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YDHP - Inner membrane transport protein YdhP
UniProt: P77389 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13950
Length: 389 (370)
Sequences: 63383
Seq/Len: 171.31
YDHP
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_P 95_T 4.096 1.00
79_I 106_N 3.503 1.00
86_L 99_S 3.42 1.00
88_A 163_L 3.235 1.00
52_G 101_I 2.923 1.00
60_M 109_A 2.865 1.00
83_G 99_S 2.817 1.00
69_R 120_S 2.807 1.00
81_T 169_G 2.781 1.00
94_M 98_L 2.755 1.00
92_D 95_T 2.669 1.00
122_V 130_A 2.528 1.00
76_L 109_A 2.487 1.00
93_Y 97_M 2.483 1.00
128_A 262_D 2.414 1.00
126_K 129_S 2.376 1.00
235_T 238_F 2.357 1.00
38_S 41_A 2.357 1.00
83_G 106_N 2.231 1.00
56_G 105_L 2.225 1.00
65_S 324_G 2.202 1.00
83_G 102_L 2.19 1.00
282_A 296_S 2.176 1.00
249_G 298_V 2.122 1.00
70_R 74_I 2.092 1.00
215_G 341_G 2.084 1.00
123_P 126_K 2.082 1.00
253_G 302_A 2.065 1.00
156_I 160_M 2.012 1.00
211_V 337_G 2.004 1.00
90_A 95_T 1.998 1.00
41_A 93_Y 1.903 1.00
275_L 303_A 1.888 1.00
74_I 177_F 1.862 1.00
85_V 166_A 1.837 1.00
90_A 99_S 1.83 1.00
219_T 345_G 1.795 1.00
81_T 173_M 1.791 1.00
45_L 96_L 1.789 1.00
37_V 93_Y 1.788 1.00
83_G 103_T 1.779 1.00
48_A 101_I 1.777 1.00
279_I 303_A 1.774 1.00
74_I 173_M 1.773 1.00
279_I 296_S 1.77 1.00
174_V 178_F 1.762 1.00
64_L 113_L 1.727 1.00
195_L 199_M 1.725 1.00
62_L 66_H 1.716 1.00
48_A 97_M 1.703 1.00
68_A 71_S 1.684 1.00
56_G 108_G 1.681 1.00
291_F 295_I 1.668 1.00
52_G 56_G 1.646 1.00
87_S 99_S 1.64 1.00
360_V 364_I 1.623 1.00
87_S 96_L 1.621 1.00
78_A 173_M 1.612 1.00
277_M 370_L 1.591 1.00
37_V 41_A 1.578 1.00
81_T 166_A 1.538 1.00
259_K 263_R 1.532 1.00
196_A 199_M 1.521 1.00
207_L 333_A 1.508 1.00
88_A 166_A 1.488 1.00
30_V 33_R 1.475 1.00
234_A 238_F 1.459 1.00
163_L 167_G 1.439 1.00
71_S 75_F 1.423 1.00
63_L 67_R 1.42 1.00
319_A 326_S 1.408 1.00
277_M 367_G 1.404 0.99
129_S 262_D 1.401 0.99
11_A 137_G 1.396 0.99
124_K 127_Q 1.393 0.99
95_T 99_S 1.387 0.99
246_I 301_G 1.382 0.99
51_V 339_A 1.374 0.99
157_G 160_M 1.372 0.99
258_G 262_D 1.371 0.99
75_F 79_I 1.366 0.99
85_V 89_I 1.362 0.99
249_G 253_G 1.355 0.99
63_L 72_A 1.354 0.99
229_Q 239_V 1.349 0.99
67_R 72_A 1.348 0.99
196_A 322_A 1.345 0.99
175_S 179_S 1.343 0.99
94_M 97_M 1.343 0.99
56_G 59_L 1.342 0.99
238_F 241_A 1.338 0.99
61_T 65_S 1.334 0.99
59_L 62_L 1.304 0.99
86_L 89_I 1.292 0.99
79_I 83_G 1.274 0.99
266_N 317_R 1.271 0.99
81_T 170_V 1.267 0.99
147_P 244_V 1.267 0.99
