May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
UIDB - Glucuronide carrier protein homolog
UniProt: P0CE44 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11658
Length: 457 (397)
Sequences: 44368
Seq/Len: 111.76
UIDB
Paralog alert: 0.90 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_L 111_Y 4.532 1.00
88_P 122_C 3.843 1.00
95_L 115_T 3.36 1.00
97_F 187_I 3.331 1.00
110_V 114_L 3.275 1.00
90_M 193_G 3.274 1.00
56_F 117_M 3.098 1.00
348_V 363_T 3.07 1.00
92_F 115_T 2.952 1.00
77_K 136_A 2.678 1.00
145_A 289_A 2.66 1.00
108_K 111_Y 2.642 1.00
64_A 125_L 2.541 1.00
85_G 125_L 2.528 1.00
109_V 113_Y 2.48 1.00
280_S 331_I 2.409 1.00
42_G 45_A 2.384 1.00
92_F 122_C 2.374 1.00
303_L 332_G 2.364 1.00
92_F 118_G 2.328 1.00
138_T 147_L 2.308 1.00
139_Q 143_S 2.307 1.00
69_D 361_G 2.305 1.00
143_S 146_R 2.287 1.00
310_L 325_A 2.273 1.00
276_G 327_A 2.243 1.00
60_A 121_L 2.216 1.00
307_G 325_A 2.206 1.00
262_T 265_F 2.153 1.00
222_Q 226_R 2.102 1.00
293_K 346_D 2.032 1.00
320_P 324_V 1.989 1.00
242_I 378_G 1.976 1.00
100_L 108_K 1.97 1.00
99_V 111_Y 1.948 1.00
300_G 335_V 1.943 1.00
60_A 124_S 1.926 1.00
307_G 332_G 1.906 1.00
349_E 359_I 1.895 1.00
41_V 109_V 1.888 1.00
66_R 70_S 1.864 1.00
99_V 115_T 1.863 1.00
351_G 359_I 1.857 1.00
52_L 113_Y 1.855 1.00
180_S 184_F 1.851 1.00
68_V 129_P 1.848 1.00
45_A 109_V 1.844 1.00
238_L 374_G 1.834 1.00
83_L 197_Y 1.819 1.00
83_L 201_F 1.818 1.00
52_L 117_M 1.814 1.00
139_Q 142_Q 1.81 1.00
96_V 115_T 1.793 1.00
49_M 112_A 1.78 1.00
90_M 197_Y 1.772 1.00
94_V 190_A 1.758 1.00
285_P 289_A 1.718 1.00
56_F 60_A 1.669 1.00
94_V 98_W 1.664 1.00
87_A 197_Y 1.645 1.00
198_F 202_K 1.636 1.00
14_S 154_A 1.634 1.00
92_F 119_L 1.609 1.00
286_G 290_R 1.605 1.00
78_F 83_L 1.558 1.00
55_V 376_A 1.553 1.00
111_Y 115_T 1.55 1.00
246_A 382_P 1.548 1.00
305_T 309_L 1.541 1.00
292_G 295_N 1.529 1.00
273_N 330_S 1.485 1.00
254_Y 259_L 1.472 1.00
95_L 98_W 1.469 1.00
283_L 286_G 1.465 1.00
294_K 298_L 1.455 1.00
300_G 332_G 1.448 1.00
223_T 359_I 1.443 1.00
302_L 306_C 1.44 1.00
225_K 231_F 1.439 1.00
76_G 79_R 1.416 1.00
84_F 88_P 1.414 1.00
276_G 280_S 1.402 0.99
41_V 45_A 1.396 0.99
374_G 378_G 1.388 0.99
223_T 226_R 1.386 0.99
65_G 69_D 1.385 0.99
58_A 369_F 1.371 0.99
144_R 346_D 1.367 0.99
70_S 75_W 1.358 0.99
90_M 190_A 1.34 0.99
245_F 375_Q 1.336 0.99
33_S 37_D 1.334 0.99
181_V 184_F 1.332 0.99
110_V 113_Y 1.322 0.99
146_R 289_A 1.314 0.99
69_D 362_L 1.313 0.99
141_P 144_R 1.312 0.99
384_F 388_L 1.307 0.99
