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OPENSEQ.org
YAGG - Uncharacterized symporter YagG
UniProt: P75683 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13346
Length: 460 (406)
Sequences: 36787
Seq/Len: 90.61
YAGG
Paralog alert: 0.90 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_P 109_Y 4.705 1.00
87_P 120_V 3.782 1.00
108_I 112_V 3.608 1.00
96_F 185_C 3.28 1.00
94_L 113_T 3.254 1.00
89_G 191_G 3.24 1.00
346_V 361_V 3.028 1.00
55_L 115_I 2.919 1.00
91_V 113_T 2.743 1.00
100_D 108_I 2.738 1.00
63_M 123_F 2.605 1.00
41_S 44_I 2.562 1.00
143_H 287_G 2.561 1.00
107_I 111_C 2.56 1.00
260_H 263_L 2.495 1.00
76_Q 134_V 2.487 1.00
100_D 109_Y 2.434 1.00
84_G 123_F 2.384 1.00
278_G 329_F 2.378 1.00
137_A 141_E 2.375 1.00
91_V 116_L 2.341 1.00
68_D 359_G 2.33 1.00
309_I 323_L 2.315 1.00
302_Y 330_V 2.284 1.00
59_T 119_L 2.265 1.00
318_A 322_A 2.249 1.00
274_A 325_I 2.244 1.00
91_V 120_V 2.237 1.00
136_T 145_L 2.205 1.00
221_K 225_G 2.171 1.00
306_S 323_L 2.144 1.00
141_E 144_A 2.142 1.00
98_T 109_Y 2.049 1.00
98_T 113_T 2.031 1.00
51_V 115_I 1.985 1.00
291_R 344_D 1.966 1.00
82_L 195_L 1.949 1.00
59_T 122_T 1.925 1.00
86_I 195_L 1.887 1.00
299_I 333_T 1.866 1.00
178_V 182_G 1.856 1.00
93_V 97_Y 1.855 1.00
347_D 357_L 1.836 1.00
44_I 107_I 1.825 1.00
137_A 140_K 1.824 1.00
196_Y 200_F 1.799 1.00
306_S 330_V 1.789 1.00
51_V 111_C 1.784 1.00
55_L 59_T 1.772 1.00
89_G 195_L 1.725 1.00
271_G 328_L 1.72 1.00
290_D 293_T 1.705 1.00
65_L 69_R 1.695 1.00
93_V 188_G 1.689 1.00
304_L 308_L 1.681 1.00
40_L 107_I 1.668 1.00
54_V 374_A 1.668 1.00
48_L 110_A 1.655 1.00
82_L 199_F 1.643 1.00
241_C 376_G 1.629 1.00
347_D 356_R 1.625 1.00
95_T 113_T 1.624 1.00
91_V 117_L 1.612 1.00
284_R 288_R 1.594 1.00
94_L 97_Y 1.591 1.00
109_Y 113_T 1.59 1.00
222_L 357_L 1.578 1.00
237_M 372_G 1.577 1.00
67_V 127_P 1.576 1.00
13_G 152_L 1.543 1.00
283_S 287_G 1.539 1.00
40_L 44_I 1.472 1.00
301_A 305_I 1.443 1.00
83_W 87_P 1.403 0.99
292_V 296_K 1.375 0.99
224_L 230_R 1.368 0.99
162_G 269_L 1.368 0.99
245_V 380_V 1.368 0.99
281_C 284_R 1.361 0.99
78_R 204_E 1.357 0.99
142_R 344_D 1.354 0.99
89_G 188_G 1.349 0.99
64_G 68_D 1.343 0.99
306_S 327_F 1.341 0.99
50_L 374_A 1.339 0.99
274_A 278_G 1.335 0.99
144_A 287_G 1.333 0.99
55_L 118_T 1.329 0.99
222_L 225_G 1.327 0.99
17_T 156_G 1.325 0.99
372_G 376_G 1.322 0.99
293_T 297_W 1.313 0.99
139_P 142_R 1.31 0.99
87_P 91_V 1.308 0.99
112_V 116_L 1.304 0.99
263_L 266_Q 1.296 0.99
108_I 111_C 1.296 0.99
253_F 258_M 1.295 0.99
217_A 221_K 1.295 0.99
57_A 367_F 1.284 0.99
90_I 94_L 1.281 0.99
109_Y 112_V 1.277 0.99
84_G 120_V 1.275 0.99
75_G 204_E 1.269 0.99
306_S 326_L 1.258 0.99
316_H 319_L 1.256 0.99
15_G 124_V 1.256 0.99
285_L 289_F 1.255 0.99