203_V 207_L 1.264 0.99
39_I 350_S 1.263 0.99
260_L 264_S 1.261 0.99
118_A 134_M 1.258 0.99
256_L 259_K 1.256 0.99
27_L 153_G 1.247 0.99
347_A 351_A 1.239 0.98
76_L 106_N 1.237 0.98
229_Q 236_P 1.235 0.98
289_N 292_G 1.235 0.98
65_S 325_L 1.225 0.98
71_S 74_I 1.216 0.98
160_M 163_L 1.211 0.98
291_F 294_A 1.207 0.98
119_A 127_Q 1.2 0.98
253_G 256_L 1.191 0.98
216_A 366_A 1.185 0.98
32_A 42_A 1.184 0.98
98_L 102_L 1.183 0.98
337_G 341_G 1.182 0.98
279_I 300_W 1.182 0.98
272_F 306_A 1.18 0.98
67_R 71_S 1.169 0.97
18_G 138_L 1.166 0.97
47_S 339_A 1.164 0.97
120_S 323_P 1.162 0.97
274_L 278_V 1.158 0.97
154_E 237_V 1.153 0.97
88_A 159_R 1.15 0.97
227_V 232_T 1.143 0.97
52_G 104_S 1.141 0.97
64_L 69_R 1.141 0.97
228_L 234_A 1.137 0.97
68_A 72_A 1.136 0.97
54_M 332_G 1.133 0.97
274_L 370_L 1.127 0.97
30_V 34_G 1.127 0.97
152_L 160_M 1.126 0.97
44_M 343_A 1.124 0.97
277_M 281_L 1.123 0.97
71_S 182_K 1.121 0.97
204_L 208_L 1.115 0.96
117_V 180_L 1.112 0.96
284_P 360_V 1.108 0.96
82_L 86_L 1.104 0.96
86_L 95_T 1.101 0.96
77_M 173_M 1.1 0.96
65_S 69_R 1.099 0.96
319_A 322_A 1.093 0.96
281_L 363_A 1.088 0.96
259_K 262_D 1.085 0.96
279_I 299_V 1.084 0.96
49_Y 53_V 1.082 0.96
353_L 357_F 1.078 0.95
198_L 204_L 1.074 0.95
72_A 75_F 1.074 0.95
237_V 241_A 1.072 0.95
44_M 48_A 1.071 0.95
295_I 299_V 1.07 0.95
167_G 171_I 1.069 0.95
40_P 350_S 1.068 0.95
89_I 163_L 1.068 0.95
49_Y 104_S 1.066 0.95
151_W 155_T 1.066 0.95
322_A 325_L 1.06 0.95
49_Y 107_H 1.058 0.95
13_G 110_F 1.056 0.95
346_G 350_S 1.055 0.95
15_F 141_A 1.048 0.94
27_L 161_S 1.043 0.94
95_T 98_L 1.042 0.94
315_V 330_N 1.041 0.94
272_F 303_A 1.038 0.94
364_I 368_L 1.034 0.94
218_F 338_N 1.031 0.94
277_M 363_A 1.029 0.94
348_V 353_L 1.028 0.94
47_S 343_A 1.025 0.93
176_L 180_L 1.022 0.93
147_P 151_W 1.021 0.93
210_T 330_N 1.02 0.93
142_N 247_G 1.017 0.93
201_P 204_L 1.012 0.93
129_S 133_T 1.009 0.93
252_I 256_L 1.008 0.93
61_T 324_G 1.003 0.93
213_G 307_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99491000.175Contact Map0.496
3wdoA10.98971000.187Contact Map0.655
2gfpA20.9461000.194Contact Map0.189
3o7qA10.97171000.224Contact Map0.641
4j05A20.99231000.224Contact Map0.611
2cfqA10.98711000.23Contact Map0.51
2xutA30.99741000.27Contact Map0.547
4jr9A10.96921000.283Contact Map0.613
4ldsA20.99231000.283Contact Map0.625
4apsA20.99491000.287Contact Map0.546
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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