18_V 158_T 1.302 0.99
234_C 370_T 1.301 0.99
16_G 126_V 1.292 0.99
51_L 376_A 1.289 0.99
96_V 112_A 1.288 0.99
228_R 232_M 1.279 0.99
187_I 191_I 1.278 0.99
287_M 291_I 1.278 0.99
134_A 151_R 1.276 0.99
67_V 75_W 1.275 0.99
307_G 328_I 1.27 0.99
133_L 204_T 1.268 0.99
284_V 335_V 1.265 0.99
79_R 206_E 1.264 0.99
97_F 190_A 1.261 0.99
85_G 122_C 1.246 0.98
295_N 299_I 1.245 0.98
88_P 92_F 1.243 0.98
67_V 80_P 1.24 0.98
79_R 84_F 1.239 0.98
415_G 419_L 1.234 0.98
307_G 329_A 1.227 0.98
320_P 323_L 1.224 0.98
56_F 120_G 1.22 0.98
60_A 63_F 1.215 0.98
306_C 310_L 1.211 0.98
21_N 155_A 1.21 0.98
114_L 118_G 1.208 0.98
91_I 95_L 1.207 0.98
90_M 194_M 1.206 0.98
288_V 339_V 1.202 0.98
199_I 203_S 1.193 0.98
68_V 77_K 1.188 0.98
318_S 321_V 1.186 0.98
65_G 361_G 1.182 0.98
97_F 183_H 1.178 0.98
299_I 303_L 1.164 0.97
77_K 206_E 1.164 0.97
280_S 283_L 1.161 0.97
53_V 123_Y 1.154 0.97
75_W 79_R 1.144 0.97
254_Y 258_V 1.142 0.97
385_I 389_S 1.139 0.97
69_D 77_K 1.138 0.97
231_F 235_I 1.132 0.97
18_V 161_C 1.131 0.97
230_L 234_C 1.131 0.97
48_T 52_L 1.126 0.97
76_G 206_E 1.124 0.97
228_R 231_F 1.121 0.97
200_C 204_T 1.117 0.96
30_F 185_W 1.116 0.96
301_A 336_T 1.108 0.96
292_G 296_T 1.103 0.96
184_F 187_I 1.096 0.96
227_N 231_F 1.095 0.96
309_L 313_W 1.095 0.96
135_T 144_R 1.093 0.96
134_A 147_L 1.092 0.96
79_R 83_L 1.092 0.96
51_L 380_S 1.091 0.96
111_Y 114_L 1.088 0.96
23_A 26_M 1.087 0.96
256_R 263_G 1.087 0.96
15_L 196_L 1.085 0.96
136_A 360_E 1.078 0.95
295_N 298_L 1.077 0.95
47_G 51_L 1.072 0.95
23_A 189_L 1.067 0.95
95_L 111_Y 1.065 0.95
44_A 387_G 1.06 0.95
26_M 185_W 1.057 0.95
255_V 259_L 1.055 0.95
86_T 197_Y 1.053 0.95
98_W 187_I 1.05 0.94
116_Y 120_G 1.044 0.94
255_V 261_D 1.041 0.94
286_G 289_A 1.039 0.94
218_N 222_Q 1.034 0.94
58_A 376_A 1.031 0.94
191_I 195_V 1.022 0.93
302_L 305_T 1.021 0.93
57_D 372_K 1.015 0.93
345_A 364_Y 1.014 0.93
165_L 168_P 1.01 0.93
324_V 328_I 1.008 0.93
145_A 285_P 1.005 0.93
344_E 367_F 1.005 0.93
291_I 295_N 1.001 0.92
62_V 66_R 1 0.92
169_S 184_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.87311000.362Contact Map0.505
3wdoA10.89281000.362Contact Map0.656
4j05A20.91031000.368Contact Map0.645
2gfpA20.81621000.391Contact Map0.173
4gc0A10.92341000.398Contact Map0.752
2cfqA10.87961000.399Contact Map0.509
3o7qA10.85561000.407Contact Map0.649
4ldsA20.8841000.41Contact Map0.641
2xutA30.91251000.42Contact Map0.522
4lepA20.94311000.439Contact Map0.603
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0352 seconds.