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MDTG - Multidrug resistance protein MdtG
UniProt: P25744 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11343
Length: 408 (379)
Sequences: 65857
Seq/Len: 173.77
MDTG
Paralog alert: 0.90 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_Q 109_Q 4.072 1.00
100_L 113_L 3.444 1.00
102_G 176_F 3.208 1.00
66_F 115_A 3.017 1.00
93_G 120_L 2.938 1.00
97_V 113_L 2.877 1.00
95_G 182_L 2.833 1.00
108_W 112_I 2.718 1.00
106_N 109_Q 2.688 1.00
340_S 348_I 2.653 1.00
83_R 133_T 2.635 1.00
135_V 143_A 2.628 1.00
107_I 111_L 2.427 1.00
141_G 283_D 2.387 1.00
139_K 142_W 2.366 1.00
70_A 119_L 2.296 1.00
97_V 116_L 2.207 1.00
304_P 317_L 2.182 1.00
136_P 139_K 2.173 1.00
79_D 346_G 2.162 1.00
229_L 359_G 2.161 1.00
47_T 50_S 2.155 1.00
297_F 324_A 2.143 1.00
84_K 88_L 2.107 1.00
270_A 319_F 2.103 1.00
274_S 323_A 2.074 1.00
253_V 259_I 2.054 1.00
233_V 363_G 2.047 1.00
104_A 109_Q 2.005 1.00
169_Y 173_P 1.996 1.00
287_P 338_Y 1.962 1.00
99_V 179_A 1.953 1.00
97_V 120_L 1.924 1.00
341_S 344_I 1.89 1.00
301_L 317_L 1.849 1.00
104_A 113_L 1.834 1.00
88_L 190_L 1.808 1.00
88_L 186_F 1.783 1.00
46_V 107_I 1.782 1.00
78_A 126_N 1.762 1.00
95_G 186_F 1.754 1.00
187_F 191_F 1.734 1.00
101_M 113_L 1.721 1.00
97_V 117_L 1.702 1.00
76_G 80_R 1.683 1.00
286_G 289_K 1.677 1.00
312_L 316_I 1.675 1.00
299_V 391_A 1.666 1.00
20_W 150_G 1.657 1.00
66_F 70_A 1.641 1.00
82_G 85_L 1.634 1.00
237_S 367_G 1.628 1.00
62_I 111_L 1.611 1.00
92_L 186_F 1.609 1.00
381_L 385_G 1.593 1.00
62_I 115_A 1.577 1.00
101_M 110_F 1.575 1.00
301_L 324_A 1.573 1.00
50_S 107_I 1.57 1.00
212_V 216_K 1.564 1.00
95_G 179_A 1.562 1.00
280_K 284_R 1.552 1.00
294_A 327_A 1.544 1.00
46_V 50_S 1.529 1.00
176_F 180_S 1.478 1.00
102_G 179_A 1.473 1.00
299_V 388_L 1.47 1.00
59_V 110_F 1.47 1.00
270_A 274_S 1.454 1.00
137_R 140_S 1.445 1.00
109_Q 113_L 1.436 1.00
85_L 89_R 1.433 1.00
77_L 81_K 1.43 1.00
213_T 216_K 1.421 1.00
39_L 42_E 1.418 1.00
77_L 86_M 1.402 0.99
142_W 283_D 1.384 0.99
89_R 93_G 1.374 0.99
93_G 97_V 1.372 0.99
99_V 103_L 1.367 0.99
65_L 361_V 1.363 0.99
279_G 283_D 1.358 0.99
81_K 86_M 1.356 0.99
70_A 73_F 1.356 0.99
252_N 259_I 1.339 0.99
108_W 111_L 1.337 0.99
75_G 79_D 1.334 0.99
188_V 192_C 1.333 0.99
267_P 322_G 1.305 0.99
170_G 173_P 1.301 0.99
100_L 103_L 1.291 0.99
259_I 262_M 1.287 0.99
277_R 280_K 1.287 0.99
288_E 292_I 1.282 0.99
306_S 381_L 1.275 0.99
90_S 120_L 1.275 0.99
132_A 140_S 1.272 0.99
131_I 147_L 1.272 0.99
73_F 76_G 1.261 0.99
85_L 88_L 1.26 0.99
