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OPENSEQ.org
UHPC - Regulatory protein UhpC
UniProt: P09836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11053
Length: 439 (406)
Sequences: 64801
Seq/Len: 159.61
UHPC
Paralog alert: 0.90 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_T 120_A 4.223 1.00
104_A 131_F 3.592 1.00
111_L 124_L 3.49 1.00
113_G 188_M 3.22 1.00
77_T 126_V 2.973 1.00
108_I 124_L 2.96 1.00
119_W 123_V 2.866 1.00
106_G 194_A 2.847 1.00
85_S 134_W 2.751 1.00
117_S 120_A 2.734 1.00
94_A 145_A 2.699 1.00
101_G 134_W 2.564 1.00
118_L 122_A 2.56 1.00
153_G 311_D 2.509 1.00
147_Y 155_W 2.479 1.00
151_E 154_G 2.441 1.00
284_D 287_T 2.424 1.00
373_S 381_A 2.407 1.00
260_V 392_G 2.367 1.00
63_S 66_D 2.355 1.00
108_I 131_F 2.296 1.00
81_S 130_F 2.294 1.00
264_V 396_A 2.264 1.00
108_I 127_L 2.23 1.00
148_S 151_E 2.164 1.00
90_D 379_G 2.159 1.00
95_R 99_G 2.101 1.00
115_S 120_A 2.061 1.00
244_K 248_L 2.04 1.00
335_S 350_C 1.994 1.00
374_H 377_A 1.984 1.00
298_G 352_F 1.981 1.00
181_Y 185_A 1.966 1.00
110_I 191_G 1.929 1.00
66_D 118_L 1.912 1.00
214_L 217_V 1.904 1.00
89_S 138_V 1.86 1.00
414_V 418_I 1.852 1.00
115_S 124_L 1.849 1.00
330_L 424_A 1.821 1.00
99_G 198_G 1.81 1.00
70_L 121_F 1.796 1.00
108_I 128_N 1.783 1.00
62_L 118_L 1.776 1.00
81_S 133_G 1.763 1.00
73_L 126_V 1.762 1.00
199_I 203_W 1.758 1.00
112_F 124_L 1.725 1.00
99_G 202_C 1.722 1.00
87_I 91_R 1.716 1.00
268_A 400_L 1.71 1.00
73_L 122_A 1.688 1.00
106_G 198_G 1.681 1.00
36_W 162_A 1.657 1.00
103_I 198_G 1.65 1.00
77_T 81_S 1.639 1.00
93_N 96_Y 1.63 1.00
308_W 312_K 1.615 1.00
112_F 121_F 1.601 1.00
302_G 356_F 1.599 1.00
330_L 421_G 1.562 1.00
332_S 350_C 1.545 1.00
345_V 349_T 1.52 1.00
96_Y 100_I 1.506 1.00
113_G 191_G 1.505 1.00
88_V 97_F 1.499 1.00
256_S 388_F 1.494 1.00
62_L 66_D 1.491 1.00
120_A 124_L 1.477 1.00
245_Y 248_L 1.476 1.00
154_G 311_D 1.456 1.00
283_V 287_T 1.44 1.00
28_R 151_E 1.434 1.00
55_E 58_A 1.434 1.00
328_G 357_F 1.415 1.00
88_V 92_S 1.41 1.00
100_I 104_A 1.407 0.99
188_M 192_C 1.407 0.99
307_G 311_D 1.405 0.99
149_R 152_R 1.402 0.99
111_L 114_F 1.393 0.99
92_S 97_F 1.391 0.99
216_A 219_E 1.389 0.99
110_I 114_F 1.38 0.99
327_A 424_A 1.375 0.99
245_Y 377_A 1.368 0.99
106_G 191_G 1.362 0.99
182_G 185_A 1.359 0.99
343_S 346_M 1.358 0.99
104_A 108_I 1.345 0.99
76_I 394_S 1.342 0.99
298_G 302_G 1.339 0.99
86_G 90_D 1.338 0.99
287_T 290_T 1.336 0.99
119_W 122_A 1.33 0.99
278_S 288_A 1.319 0.99
81_S 84_V 1.318 0.99
252_I 256_S 1.314 0.99
200_F 204_R 1.29 0.99
123_V 127_L 1.289 0.99
143_L 159_W 1.289 0.99
305_V 308_W 1.283 0.99
90_D 380_A 1.281 0.99
402_K 406_T 1.268 0.99
278_S 285_L 1.262 0.99
332_S 357_F 1.254 0.99
