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OPENSEQ.org
AMPG - Protein AmpG
UniProt: P0AE16 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12183
Length: 491 (395)
Sequences: 20119
Seq/Len: 50.93
AMPG
Paralog alert: 0.85 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_T 109_W 4.403 1.00
108_R 112_A 3.742 1.00
99_G 178_W 3.708 1.00
90_L 120_C 3.354 1.00
97_A 113_L 3.228 1.00
298_L 329_C 2.756 1.00
142_G 284_Q 2.605 1.00
345_C 353_Q 2.597 1.00
106_Q 109_W 2.59 1.00
70_D 351_A 2.524 1.00
58_A 115_V 2.494 1.00
136_L 144_G 2.49 1.00
216_R 220_G 2.461 1.00
288_L 343_T 2.428 1.00
94_A 113_L 2.42 1.00
92_L 184_L 2.405 1.00
386_L 390_A 2.266 1.00
79_R 134_D 2.257 1.00
65_W 123_S 2.257 1.00
256_D 259_E 2.208 1.00
107_L 111_A 2.207 1.00
302_S 322_A 2.185 1.00
275_G 328_L 2.156 1.00
232_V 364_G 2.152 1.00
137_P 140_E 2.111 1.00
96_A 181_A 2.107 1.00
297_I 396_L 2.078 1.00
346_N 349_F 2.044 1.00
300_G 396_L 2.041 1.00
300_G 393_V 2.024 1.00
45_D 48_T 2.019 1.00
140_E 143_A 1.929 1.00
54_L 115_V 1.919 1.00
94_A 120_C 1.919 1.00
305_G 322_A 1.915 1.00
281_I 285_R 1.914 1.00
271_A 324_F 1.903 1.00
69_M 127_V 1.893 1.00
302_S 329_C 1.871 1.00
317_Y 321_A 1.846 1.00
293_L 396_L 1.83 1.00
87_T 123_S 1.81 1.00
101_L 113_L 1.792 1.00
171_L 175_G 1.79 1.00
287_S 290_R 1.77 1.00
67_P 71_R 1.751 1.00
390_A 394_P 1.723 1.00
374_W 378_A 1.721 1.00
239_A 365_R 1.689 1.00
94_A 117_I 1.669 1.00
101_L 109_W 1.666 1.00
94_A 116_V 1.634 1.00
57_Q 366_V 1.628 1.00
54_L 111_A 1.621 1.00
68_L 82_G 1.616 1.00
217_D 348_S 1.601 1.00
96_A 100_F 1.599 1.00
89_I 93_V 1.569 1.00
52_F 110_M 1.563 1.00
97_A 100_F 1.529 1.00
387_F 391_A 1.512 1.00
78_G 196_E 1.511 1.00
99_G 181_A 1.503 1.00
68_L 72_Y 1.502 1.00
304_A 389_V 1.489 1.00
375_F 379_H 1.477 1.00
18_L 151_G 1.465 1.00
295_F 333_G 1.463 1.00
268_G 327_N 1.451 1.00
89_I 188_I 1.45 1.00
393_V 397_I 1.441 1.00
300_G 392_A 1.43 1.00
296_G 395_G 1.42 1.00
22_F 158_V 1.416 1.00
37_A 40_T 1.412 1.00
297_I 301_A 1.412 1.00
92_L 188_I 1.408 1.00
98_M 113_L 1.407 0.99
217_D 220_G 1.405 0.99
46_L 377_E 1.397 0.99
300_G 304_A 1.385 0.99
48_T 107_L 1.38 0.99
277_L 281_I 1.374 0.99
84_L 191_T 1.37 0.99
385_Y 389_V 1.368 0.99
79_R 196_E 1.359 0.99
189_I 193_L 1.355 0.99
290_R 294_I 1.355 0.99
78_G 81_R 1.354 0.99
222_N 225_W 1.352 0.99
70_D 352_T 1.347 0.99
289_F 293_L 1.346 0.99
90_L 94_A 1.343 0.99
189_I 192_L 1.339 0.99
172_G 175_G 1.336 0.99
66_S 351_A 1.332 0.99
278_Y 281_I 1.322 0.99
178_W 182_A 1.32 0.99
132_K 144_G 1.309 0.99
250_I 257_A 1.306 0.99
84_L 188_I 1.301 0.99
112_A 116_V 1.286 0.99
293_L 400_L 1.282 0.99
72_Y 81_R 1.279 0.99
53_S 366_V 1.279 0.99
280_G 284_Q 1.279 0.99
387_F 390_A 1.279 0.99
131_W 194_A 1.276 0.99
237_G 392_A 1.273 0.99
72_Y 82_G 1.268 0.99
295_F 332_M 1.267 0.99
