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OPENSEQ.org
DTPA - Dipeptide and tripeptide permease A
UniProt: P77304 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13939
Length: 500 (447)
Sequences: 35030
Seq/Len: 78.37
DTPA
Paralog alert: 0.84 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_G 114_I 5.388 1.00
113_G 117_M 3.758 1.00
106_A 184_A 3.729 1.00
97_V 125_G 3.599 1.00
104_L 118_G 3.4 1.00
99_A 190_L 3.387 1.00
214_E 217_N 3.292 1.00
411_V 419_I 2.971 1.00
111_D 114_I 2.891 1.00
87_T 139_T 2.881 1.00
69_L 120_A 2.752 1.00
220_N 223_L 2.707 1.00
144_N 147_R 2.632 1.00
55_S 58_D 2.603 1.00
101_G 118_G 2.597 1.00
366_I 388_S 2.449 1.00
94_G 128_L 2.421 1.00
361_S 469_A 2.344 1.00
101_G 121_A 2.338 1.00
217_N 220_N 2.322 1.00
65_S 120_A 2.304 1.00
77_G 128_L 2.286 1.00
112_A 116_Y 2.241 1.00
101_G 125_G 2.22 1.00
332_G 394_I 2.198 1.00
92_M 194_I 2.163 1.00
359_M 395_G 2.147 1.00
462_L 466_V 2.132 1.00
92_M 198_A 2.108 1.00
82_D 417_G 2.105 1.00
108_S 114_I 2.092 1.00
141_Y 151_A 2.042 1.00
412_P 415_L 2.036 1.00
310_S 317_E 2.033 1.00
195_V 199_F 2.032 1.00
358_V 472_A 1.991 1.00
363_A 395_G 1.983 1.00
361_S 472_A 1.98 1.00
328_W 390_G 1.98 1.00
149_D 341_N 1.973 1.00
147_R 150_G 1.969 1.00
103_A 107_W 1.961 1.00
365_L 465_G 1.953 1.00
177_Y 181_V 1.952 1.00
363_A 388_S 1.93 1.00
142_E 147_R 1.921 1.00
73_L 124_V 1.9 1.00
286_I 430_A 1.888 1.00
368_P 462_L 1.839 1.00
105_V 118_G 1.828 1.00
99_A 194_I 1.788 1.00
108_S 118_G 1.774 1.00
96_I 194_I 1.76 1.00
290_V 434_G 1.757 1.00
103_A 187_V 1.746 1.00
354_A 472_A 1.744 1.00
114_I 118_G 1.741 1.00
383_S 387_A 1.721 1.00
80_L 90_V 1.7 1.00
65_S 116_Y 1.697 1.00
79_W 83_K 1.696 1.00
88_K 92_M 1.692 1.00
356_G 398_M 1.689 1.00
54_M 112_A 1.626 1.00
62_L 115_V 1.617 1.00
361_S 365_L 1.587 1.00
73_L 127_G 1.574 1.00
68_A 432_L 1.554 1.00
101_G 122_I 1.548 1.00
54_M 58_D 1.546 1.00
361_S 465_G 1.528 1.00
86_G 89_R 1.522 1.00
81_G 132_N 1.519 1.00
173_L 181_V 1.516 1.00
317_E 320_Q 1.513 1.00
27_F 158_S 1.51 1.00
337_A 341_N 1.507 1.00
338_A 342_K 1.495 1.00
234_I 237_W 1.494 1.00
178_G 181_V 1.484 1.00
58_D 112_A 1.475 1.00
89_R 93_L 1.458 1.00
466_V 470_V 1.447 1.00
31_L 162_G 1.418 1.00
294_Q 438_A 1.4 0.99
328_W 332_G 1.391 0.99
97_V 101_G 1.384 0.99
169_A 172_W 1.379 0.99
105_V 115_V 1.373 0.99
358_V 362_G 1.37 0.99
197_F 201_Q 1.367 0.99
363_A 392_Q 1.36 0.99
99_A 187_V 1.355 0.99
73_L 76_I 1.34 0.99
351_T 355_I 1.339 0.99
93_L 97_V 1.338 0.99
92_M 197_F 1.328 0.99
175_A 316_V 1.326 0.99
274_K 277_V 1.317 0.99
356_G 399_I 1.309 0.99
104_L 107_W 1.308 0.99
104_L 114_I 1.306 0.99
69_L 123_A 1.303 0.99
117_M 121_A 1.299 0.99
34_R 159_V 1.296 0.99
143_K 148_L 1.295 0.99
354_A 476_L 1.289 0.99
191_L 195_V 1.282 0.99
29_I 91_I 1.275 0.99
81_G 87_T 1.274 0.99
