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MHPT - Putative 3-hydroxyphenylpropionic acid transporter
UniProt: P77589 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13293
Length: 403 (383)
Sequences: 65812
Seq/Len: 171.83
MHPT
Paralog alert: 0.90 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_W 105_S 4.06 1.00
89_L 116_G 3.553 1.00
96_A 109_A 3.49 1.00
98_A 172_W 3.292 1.00
62_G 111_L 3.039 1.00
104_P 108_F 3.023 1.00
93_F 109_A 2.856 1.00
70_G 119_A 2.781 1.00
102_D 105_S 2.729 1.00
79_R 130_E 2.686 1.00
332_Y 340_G 2.575 1.00
103_F 107_V 2.547 1.00
248_Q 251_Q 2.52 1.00
132_A 140_A 2.486 1.00
138_G 275_D 2.48 1.00
86_S 119_A 2.464 1.00
48_D 51_Q 2.442 1.00
136_F 139_T 2.353 1.00
91_G 178_P 2.35 1.00
289_G 316_F 2.319 1.00
93_F 112_M 2.317 1.00
66_G 115_V 2.305 1.00
225_F 351_G 2.253 1.00
93_F 116_G 2.252 1.00
296_A 309_A 2.219 1.00
229_L 355_G 2.178 1.00
75_D 338_A 2.171 1.00
262_G 311_F 2.126 1.00
165_L 169_T 2.098 1.00
133_G 136_F 2.075 1.00
266_G 315_L 2.02 1.00
206_R 210_A 2.015 1.00
80_K 84_I 2.011 1.00
100_A 105_S 1.903 1.00
100_A 109_A 1.897 1.00
95_L 175_G 1.884 1.00
333_S 336_I 1.877 1.00
293_S 316_F 1.835 1.00
51_Q 103_F 1.833 1.00
293_S 309_A 1.819 1.00
66_G 118_G 1.812 1.00
55_I 106_L 1.803 1.00
58_A 111_L 1.798 1.00
93_F 113_T 1.793 1.00
47_L 103_F 1.79 1.00
279_P 330_L 1.779 1.00
58_A 107_V 1.769 1.00
84_I 186_M 1.761 1.00
72_M 76_R 1.713 1.00
304_N 308_L 1.712 1.00
74_A 123_N 1.69 1.00
183_P 187_R 1.689 1.00
278_R 281_T 1.678 1.00
97_T 109_A 1.675 1.00
233_M 359_A 1.654 1.00
62_G 66_G 1.618 1.00
78_G 81_R 1.611 1.00
272_A 276_K 1.596 1.00
374_A 378_P 1.574 1.00
286_I 319_G 1.572 1.00
84_I 182_V 1.57 1.00
21_F 147_G 1.56 1.00
47_L 51_Q 1.543 1.00
97_T 106_L 1.542 1.00
91_G 182_V 1.54 1.00
184_L 188_W 1.517 1.00
221_W 347_V 1.499 1.00
88_A 182_V 1.499 1.00
98_A 175_G 1.494 1.00
207_A 336_I 1.485 1.00
81_R 85_G 1.477 1.00
73_L 82_I 1.475 1.00
105_S 109_A 1.468 1.00
91_G 175_G 1.467 1.00
291_L 384_G 1.462 1.00
207_A 210_A 1.46 1.00
247_F 251_Q 1.451 1.00
77_Y 82_I 1.446 1.00
139_T 275_D 1.436 1.00
96_A 99_I 1.429 1.00
40_G 43_Q 1.429 1.00
73_L 77_Y 1.407 0.99
108_F 112_M 1.405 0.99
91_G 179_L 1.396 0.99
259_L 314_G 1.395 0.99
134_P 137_R 1.39 0.99
262_G 266_G 1.382 0.99
71_G 75_D 1.38 0.99
85_G 89_L 1.378 0.99
13_L 136_F 1.376 0.99
89_L 93_F 1.374 0.99
166_A 169_T 1.37 0.99
271_G 275_D 1.353 0.99
95_L 99_I 1.352 0.99
273_L 277_L 1.348 0.99
