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OPENSEQ.org
KGTP - Alpha-ketoglutarate permease
UniProt: P0AEX3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10522
Length: 432 (393)
Sequences: 59500
Seq/Len: 151.40
KGTP
Paralog alert: 0.90 [within 20: 0.62] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_M 137_S 3.788 1.00
114_P 118_T 3.756 1.00
109_V 130_A 3.533 1.00
111_A 202_A 3.328 1.00
75_M 132_L 3.082 1.00
104_C 208_A 2.953 1.00
106_G 130_A 2.929 1.00
83_F 140_G 2.888 1.00
92_R 151_E 2.732 1.00
117_E 129_L 2.67 1.00
365_F 373_G 2.61 1.00
153_A 161_Y 2.593 1.00
99_S 140_G 2.581 1.00
115_G 118_T 2.58 1.00
277_H 280_V 2.514 1.00
56_G 59_T 2.487 1.00
159_G 304_D 2.483 1.00
157_R 160_F 2.445 1.00
116_Y 128_L 2.43 1.00
106_G 137_S 2.326 1.00
253_A 385_F 2.283 1.00
79_G 136_L 2.273 1.00
291_V 344_M 2.254 1.00
106_G 133_F 2.251 1.00
154_V 157_R 2.22 1.00
93_K 97_L 2.217 1.00
88_D 371_A 2.165 1.00
308_R 363_E 2.111 1.00
195_W 199_I 2.041 1.00
366_P 369_V 2.031 1.00
108_L 205_A 1.963 1.00
87_A 144_T 1.932 1.00
113_L 130_A 1.925 1.00
106_G 134_Q 1.884 1.00
113_L 118_T 1.865 1.00
79_G 139_G 1.862 1.00
59_T 116_Y 1.803 1.00
110_I 130_A 1.788 1.00
85_R 89_K 1.779 1.00
261_T 393_A 1.751 1.00
307_G 310_T 1.737 1.00
322_F 342_L 1.737 1.00
28_S 168_T 1.722 1.00
295_I 348_L 1.715 1.00
91_G 94_K 1.712 1.00
66_A 132_L 1.691 1.00
257_L 389_A 1.683 1.00
63_L 127_L 1.676 1.00
318_L 349_I 1.649 1.00
315_F 352_F 1.624 1.00
66_A 128_L 1.617 1.00
301_A 305_K 1.616 1.00
75_M 79_G 1.602 1.00
97_L 215_R 1.587 1.00
86_I 95_S 1.583 1.00
337_Y 341_G 1.58 1.00
55_S 116_Y 1.579 1.00
94_K 98_L 1.559 1.00
104_C 205_A 1.553 1.00
110_I 127_L 1.55 1.00
86_I 90_H 1.515 1.00
202_A 206_V 1.505 1.00
111_A 205_A 1.504 1.00
90_H 95_S 1.474 1.00
47_Y 50_H 1.47 1.00
407_W 411_L 1.462 1.00
276_M 280_V 1.461 1.00
155_E 158_K 1.419 1.00
160_F 304_D 1.418 1.00
291_V 295_I 1.418 1.00
55_S 59_T 1.413 1.00
395_S 399_I 1.412 1.00
20_R 157_R 1.411 1.00
79_G 82_L 1.408 1.00
196_G 199_I 1.397 0.99
178_L 286_T 1.397 0.99
102_M 106_G 1.396 0.99
320_A 417_F 1.389 0.99
300_G 304_D 1.385 0.99
322_F 349_I 1.382 0.99
98_L 102_M 1.375 0.99
320_A 414_V 1.36 0.99
109_V 112_C 1.359 0.99
108_L 112_C 1.355 0.99
302_L 306_I 1.355 0.99
271_V 281_A 1.351 0.99
84_G 88_D 1.35 0.99
335_S 338_A 1.344 0.99
299_I 352_F 1.342 0.99
213_W 217_Q 1.341 0.99
271_V 278_A 1.338 0.99
385_F 389_A 1.327 0.99
149_M 165_Q 1.318 0.99
57_N 398_S 1.318 0.99
90_H 94_K 1.315 0.99
280_V 283_G 1.312 0.99
237_G 369_V 1.302 0.99
298_L 301_A 1.302 0.99
94_K 97_L 1.299 0.99
49_A 60_T 1.289 0.99
234_S 237_G 1.28 0.99
88_D 372_L 1.278 0.99
35_W 169_L 1.276 0.99
310_T 314_C 1.275 0.99
