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YIHN - Inner membrane protein YihN
UniProt: P32135 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11840
Length: 421 (401)
Sequences: 65905
Seq/Len: 164.35
YIHN
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_P 98_G 4.19 1.00
82_A 109_T 3.471 1.00
89_Y 102_V 3.469 1.00
91_T 172_W 3.237 1.00
55_V 104_A 2.983 1.00
97_W 101_F 2.918 1.00
86_L 102_V 2.88 1.00
84_G 178_V 2.852 1.00
95_G 98_G 2.749 1.00
72_R 124_R 2.68 1.00
63_S 113_M 2.548 1.00
252_P 255_L 2.547 1.00
96_Y 100_L 2.539 1.00
126_G 134_L 2.445 1.00
79_S 113_M 2.444 1.00
132_G 280_D 2.411 1.00
344_I 352_A 2.384 1.00
41_T 44_Q 2.377 1.00
130_Q 133_R 2.332 1.00
86_L 105_L 2.33 1.00
59_G 108_V 2.304 1.00
303_L 320_C 2.29 1.00
68_D 350_G 2.282 1.00
86_L 109_T 2.271 1.00
229_F 363_P 2.2 1.00
213_T 217_K 2.176 1.00
233_A 367_C 2.168 1.00
127_N 130_Q 2.124 1.00
267_L 322_L 2.046 1.00
93_M 98_G 2.039 1.00
165_L 169_A 1.996 1.00
296_I 327_I 1.992 1.00
271_G 326_A 1.976 1.00
73_R 77_S 1.963 1.00
77_S 182_G 1.934 1.00
345_A 348_K 1.921 1.00
183_I 187_F 1.913 1.00
44_Q 96_Y 1.889 1.00
88_V 175_S 1.883 1.00
93_M 102_V 1.879 1.00
298_T 399_A 1.853 1.00
389_G 393_C 1.83 1.00
300_A 320_C 1.828 1.00
293_T 330_T 1.801 1.00
285_S 341_E 1.794 1.00
51_V 104_A 1.789 1.00
77_S 186_F 1.787 1.00
40_L 96_Y 1.786 1.00
84_G 182_G 1.783 1.00
48_A 99_I 1.783 1.00
298_T 396_F 1.764 1.00
51_V 100_L 1.755 1.00
81_I 182_G 1.755 1.00
86_L 106_F 1.753 1.00
65_Y 69_K 1.709 1.00
59_G 112_M 1.693 1.00
90_L 102_V 1.684 1.00
67_A 117_V 1.647 1.00
300_A 327_I 1.644 1.00
277_M 281_K 1.644 1.00
71_P 74_Y 1.61 1.00
55_V 59_G 1.59 1.00
284_K 288_K 1.557 1.00
295_I 399_A 1.546 1.00
251_L 255_L 1.539 1.00
98_G 102_V 1.535 1.00
40_L 44_Q 1.524 1.00
89_Y 92_T 1.511 1.00
90_L 99_I 1.509 1.00
214_S 217_K 1.502 1.00
315_Y 319_A 1.481 1.00
70_L 75_T 1.472 1.00
291_C 399_A 1.467 1.00
225_A 359_I 1.464 1.00
74_Y 78_F 1.456 1.00
33_P 36_E 1.453 1.00
214_S 348_K 1.453 1.00
66_F 75_T 1.452 1.00
133_R 280_D 1.427 1.00
78_F 82_A 1.423 1.00
84_G 175_S 1.418 1.00
91_T 175_S 1.415 1.00
288_K 292_Y 1.409 1.00
373_Y 377_L 1.407 0.99
88_V 92_T 1.402 0.99
276_G 280_D 1.397 0.99
172_W 176_L 1.395 0.99
64_I 68_D 1.394 0.99
66_F 70_L 1.393 0.99
128_S 131_Q 1.39 0.99
82_A 86_L 1.381 0.99
196_P 199_E 1.37 0.99
255_L 258_A 1.37 0.99
101_F 105_L 1.367 0.99
264_Q 325_G 1.362 0.99
267_L 271_G 1.35 0.99
298_T 392_A 1.344 0.99
166_G 169_A 1.342 0.99
302_V 392_A 1.332 0.99
184_I 188_V 1.329 0.99
54_F 365_M 1.329 0.99
97_W 100_L 1.326 0.99
246_K 253_V 1.318 0.99
6_K 130_Q 1.317 0.99
