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OPENSEQ.org
GLPT - Glycerol-3-phosphate transporter
UniProt: P08194 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10401
Length: 452 (403)
Sequences: 61895
Seq/Len: 153.59
GLPT
Paralog alert: 0.90 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
118_S 122_V 4.26 1.00
102_L 133_F 3.559 1.00
109_F 126_L 3.424 1.00
111_G 191_Y 3.232 1.00
121_A 125_V 3.005 1.00
75_A 128_F 2.93 1.00
106_V 126_L 2.842 1.00
104_A 197_A 2.816 1.00
119_S 122_V 2.731 1.00
83_M 136_M 2.711 1.00
120_I 124_F 2.549 1.00
92_P 147_H 2.507 1.00
149_W 157_I 2.461 1.00
287_A 290_K 2.457 1.00
376_A 384_A 2.432 1.00
99_G 136_M 2.409 1.00
61_S 64_D 2.402 1.00
153_E 156_G 2.336 1.00
263_V 396_G 2.316 1.00
106_V 129_L 2.313 1.00
155_G 314_D 2.294 1.00
79_S 132_W 2.244 1.00
247_Q 251_P 2.18 1.00
106_V 133_F 2.15 1.00
88_D 382_G 2.11 1.00
150_S 153_E 2.094 1.00
267_L 400_A 2.077 1.00
301_A 355_I 2.068 1.00
377_P 380_A 1.966 1.00
93_R 97_P 1.959 1.00
108_L 194_A 1.953 1.00
184_N 188_A 1.951 1.00
64_D 120_I 1.938 1.00
117_T 122_V 1.931 1.00
418_M 422_G 1.909 1.00
338_V 353_C 1.891 1.00
202_L 206_A 1.857 1.00
97_P 201_A 1.843 1.00
97_P 205_F 1.834 1.00
333_T 428_V 1.805 1.00
71_G 128_F 1.802 1.00
117_T 126_L 1.786 1.00
68_A 123_M 1.784 1.00
106_V 130_C 1.742 1.00
60_F 120_I 1.741 1.00
87_S 140_P 1.734 1.00
110_M 126_L 1.72 1.00
101_I 201_A 1.717 1.00
71_G 124_F 1.715 1.00
305_G 359_F 1.704 1.00
104_A 201_A 1.7 1.00
79_S 135_G 1.699 1.00
348_T 352_I 1.694 1.00
311_W 315_K 1.681 1.00
331_L 360_L 1.673 1.00
35_F 164_A 1.659 1.00
85_S 89_R 1.657 1.00
91_N 94_V 1.633 1.00
248_Y 251_P 1.629 1.00
271_G 404_V 1.564 1.00
320_N 374_E 1.562 1.00
122_V 126_L 1.561 1.00
333_T 425_I 1.545 1.00
94_V 98_A 1.513 1.00
75_A 79_S 1.51 1.00
110_M 123_M 1.488 1.00
60_F 64_D 1.487 1.00
335_A 353_C 1.484 1.00
54_Y 57_E 1.475 1.00
27_R 153_E 1.454 1.00
109_F 112_F 1.454 1.00
86_V 95_F 1.452 1.00
108_L 112_F 1.448 1.00
248_Y 380_A 1.447 1.00
218_P 221_E 1.447 1.00
111_G 194_A 1.44 1.00
219_P 222_E 1.431 1.00
98_A 102_L 1.426 1.00
90_S 95_F 1.42 1.00
151_Q 154_R 1.419 1.00
286_F 290_K 1.414 1.00
330_T 428_V 1.408 1.00
259_A 391_F 1.386 0.99
156_G 314_D 1.383 0.99
301_A 305_G 1.378 0.99
406_Y 410_F 1.377 0.99
203_F 207_M 1.375 0.99
312_M 316_V 1.361 0.99
86_V 90_S 1.36 0.99
346_N 349_V 1.347 0.99
290_K 293_W 1.345 0.99
102_L 106_V 1.345 0.99
125_V 129_L 1.344 0.99
104_A 194_A 1.338 0.99
310_G 314_D 1.326 0.99
121_A 124_F 1.32 0.99
308_L 311_W 1.32 0.99
335_A 360_L 1.319 0.99
270_Y 397_S 1.31 0.99
281_K 288_L 1.303 0.99
185_D 188_A 1.297 0.99
94_V 97_P 1.293 0.99
94_V 210_D 1.284 0.99
79_S 82_I 1.283 0.99
191_Y 195_F 1.282 0.99
74_I 398_V 1.27 0.99
