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OPENSEQ.org
GARP - Probable galactarate transporter
UniProt: P0AA80 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12760
Length: 444 (410)
Sequences: 62794
Seq/Len: 153.16
GARP
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_D 114_S 4.387 1.00
92_F 125_S 3.611 1.00
99_L 118_M 3.562 1.00
101_G 182_T 3.27 1.00
105_M 113_I 3.092 1.00
65_A 120_F 3.021 1.00
113_I 117_F 3.021 1.00
96_F 118_M 3.013 1.00
94_S 188_G 2.892 1.00
73_G 128_P 2.789 1.00
105_M 114_S 2.782 1.00
82_S 139_A 2.739 1.00
375_A 383_C 2.609 1.00
147_G 311_D 2.59 1.00
106_F 116_F 2.582 1.00
284_S 287_K 2.536 1.00
141_F 149_A 2.482 1.00
89_S 128_P 2.465 1.00
260_Y 394_A 2.426 1.00
145_E 148_T 2.413 1.00
51_S 54_S 2.363 1.00
96_F 121_M 2.313 1.00
96_F 125_S 2.296 1.00
78_D 381_G 2.265 1.00
69_M 124_F 2.262 1.00
264_T 398_T 2.216 1.00
214_K 217_S 2.178 1.00
142_P 145_E 2.174 1.00
83_K 87_T 2.114 1.00
103_V 114_S 2.113 1.00
244_K 248_S 2.054 1.00
175_W 179_H 2.051 1.00
376_P 379_I 2.033 1.00
103_V 118_M 2.031 1.00
207_R 210_A 1.923 1.00
98_F 185_G 1.916 1.00
69_M 127_A 1.886 1.00
106_F 113_I 1.883 1.00
87_T 192_T 1.882 1.00
96_F 122_L 1.822 1.00
77_L 132_A 1.82 1.00
417_V 421_C 1.801 1.00
61_A 120_F 1.792 1.00
54_S 106_F 1.791 1.00
58_I 115_M 1.785 1.00
268_F 402_I 1.783 1.00
61_A 116_F 1.775 1.00
75_W 79_K 1.757 1.00
50_L 106_F 1.753 1.00
100_Q 118_M 1.747 1.00
94_S 192_T 1.732 1.00
24_F 156_A 1.729 1.00
87_T 196_I 1.716 1.00
193_A 197_K 1.714 1.00
81_G 84_K 1.692 1.00
65_A 69_M 1.685 1.00
315_K 373_D 1.674 1.00
308_V 312_Y 1.602 1.00
100_Q 115_M 1.599 1.00
91_F 192_T 1.594 1.00
50_L 54_S 1.582 1.00
76_L 85_V 1.558 1.00
101_G 185_G 1.555 1.00
84_K 88_Y 1.531 1.00
256_F 390_F 1.514 1.00
16_R 145_E 1.514 1.00
245_Q 248_S 1.509 1.00
302_G 359_F 1.508 1.00
298_C 355_A 1.508 1.00
314_I 317_G 1.501 1.00
298_C 302_G 1.493 1.00
98_F 102_F 1.491 1.00
99_L 102_F 1.489 1.00
348_T 352_M 1.484 1.00
307_G 311_D 1.477 1.00
76_L 80_F 1.465 1.00
176_G 179_H 1.463 1.00
80_F 85_V 1.462 1.00
88_Y 92_F 1.44 1.00
283_M 287_K 1.439 1.00
64_W 396_I 1.438 1.00
114_S 118_M 1.429 1.00
74_G 78_D 1.426 1.00
245_Q 379_I 1.418 1.00
278_V 288_V 1.418 1.00
43_E 46_K 1.412 1.00
143_T 146_R 1.41 1.00
94_S 185_G 1.409 1.00
92_F 96_F 1.385 0.99
182_T 186_V 1.364 0.99
148_T 311_D 1.363 0.99
117_F 121_M 1.354 0.99
287_K 290_L 1.336 0.99
69_M 72_P 1.332 0.99
195_W 199_I 1.324 0.99
113_I 116_F 1.324 0.99
404_Y 408_E 1.323 0.99
137_V 153_F 1.323 0.99
252_M 256_F 1.312 0.99
101_G 178_E 1.29 0.99
305_L 308_V 1.281 0.99
340_L 353_L 1.277 0.99
80_F 84_K 1.274 0.99
84_K 87_T 1.27 0.99