383_I 387_V 1.251 0.99
32_Y 36_D 1.249 0.99
94_L 109_Y 1.242 0.98
96_F 181_F 1.233 0.98
253_F 257_V 1.231 0.98
47_T 51_V 1.23 0.98
96_F 188_G 1.229 0.98
227_S 231_I 1.227 0.98
305_I 309_I 1.225 0.98
95_T 110_A 1.221 0.98
132_P 149_R 1.219 0.98
169_S 262_E 1.219 0.98
50_L 378_A 1.215 0.98
85_A 195_L 1.214 0.98
198_C 202_T 1.212 0.98
192_V 196_Y 1.206 0.98
227_S 230_R 1.205 0.98
382_W 386_Y 1.203 0.98
59_T 62_L 1.198 0.98
131_M 202_T 1.196 0.98
114_Y 118_T 1.193 0.98
226_N 230_R 1.192 0.98
299_I 330_V 1.19 0.98
20_G 153_A 1.188 0.98
179_G 182_G 1.187 0.98
78_R 82_L 1.185 0.98
185_C 189_L 1.185 0.98
280_L 284_R 1.184 0.98
197_V 201_T 1.178 0.98
233_C 368_S 1.174 0.98
77_F 82_L 1.173 0.98
230_R 234_A 1.165 0.97
25_A 183_A 1.164 0.97
286_L 337_L 1.163 0.97
282_S 333_T 1.162 0.97
68_D 360_L 1.158 0.97
67_V 76_Q 1.158 0.97
244_V 373_L 1.156 0.97
254_V 258_M 1.155 0.97
89_G 192_V 1.15 0.97
290_D 294_A 1.147 0.97
78_R 83_W 1.147 0.97
322_A 326_L 1.145 0.97
182_G 185_C 1.144 0.97
134_V 358_D 1.137 0.97
52_S 121_Y 1.135 0.97
56_D 370_K 1.13 0.97
304_L 416_Y 1.126 0.97
76_Q 204_E 1.125 0.97
163_I 166_P 1.123 0.97
322_A 325_I 1.123 0.97
64_G 359_G 1.115 0.96
289_F 294_A 1.115 0.96
255_K 264_A 1.114 0.96
414_V 418_G 1.11 0.96
318_A 321_F 1.108 0.96
379_V 382_W 1.106 0.96
85_A 194_L 1.105 0.96
167_L 182_G 1.096 0.96
301_A 304_L 1.093 0.96
66_L 79_P 1.092 0.96
75_G 78_R 1.09 0.96
293_T 296_K 1.086 0.96
132_P 145_L 1.084 0.96
11_G 197_V 1.078 0.95
381_G 385_A 1.077 0.95
70_T 78_R 1.077 0.95
143_H 283_S 1.074 0.95
46_G 50_L 1.072 0.95
273_L 277_F 1.071 0.95
252_Y 256_Y 1.063 0.95
44_I 111_C 1.053 0.95
319_L 322_A 1.052 0.95
189_L 193_V 1.051 0.94
66_L 70_T 1.047 0.94
431_A 435_A 1.044 0.94
284_R 287_G 1.043 0.94
133_G 142_R 1.041 0.94
266_Q 270_Y 1.041 0.94
47_T 378_A 1.039 0.94
22_V 187_L 1.039 0.94
42_A 385_A 1.035 0.94
278_G 281_C 1.035 0.94
294_A 297_W 1.027 0.94
154_A 275_T 1.025 0.93
405_K 408_F 1.023 0.93
14_L 194_L 1.021 0.93
13_G 148_W 1.02 0.93
99_P 181_F 1.02 0.93
182_G 189_L 1.016 0.93
97_Y 109_Y 1.016 0.93
182_G 186_V 1.015 0.93
342_A 365_Y 1.015 0.93
248_G 251_L 1.011 0.93
9_K 136_T 1.011 0.93
97_Y 185_C 1.01 0.93
68_D 76_Q 1.01 0.93
188_G 192_V 1.003 0.93
57_A 371_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.91000.359Contact Map0.621
1pw4A10.86741000.375Contact Map0.481
4j05A20.91521000.395Contact Map0.628
2cfqA10.87391000.402Contact Map0.505
2gfpA20.80431000.414Contact Map0.156
3o7qA10.851000.416Contact Map0.624
2xutA30.91000.42Contact Map0.51
4gc0A10.91521000.424Contact Map0.736
4ldsA20.87831000.428Contact Map0.653
4lepA20.94781000.437Contact Map0.603
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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