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YHHS - UPF0226 protein YhhS
UniProt: P37621 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12219
Length: 405 (370)
Sequences: 64719
Seq/Len: 174.92
YHHS
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
112_I 116_L 3.986 1.00
92_G 127_G 3.389 1.00
65_A 122_V 3.053 1.00
82_P 141_G 2.905 1.00
73_A 130_F 2.872 1.00
96_S 120_G 2.826 1.00
94_F 190_A 2.821 1.00
115_L 119_L 2.78 1.00
113_S 116_L 2.761 1.00
104_G 184_L 2.7 1.00
333_V 341_A 2.678 1.00
143_V 151_V 2.587 1.00
89_G 130_F 2.57 1.00
102_T 120_G 2.54 1.00
149_G 276_N 2.469 1.00
114_L 118_C 2.465 1.00
147_H 150_R 2.419 1.00
51_S 54_W 2.417 1.00
69_S 126_I 2.3 1.00
96_S 127_G 2.257 1.00
96_S 123_I 2.235 1.00
290_V 317_G 2.233 1.00
144_G 147_H 2.186 1.00
263_A 312_L 2.186 1.00
83_K 87_V 2.17 1.00
297_L 310_G 2.168 1.00
78_D 339_G 2.163 1.00
267_T 316_A 2.116 1.00
280_G 331_K 2.088 1.00
177_G 181_A 2.071 1.00
334_P 337_N 1.935 1.00
54_W 114_L 1.884 1.00
50_F 114_L 1.865 1.00
106_T 116_L 1.843 1.00
294_G 310_G 1.808 1.00
77_A 134_G 1.793 1.00
69_S 129_S 1.784 1.00
96_S 124_L 1.768 1.00
106_T 120_G 1.767 1.00
58_V 117_L 1.767 1.00
65_A 69_S 1.764 1.00
374_L 378_G 1.763 1.00
236_V 360_A 1.756 1.00
232_A 356_T 1.754 1.00
61_L 122_V 1.754 1.00
228_A 352_S 1.733 1.00
294_G 317_G 1.706 1.00
75_R 79_S 1.702 1.00
61_L 118_C 1.696 1.00
305_W 309_I 1.691 1.00
292_I 384_L 1.68 1.00
81_G 84_K 1.67 1.00
87_V 194_I 1.64 1.00
287_C 320_L 1.623 1.00
50_F 54_W 1.597 1.00
273_N 277_R 1.583 1.00
279_G 282_N 1.558 1.00
94_F 194_I 1.54 1.00
76_Y 85_I 1.52 1.00
91_C 194_I 1.508 1.00
84_K 88_F 1.484 1.00
23_V 158_V 1.467 1.00
76_Y 80_L 1.466 1.00
184_L 188_G 1.466 1.00
74_G 78_D 1.446 1.00
116_L 120_G 1.442 1.00
272_P 276_N 1.442 1.00
150_R 276_N 1.441 1.00
102_T 105_L 1.432 1.00
195_L 198_I 1.414 1.00
94_F 187_M 1.414 1.00
292_I 381_A 1.396 0.99
145_S 148_I 1.384 0.99
80_L 85_I 1.37 0.99
263_A 267_T 1.37 0.99
178_G 181_A 1.37 0.99
64_F 354_G 1.368 0.99
88_F 92_G 1.361 0.99
69_S 72_H 1.353 0.99
92_G 96_S 1.351 0.99
139_G 155_N 1.331 0.99
260_F 315_G 1.321 0.99
214_R 218_G 1.316 0.99
274_G 278_I 1.307 0.99
362_L 366_W 1.306 0.99
115_L 118_C 1.303 0.99
101_L 105_L 1.302 0.99
119_L 123_I 1.296 0.99
299_G 374_L 1.291 0.99
181_A 184_L 1.287 0.99
352_S 356_T 1.276 0.99
270_L 273_N 1.275 0.99
39_V 174_Y 1.273 0.99
282_N 285_M 1.272 0.99
80_L 84_K 1.272 0.99
106_T 112_I 1.266 0.99
84_K 87_V 1.261 0.99
72_H 75_R 1.259 0.99
224_G 348_F 1.251 0.99