309_F 313_L 1.269 0.99
166_P 293_S 1.269 0.99
278_V 285_I 1.267 0.99
89_S 125_S 1.267 0.99
138_A 146_R 1.259 0.99
78_D 382_L 1.258 0.99
40_A 172_T 1.254 0.99
267_W 395_S 1.253 0.99
26_V 129_S 1.253 0.99
60_S 396_I 1.248 0.99
194_L 198_L 1.244 0.98
31_Y 157_Q 1.235 0.98
186_V 190_V 1.234 0.98
209_S 212_E 1.225 0.98
45_A 55_M 1.216 0.98
94_S 189_F 1.216 0.98
171_L 179_H 1.212 0.98
265_I 423_A 1.2 0.98
302_G 305_L 1.199 0.98
72_P 75_W 1.196 0.98
394_A 398_T 1.193 0.98
173_F 286_L 1.193 0.98
179_H 182_T 1.188 0.98
85_V 88_Y 1.187 0.98
67_L 389_V 1.187 0.98
78_D 82_S 1.186 0.98
77_L 82_S 1.183 0.98
99_L 114_S 1.18 0.98
87_T 195_W 1.168 0.97
335_A 427_M 1.166 0.97
421_C 425_M 1.161 0.97
276_Y 281_K 1.159 0.97
139_A 380_V 1.156 0.97
52_A 407_S 1.147 0.97
43_E 47_E 1.145 0.97
277_L 283_M 1.145 0.97
74_G 381_G 1.144 0.97
330_L 334_L 1.143 0.97
352_M 355_A 1.14 0.97
148_T 152_I 1.14 0.97
371_I 387_F 1.14 0.97
95_L 99_L 1.129 0.97
403_G 407_S 1.125 0.97
62_F 126_E 1.125 0.97
53_V 407_S 1.124 0.97
47_E 178_E 1.122 0.97
337_T 353_L 1.12 0.96
32_A 164_F 1.116 0.96
189_F 193_A 1.115 0.96
297_L 301_A 1.112 0.96
114_S 117_F 1.111 0.96
185_G 189_F 1.108 0.96
102_F 182_T 1.106 0.96
22_I 194_L 1.102 0.96
253_L 257_F 1.102 0.96
259_Q 387_F 1.094 0.96
65_A 123_G 1.093 0.96
62_F 66_Y 1.091 0.96
405_L 409_L 1.089 0.96
57_Y 61_A 1.087 0.96
57_Y 400_L 1.086 0.96
28_A 160_S 1.084 0.96
166_P 170_W 1.081 0.95
90_L 192_T 1.078 0.95
32_A 184_M 1.074 0.95
339_I 420_G 1.074 0.95
81_G 85_V 1.071 0.95
247_L 253_L 1.071 0.95
104_D 178_E 1.062 0.95
84_K 201_N 1.055 0.95
26_V 86_Y 1.051 0.94
170_W 174_A 1.046 0.94
335_A 424_L 1.045 0.94
242_Y 245_Q 1.044 0.94
290_L 294_I 1.043 0.94
60_S 400_L 1.043 0.94
357_A 360_G 1.042 0.94
58_I 106_F 1.029 0.94
169_G 289_G 1.029 0.94
192_T 196_I 1.028 0.94
414_A 418_F 1.028 0.94
71_I 75_W 1.027 0.94
413_N 417_V 1.024 0.93
148_T 308_V 1.02 0.93
348_T 351_V 1.016 0.93
40_A 180_V 1.014 0.93
45_A 50_L 1.012 0.93
167_L 170_W 1.011 0.93
28_A 163_L 1.011 0.93
250_R 254_G 1.011 0.93
87_T 91_F 1.007 0.93
138_A 380_V 1.006 0.93
45_A 52_A 1.004 0.93
379_I 382_L 1.002 0.92
214_K 218_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.94371000.193Contact Map0.475
4j05A20.9551000.216Contact Map0.622
3wdoA10.88291000.227Contact Map0.636
3o7qA10.89641000.24Contact Map0.608
2cfqA10.89191000.253Contact Map0.459
4gc0A10.94141000.253Contact Map0.714
2gfpA20.83111000.255Contact Map0.181
4ldsA20.93021000.265Contact Map0.621
2xutA30.95951000.281Contact Map0.513
4jr9A10.88061000.311Contact Map0.604
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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