117_E 128_L 1.274 0.99
309_R 313_L 1.271 0.99
82_L 85_R 1.266 0.99
326_I 342_L 1.262 0.99
199_I 202_A 1.258 0.99
99_S 137_S 1.257 0.99
183_L 199_I 1.25 0.99
396_L 400_G 1.25 0.99
74_L 387_G 1.249 0.99
288_A 347_L 1.249 0.99
45_S 60_T 1.245 0.98
337_Y 340_F 1.244 0.98
295_I 298_L 1.24 0.98
317_S 321_I 1.239 0.98
118_T 130_A 1.236 0.98
129_L 133_F 1.231 0.98
150_S 158_K 1.228 0.98
104_C 209_V 1.218 0.98
270_L 276_M 1.216 0.98
310_T 313_L 1.211 0.98
318_L 322_F 1.21 0.98
151_E 370_R 1.21 0.98
58_T 398_S 1.209 0.98
325_P 342_L 1.197 0.98
269_Y 274_A 1.194 0.98
322_F 346_A 1.191 0.98
178_L 182_V 1.189 0.98
111_A 198_R 1.186 0.98
369_V 372_L 1.183 0.98
206_V 210_V 1.179 0.98
36_F 176_A 1.169 0.97
94_K 220_E 1.167 0.97
44_C 184_Q 1.164 0.97
105_F 109_V 1.161 0.97
91_G 95_S 1.138 0.97
95_S 98_L 1.136 0.97
30_G 141_E 1.135 0.97
160_F 164_F 1.135 0.97
361_K 377_S 1.133 0.97
158_K 363_E 1.132 0.97
320_A 324_V 1.13 0.97
32_L 172_G 1.125 0.97
44_C 200_P 1.123 0.97
394_L 398_S 1.12 0.96
301_A 304_D 1.115 0.96
37_D 40_V 1.114 0.96
84_G 371_A 1.108 0.96
112_C 202_A 1.106 0.96
283_G 287_A 1.1 0.96
181_V 282_S 1.1 0.96
148_Y 218_L 1.095 0.96
255_G 353_Y 1.091 0.96
87_A 92_R 1.084 0.96
260_Y 386_G 1.081 0.95
341_G 345_C 1.081 0.95
290_F 294_L 1.08 0.95
47_Y 51_I 1.078 0.95
246_I 250_G 1.076 0.95
97_L 101_C 1.069 0.95
390_E 394_L 1.067 0.95
367_A 370_R 1.066 0.95
400_G 404_A 1.064 0.95
303_S 356_I 1.057 0.95
306_I 311_S 1.056 0.95
193_R 279_N 1.053 0.95
75_M 135_G 1.051 0.94
279_N 283_G 1.049 0.94
32_L 175_L 1.046 0.94
97_L 212_L 1.046 0.94
65_T 387_G 1.042 0.94
26_G 214_L 1.042 0.94
236_K 240_R 1.039 0.94
174_L 290_F 1.039 0.94
294_L 297_P 1.037 0.94
91_G 220_E 1.037 0.94
315_F 349_I 1.034 0.94
269_Y 273_T 1.029 0.94
338_A 341_G 1.029 0.94
150_S 370_R 1.028 0.94
36_F 204_G 1.028 0.94
62_L 66_A 1.026 0.94
322_F 345_C 1.026 0.94
294_L 298_L 1.018 0.93
404_A 408_Y 1.016 0.93
179_V 182_V 1.015 0.93
88_D 92_R 1.014 0.93
24_I 153_A 1.009 0.93
107_S 205_A 1.008 0.93
39_Y 173_Q 1.007 0.93
205_A 209_V 1.006 0.93
242_R 246_I 1.006 0.93
43_F 180_V 1.005 0.93
30_G 96_M 1.005 0.93
101_C 105_F 1.004 0.93
411_L 415_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.93751000.205Contact Map0.495
4j05A20.96061000.216Contact Map0.618
3wdoA10.90281000.23Contact Map0.64
2gfpA20.86571000.245Contact Map0.199
3o7qA10.93981000.245Contact Map0.644
4gc0A10.93751000.259Contact Map0.739
4ldsA20.90741000.28Contact Map0.639
2cfqA10.89121000.284Contact Map0.492
2xutA30.91671000.306Contact Map0.534
4jr9A10.92821000.319Contact Map0.603
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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