140_V 148_I 1.248 0.99
141_G 338_Q 1.246 0.98
89_G 127_G 1.241 0.98
294_G 314_A 1.238 0.98
52_A 365_S 1.234 0.98
42_G 46_D 1.225 0.98
267_T 270_L 1.223 0.98
103_A 117_L 1.223 0.98
78_D 340_A 1.222 0.98
378_G 382_I 1.22 0.98
85_I 88_F 1.21 0.98
81_G 85_I 1.203 0.98
289_S 293_I 1.197 0.98
77_A 82_P 1.196 0.98
281_L 285_M 1.191 0.98
87_V 197_A 1.188 0.98
103_A 120_G 1.187 0.98
329_A 345_Y 1.184 0.98
363_V 367_A 1.175 0.98
94_F 191_L 1.174 0.98
138_W 200_R 1.17 0.97
65_A 125_G 1.168 0.97
196_L 199_P 1.166 0.97
60_S 354_G 1.166 0.97
289_S 384_L 1.165 0.97
292_I 296_L 1.162 0.97
285_M 384_L 1.161 0.97
282_N 286_I 1.161 0.97
168_P 258_T 1.16 0.97
296_L 300_V 1.158 0.97
84_K 202_T 1.157 0.97
255_F 259_L 1.154 0.97
78_D 82_P 1.148 0.97
287_C 317_G 1.144 0.97
294_G 313_L 1.14 0.97
296_L 377_A 1.139 0.97
286_I 290_V 1.138 0.97
173_F 181_A 1.135 0.97
305_W 308_K 1.127 0.97
367_A 371_V 1.118 0.96
99_G 120_G 1.114 0.96
273_N 276_N 1.112 0.96
191_L 195_L 1.111 0.96
116_L 119_L 1.11 0.96
299_G 377_A 1.108 0.96
246_D 252_G 1.105 0.96
57_L 61_L 1.104 0.96
271_F 320_L 1.103 0.96
57_L 358_P 1.097 0.96
67_L 347_V 1.09 0.96
53_F 365_S 1.089 0.96
292_I 377_A 1.088 0.96
290_V 294_G 1.088 0.96
74_G 339_G 1.087 0.96
287_C 321_V 1.085 0.96
62_Q 128_Q 1.077 0.95
337_N 340_A 1.072 0.95
188_G 192_V 1.071 0.95
214_R 217_L 1.069 0.95
105_L 184_L 1.066 0.95
168_P 172_V 1.061 0.95
371_V 374_L 1.057 0.95
121_R 125_G 1.055 0.95
148_I 331_K 1.052 0.95
150_R 154_W 1.051 0.94
361_G 365_S 1.051 0.94
172_V 176_W 1.051 0.94
262_C 266_G 1.046 0.94
309_I 313_L 1.045 0.94
90_L 194_I 1.039 0.94
25_F 131_A 1.037 0.94
101_L 187_M 1.037 0.94
30_Y 159_T 1.036 0.94
233_G 380_V 1.034 0.94
278_I 283_V 1.033 0.94
197_A 200_R 1.023 0.93
187_M 191_L 1.014 0.93
150_R 273_N 1.013 0.93
235_G 353_L 1.012 0.93
32_T 35_L 1.011 0.93
62_Q 125_G 1.01 0.93
87_V 91_C 1.007 0.93
335_Q 338_Q 1.006 0.93
266_G 270_L 1.005 0.93
264_F 319_S 1.005 0.93
163_M 261_S 1.001 0.92
375_A 379_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.97281000.219Contact Map0.491
3wdoA10.95561000.226Contact Map0.643
4j05A20.97781000.228Contact Map0.615
3o7qA10.95561000.245Contact Map0.644
2cfqA10.96791000.267Contact Map0.522
2gfpA20.89381000.267Contact Map0.169
2xutA30.96791000.269Contact Map0.538
4ldsA20.95311000.301Contact Map0.638
4gc0A10.97281000.304Contact Map0.736
4apsA20.96791000.307Contact Map0.528
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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