89_R 92_M 1.273 0.99
78_G 417_G 1.269 0.99
269_G 272_R 1.256 0.99
368_P 465_G 1.256 0.99
80_L 84_V 1.255 0.99
291_L 468_T 1.251 0.99
381_S 384_W 1.249 0.99
84_V 90_V 1.231 0.98
430_A 434_G 1.23 0.98
39_G 182_A 1.226 0.98
304_I 318_P 1.225 0.98
302_F 307_V 1.223 0.98
82_D 87_T 1.222 0.98
293_S 431_N 1.218 0.98
114_I 117_M 1.21 0.98
168_I 323_A 1.204 0.98
335_I 338_A 1.203 0.98
100_I 104_L 1.201 0.98
441_M 445_D 1.194 0.98
253_A 257_V 1.194 0.98
82_D 418_F 1.192 0.98
282_M 426_T 1.178 0.98
106_A 180_S 1.167 0.97
36_G 186_S 1.164 0.97
46_V 50_K 1.16 0.97
106_A 187_V 1.156 0.97
458_G 462_L 1.152 0.97
287_I 471_I 1.145 0.97
113_G 116_Y 1.145 0.97
139_T 416_M 1.141 0.97
107_W 184_A 1.141 0.97
271_A 275_M 1.14 0.97
362_G 366_I 1.139 0.97
282_M 422_S 1.138 0.97
66_F 126_N 1.138 0.97
351_T 354_A 1.138 0.97
95_A 194_I 1.137 0.97
355_I 359_M 1.131 0.97
459_R 463_Q 1.129 0.97
283_L 287_I 1.128 0.97
138_S 148_L 1.126 0.97
215_P 219_R 1.123 0.97
363_A 391_L 1.119 0.96
219_R 223_L 1.107 0.96
105_V 183_F 1.106 0.96
43_I 174_A 1.105 0.96
71_Y 425_L 1.102 0.96
365_L 369_L 1.102 0.96
78_G 82_D 1.099 0.96
92_M 96_I 1.098 0.96
310_S 315_A 1.098 0.96
440_M 444_P 1.096 0.96
437_V 440_M 1.095 0.96
469_A 473_V 1.094 0.96
107_W 114_I 1.091 0.96
223_L 226_I 1.09 0.96
99_A 191_L 1.088 0.96
49_V 59_S 1.083 0.96
325_N 393_S 1.082 0.96
463_Q 466_V 1.082 0.96
90_V 93_L 1.08 0.95
43_I 182_A 1.078 0.95
91_I 136_L 1.078 0.95
194_I 198_A 1.073 0.95
361_S 468_T 1.07 0.95
354_A 358_V 1.067 0.95
309_H 317_E 1.067 0.95
387_A 391_L 1.061 0.95
69_L 73_L 1.059 0.95
31_L 158_S 1.055 0.95
339_I 343_M 1.049 0.94
202_R 206_Q 1.047 0.94
473_V 477_L 1.047 0.94
348_P 351_T 1.046 0.94
445_D 463_Q 1.045 0.94
137_L 151_A 1.044 0.94
284_E 287_I 1.042 0.94
383_S 386_V 1.041 0.94
88_K 198_A 1.037 0.94
64_S 432_L 1.037 0.94
459_R 462_L 1.036 0.94
201_Q 204_V 1.034 0.94
271_A 274_K 1.031 0.94
230_A 257_V 1.03 0.94
62_L 112_A 1.03 0.94
84_V 89_R 1.029 0.94
357_M 471_I 1.024 0.93
102_Y 186_S 1.021 0.93
334_P 338_A 1.021 0.93
36_G 39_G 1.016 0.93
304_I 315_A 1.016 0.93
384_W 387_A 1.016 0.93
247_M 251_V 1.014 0.93
71_Y 432_L 1.014 0.93
150_G 341_N 1.014 0.93
360_C 468_T 1.008 0.93
95_A 193_T 1.008 0.93
160_N 329_I 1.007 0.93
340_Y 402_L 1.006 0.93
109_G 180_S 1.005 0.93
465_G 469_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.8661000.325Contact Map0.525
4j05A20.9341000.338Contact Map0.656
3wdoA10.8121000.348Contact Map0.692
4lepA20.9721000.351Contact Map0.654
4gc0A10.8981000.356Contact Map0.73
4ldsA20.8781000.364Contact Map0.692
2xutA30.961000.368Contact Map0.556
4apsA20.9461000.376Contact Map0.575
3o7qA10.8061000.377Contact Map0.649
2cfqA10.8081000.379Contact Map0.516
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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