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MDTD - Putative multidrug resistance protein MdtD
UniProt: P36554 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12136
Length: 471 (438)
Sequences: 45670
Seq/Len: 104.27
MDTD
Paralog alert: 0.89 [within 20: 0.57] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_G 100_E 4.775 1.00
84_L 111_G 3.642 1.00
93_A 168_L 3.544 1.00
99_N 103_L 3.476 1.00
86_T 174_G 3.323 1.00
91_F 104_A 3.296 1.00
57_T 106_A 2.91 1.00
97_T 100_E 2.901 1.00
88_G 104_A 2.785 1.00
194_R 197_L 2.718 1.00
382_L 390_G 2.714 1.00
65_S 114_M 2.645 1.00
98_L 102_L 2.624 1.00
74_V 125_K 2.591 1.00
295_S 298_H 2.487 1.00
81_A 114_M 2.445 1.00
133_M 322_N 2.426 1.00
43_S 46_H 2.403 1.00
313_M 365_M 2.372 1.00
70_D 388_S 2.364 1.00
88_G 111_G 2.33 1.00
127_V 135_A 2.322 1.00
131_Q 134_A 2.293 1.00
88_G 107_L 2.282 1.00
61_M 110_V 2.262 1.00
343_L 359_V 2.257 1.00
309_G 361_F 2.25 1.00
275_I 405_G 2.183 1.00
95_S 100_E 2.17 1.00
336_G 366_V 2.167 1.00
383_P 386_L 2.073 1.00
340_V 359_V 2.062 1.00
53_S 106_A 2.052 1.00
271_F 401_S 2.041 1.00
206_G 238_L 1.98 1.00
95_S 104_A 1.937 1.00
128_P 131_Q 1.928 1.00
338_S 447_A 1.885 1.00
437_L 441_L 1.862 1.00
79_F 182_L 1.859 1.00
75_R 79_F 1.856 1.00
338_S 444_A 1.839 1.00
53_S 102_L 1.802 1.00
90_L 94_L 1.783 1.00
90_L 171_I 1.78 1.00
92_C 104_A 1.771 1.00
50_V 101_L 1.766 1.00
69_A 118_V 1.762 1.00
161_A 165_W 1.758 1.00
46_H 98_L 1.755 1.00
68_L 77_I 1.744 1.00
61_M 113_A 1.74 1.00
279_M 409_A 1.727 1.00
79_F 178_A 1.722 1.00
202_L 244_H 1.711 1.00
354_Y 358_F 1.706 1.00
16_A 142_P 1.703 1.00
129_R 132_Y 1.698 1.00
92_C 101_L 1.685 1.00
340_V 366_V 1.681 1.00
42_E 98_L 1.678 1.00
67_W 71_K 1.65 1.00
179_I 183_L 1.63 1.00
86_T 178_A 1.61 1.00
42_E 46_H 1.61 1.00
57_T 61_M 1.593 1.00
255_L 259_R 1.582 1.00
100_E 104_A 1.572 1.00
83_V 178_A 1.564 1.00
205_V 237_A 1.54 1.00
68_L 72_V 1.527 1.00
326_Y 380_K 1.522 1.00
56_L 403_S 1.507 1.00
256_K 386_L 1.499 1.00
88_G 108_Q 1.49 1.00
319_Q 323_R 1.482 1.00
73_G 76_N 1.481 1.00
210_L 234_G 1.478 1.00
342_L 440_A 1.477 1.00
309_G 313_M 1.468 1.00
86_T 171_I 1.456 1.00
338_S 342_L 1.455 1.00
318_V 322_N 1.452 1.00
76_N 80_T 1.452 1.00
196_D 199_G 1.447 1.00
345_M 437_L 1.434 1.00
80_T 84_L 1.429 1.00
325_G 328_R 1.419 1.00
256_K 259_R 1.416 1.00
91_F 94_L 1.414 1.00
162_S 165_W 1.404 0.99
72_V 77_I 1.397 0.99
35_S 38_Q 1.392 0.99
84_L 88_G 1.387 0.99
267_L 397_I 1.379 0.99
298_H 301_L 1.366 0.99
340_V 363_Q 1.363 0.99
157_L 165_W 1.343 0.99
333_T 369_T 1.341 0.99
316_I 319_Q 1.33 0.99
52_V 403_S 1.322 0.99
61_M 64_A 1.322 0.99
294_F 298_H 1.319 0.99
99_N 102_L 1.315 0.99
333_T 370_R 1.313 0.99
306_M 364_G 1.312 0.99
335_L 447_A 1.308 0.99
217_S 222_L 1.308 0.99
76_N 187_N 1.304 0.99
228_A 232_A 1.301 0.99
335_L 339_L 1.3 0.99
93_A 171_I 1.295 0.99
278_G 402_M 1.293 0.99
152_A 304_I 1.289 0.99
