May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YQCE - Inner membrane protein YqcE
UniProt: P77031 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13174
Length: 425 (386)
Sequences: 62901
Seq/Len: 162.96
YQCE
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_P 100_V 4.124 1.00
84_I 111_T 3.497 1.00
91_L 104_I 3.457 1.00
93_A 175_I 3.23 1.00
86_G 181_Y 2.958 1.00
57_A 106_I 2.957 1.00
99_W 103_C 2.929 1.00
88_L 104_I 2.912 1.00
97_P 100_V 2.785 1.00
74_H 126_L 2.706 1.00
65_S 114_L 2.617 1.00
98_L 102_L 2.542 1.00
254_S 257_A 2.52 1.00
134_G 282_T 2.422 1.00
128_G 136_I 2.416 1.00
347_T 355_T 2.383 1.00
43_S 46_E 2.328 1.00
88_L 111_T 2.315 1.00
132_E 135_K 2.299 1.00
81_A 114_L 2.289 1.00
61_L 110_I 2.276 1.00
88_L 107_A 2.247 1.00
306_A 323_L 2.241 1.00
231_F 366_P 2.206 1.00
215_L 219_R 2.192 1.00
70_D 353_G 2.169 1.00
129_D 132_E 2.115 1.00
269_F 325_L 2.108 1.00
235_T 370_V 2.073 1.00
168_T 172_T 2.014 1.00
79_T 185_G 1.985 1.00
75_R 79_T 1.982 1.00
299_L 330_T 1.982 1.00
348_P 351_I 1.943 1.00
95_Y 100_V 1.933 1.00
61_L 113_I 1.932 1.00
90_L 178_S 1.932 1.00
186_I 190_F 1.926 1.00
95_Y 104_I 1.921 1.00
273_C 329_F 1.919 1.00
303_T 323_L 1.864 1.00
86_G 185_G 1.835 1.00
50_I 101_M 1.831 1.00
53_T 106_I 1.824 1.00
46_E 98_L 1.82 1.00
53_T 102_L 1.775 1.00
42_F 98_L 1.76 1.00
83_I 185_G 1.753 1.00
79_T 189_W 1.752 1.00
296_L 333_A 1.748 1.00
88_L 108_F 1.747 1.00
92_M 104_I 1.69 1.00
288_S 344_E 1.683 1.00
67_V 71_K 1.683 1.00
69_A 119_V 1.676 1.00
303_T 330_T 1.649 1.00
279_I 285_K 1.604 1.00
73_S 76_K 1.599 1.00
301_L 397_A 1.58 1.00
57_A 61_L 1.561 1.00
287_K 291_R 1.54 1.00
68_I 77_M 1.519 1.00
253_M 257_A 1.517 1.00
42_F 46_E 1.501 1.00
216_A 219_R 1.5 1.00
301_L 400_M 1.498 1.00
92_M 101_M 1.486 1.00
91_L 94_T 1.476 1.00
72_F 77_M 1.462 1.00
100_V 104_I 1.459 1.00
216_A 351_I 1.456 1.00
227_S 362_I 1.443 1.00
35_P 38_K 1.442 1.00
76_K 80_S 1.437 1.00
175_I 179_V 1.43 1.00
93_A 178_S 1.416 1.00
318_A 322_G 1.416 1.00
282_T 285_K 1.414 1.00
298_V 400_M 1.405 0.99
80_S 84_I 1.404 0.99
130_H 133_Q 1.397 0.99
291_R 295_I 1.393 0.99
257_A 260_Y 1.393 0.99
68_I 72_F 1.386 0.99
86_G 178_S 1.385 0.99
151_L 155_T 1.382 0.99
90_L 94_T 1.373 0.99
278_G 282_T 1.371 0.99
269_F 273_C 1.371 0.99
187_L 191_F 1.369 0.99
376_H 380_T 1.365 0.99
84_I 88_L 1.361 0.99
301_L 305_T 1.345 0.99
135_K 282_T 1.343 0.99
66_G 70_D 1.334 0.99
8_R 132_E 1.323 0.99
248_T 258_A 1.321 0.99
169_S 172_T 1.319 0.99
56_I 368_V 1.317 0.99
248_T 255_L 1.314 0.99
103_C 107_A 1.314 0.99
81_A 111_T 1.309 0.99
280_I 286_V 1.295 0.99
