99
242_Q 252_A 1.289 0.99
104_L 109_L 1.288 0.99
57_L 354_I 1.283 0.99
242_Q 249_V 1.274 0.99
77_R 80_M 1.272 0.99
100_M 103_W 1.266 0.99
71_E 340_K 1.258 0.99
87_G 172_G 1.251 0.99
240_I 245_A 1.248 0.99
38_S 48_V 1.246 0.98
153_F 257_T 1.239 0.98
375_A 379_L 1.239 0.98
82_S 113_A 1.235 0.98
266_G 269_V 1.232 0.98
10_R 132_R 1.232 0.98
65_V 68_K 1.23 0.98
166_K 169_V 1.226 0.98
298_L 371_Y 1.215 0.98
126_V 133_K 1.211 0.98
73_F 77_R 1.206 0.98
58_G 111_G 1.202 0.98
284_T 381_L 1.195 0.98
291_L 295_A 1.193 0.98
127_K 338_L 1.18 0.98
288_V 292_V 1.179 0.98
293_G 313_C 1.179 0.98
78_V 81_A 1.176 0.98
231_L 353_S 1.175 0.98
357_S 361_S 1.171 0.98
303_N 306_T 1.16 0.97
173_A 177_L 1.159 0.97
55_L 114_D 1.155 0.97
50_F 54_L 1.153 0.97
92_L 101_M 1.153 0.97
158_L 166_K 1.151 0.97
281_R 284_T 1.149 0.97
329_V 345_I 1.148 0.97
88_L 92_L 1.146 0.97
60_A 347_L 1.144 0.97
160_E 250_V 1.144 0.97
74_G 78_V 1.143 0.97
281_R 285_I 1.136 0.97
270_L 320_G 1.135 0.97
77_R 188_D 1.132 0.97
94_A 165_E 1.128 0.97
288_V 381_L 1.122 0.97
293_G 314_V 1.117 0.96
241_A 247_L 1.111 0.96
352_G 356_G 1.108 0.96
33_F 159_L 1.108 0.96
70_Q 75_V 1.105 0.96
295_A 374_F 1.105 0.96
229_S 377_L 1.102 0.96
36_A 40_K 1.099 0.96
53_G 358_I 1.095 0.96
240_I 244_L 1.095 0.96
53_G 354_I 1.092 0.96
67_G 339_A 1.092 0.96
286_G 317_N 1.092 0.96
305_V 308_F 1.091 0.96
153_F 157_Q 1.09 0.96
38_S 45_V 1.084 0.96
95_H 169_V 1.082 0.96
261_I 265_S 1.077 0.95
148_S 260_S 1.073 0.95
40_K 165_E 1.065 0.95
272_I 275_D 1.065 0.95
101_M 104_L 1.064 0.95
291_L 374_F 1.052 0.95
64_S 68_K 1.051 0.94
254_N 258_V 1.049 0.94
157_Q 161_T 1.045 0.94
211_M 217_W 1.043 0.94
80_M 84_I 1.042 0.94
214_P 217_W 1.042 0.94
372_V 376_L 1.04 0.94
250_V 254_N 1.04 0.94
50_F 358_I 1.039 0.94
183_A 187_K 1.037 0.94
71_E 75_V 1.035 0.94
382_A 386_T 1.034 0.94
135_L 139_F 1.024 0.93
265_S 268_L 1.021 0.93
337_N 340_K 1.013 0.93
277_I 282_V 1.011 0.93
370_F 374_F 1.01 0.93
274_S 324_V 1.009 0.93
217_W 221_V 1.005 0.93
54_L 58_G 1.004 0.93
368_V 371_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99251000.172Contact Map0.479
3wdoA10.98011000.19Contact Map0.621
4j05A20.991000.197Contact Map0.601
3o7qA10.96271000.213Contact Map0.621
2gfpA20.91291000.224Contact Map0.194
2cfqA10.98011000.233Contact Map0.519
4gc0A10.99251000.238Contact Map0.702
4ldsA20.98011000.257Contact Map0.627
2xutA30.99751000.278Contact Map0.551
4apsA20.99751000.285Contact Map0.545
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0215 seconds.