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YICJ - Inner membrane symporter YicJ
UniProt: P31435 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11686
Length: 460 (406)
Sequences: 38887
Seq/Len: 95.78
YICJ
Paralog alert: 0.91 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_P 111_Y 4.579 1.00
89_P 122_L 3.766 1.00
110_I 114_I 3.575 1.00
91_G 193_A 3.316 1.00
96_L 115_T 3.294 1.00
98_Y 187_A 3.288 1.00
57_L 117_T 3.09 1.00
347_V 362_S 3.086 1.00
93_V 115_T 2.941 1.00
145_I 288_D 2.782 1.00
102_D 110_I 2.67 1.00
65_M 125_V 2.61 1.00
109_M 113_A 2.547 1.00
78_K 136_V 2.49 1.00
86_G 125_V 2.433 1.00
102_D 111_Y 2.427 1.00
302_L 331_L 2.427 1.00
43_P 46_F 2.394 1.00
139_N 143_Q 2.386 1.00
93_V 118_L 2.326 1.00
70_D 360_G 2.296 1.00
279_G 330_V 2.292 1.00
309_A 324_F 2.28 1.00
275_G 326_F 2.257 1.00
222_R 226_Q 2.248 1.00
93_V 122_L 2.232 1.00
61_S 121_L 2.225 1.00
306_I 324_F 2.207 1.00
292_K 345_D 2.201 1.00
138_T 147_L 2.179 1.00
143_Q 146_S 2.166 1.00
319_I 323_V 2.158 1.00
61_S 124_T 2.04 1.00
306_I 331_L 2.021 1.00
100_T 111_Y 1.977 1.00
84_L 197_L 1.947 1.00
299_T 334_L 1.913 1.00
100_T 115_T 1.91 1.00
53_V 117_T 1.856 1.00
95_V 190_S 1.837 1.00
95_V 99_S 1.837 1.00
348_D 358_L 1.826 1.00
57_L 61_S 1.813 1.00
180_L 184_G 1.804 1.00
50_M 112_A 1.799 1.00
46_F 109_M 1.787 1.00
304_A 418_L 1.778 1.00
262_P 265_F 1.767 1.00
198_A 202_F 1.763 1.00
272_Y 329_G 1.756 1.00
238_I 373_G 1.754 1.00
91_G 197_L 1.738 1.00
67_L 71_R 1.733 1.00
53_V 113_A 1.718 1.00
88_L 197_L 1.717 1.00
284_K 288_D 1.712 1.00
139_N 142_T 1.711 1.00
69_A 129_P 1.697 1.00
84_L 201_F 1.674 1.00
242_L 377_G 1.671 1.00
96_L 99_S 1.658 1.00
304_A 308_L 1.653 1.00
93_V 119_L 1.645 1.00
291_C 294_T 1.638 1.00
97_A 115_T 1.615 1.00
285_P 289_W 1.611 1.00
56_A 375_A 1.595 1.00
348_D 357_R 1.536 1.00
297_W 421_A 1.531 1.00
42_I 109_M 1.52 1.00
301_A 305_V 1.517 1.00
308_L 414_A 1.498 1.00
111_Y 115_T 1.492 1.00
15_G 154_L 1.442 1.00
275_G 279_G 1.44 1.00
52_L 375_A 1.436 1.00
373_G 377_G 1.425 1.00
223_D 358_L 1.423 1.00
305_V 309_A 1.413 1.00
114_I 118_L 1.412 1.00
301_A 421_A 1.393 0.99
164_V 270_T 1.384 0.99
85_F 89_P 1.379 0.99
299_T 331_L 1.366 0.99
293_V 297_W 1.364 0.99
282_L 285_P 1.363 0.99
246_V 381_I 1.361 0.99
146_S 288_D 1.346 0.99
42_I 46_F 1.341 0.99
383_W 387_Y 1.338 0.99
144_R 345_D 1.334 0.99
304_A 421_A 1.328 0.99
77_G 206_E 1.323 0.99
66_G 70_D 1.322 0.99
223_D 226_Q 1.315 0.99
57_L 120_T 1.305 0.99
245_C 374_L 1.299 0.99
77_G 80_R 1.298 0.99
59_A 368_F 1.295 0.99
116_Y 120_T 1.287 0.99
298_W 302_L 1.285 0.99
141_P 144_R 1.283 0.99
19_A 158_G 1.27 0.99
86_G 122_L 1.27 0.99
80_R 206_E 1.269 0.99
66_G 360_G 1.266 0.99
228_D 232_I 1.261 0.99
254_Y 258_I 1.261 0.99
110_I 113_A 1.257 0.99
