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OPENSEQ.org
SETB - Sugar efflux transporter B
UniProt: P33026 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12034
Length: 393 (371)
Sequences: 64852
Seq/Len: 174.80
SETB
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
103_R 107_V 4.005 1.00
91_L 119_G 3.341 1.00
100_A 177_L 3.239 1.00
98_L 112_G 3.214 1.00
63_I 114_F 2.966 1.00
93_V 183_F 2.796 1.00
104_N 107_V 2.6 1.00
95_A 112_G 2.514 1.00
334_M 341_A 2.432 1.00
142_V 277_K 2.427 1.00
134_A 144_F 2.41 1.00
49_R 52_M 2.395 1.00
250_P 253_L 2.386 1.00
137_T 140_E 2.375 1.00
140_E 143_M 2.299 1.00
105_Y 109_L 2.278 1.00
298_G 311_L 2.274 1.00
291_G 318_F 2.271 1.00
95_A 119_G 2.238 1.00
67_V 118_F 2.186 1.00
76_D 339_G 2.185 1.00
226_T 352_G 2.153 1.00
264_L 313_L 2.15 1.00
268_T 317_I 2.126 1.00
95_A 115_L 2.111 1.00
230_G 356_A 2.095 1.00
170_F 174_V 2.026 1.00
135_D 140_E 1.915 1.00
97_T 180_A 1.905 1.00
188_V 192_L 1.9 1.00
52_M 105_Y 1.896 1.00
86_V 187_G 1.896 1.00
102_N 107_V 1.879 1.00
48_A 105_Y 1.867 1.00
281_K 332_D 1.857 1.00
86_V 191_W 1.856 1.00
82_K 86_V 1.853 1.00
210_A 214_N 1.842 1.00
295_F 311_L 1.84 1.00
234_L 360_A 1.837 1.00
295_F 318_F 1.787 1.00
75_S 125_Q 1.775 1.00
93_V 187_G 1.773 1.00
306_V 310_G 1.769 1.00
95_A 116_S 1.719 1.00
73_G 77_K 1.716 1.00
56_F 108_L 1.688 1.00
59_G 114_F 1.67 1.00
106_F 110_F 1.669 1.00
63_I 67_V 1.667 1.00
90_L 187_G 1.659 1.00
102_N 112_G 1.644 1.00
280_G 283_F 1.632 1.00
48_A 52_M 1.629 1.00
293_V 384_L 1.597 1.00
374_W 378_V 1.569 1.00
274_Y 278_R 1.565 1.00
288_A 321_I 1.558 1.00
81_R 132_E 1.534 1.00
59_G 109_L 1.533 1.00
93_V 180_A 1.529 1.00
99_F 112_G 1.522 1.00
222_F 348_T 1.511 1.00
80_D 132_E 1.509 1.00
249_L 253_L 1.508 1.00
72_A 76_D 1.499 1.00
211_P 337_Q 1.481 1.00
21_L 151_Q 1.462 1.00
211_P 214_N 1.459 1.00
273_G 277_K 1.453 1.00
106_F 111_V 1.449 1.00
264_L 268_T 1.439 1.00
74_R 78_R 1.427 1.00
99_F 108_L 1.422 1.00
177_L 181_V 1.414 1.00
100_A 180_A 1.401 0.99
62_V 354_I 1.394 0.99
87_F 91_L 1.389 0.99
189_M 193_F 1.385 0.99
261_A 316_A 1.372 0.99
143_M 277_K 1.37 0.99
253_L 256_V 1.369 0.99
40_I 44_D 1.365 0.99
67_V 70_F 1.36 0.99
171_S 174_V 1.358 0.99
98_L 101_W 1.334 0.99
293_V 381_I 1.332 0.99
97_T 101_W 1.324 0.99
275_F 279_L 1.302 0.99
67_V 121_T 1.3 0.99
271_I 274_Y 1.296 0.99
91_L 95_A 1.292 0.99
300_L 374_W 1.28 0.99
290_V 294_C 1.275 0.99
161_P 259_G 1.272 0.99
244_I 251_E 1.263 0.99
50_P 365_E 1.256 0.99
113_V 117_S 1.253 0.99
83_S 87_F 1.249 0.99
70_F 73_G 1.248 0.99
107_V 112_G 1.248 0.99
