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OPENSEQ.org
SOTB - Sugar efflux transporter
UniProt: P31122 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11636
Length: 396 (372)
Sequences: 66135
Seq/Len: 177.78
SOTB
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_W 103_V 4.108 1.00
87_V 114_A 3.542 1.00
94_L 107_S 3.408 1.00
96_F 171_F 3.187 1.00
60_V 109_I 2.883 1.00
102_T 106_I 2.814 1.00
91_S 107_S 2.81 1.00
89_I 177_A 2.787 1.00
77_R 128_R 2.772 1.00
68_F 117_I 2.757 1.00
100_S 103_V 2.646 1.00
136_A 270_N 2.514 1.00
84_L 117_I 2.485 1.00
130_A 138_A 2.482 1.00
243_S 246_F 2.471 1.00
101_F 105_V 2.456 1.00
46_Q 49_Q 2.443 1.00
134_K 137_Q 2.33 1.00
91_S 114_A 2.3 1.00
64_M 113_F 2.28 1.00
91_S 110_G 2.274 1.00
73_S 332_D 2.251 1.00
223_T 349_G 2.174 1.00
219_V 345_G 2.165 1.00
257_A 306_I 2.119 1.00
261_G 310_I 2.097 1.00
131_P 134_K 2.044 1.00
203_P 207_R 1.997 1.00
98_S 103_V 1.995 1.00
78_R 82_I 1.991 1.00
164_F 168_M 1.952 1.00
82_I 185_I 1.895 1.00
274_S 325_A 1.889 1.00
98_S 107_S 1.882 1.00
182_L 186_K 1.879 1.00
299_I 303_V 1.872 1.00
290_L 304_L 1.858 1.00
93_V 174_G 1.829 1.00
49_Q 101_F 1.828 1.00
82_I 181_L 1.812 1.00
53_M 104_L 1.785 1.00
91_S 111_V 1.768 1.00
64_M 116_A 1.759 1.00
45_M 101_F 1.742 1.00
56_I 109_I 1.738 1.00
56_I 105_V 1.717 1.00
72_T 121_I 1.699 1.00
70_L 74_Q 1.692 1.00
89_I 181_L 1.685 1.00
227_T 353_G 1.664 1.00
86_V 181_L 1.657 1.00
60_V 64_M 1.625 1.00
76_E 79_K 1.619 1.00
367_Y 371_V 1.617 1.00
273_A 276_L 1.61 1.00
287_C 304_L 1.603 1.00
95_S 107_S 1.602 1.00
204_L 207_R 1.591 1.00
267_K 271_Q 1.579 1.00
19_A 145_G 1.544 1.00
45_M 49_Q 1.53 1.00
283_L 311_A 1.528 1.00
95_S 104_L 1.517 1.00
89_I 174_G 1.493 1.00
103_V 107_S 1.484 1.00
242_F 246_F 1.48 1.00
215_Y 341_I 1.478 1.00
254_L 309_G 1.475 1.00
171_F 175_I 1.47 1.00
327_A 334_A 1.469 1.00
287_C 311_A 1.468 1.00
285_L 377_L 1.455 1.00
94_L 97_L 1.455 1.00
38_D 41_Q 1.453 1.00
257_A 261_G 1.426 1.00
266_G 270_N 1.423 1.00
83_C 87_V 1.409 1.00
69_M 73_S 1.409 1.00
71_M 80_L 1.409 1.00
137_Q 270_N 1.404 0.99
75_V 80_L 1.402 0.99
204_L 330_A 1.398 0.99
79_K 83_C 1.397 0.99
93_V 97_L 1.391 0.99
183_C 187_L 1.376 0.99
165_G 168_M 1.371 0.99
132_A 135_R 1.37 0.99
246_F 249_A 1.354 0.99
96_F 174_G 1.353 0.99
71_M 75_V 1.349 0.99
355_Q 359_H 1.347 0.99
102_T 105_V 1.339 0.99
64_M 67_P 1.336 0.99
84_L 114_A 1.334 0.99
87_V 91_S 1.319 0.99