89_P 93_V 1.257 0.99
91_G 190_S 1.247 0.99
254_Y 259_L 1.247 0.99
294_T 298_W 1.242 0.98
286_L 290_K 1.237 0.98
92_I 96_L 1.236 0.98
317_A 320_T 1.235 0.98
134_G 147_L 1.234 0.98
71_R 76_W 1.23 0.98
225_W 231_R 1.228 0.98
97_A 112_A 1.227 0.98
194_F 198_A 1.226 0.98
384_M 388_G 1.223 0.98
98_Y 183_Q 1.222 0.98
68_L 81_P 1.213 0.98
306_I 328_I 1.212 0.98
306_I 327_V 1.207 0.98
231_R 235_L 1.206 0.98
133_L 204_T 1.205 0.98
164_V 168_P 1.202 0.98
287_T 338_I 1.201 0.98
218_R 222_R 1.2 0.98
228_D 231_R 1.194 0.98
96_L 111_Y 1.193 0.98
70_D 78_K 1.188 0.98
91_G 194_F 1.188 0.98
145_I 284_K 1.188 0.98
70_D 361_I 1.187 0.98
134_G 151_R 1.185 0.98
22_H 155_A 1.183 0.98
169_L 184_G 1.179 0.98
323_V 327_V 1.172 0.98
69_A 78_K 1.172 0.98
98_Y 190_S 1.171 0.98
200_C 204_T 1.169 0.97
17_G 126_V 1.168 0.97
68_L 76_W 1.161 0.97
234_G 369_V 1.161 0.97
281_A 285_P 1.16 0.97
223_D 357_R 1.156 0.97
274_V 278_I 1.155 0.97
52_L 379_A 1.155 0.97
187_A 191_V 1.149 0.97
80_R 84_L 1.145 0.97
136_V 359_T 1.141 0.97
76_W 80_R 1.135 0.97
255_V 259_L 1.135 0.97
111_Y 114_I 1.131 0.97
78_K 206_E 1.121 0.97
256_T 263_E 1.118 0.96
61_S 64_C 1.117 0.96
19_A 161_L 1.111 0.96
34_F 38_D 1.109 0.96
58_D 371_K 1.108 0.96
80_R 85_F 1.102 0.96
308_L 312_F 1.1 0.96
16_M 196_M 1.096 0.96
49_T 53_V 1.093 0.96
291_C 295_I 1.088 0.96
79_F 84_L 1.083 0.96
101_P 183_Q 1.083 0.96
279_G 282_L 1.082 0.96
54_A 123_Y 1.078 0.95
24_I 189_L 1.077 0.95
294_T 297_W 1.071 0.95
290_K 295_I 1.071 0.95
382_G 386_A 1.068 0.95
184_G 188_V 1.052 0.95
323_V 326_F 1.05 0.94
302_L 306_I 1.049 0.94
300_N 335_V 1.046 0.94
380_L 383_W 1.045 0.94
283_A 334_L 1.045 0.94
298_W 301_A 1.044 0.94
297_W 301_A 1.039 0.94
191_V 195_M 1.036 0.94
181_G 184_G 1.033 0.94
49_T 379_A 1.03 0.94
76_W 81_P 1.028 0.94
199_F 203_T 1.027 0.94
44_A 386_A 1.027 0.94
433_H 437_T 1.027 0.94
249_G 252_M 1.026 0.94
190_S 194_F 1.025 0.93
320_T 323_V 1.024 0.93
319_I 322_F 1.023 0.93
295_I 298_W 1.021 0.93
45_G 386_A 1.019 0.93
230_W 234_G 1.018 0.93
48_G 52_L 1.018 0.93
27_N 185_G 1.017 0.93
349_Y 357_R 1.014 0.93
168_P 172_L 1.013 0.93
415_I 419_L 1.012 0.93
99_S 111_Y 1.012 0.93
301_A 304_A 1.012 0.93
87_A 196_M 1.011 0.93
24_I 27_N 1.006 0.93
165_L 168_P 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.89781000.363Contact Map0.62
1pw4A10.87171000.375Contact Map0.481
4j05A20.91961000.386Contact Map0.635
4gc0A10.91961000.394Contact Map0.732
2gfpA20.81091000.408Contact Map0.154
2cfqA10.87171000.413Contact Map0.535
4ldsA20.87831000.415Contact Map0.651
3o7qA10.85221000.417Contact Map0.622
2xutA30.90871000.424Contact Map0.497
4lepA20.94781000.446Contact Map0.592
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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