174_V 177_L 1.247 0.99
244_I 254_A 1.247 0.99
282_R 286_R 1.242 0.98
136_K 141_A 1.24 0.98
362_I 366_I 1.237 0.98
93_V 184_I 1.235 0.98
130_A 148_L 1.232 0.98
268_T 271_I 1.228 0.98
88_C 119_G 1.217 0.98
295_F 314_L 1.212 0.98
363_V 367_W 1.21 0.98
378_V 382_A 1.209 0.98
43_T 53_V 1.199 0.98
76_D 340_S 1.196 0.98
106_F 109_L 1.196 0.98
283_F 286_R 1.185 0.98
304_S 307_I 1.184 0.98
213_R 219_L 1.184 0.98
168_M 252_K 1.179 0.98
295_F 315_N 1.176 0.98
79_G 83_S 1.173 0.98
293_V 297_A 1.163 0.97
306_V 309_L 1.161 0.97
166_L 174_V 1.159 0.97
219_L 223_V 1.158 0.97
288_A 318_F 1.158 0.97
367_W 371_A 1.152 0.97
352_G 356_A 1.151 0.97
131_R 141_A 1.149 0.97
243_I 249_L 1.145 0.97
78_R 84_L 1.143 0.97
274_Y 277_K 1.138 0.97
272_A 321_I 1.135 0.97
51_A 365_E 1.135 0.97
94_L 98_L 1.135 0.97
58_T 354_I 1.134 0.97
129_L 194_L 1.132 0.97
231_S 380_I 1.132 0.97
28_G 152_V 1.131 0.97
89_C 187_G 1.127 0.97
330_F 345_Y 1.126 0.97
297_A 377_M 1.125 0.97
132_E 338_A 1.125 0.97
283_F 287_V 1.123 0.97
290_V 384_L 1.122 0.97
101_W 177_L 1.114 0.96
297_A 301_M 1.112 0.96
181_V 185_V 1.111 0.96
55_F 59_G 1.111 0.96
63_I 117_S 1.105 0.96
242_F 247_L 1.102 0.96
161_P 165_A 1.096 0.96
25_F 155_A 1.093 0.96
233_S 353_W 1.09 0.96
84_L 87_F 1.088 0.96
218_T 222_F 1.085 0.96
65_I 347_N 1.079 0.95
190_V 194_L 1.076 0.95
74_R 84_L 1.076 0.95
72_A 339_G 1.07 0.95
43_T 50_P 1.068 0.95
37_T 167_A 1.068 0.95
287_V 291_G 1.063 0.95
288_A 322_L 1.061 0.95
71_L 122_A 1.061 0.95
263_G 267_P 1.058 0.95
55_F 358_S 1.057 0.95
216_R 219_L 1.054 0.95
82_K 196_S 1.053 0.95
98_L 107_V 1.049 0.94
100_A 173_T 1.047 0.94
286_R 384_L 1.046 0.94
143_M 147_F 1.044 0.94
361_G 365_E 1.044 0.94
293_V 377_M 1.041 0.94
165_A 169_G 1.038 0.94
83_S 86_V 1.035 0.94
252_K 256_V 1.035 0.94
58_T 358_S 1.027 0.94
156_W 262_A 1.027 0.94
310_G 314_L 1.026 0.94
300_L 377_M 1.021 0.93
54_G 58_T 1.02 0.93
267_P 270_L 1.016 0.93
267_P 271_I 1.012 0.93
279_L 284_L 1.01 0.93
243_I 308_L 1.007 0.93
143_M 274_Y 1.006 0.93
276_A 325_I 1.004 0.93
65_I 354_I 1.004 0.93
241_L 245_N 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.96951000.196Contact Map0.64
1pw4A10.98471000.197Contact Map0.502
2gfpA20.93891000.207Contact Map0.175
3o7qA10.98221000.218Contact Map0.629
4j05A20.98221000.224Contact Map0.615
2cfqA10.96181000.232Contact Map0.55
2xutA30.98221000.264Contact Map0.515
4jr9A10.97461000.284Contact Map0.626
4apsA20.98731000.289Contact Map0.562
4lepA20.98221000.299Contact Map0.624
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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