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YDHC - Inner membrane transport protein YdhC
UniProt: P37597 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12141
Length: 403 (368)
Sequences: 66799
Seq/Len: 181.52
YDHC
Paralog alert: 0.90 [within 20: 0.68] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_E 96_T 3.999 1.00
80_I 107_G 3.556 1.00
87_G 100_L 3.496 1.00
89_L 164_A 3.198 1.00
84_G 100_L 2.984 1.00
53_G 102_F 2.927 1.00
82_A 170_T 2.803 1.00
61_W 110_A 2.8 1.00
95_A 99_V 2.783 1.00
70_R 121_D 2.762 1.00
325_F 332_A 2.745 1.00
93_N 96_T 2.678 1.00
129_N 263_Q 2.538 1.00
123_Y 131_I 2.536 1.00
236_S 239_V 2.516 1.00
94_A 98_L 2.506 1.00
77_G 110_A 2.497 1.00
39_P 42_A 2.411 1.00
84_G 107_G 2.33 1.00
127_K 130_R 2.305 1.00
57_A 106_V 2.286 1.00
66_D 330_G 2.256 1.00
213_A 343_L 2.211 1.00
250_A 304_C 2.203 1.00
84_G 103_V 2.187 1.00
277_L 309_A 2.183 1.00
254_G 308_I 2.162 1.00
217_A 347_A 2.139 1.00
124_P 127_K 2.104 1.00
71_K 75_L 2.083 1.00
267_G 323_R 2.064 1.00
284_A 302_P 1.985 1.00
197_T 201_R 1.973 1.00
91_V 96_T 1.972 1.00
157_F 161_A 1.971 1.00
86_L 167_F 1.967 1.00
57_A 109_C 1.907 1.00
91_V 100_L 1.871 1.00
281_S 302_P 1.862 1.00
42_A 94_A 1.824 1.00
75_L 174_I 1.796 1.00
297_V 301_I 1.79 1.00
82_A 174_I 1.785 1.00
65_S 114_I 1.769 1.00
38_T 94_A 1.718 1.00
63_P 67_R 1.712 1.00
84_G 104_Q 1.711 1.00
266_Q 269_Q 1.701 1.00
75_L 177_I 1.699 1.00
53_G 57_A 1.691 1.00
88_M 100_L 1.665 1.00
49_L 102_F 1.652 1.00
46_S 97_L 1.643 1.00
49_L 98_L 1.619 1.00
221_A 351_V 1.611 1.00
175_L 178_F 1.602 1.00
79_T 174_I 1.573 1.00
69_G 72_P 1.556 1.00
12_A 138_L 1.555 1.00
82_A 167_F 1.552 1.00
209_V 339_L 1.544 1.00
235_Y 239_V 1.538 1.00
260_A 264_K 1.536 1.00
250_A 254_G 1.527 1.00
62_G 66_D 1.521 1.00
281_S 309_A 1.505 1.00
38_T 42_A 1.483 1.00
64_L 73_V 1.483 1.00
164_A 168_A 1.481 1.00
88_M 97_L 1.475 1.00
198_D 201_R 1.473 1.00
89_L 167_F 1.44 1.00
259_R 263_Q 1.435 1.00
247_Q 307_A 1.414 1.00
274_L 312_A 1.409 1.00
96_T 100_L 1.405 0.99
68_Y 73_V 1.402 0.99
295_S 298_E 1.396 0.99
77_G 107_G 1.396 0.99
158_S 161_A 1.394 0.99
64_L 68_Y 1.389 0.99
198_D 328_A 1.38 0.99
87_G 90_W 1.379 0.99
72_P 76_I 1.374 0.99
130_R 263_Q 1.372 0.99
76_I 80_I 1.365 0.99
80_I 84_G 1.364 0.99
52_A 345_F 1.361 0.99
86_L 90_W 1.351 0.99
125_S 128_V 1.323 0.99
95_A 98_L 1.311 0.99
268_K 272_P 1.308 0.99
31_A 34_A 1.302 0.99
57_A 60_L 1.301 0.99
82_A 171_V 1.293 0.99
40_A 356_S 1.285 0.99