106_G 195_I 1.253 0.99
265_V 420_A 1.251 0.99
267_A 393_A 1.249 0.99
96_Y 99_G 1.242 0.98
72_T 394_S 1.238 0.98
172_I 293_T 1.234 0.98
330_L 417_S 1.227 0.98
92_S 96_Y 1.223 0.98
327_A 331_L 1.222 0.98
144_T 152_R 1.221 0.98
57_L 67_I 1.219 0.98
101_G 131_F 1.215 0.98
113_G 184_R 1.215 0.98
337_W 414_V 1.214 0.98
84_V 87_I 1.209 0.98
43_Y 163_H 1.209 0.98
96_Y 207_D 1.206 0.98
185_A 188_M 1.199 0.98
330_L 334_G 1.194 0.98
276_Y 281_L 1.192 0.98
345_V 348_A 1.191 0.98
334_G 417_S 1.188 0.98
315_N 318_R 1.185 0.98
145_A 378_A 1.185 0.98
302_G 305_V 1.184 0.98
201_L 205_L 1.181 0.98
64_R 405_D 1.173 0.98
418_I 422_I 1.17 0.97
52_A 178_A 1.164 0.97
38_G 135_G 1.161 0.97
89_S 94_A 1.155 0.97
177_A 185_A 1.151 0.97
237_T 240_E 1.15 0.97
44_F 170_I 1.147 0.97
192_C 196_V 1.145 0.97
295_F 355_G 1.144 0.97
97_F 100_I 1.139 0.97
326_A 423_S 1.138 0.97
392_G 396_A 1.131 0.97
403_V 407_W 1.131 0.97
79_G 387_L 1.129 0.97
74_F 78_Y 1.127 0.97
411_G 414_V 1.127 0.97
179_L 286_V 1.125 0.97
213_G 216_A 1.125 0.97
102_L 198_G 1.124 0.97
55_E 59_N 1.123 0.97
324_I 328_G 1.121 0.97
111_L 120_A 1.12 0.96
172_I 176_A 1.119 0.96
77_T 129_A 1.119 0.96
107_I 111_L 1.117 0.96
90_D 94_A 1.109 0.96
277_M 283_V 1.109 0.96
142_L 205_L 1.107 0.96
69_L 73_L 1.106 0.96
407_W 411_G 1.1 0.96
74_F 132_Q 1.1 0.96
99_G 201_L 1.094 0.96
213_G 218_G 1.091 0.96
154_G 158_L 1.084 0.96
69_L 398_W 1.083 0.96
93_N 97_F 1.082 0.96
40_A 166_G 1.082 0.96
308_W 311_D 1.077 0.95
328_G 332_S 1.076 0.95
337_W 417_S 1.076 0.95
120_A 123_V 1.072 0.95
114_F 188_M 1.069 0.95
401_A 405_D 1.064 0.95
297_L 301_I 1.059 0.95
329_I 420_A 1.058 0.95
290_T 294_M 1.057 0.95
72_T 398_W 1.056 0.95
38_G 98_M 1.048 0.94
34_T 200_F 1.046 0.94
59_N 184_R 1.045 0.94
377_A 380_A 1.044 0.94
353_T 357_F 1.043 0.94
316_G 371_E 1.039 0.94
323_L 424_A 1.038 0.94
52_A 186_G 1.038 0.94
74_F 129_A 1.037 0.94
176_A 180_H 1.033 0.94
68_G 72_T 1.033 0.94
247_L 253_W 1.033 0.94
86_G 379_G 1.027 0.94
253_W 257_F 1.025 0.93
286_V 290_T 1.024 0.93
53_V 67_I 1.023 0.93
93_N 207_D 1.02 0.93
219_E 222_H 1.014 0.93
410_S 414_V 1.013 0.93
95_R 207_D 1.012 0.93
152_R 371_E 1.004 0.93
259_Y 385_V 1.001 0.92
330_L 420_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98411000.227Contact Map0.497
4j05A20.98411000.288Contact Map0.622
3wdoA10.89751000.293Contact Map0.641
3o7qA10.92711000.313Contact Map0.622
2gfpA20.84741000.329Contact Map0.18
2cfqA10.89981000.347Contact Map0.475
4ldsA20.93391000.356Contact Map0.63
4gc0A10.94761000.362Contact Map0.709
2xutA30.95671000.373Contact Map0.53
4jr9A10.92261000.378Contact Map0.62
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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