79_S 109_T 1.312 0.99
298_T 302_V 1.302 0.99
149_V 153_A 1.3 0.99
278_I 282_I 1.298 0.99
59_G 62_L 1.296 0.99
74_Y 191_D 1.293 0.99
122_V 138_F 1.288 0.99
378_N 383_G 1.283 0.99
274_I 277_M 1.278 0.99
74_Y 77_S 1.271 0.99
288_K 291_C 1.261 0.99
68_D 351_A 1.256 0.99
14_T 141_G 1.251 0.99
70_L 74_Y 1.247 0.99
295_I 299_A 1.247 0.99
84_G 179_I 1.234 0.98
246_K 256_V 1.23 0.98
305_I 389_G 1.227 0.98
121_S 189_L 1.215 0.98
91_T 168_K 1.205 0.98
300_A 324_F 1.187 0.98
42_N 376_D 1.185 0.98
244_F 249_Y 1.183 0.98
176_L 180_A 1.181 0.98
169_A 172_W 1.179 0.98
275_G 330_T 1.178 0.98
55_V 107_G 1.173 0.98
62_L 65_Y 1.172 0.98
85_L 89_Y 1.169 0.97
292_Y 296_I 1.169 0.97
123_S 131_Q 1.166 0.97
374_I 378_N 1.164 0.97
89_Y 98_G 1.162 0.97
33_P 37_Y 1.161 0.97
75_T 78_F 1.157 0.97
271_G 274_I 1.156 0.97
124_R 349_T 1.15 0.97
35_Q 45_I 1.149 0.97
363_P 367_C 1.141 0.97
57_T 358_F 1.139 0.97
258_A 262_I 1.139 0.97
372_G 376_D 1.134 0.97
339_I 356_G 1.129 0.97
277_M 280_D 1.12 0.96
294_F 398_G 1.12 0.96
386_I 389_G 1.118 0.96
98_G 101_F 1.117 0.96
18_G 145_V 1.115 0.96
50_S 365_M 1.111 0.96
23_L 27_K 1.109 0.96
221_I 225_A 1.101 0.96
385_K 389_G 1.1 0.96
293_T 327_I 1.099 0.96
278_I 289_Y 1.099 0.96
67_A 72_R 1.098 0.96
47_N 369_S 1.098 0.96
156_V 169_A 1.096 0.96
71_P 75_T 1.096 0.96
393_C 397_S 1.095 0.96
68_D 72_R 1.091 0.96
286_P 291_C 1.09 0.96
302_V 306_M 1.088 0.96
300_A 323_G 1.085 0.96
92_T 172_W 1.082 0.96
64_I 350_G 1.081 0.95
80_L 182_G 1.08 0.95
43_G 376_D 1.077 0.95
222_W 226_F 1.073 0.95
305_I 392_A 1.062 0.95
266_C 270_I 1.061 0.95
77_S 81_I 1.052 0.95
133_R 137_F 1.045 0.94
37_Y 168_K 1.042 0.94
254_A 258_A 1.041 0.94
47_N 51_V 1.04 0.94
216_L 222_W 1.039 0.94
50_S 369_S 1.031 0.94
396_F 400_V 1.03 0.94
337_A 341_E 1.026 0.94
185_I 189_L 1.026 0.94
57_T 365_M 1.023 0.93
151_F 155_A 1.023 0.93
296_I 300_A 1.018 0.93
245_L 251_L 1.015 0.93
219_K 222_W 1.014 0.93
386_I 390_I 1.014 0.93
71_P 191_D 1.014 0.93
299_A 303_L 1.012 0.93
131_Q 341_E 1.009 0.93
133_R 277_M 1.008 0.93
179_I 183_I 1.008 0.93
23_L 26_L 1.004 0.93
52_N 107_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.95961000.114Contact Map0.499
3wdoA10.9431000.129Contact Map0.626
4j05A20.97151000.138Contact Map0.618
2cfqA10.94771000.164Contact Map0.495
2gfpA20.8861000.17Contact Map0.182
3o7qA10.93111000.171Contact Map0.627
4ldsA20.95721000.182Contact Map0.652
4gc0A10.9811000.186Contact Map0.731
2xutA30.97861000.209Contact Map0.524
4apsA20.96671000.238Contact Map0.523
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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