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OPENSEQ.org
DGOT - D-galactonate transporter
UniProt: P0AA76 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11715
Length: 430 (406)
Sequences: 64563
Seq/Len: 159.02
DGOT
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_T 106_S 4.317 1.00
90_G 117_F 3.633 1.00
97_F 110_L 3.583 1.00
99_G 174_I 3.261 1.00
63_L 112_A 3.104 1.00
94_A 110_L 3.061 1.00
105_M 109_G 2.993 1.00
92_S 180_G 2.948 1.00
103_G 106_S 2.88 1.00
80_S 131_S 2.859 1.00
71_G 120_P 2.753 1.00
104_L 108_I 2.66 1.00
139_A 301_D 2.642 1.00
274_T 277_K 2.574 1.00
365_A 373_T 2.556 1.00
87_A 120_P 2.535 1.00
250_F 384_G 2.526 1.00
133_F 141_A 2.508 1.00
137_E 140_S 2.416 1.00
49_T 52_E 2.403 1.00
94_A 117_F 2.389 1.00
67_C 116_I 2.37 1.00
254_S 388_V 2.363 1.00
76_D 371_G 2.325 1.00
94_A 113_I 2.315 1.00
134_P 137_E 2.12 1.00
101_A 106_S 2.063 1.00
167_L 171_W 2.042 1.00
366_P 369_L 2.034 1.00
81_R 85_F 2.03 1.00
96_L 177_G 2.021 1.00
101_A 110_L 1.988 1.00
67_C 119_A 1.961 1.00
56_V 107_L 1.908 1.00
406_V 410_A 1.897 1.00
59_A 112_A 1.895 1.00
52_E 104_L 1.884 1.00
59_A 108_I 1.86 1.00
85_F 188_F 1.852 1.00
85_F 184_S 1.842 1.00
94_A 114_T 1.821 1.00
48_I 104_L 1.8 1.00
258_F 392_V 1.798 1.00
185_L 189_K 1.783 1.00
75_L 124_T 1.758 1.00
89_F 184_S 1.741 1.00
98_Q 110_L 1.719 1.00
305_R 363_S 1.712 1.00
73_W 77_R 1.711 1.00
92_S 184_S 1.706 1.00
298_W 302_L 1.703 1.00
22_F 148_G 1.68 1.00
63_L 67_C 1.667 1.00
187_W 191_Y 1.659 1.00
199_G 202_K 1.652 1.00
292_G 349_F 1.631 1.00
79_G 82_V 1.625 1.00
48_I 52_E 1.613 1.00
246_Y 380_A 1.599 1.00
288_A 345_A 1.593 1.00
297_G 301_D 1.555 1.00
98_Q 107_L 1.552 1.00
74_F 83_T 1.527 1.00
330_G 343_L 1.523 1.00
97_F 100_F 1.523 1.00
106_S 110_L 1.516 1.00
82_V 86_I 1.513 1.00
236_L 369_L 1.503 1.00
86_I 90_G 1.49 1.00
273_I 277_K 1.487 1.00
14_R 137_E 1.479 1.00
78_V 83_T 1.464 1.00
135_E 138_R 1.461 1.00
99_G 177_G 1.458 1.00
96_L 100_F 1.453 1.00
168_S 171_W 1.448 1.00
72_G 76_D 1.44 1.00
74_F 78_V 1.435 1.00
41_H 44_E 1.43 1.00
67_C 70_P 1.428 1.00
140_S 301_D 1.428 1.00
92_S 177_G 1.423 1.00
62_W 386_I 1.418 1.00
277_K 280_F 1.415 1.00
90_G 94_A 1.407 0.99
338_M 342_C 1.403 0.99
174_I 178_G 1.389 0.99
288_A 292_G 1.383 0.99
109_G 113_I 1.378 0.99
394_Y 398_G 1.363 0.99
257_W 385_G 1.338 0.99
99_G 170_H 1.322 0.99
87_A 117_F 1.315 0.99
268_T 275_A 1.304 0.99
105_M 108_I 1.295 0.99
78_V 82_V 1.294 0.99
186_I 190_V 1.292 0.99
82_V 85_F 1.289 0.99
131_S 370_I 1.288 0.99
299_V 303_L 1.288 0.99
295_L 298_W 1.281 0.99
24_T 121_A 1.274 0.99
268_T 278_A 1.271 0.99