268_L 272_Y 1.311 0.99
212_M 216_L 1.306 0.99
264_I 267_K 1.298 0.99
89_I 178_L 1.298 0.99
297_S 300_H 1.296 0.99
237_Q 244_A 1.295 0.99
47_T 358_L 1.278 0.99
106_I 110_G 1.278 0.99
79_K 82_I 1.257 0.99
59_W 347_G 1.256 0.99
155_P 252_L 1.255 0.99
237_Q 247_A 1.255 0.99
67_P 70_L 1.25 0.99
127_I 135_R 1.246 0.98
128_R 331_T 1.232 0.98
75_V 79_K 1.225 0.98
126_A 142_I 1.223 0.98
79_K 190_L 1.218 0.98
168_M 171_F 1.215 0.98
26_N 146_T 1.211 0.98
345_G 349_G 1.196 0.98
21_A 118_F 1.178 0.98
299_I 302_G 1.173 0.98
35_L 161_G 1.171 0.98
125_L 188_L 1.17 0.97
261_G 264_I 1.168 0.97
90_A 94_L 1.166 0.97
371_V 375_A 1.16 0.97
235_F 240_A 1.16 0.97
162_Q 245_N 1.158 0.97
73_S 333_V 1.155 0.97
360_W 364_M 1.153 0.97
267_K 270_N 1.146 0.97
160_V 168_M 1.146 0.97
76_E 80_L 1.142 0.97
55_T 347_G 1.142 0.97
60_V 112_A 1.138 0.97
175_I 179_I 1.132 0.97
211_L 215_Y 1.13 0.97
224_A 373_A 1.124 0.97
356_V 360_W 1.122 0.97
94_L 103_V 1.12 0.96
72_T 77_R 1.119 0.96
96_F 167_R 1.119 0.96
48_A 358_L 1.117 0.96
69_M 332_D 1.109 0.96
80_L 83_C 1.109 0.96
40_A 50_V 1.106 0.96
62_A 340_G 1.102 0.96
226_Y 346_I 1.095 0.96
236_V 242_F 1.095 0.96
52_I 351_L 1.093 0.96
206_F 212_M 1.086 0.96
38_D 42_S 1.086 0.96
85_F 181_L 1.084 0.96
303_V 307_F 1.084 0.96
103_V 106_I 1.073 0.95
265_F 314_I 1.069 0.95
23_F 149_A 1.068 0.95
57_Y 61_V 1.067 0.95
52_I 56_I 1.065 0.95
55_T 351_L 1.062 0.95
323_V 338_F 1.061 0.95
256_G 260_I 1.059 0.95
245_N 249_A 1.052 0.95
354_N 358_L 1.052 0.95
218_T 338_F 1.05 0.94
73_S 77_R 1.046 0.94
97_L 171_F 1.041 0.94
135_R 325_A 1.038 0.94
285_L 374_F 1.035 0.94
289_A 293_P 1.034 0.94
155_P 159_I 1.031 0.94
178_L 182_L 1.027 0.94
82_I 86_V 1.023 0.93
285_L 289_A 1.022 0.93
321_V 325_A 1.015 0.93
42_S 167_R 1.014 0.93
137_Q 141_L 1.01 0.93
286_V 290_L 1.006 0.93
62_A 347_G 1.004 0.93
184_L 188_L 1.003 0.93
209_P 212_M 1.002 0.92
35_L 169_T 1.001 0.92
150_M 255_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99751000.169Contact Map0.475
3wdoA10.98481000.185Contact Map0.643
4j05A20.99491000.21Contact Map0.626
2gfpA20.93181000.218Contact Map0.186
3o7qA10.97471000.227Contact Map0.637
2cfqA10.97471000.246Contact Map0.49
4gc0A10.99241000.27Contact Map0.725
2xutA30.99751000.273Contact Map0.529
4ldsA20.97981000.277Contact Map0.629
4apsA20.99751000.277Contact Map0.545
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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