109_W 113_L 1.265 0.99
300_G 389_V 1.262 0.99
236_L 368_V 1.259 0.99
307_W 386_L 1.254 0.99
134_D 350_S 1.243 0.98
166_L 175_G 1.239 0.98
51_F 370_P 1.238 0.98
185_I 189_I 1.224 0.98
66_S 70_D 1.213 0.98
44_I 48_T 1.21 0.98
81_R 196_E 1.203 0.98
382_S 386_L 1.193 0.98
80_R 84_L 1.183 0.98
317_Y 320_G 1.182 0.98
259_E 262_V 1.182 0.98
33_G 163_A 1.181 0.98
240_F 372_A 1.176 0.98
286_L 291_A 1.173 0.98
294_I 298_L 1.171 0.98
397_I 401_V 1.17 0.97
222_N 226_L 1.166 0.97
383_T 386_L 1.162 0.97
315_H 318_S 1.158 0.97
304_A 308_L 1.156 0.97
58_A 118_A 1.155 0.97
271_A 275_G 1.155 0.97
26_L 159_S 1.147 0.97
282_L 286_L 1.144 0.97
109_W 112_A 1.142 0.97
301_A 305_G 1.138 0.97
379_H 383_T 1.136 0.97
321_A 325_F 1.131 0.97
255_F 259_E 1.127 0.97
101_L 105_T 1.127 0.97
79_R 130_A 1.127 0.97
217_D 349_F 1.124 0.97
161_G 165_W 1.123 0.97
50_G 373_G 1.12 0.96
70_D 79_R 1.119 0.96
236_L 391_A 1.113 0.96
383_T 387_F 1.113 0.96
52_F 107_L 1.109 0.96
293_L 297_I 1.108 0.96
143_A 284_Q 1.103 0.96
48_T 111_A 1.101 0.96
225_W 229_L 1.099 0.96
340_L 402_C 1.096 0.96
274_V 278_Y 1.092 0.96
132_K 148_S 1.087 0.96
145_A 339_A 1.086 0.96
162_L 165_W 1.084 0.96
302_S 325_F 1.083 0.96
98_M 110_M 1.083 0.96
61_F 122_A 1.081 0.95
22_F 155_G 1.079 0.95
290_R 293_L 1.078 0.95
34_T 177_Y 1.076 0.95
101_L 106_Q 1.073 0.95
229_L 398_L 1.071 0.95
142_G 283_M 1.067 0.95
295_F 329_C 1.065 0.95
367_Y 371_V 1.059 0.95
142_G 280_G 1.056 0.95
25_G 152_Y 1.055 0.95
299_Q 392_A 1.054 0.95
161_G 266_T 1.054 0.95
214_P 217_D 1.052 0.95
282_L 291_A 1.051 0.94
55_V 114_A 1.051 0.94
20_L 83_W 1.051 0.94
339_A 343_T 1.048 0.94
373_G 377_E 1.048 0.94
298_L 302_S 1.045 0.94
386_L 389_V 1.044 0.94
233_L 395_G 1.043 0.94
44_I 107_L 1.042 0.94
92_L 181_A 1.041 0.94
230_L 399_L 1.04 0.94
371_V 374_W 1.039 0.94
240_F 388_S 1.038 0.94
318_S 321_A 1.038 0.94
283_M 336_A 1.038 0.94
81_R 84_L 1.037 0.94
175_G 178_W 1.034 0.94
22_F 151_G 1.033 0.94
47_K 377_E 1.032 0.94
23_A 27_P 1.032 0.94
108_R 111_A 1.031 0.94
12_P 16_I 1.026 0.94
138_A 141_R 1.024 0.93
60_V 359_A 1.02 0.93
69_M 79_R 1.019 0.93
100_F 178_W 1.015 0.93
182_A 186_P 1.015 0.93
219_F 225_W 1.014 0.93
141_R 343_T 1.009 0.93
26_L 180_M 1.009 0.93
305_G 308_L 1.004 0.93
270_L 274_V 1.003 0.93
248_F 252_G 1.003 0.93
294_I 297_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.82281000.507Contact Map0.472
4j05A20.84931000.52Contact Map0.654
3wdoA10.88191000.528Contact Map0.617
3o7qA10.79021000.533Contact Map0.623
2gfpA20.75561000.534Contact Map0.149
2cfqA10.81261000.54Contact Map0.506
4gc0A10.85131000.545Contact Map0.733
2xutA30.83911000.556Contact Map0.51
4ldsA20.8331000.556Contact Map0.64
4apsA20.8331000.573Contact Map0.494
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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