281_L 285_I 1.259 0.99
55_W 58_I 1.258 0.99
167_D 258_F 1.256 0.99
303_I 384_A 1.251 0.99
296_I 391_A 1.249 0.99
95_G 183_I 1.248 0.99
81_K 85_L 1.242 0.98
299_V 303_I 1.234 0.98
112_I 116_L 1.234 0.98
58_I 62_I 1.233 0.98
173_P 176_F 1.226 0.98
70_A 122_G 1.224 0.98
27_G 151_G 1.223 0.98
296_I 300_L 1.215 0.98
36_F 166_A 1.215 0.98
79_D 347_R 1.211 0.98
369_A 373_N 1.208 0.98
274_S 277_R 1.208 0.98
310_T 313_Q 1.206 0.98
218_P 221_V 1.198 0.98
247_R 260_S 1.196 0.98
289_K 292_I 1.194 0.98
301_L 320_L 1.19 0.98
160_M 265_S 1.182 0.98
292_I 391_A 1.175 0.98
165_L 173_P 1.171 0.98
85_L 195_E 1.17 0.97
130_L 193_I 1.16 0.97
301_L 321_L 1.158 0.97
370_I 374_Y 1.157 0.97
278_L 327_A 1.157 0.97
312_L 315_G 1.156 0.97
61_S 361_V 1.153 0.97
100_L 109_Q 1.144 0.97
336_L 352_N 1.141 0.97
102_G 172_R 1.136 0.97
96_I 100_L 1.134 0.97
133_T 345_A 1.132 0.97
189_T 193_I 1.132 0.97
294_A 324_A 1.132 0.97
86_M 89_R 1.127 0.97
289_K 293_T 1.125 0.97
68_A 354_S 1.122 0.97
374_Y 378_A 1.12 0.96
66_F 118_G 1.116 0.96
245_Y 250_A 1.113 0.96
368_A 372_A 1.105 0.96
359_G 363_G 1.103 0.96
306_S 384_A 1.101 0.96
78_A 83_R 1.099 0.96
39_L 43_Q 1.098 0.96
299_V 384_A 1.097 0.96
82_G 86_M 1.096 0.96
180_S 184_L 1.095 0.96
164_L 168_S 1.095 0.96
344_I 347_R 1.092 0.96
160_M 164_L 1.086 0.96
253_V 258_F 1.085 0.96
293_T 297_F 1.083 0.96
91_A 186_F 1.081 0.95
79_D 83_R 1.079 0.95
269_V 273_L 1.076 0.95
385_G 389_F 1.074 0.95
280_K 283_D 1.068 0.95
294_A 328_L 1.067 0.95
29_A 32_L 1.062 0.95
142_W 146_T 1.06 0.95
303_I 307_Y 1.053 0.95
90_S 122_G 1.052 0.95
48_G 372_A 1.052 0.95
103_L 176_F 1.052 0.95
109_Q 112_I 1.049 0.94
183_I 187_F 1.049 0.94
75_G 346_G 1.041 0.94
142_W 280_K 1.039 0.94
41_V 46_V 1.032 0.94
297_F 301_L 1.032 0.94
140_S 338_Y 1.032 0.94
316_I 320_L 1.03 0.94
28_A 158_G 1.029 0.94
262_M 266_V 1.026 0.94
22_G 123_F 1.021 0.93
24_F 154_G 1.02 0.93
236_G 360_N 1.019 0.93
215_L 221_V 1.019 0.93
285_I 290_I 1.018 0.93
246_V 252_N 1.013 0.93
231_I 328_L 1.008 0.93
230_I 390_N 1.006 0.93
61_S 365_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.9731000.203Contact Map0.477
3wdoA10.96321000.216Contact Map0.656
3o7qA10.95831000.24Contact Map0.656
2gfpA20.90931000.245Contact Map0.173
4j05A20.97791000.246Contact Map0.627
2cfqA10.95341000.252Contact Map0.506
2xutA30.97791000.275Contact Map0.517
4ldsA20.95831000.288Contact Map0.633
4gc0A10.98281000.299Contact Map0.726
4apsA20.97551000.301Contact Map0.535
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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