331_V 447_A 1.278 0.99
338_S 440_A 1.275 0.99
103_L 107_L 1.273 0.99
76_N 79_F 1.266 0.99
441_L 445_L 1.254 0.99
276_G 443_I 1.249 0.99
401_S 405_G 1.248 0.99
352_W 355_V 1.247 0.99
66_G 70_D 1.244 0.98
59_A 396_M 1.225 0.98
37_A 47_M 1.222 0.98
70_D 74_V 1.222 0.98
54_Y 112_G 1.222 0.98
287_F 292_L 1.221 0.98
320_V 324_F 1.218 0.98
134_A 322_N 1.212 0.98
69_A 74_V 1.21 0.98
327_R 331_V 1.208 0.98
32_A 158_V 1.208 0.98
289_Q 299_A 1.202 0.98
159_E 297_F 1.195 0.98
70_D 389_S 1.195 0.98
209_V 230_L 1.193 0.98
248_N 251_A 1.192 0.98
213_A 231_V 1.19 0.98
198_S 244_H 1.185 0.98
93_A 164_H 1.182 0.98
258_F 264_S 1.182 0.98
153_L 156_L 1.179 0.98
57_T 109_G 1.168 0.97
180_A 184_L 1.165 0.97
181_T 185_M 1.159 0.97
91_F 100_E 1.158 0.97
206_G 234_G 1.158 0.97
134_A 138_F 1.154 0.97
72_V 76_N 1.154 0.97
44_P 414_G 1.153 0.97
23_S 143_G 1.153 0.97
354_Y 357_P 1.149 0.97
81_A 111_G 1.145 0.97
328_R 332_A 1.137 0.97
18_G 78_F 1.134 0.97
79_F 83_V 1.13 0.97
123_V 139_V 1.122 0.97
96_G 164_H 1.116 0.96
434_Y 438_S 1.115 0.96
165_W 168_L 1.108 0.96
261_R 265_L 1.105 0.96
66_G 388_S 1.1 0.96
264_S 268_A 1.098 0.96
239_V 243_L 1.09 0.96
279_M 439_M 1.087 0.96
86_T 175_I 1.086 0.96
50_V 98_L 1.085 0.96
59_A 403_S 1.085 0.96
345_M 440_A 1.085 0.96
77_I 80_T 1.084 0.96
100_E 103_L 1.084 0.96
195_F 199_G 1.083 0.96
20_F 146_G 1.083 0.96
87_L 91_F 1.08 0.95
333_T 366_V 1.074 0.95
32_A 166_I 1.073 0.95
28_I 166_I 1.072 0.95
73_G 77_I 1.071 0.95
261_R 264_S 1.069 0.95
125_K 387_A 1.067 0.95
156_L 160_Y 1.064 0.95
378_T 394_L 1.061 0.95
168_L 172_P 1.06 0.95
52_V 407_T 1.056 0.95
328_R 331_V 1.055 0.95
254_S 386_L 1.054 0.95
313_M 316_I 1.053 0.95
289_Q 296_P 1.047 0.94
209_V 233_V 1.047 0.94
124_M 132_Y 1.046 0.94
49_M 53_S 1.046 0.94
37_A 42_E 1.046 0.94
411_L 415_L 1.043 0.94
338_S 443_I 1.036 0.94
20_F 149_L 1.035 0.94
331_V 451_A 1.034 0.94
340_V 362_L 1.032 0.94
434_Y 437_L 1.029 0.94
229_G 233_V 1.028 0.94
342_L 346_T 1.027 0.94
287_F 291_G 1.022 0.93
408_I 411_L 1.021 0.93
310_S 368_S 1.021 0.93
294_F 302_M 1.018 0.93
35_S 39_S 1.018 0.93
39_S 164_H 1.015 0.93
24_L 150_G 1.014 0.93
270_S 394_L 1.012 0.93
172_P 176_I 1.012 0.93
317_V 369_T 1.011 0.93
358_F 362_L 1.009 0.93
263_F 267_L 1.009 0.93
159_E 295_S 1.008 0.93
94_L 168_L 1.007 0.93
89_S 170_N 1.005 0.93
308_L 312_G 1.003 0.93
241_Y 245_A 1.001 0.92
74_V 187_N 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.89811000.276Contact Map0.498
3wdoA10.85141000.311Contact Map0.65
4j05A20.94481000.325Contact Map0.623
4gc0A10.92991000.329Contact Map0.715
2gfpA20.79621000.331Contact Map0.162
4ldsA20.90451000.334Contact Map0.641
2cfqA10.85771000.34Contact Map0.531
3o7qA10.8281000.343Contact Map0.632
2xutA30.99361000.347Contact Map0.528
4apsA20.95971000.372Contact Map0.558
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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