254_G 257_G 1.279 0.99
274_L 313_I 1.278 0.99
257_G 260_A 1.274 0.99
148_L 245_V 1.271 0.99
261_A 265_W 1.262 0.99
119_V 135_I 1.258 0.99
239_V 242_L 1.258 0.99
155_V 238_A 1.256 0.99
121_D 329_T 1.255 0.99
99_V 103_V 1.249 0.99
161_A 164_A 1.245 0.98
258_C 312_A 1.237 0.98
120_T 128_V 1.231 0.98
41_S 356_S 1.228 0.98
276_V 280_V 1.228 0.98
72_P 75_L 1.228 0.98
274_L 309_A 1.228 0.98
153_L 161_A 1.224 0.98
343_L 347_A 1.222 0.98
60_L 63_P 1.208 0.98
28_A 154_L 1.202 0.98
279_A 283_I 1.201 0.98
66_D 331_R 1.197 0.98
168_A 172_V 1.196 0.98
269_Q 272_P 1.195 0.98
62_G 330_G 1.193 0.98
53_G 105_A 1.19 0.98
68_Y 72_P 1.19 0.98
73_V 76_I 1.184 0.98
72_P 182_P 1.178 0.98
87_G 96_T 1.175 0.98
69_G 73_V 1.173 0.98
269_Q 273_W 1.172 0.98
83_L 87_G 1.172 0.98
171_V 175_L 1.169 0.97
33_Q 43_V 1.162 0.97
176_P 179_W 1.161 0.97
118_L 180_L 1.161 0.97
200_L 206_R 1.16 0.97
19_F 139_V 1.159 0.97
297_V 300_L 1.159 0.97
205_Y 209_V 1.155 0.97
321_A 336_Q 1.148 0.97
65_S 70_R 1.148 0.97
50_F 54_F 1.14 0.97
206_R 210_L 1.138 0.97
48_S 345_F 1.137 0.97
220_F 344_C 1.131 0.97
89_L 160_Q 1.117 0.96
128_V 323_R 1.102 0.96
96_T 99_V 1.097 0.96
281_S 306_M 1.093 0.96
14_L 111_A 1.092 0.96
249_I 253_I 1.083 0.96
273_W 277_L 1.08 0.95
266_Q 270_L 1.076 0.95
260_A 263_Q 1.075 0.95
280_V 284_A 1.075 0.95
78_L 174_I 1.072 0.95
55_A 338_T 1.067 0.95
251_F 311_G 1.066 0.95
151_S 241_G 1.066 0.95
242_L 246_P 1.066 0.95
283_I 287_A 1.064 0.95
130_R 134_A 1.064 0.95
21_A 166_L 1.062 0.95
212_Y 336_Q 1.061 0.95
45_A 49_L 1.059 0.95
48_S 349_L 1.059 0.95
148_L 152_W 1.058 0.95
35_D 160_Q 1.057 0.95
31_A 35_D 1.053 0.95
90_W 164_A 1.052 0.95
265_W 270_L 1.049 0.94
16_V 142_S 1.049 0.94
366_S 370_S 1.04 0.94
262_L 316_I 1.036 0.94
281_S 305_V 1.033 0.94
50_F 108_V 1.031 0.94
149_L 152_W 1.02 0.93
45_A 349_L 1.019 0.93
66_D 70_R 1.017 0.93
276_V 279_A 1.016 0.93
75_L 79_T 1.013 0.93
301_I 305_V 1.012 0.93
210_L 214_A 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98011000.2Contact Map0.492
3wdoA10.98261000.206Contact Map0.645
4j05A20.99261000.227Contact Map0.63
2cfqA10.97021000.242Contact Map0.503
3o7qA10.94541000.261Contact Map0.642
2gfpA20.92311000.261Contact Map0.173
4gc0A10.9951000.267Contact Map0.735
4ldsA20.99751000.271Contact Map0.634
2xutA30.99751000.272Contact Map0.547
4apsA20.99011000.3Contact Map0.559
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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