129_V 145_Y 1.258 0.99
70_P 73_W 1.248 0.99
93_V 97_F 1.247 0.99
158_P 283_T 1.242 0.98
130_T 138_R 1.241 0.98
233_D 236_L 1.234 0.98
266_Y 271_K 1.232 0.98
329_M 409_S 1.231 0.98
171_W 174_I 1.225 0.98
327_C 343_L 1.224 0.98
163_I 171_W 1.222 0.98
38_A 164_Q 1.222 0.98
63_L 115_G 1.22 0.98
76_D 372_L 1.21 0.98
29_Y 149_Q 1.209 0.98
384_G 388_V 1.2 0.98
75_L 80_S 1.199 0.98
92_S 181_I 1.195 0.98
325_S 413_L 1.193 0.98
242_L 246_Y 1.193 0.98
304_V 307_G 1.189 0.98
50_K 397_Q 1.187 0.98
76_D 80_S 1.184 0.98
243_I 247_L 1.181 0.98
83_T 86_I 1.177 0.98
58_S 386_I 1.176 0.98
60_F 64_Y 1.175 0.98
393_G 397_Q 1.17 0.97
255_T 412_A 1.162 0.97
292_G 295_L 1.162 0.97
158_P 162_W 1.157 0.97
88_I 184_S 1.154 0.97
410_A 414_I 1.154 0.97
327_C 350_G 1.153 0.97
162_W 166_M 1.152 0.97
178_G 182_I 1.148 0.97
97_F 106_S 1.147 0.97
72_G 371_G 1.146 0.97
79_G 83_T 1.146 0.97
43_Q 53_M 1.145 0.97
399_Y 403_P 1.145 0.97
325_S 416_A 1.141 0.97
20_M 186_I 1.137 0.97
60_F 118_E 1.135 0.97
45_E 170_H 1.134 0.97
24_T 84_Y 1.134 0.97
181_I 185_L 1.131 0.97
106_S 109_G 1.129 0.97
41_H 45_E 1.128 0.97
165_E 276_L 1.126 0.97
85_F 187_W 1.121 0.97
26_V 152_G 1.119 0.96
51_A 397_Q 1.118 0.96
361_V 377_F 1.116 0.96
55_Y 390_L 1.112 0.96
240_R 244_G 1.112 0.96
138_R 363_S 1.101 0.96
287_L 291_V 1.098 0.96
338_M 341_M 1.098 0.96
30_V 156_L 1.094 0.96
65_T 379_F 1.093 0.96
249_Q 377_F 1.092 0.96
267_L 273_I 1.085 0.96
39_S 53_M 1.085 0.96
82_V 193_P 1.083 0.96
102_T 170_H 1.078 0.95
342_C 345_A 1.076 0.95
140_S 144_F 1.074 0.95
403_P 406_V 1.073 0.95
100_F 174_I 1.07 0.95
395_L 399_Y 1.069 0.95
298_W 301_D 1.067 0.95
238_F 243_I 1.062 0.95
280_F 284_V 1.055 0.95
55_Y 59_A 1.054 0.95
85_F 89_F 1.051 0.94
413_L 417_L 1.049 0.94
402_A 406_V 1.049 0.94
336_D 339_M 1.046 0.94
128_M 191_Y 1.036 0.94
38_A 172_V 1.032 0.94
58_S 390_L 1.031 0.94
316_T 319_I 1.031 0.94
140_S 298_W 1.024 0.93
215_V 218_D 1.017 0.93
251_A 415_G 1.016 0.93
60_F 115_G 1.009 0.93
246_Y 376_V 1.009 0.93
240_R 243_I 1.009 0.93
129_V 141_A 1.006 0.93
276_L 280_F 1.003 0.93
177_G 181_I 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.96051000.187Contact Map0.496
4j05A20.97441000.217Contact Map0.631
3wdoA10.90231000.226Contact Map0.646
3o7qA10.91861000.237Contact Map0.622
2gfpA20.85811000.249Contact Map0.181
2cfqA10.91161000.259Contact Map0.477
4ldsA20.95351000.271Contact Map0.629
4gc0A10.96741000.273Contact Map0.717
2xutA30.97911000.285Contact Map0.524
4jr9A10.91000.307Contact Map0.613
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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