May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YIHP - Inner membrane symporter YihP
UniProt: P32137 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11842
Length: 461 (401)
Sequences: 42347
Seq/Len: 105.60
YIHP
Paralog alert: 0.89 [within 20: 0.52] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_T 121_M 4.864 1.00
99_P 132_F 3.708 1.00
120_V 124_I 3.429 1.00
108_F 196_T 3.349 1.00
106_A 125_L 3.301 1.00
101_T 202_G 3.298 1.00
65_F 127_M 3.025 1.00
360_V 375_V 2.893 1.00
103_L 125_L 2.781 1.00
155_A 302_R 2.704 1.00
88_K 146_A 2.663 1.00
119_T 123_T 2.602 1.00
73_T 135_M 2.554 1.00
316_I 344_G 2.546 1.00
112_P 121_M 2.493 1.00
323_L 337_F 2.439 1.00
51_P 54_Y 2.401 1.00
112_P 120_V 2.374 1.00
96_A 135_M 2.352 1.00
103_L 128_L 2.329 1.00
293_G 343_F 2.316 1.00
103_L 132_F 2.281 1.00
236_R 240_G 2.252 1.00
69_T 131_L 2.251 1.00
78_D 373_G 2.233 1.00
149_K 153_E 2.212 1.00
153_E 156_S 2.204 1.00
289_C 339_C 2.197 1.00
148_T 157_L 2.191 1.00
306_K 358_D 2.19 1.00
320_G 337_F 2.172 1.00
69_T 134_S 2.057 1.00
252_L 386_S 2.022 1.00
332_V 336_A 1.983 1.00
320_G 344_G 1.965 1.00
110_G 125_L 1.955 1.00
189_L 193_F 1.935 1.00
110_G 121_M 1.931 1.00
361_E 371_S 1.887 1.00
58_I 122_A 1.863 1.00
313_G 347_F 1.86 1.00
61_I 127_M 1.851 1.00
94_L 206_M 1.825 1.00
363_G 371_S 1.82 1.00
256_G 390_A 1.782 1.00
105_I 199_S 1.78 1.00
61_I 123_T 1.766 1.00
98_F 206_M 1.762 1.00
105_I 109_V 1.759 1.00
101_T 206_M 1.744 1.00
54_Y 119_T 1.734 1.00
149_K 152_N 1.731 1.00
77_L 139_S 1.724 1.00
107_N 125_L 1.694 1.00
121_M 125_L 1.659 1.00
286_S 342_F 1.654 1.00
299_A 303_R 1.65 1.00
207_W 211_S 1.644 1.00
50_L 119_T 1.627 1.00
298_P 302_R 1.624 1.00
65_F 69_T 1.61 1.00
305_G 308_K 1.595 1.00
103_L 129_Y 1.591 1.00
106_A 109_V 1.587 1.00
318_V 322_L 1.585 1.00
260_V 394_P 1.582 1.00
75_I 85_P 1.577 1.00
315_L 319_L 1.577 1.00
318_V 430_V 1.525 1.00
94_L 210_Y 1.504 1.00
237_A 371_S 1.5 1.00
289_C 293_G 1.491 1.00
307_K 311_I 1.475 1.00
386_S 390_A 1.471 1.00
64_F 388_A 1.465 1.00
268_Y 273_L 1.44 1.00
50_L 54_Y 1.422 1.00
423_I 427_A 1.396 0.99
151_P 154_R 1.382 0.99
237_A 240_G 1.376 0.99
296_L 299_A 1.374 0.99
74_G 78_D 1.367 0.99
60_L 388_A 1.363 0.99
242_R 246_I 1.356 0.99
313_G 344_G 1.354 0.99
90_R 95_Y 1.346 0.99
322_L 426_S 1.345 0.99
95_Y 99_P 1.343 0.99
23_G 164_G 1.336 0.99
239_A 245_F 1.33 0.99
278_L 281_Y 1.326 0.99
300_S 304_F 1.323 0.99
120_V 123_T 1.319 0.99
87_G 90_R 1.316 0.99
174_V 284_F 1.315 0.99
65_F 130_G 1.314 0.99
76_M 86_K 1.312 0.99
311_I 433_I 1.302 0.99
396_W 400_Q 1.301 0.99
124_I 128_L 1.3 0.99
90_R 215_E 1.296 0.99
99_P 103_L 1.284 0.99
320_G 341_A 1.279 0.99
108_F 192_I 1.278 0.99
101_T 199_S 1.272 0.99
242_R 245_F 1.27 0.99
232_L 236_R 1.27 0.99