266_N 328_G 1.291 0.99
276_L 279_I 1.279 0.99
76_K 79_T 1.273 0.99
61_L 64_P 1.273 0.99
381_L 386_A 1.262 0.99
99_W 102_L 1.26 0.99
298_V 302_L 1.255 0.99
72_F 76_K 1.251 0.99
291_R 294_Q 1.243 0.98
70_D 354_T 1.241 0.98
57_A 109_A 1.239 0.98
93_A 171_K 1.235 0.98
294_Q 400_M 1.232 0.98
124_A 140_M 1.227 0.98
86_G 182_I 1.219 0.98
246_Y 251_Y 1.219 0.98
295_I 299_L 1.205 0.98
16_S 143_L 1.192 0.98
44_N 379_D 1.183 0.98
188_C 192_V 1.183 0.98
125_S 133_Q 1.181 0.98
303_T 327_L 1.177 0.98
76_K 194_D 1.176 0.98
87_L 91_L 1.172 0.98
32_Y 159_F 1.169 0.97
123_A 192_V 1.168 0.97
126_L 352_M 1.164 0.97
64_P 67_V 1.157 0.97
25_L 29_R 1.157 0.97
77_M 80_S 1.15 0.97
35_P 39_F 1.144 0.97
389_N 392_L 1.143 0.97
342_P 359_C 1.141 0.97
52_S 368_V 1.14 0.97
260_Y 264_V 1.139 0.97
366_P 370_V 1.135 0.97
37_A 47_I 1.134 0.97
91_L 100_V 1.133 0.97
153_V 157_W 1.131 0.97
289_P 294_Q 1.127 0.97
179_V 183_L 1.127 0.97
210_Q 213_D 1.118 0.96
273_C 276_L 1.115 0.96
277_G 333_A 1.113 0.96
377_W 381_L 1.112 0.96
66_G 353_G 1.106 0.96
100_V 103_C 1.104 0.96
49_L 372_P 1.104 0.96
158_V 172_T 1.102 0.96
223_T 227_S 1.102 0.96
172_T 175_I 1.101 0.96
54_F 112_T 1.097 0.96
54_F 58_A 1.094 0.96
303_T 326_L 1.091 0.96
218_L 224_W 1.091 0.96
391_W 395_M 1.088 0.96
305_T 309_V 1.085 0.96
69_A 74_H 1.08 0.95
279_I 282_T 1.077 0.95
296_L 330_T 1.076 0.95
79_T 188_C 1.071 0.95
45_T 379_D 1.065 0.95
322_G 326_L 1.062 0.95
73_S 77_M 1.062 0.95
224_W 228_M 1.062 0.95
135_K 139_W 1.061 0.95
147_G 151_L 1.06 0.95
79_T 83_I 1.058 0.95
49_L 53_T 1.057 0.95
39_F 171_K 1.056 0.95
94_T 175_I 1.053 0.95
59_I 361_V 1.052 0.95
308_L 392_L 1.051 0.94
82_M 185_G 1.051 0.94
280_I 292_V 1.048 0.94
305_T 395_M 1.048 0.94
73_S 194_D 1.044 0.94
268_I 272_L 1.042 0.94
96_P 171_K 1.04 0.94
375_G 379_D 1.035 0.94
25_L 28_L 1.028 0.94
256_V 260_Y 1.027 0.94
340_A 344_E 1.026 0.94
302_L 306_A 1.025 0.93
247_L 253_M 1.024 0.93
39_F 170_L 1.023 0.93
322_G 325_L 1.02 0.93
230_I 359_C 1.016 0.93
133_Q 344_E 1.016 0.93
178_S 182_I 1.011 0.93
221_S 224_W 1.009 0.93
70_D 74_H 1.006 0.93
388_R 392_L 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.95061000.125Contact Map0.501
3wdoA10.93881000.147Contact Map0.642
4j05A20.96711000.171Contact Map0.611
2gfpA20.87291000.188Contact Map0.186
3o7qA10.92471000.19Contact Map0.635
2cfqA10.93411000.196Contact Map0.481
2xutA30.96241000.226Contact Map0.524
4ldsA20.94821000.232Contact Map0.633
4gc0A10.96471000.244Contact Map0.72
4apsA20.95761000.259Contact Map0.536
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0251 seconds.