291_L 295_L 1.346 0.99
66_G 69_V 1.338 0.99
251_Q 254_G 1.325 0.99
104_P 107_V 1.323 0.99
61_L 353_M 1.316 0.99
172_W 176_V 1.31 0.99
269_M 272_A 1.295 0.99
169_T 172_W 1.293 0.99
86_S 116_G 1.29 0.99
361_K 365_L 1.288 0.99
128_T 144_M 1.277 0.99
81_R 84_I 1.268 0.99
302_S 305_G 1.263 0.99
212_E 215_T 1.258 0.99
293_S 313_A 1.247 0.99
288_S 292_A 1.236 0.98
77_Y 81_R 1.231 0.98
157_T 257_F 1.226 0.98
49_K 364_A 1.214 0.98
130_E 337_R 1.211 0.98
81_R 191_E 1.21 0.98
295_L 299_T 1.2 0.98
28_G 148_V 1.2 0.98
129_S 137_R 1.2 0.98
98_A 168_Q 1.193 0.98
286_I 316_F 1.192 0.98
281_T 285_L 1.185 0.98
69_V 72_M 1.184 0.98
127_L 189_L 1.183 0.98
280_V 284_L 1.179 0.98
92_L 96_A 1.177 0.98
82_I 85_G 1.175 0.98
293_S 312_V 1.171 0.98
291_L 381_L 1.165 0.97
78_G 82_I 1.163 0.97
266_G 269_M 1.162 0.97
50_M 364_A 1.155 0.97
362_M 366_G 1.148 0.97
42_A 52_M 1.143 0.97
23_V 120_A 1.14 0.97
75_D 339_T 1.138 0.97
232_Y 352_A 1.135 0.97
62_G 114_G 1.134 0.97
57_S 353_M 1.133 0.97
351_G 355_G 1.126 0.97
360_G 364_A 1.116 0.96
96_A 105_S 1.113 0.96
105_S 108_F 1.111 0.96
328_A 344_A 1.111 0.96
270_L 319_G 1.109 0.96
25_L 151_G 1.109 0.96
242_L 247_F 1.102 0.96
281_T 284_L 1.1 0.96
71_G 338_A 1.1 0.96
59_G 117_L 1.098 0.96
74_A 79_R 1.088 0.96
272_A 275_D 1.085 0.96
64_L 346_A 1.08 0.95
40_G 44_A 1.072 0.95
99_I 172_W 1.071 0.95
254_G 258_A 1.07 0.95
139_T 143_L 1.069 0.95
137_R 330_L 1.067 0.95
261_M 265_S 1.066 0.95
284_L 384_G 1.064 0.95
54_W 357_L 1.063 0.95
54_W 58_A 1.056 0.95
176_V 180_I 1.054 0.95
44_A 168_Q 1.05 0.94
37_A 162_G 1.045 0.94
163_A 250_S 1.044 0.94
373_M 377_A 1.042 0.94
241_L 245_Q 1.042 0.94
29_L 155_A 1.04 0.94
182_V 186_M 1.037 0.94
204_P 207_A 1.034 0.94
84_I 88_A 1.034 0.94
308_L 312_V 1.033 0.94
288_S 384_G 1.032 0.94
227_T 320_G 1.027 0.94
25_L 154_L 1.012 0.93
243_V 249_P 1.007 0.93
57_S 357_L 1.004 0.93
152_A 260_Q 1.003 0.93
75_D 79_R 1.002 0.92
278_R 282_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98761000.21Contact Map0.499
4j05A20.9951000.219Contact Map0.606
3wdoA10.97271000.224Contact Map0.642
2gfpA20.91561000.258Contact Map0.179
3o7qA10.96771000.258Contact Map0.647
2cfqA10.96281000.279Contact Map0.508
4gc0A10.98761000.282Contact Map0.732
4ldsA20.97521000.283Contact Map0.631
2xutA30.99261000.287Contact Map0.533
4jr9A10.95781000.318Contact Map0.624
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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