90_S 94_V 1.264 0.99
240_T 243_Q 1.255 0.99
279_Y 284_K 1.241 0.98
328_F 363_G 1.236 0.98
348_T 351_M 1.23 0.98
84_G 88_D 1.218 0.98
333_T 421_I 1.218 0.98
333_T 337_I 1.216 0.98
217_L 220_I 1.213 0.98
281_K 291_S 1.213 0.98
88_D 383_T 1.213 0.98
188_A 191_Y 1.21 0.98
99_G 133_F 1.207 0.98
204_A 208_M 1.206 0.98
298_Y 358_G 1.204 0.98
330_T 334_I 1.203 0.98
104_A 198_I 1.203 0.98
174_L 296_F 1.2 0.98
255_L 259_A 1.2 0.98
340_W 418_M 1.196 0.98
145_M 161_W 1.194 0.98
37_G 137_G 1.194 0.98
317_F 322_G 1.191 0.98
415_G 418_M 1.183 0.98
77_G 390_L 1.178 0.98
111_G 187_H 1.178 0.98
268_L 424_S 1.171 0.98
326_V 428_V 1.171 0.98
146_V 154_R 1.168 0.97
195_F 199_L 1.166 0.97
422_G 426_L 1.155 0.97
337_I 421_I 1.148 0.97
122_V 125_V 1.144 0.97
305_G 308_L 1.14 0.97
54_Y 58_Q 1.139 0.97
105_A 109_F 1.134 0.97
33_G 203_F 1.127 0.97
223_Y 227_Y 1.124 0.97
62_R 409_D 1.122 0.97
293_W 297_L 1.118 0.96
42_Y 165_H 1.114 0.96
109_F 122_V 1.109 0.96
144_T 208_M 1.107 0.96
335_A 357_I 1.106 0.96
396_G 400_A 1.105 0.96
100_L 201_A 1.105 0.96
70_S 398_V 1.103 0.96
216_G 219_P 1.102 0.96
311_W 314_D 1.102 0.96
147_H 381_A 1.1 0.96
300_Y 304_P 1.099 0.96
256_W 260_I 1.099 0.96
72_I 76_Y 1.098 0.96
156_G 160_V 1.094 0.96
67_F 71_G 1.092 0.96
174_L 180_M 1.091 0.96
97_P 204_A 1.089 0.96
91_N 210_D 1.088 0.96
221_E 225_N 1.085 0.96
407_T 411_F 1.082 0.96
405_G 409_D 1.079 0.95
56_V 65_L 1.076 0.95
67_F 402_A 1.076 0.95
411_F 415_G 1.071 0.95
39_A 168_G 1.071 0.95
327_F 331_L 1.071 0.95
87_S 92_P 1.07 0.95
280_L 286_F 1.064 0.95
352_I 355_I 1.06 0.95
75_A 131_G 1.056 0.95
84_G 382_G 1.055 0.95
58_Q 187_H 1.054 0.95
372_A 388_T 1.053 0.95
82_I 85_S 1.051 0.94
95_F 98_A 1.051 0.94
414_D 418_M 1.051 0.94
250_L 256_W 1.048 0.94
219_P 223_Y 1.048 0.94
180_M 183_F 1.044 0.94
340_W 421_I 1.042 0.94
224_K 227_Y 1.041 0.94
112_F 191_Y 1.04 0.94
156_G 311_W 1.038 0.94
37_G 96_L 1.038 0.94
194_A 198_I 1.033 0.94
262_N 388_T 1.03 0.94
198_I 202_L 1.026 0.94
72_I 134_Q 1.026 0.94
43_L 172_P 1.025 0.93
329_M 427_A 1.023 0.93
63_G 409_D 1.02 0.93
313_S 367_L 1.015 0.93
91_N 95_F 1.014 0.93
278_T 282_E 1.012 0.93
43_L 193_P 1.011 0.93
154_R 374_E 1.011 0.93
309_C 363_G 1.01 0.93
97_P 101_I 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98671000.215Contact Map0.518
3wdoA10.88721000.273Contact Map0.647
4j05A20.9691000.292Contact Map0.618
3o7qA10.8961000.301Contact Map0.639
2gfpA20.81861000.316Contact Map0.181
2cfqA10.89821000.334Contact Map0.49
4ldsA20.92261000.348Contact Map0.634
2xutA30.94471000.35Contact Map0.519
4gc0A10.93581000.354Contact Map0.726
4apsA20.94031000.376Contact Map0.541
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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