154_R 358_D 1.263 0.99
190_G 193_F 1.258 0.99
143_M 213_V 1.253 0.99
156_S 302_R 1.246 0.98
308_K 312_G 1.238 0.98
319_L 323_L 1.236 0.98
96_A 132_F 1.236 0.98
146_A 372_E 1.231 0.98
245_F 249_I 1.23 0.98
60_L 392_F 1.23 0.98
107_N 122_A 1.23 0.98
62_S 133_F 1.227 0.98
27_L 168_G 1.226 0.98
209_C 213_V 1.225 0.98
275_D 278_L 1.222 0.98
25_G 136_M 1.216 0.98
330_G 333_S 1.214 0.98
67_A 381_F 1.214 0.98
89_F 94_L 1.212 0.98
69_T 72_G 1.206 0.98
322_L 326_F 1.205 0.98
76_M 91_P 1.201 0.98
320_G 340_L 1.201 0.98
74_G 373_G 1.2 0.98
259_N 387_Q 1.196 0.98
88_K 215_E 1.192 0.98
196_T 200_L 1.185 0.98
318_V 433_I 1.184 0.98
106_A 121_M 1.183 0.98
179_V 193_F 1.183 0.98
268_Y 272_V 1.182 0.98
121_M 124_I 1.178 0.98
248_C 382_F 1.176 0.98
108_F 199_S 1.175 0.98
315_L 433_I 1.174 0.98
78_D 374_T 1.173 0.98
312_G 316_I 1.172 0.98
77_L 88_K 1.171 0.98
42_K 46_D 1.166 0.97
86_K 90_R 1.16 0.97
155_A 298_P 1.152 0.97
101_T 203_L 1.146 0.97
102_L 106_A 1.138 0.97
30_N 165_A 1.134 0.97
144_V 161_R 1.131 0.97
208_I 212_G 1.128 0.97
32_L 198_F 1.126 0.97
57_I 61_I 1.124 0.97
336_A 340_L 1.12 0.96
305_G 309_V 1.117 0.96
175_G 178_P 1.115 0.96
270_Q 279_L 1.11 0.96
87_G 215_E 1.107 0.96
144_V 157_L 1.105 0.96
237_A 363_G 1.099 0.96
174_V 178_P 1.098 0.96
293_G 296_L 1.098 0.96
244_L 248_C 1.091 0.96
395_G 399_T 1.089 0.96
397_M 401_I 1.083 0.96
315_L 318_V 1.081 0.95
32_L 35_I 1.077 0.95
336_A 339_C 1.077 0.95
193_F 196_T 1.075 0.95
297_M 347_F 1.074 0.95
288_G 292_I 1.074 0.95
316_I 320_G 1.073 0.95
304_F 309_V 1.069 0.95
200_L 204_L 1.067 0.95
35_I 194_A 1.066 0.95
269_T 273_L 1.066 0.95
181_N 188_Q 1.064 0.95
97_S 206_M 1.062 0.95
67_A 388_A 1.06 0.95
301_V 351_L 1.059 0.95
311_I 315_L 1.058 0.95
126_F 130_G 1.052 0.95
52_G 399_T 1.05 0.94
109_V 196_T 1.046 0.94
203_L 207_W 1.046 0.94
66_T 384_K 1.038 0.94
292_I 295_F 1.036 0.94
393_F 396_W 1.035 0.94
308_K 311_I 1.034 0.94
39_Y 194_A 1.034 0.94
332_V 335_V 1.033 0.94
78_D 88_K 1.032 0.94
295_F 299_A 1.026 0.94
90_R 94_L 1.022 0.93
145_P 154_R 1.021 0.93
97_S 205_F 1.02 0.93
24_I 205_F 1.018 0.93
309_V 312_G 1.018 0.93
53_T 399_T 1.017 0.93
56_G 60_L 1.015 0.93
299_A 302_R 1.015 0.93
312_G 315_L 1.014 0.93
314_L 348_V 1.011 0.93
241_N 245_F 1.008 0.93
427_A 431_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.89591000.348Contact Map0.489
3wdoA10.87641000.354Contact Map0.648
4j05A20.92411000.369Contact Map0.636
3o7qA10.8721000.385Contact Map0.636
2cfqA10.88291000.387Contact Map0.53
2gfpA20.80691000.394Contact Map0.167
4gc0A10.91761000.401Contact Map0.745
2xutA30.91971000.406Contact Map0.511
4ldsA20.88071000.412Contact Map0.65
4apsA20.89371000.423Contact Map0.545
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.2999 seconds.