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RHMT - Inner membrane transport protein RhmT
UniProt: P76470 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14084
Length: 429 (403)
Sequences: 66677
Seq/Len: 165.45
RHMT
Paralog alert: 0.91 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_D 106_K 3.959 1.00
90_L 117_A 3.57 1.00
97_A 110_V 3.424 1.00
99_A 180_V 3.17 1.00
94_L 110_V 2.907 1.00
63_V 112_T 2.893 1.00
105_A 109_I 2.85 1.00
71_A 120_G 2.777 1.00
92_G 186_A 2.769 1.00
103_T 106_K 2.753 1.00
80_A 131_Q 2.681 1.00
357_L 365_G 2.59 1.00
139_A 300_D 2.558 1.00
104_E 108_L 2.556 1.00
87_T 120_G 2.537 1.00
133_F 141_I 2.524 1.00
273_V 276_T 2.487 1.00
49_S 52_A 2.396 1.00
137_N 140_S 2.351 1.00
94_L 117_A 2.35 1.00
67_L 116_A 2.258 1.00
248_L 376_G 2.258 1.00
287_A 336_C 2.22 1.00
322_L 334_A 2.197 1.00
252_V 380_A 2.178 1.00
94_L 113_L 2.157 1.00
134_P 137_N 2.142 1.00
76_R 363_A 2.134 1.00
232_S 236_R 2.071 1.00
81_R 85_G 2.029 1.00
304_E 355_Q 1.975 1.00
358_S 361_A 1.921 1.00
319_G 334_A 1.9 1.00
101_A 110_V 1.882 1.00
85_G 190_G 1.88 1.00
291_G 340_I 1.878 1.00
101_A 106_K 1.877 1.00
96_A 183_G 1.87 1.00
52_A 104_E 1.86 1.00
67_L 119_A 1.858 1.00
94_L 114_L 1.803 1.00
399_L 403_A 1.796 1.00
75_M 124_G 1.789 1.00
48_L 104_E 1.783 1.00
73_L 77_K 1.781 1.00
56_G 107_F 1.78 1.00
92_G 190_G 1.771 1.00
63_V 67_L 1.754 1.00
22_L 148_G 1.744 1.00
329_V 333_V 1.722 1.00
319_G 341_G 1.708 1.00
315_A 341_G 1.702 1.00
59_I 108_L 1.697 1.00
191_V 195_F 1.696 1.00
317_G 409_S 1.676 1.00
59_I 112_T 1.675 1.00
98_M 110_V 1.665 1.00
89_L 190_G 1.652 1.00
85_G 194_F 1.64 1.00
303_G 306_R 1.62 1.00
79_G 82_T 1.588 1.00
284_P 339_A 1.577 1.00
297_R 301_K 1.569 1.00
167_H 177_W 1.557 1.00
256_G 384_R 1.551 1.00
48_L 52_A 1.538 1.00
74_L 83_W 1.504 1.00
98_M 107_F 1.493 1.00
296_P 300_D 1.492 1.00
287_A 291_G 1.481 1.00
72_N 76_R 1.48 1.00
99_A 183_G 1.476 1.00
97_A 100_W 1.474 1.00
244_A 372_F 1.464 1.00
312_T 344_A 1.451 1.00
92_G 183_G 1.446 1.00
233_D 236_R 1.441 1.00
213_T 216_I 1.43 1.00
78_L 83_W 1.422 1.00
82_T 86_T 1.421 1.00
74_L 78_L 1.402 0.99
86_T 90_L 1.4 0.99
180_V 184_L 1.397 0.99
174_G 177_W 1.391 0.99
106_K 110_V 1.389 0.99
271_T 276_T 1.388 0.99
140_S 300_D 1.385 0.99
317_G 406_V 1.375 0.99
192_F 196_W 1.357 0.99
90_L 94_L 1.345 0.99
266_A 277_A 1.335 0.99
62_V 378_F 1.333 0.99
135_Q 138_R 1.331 0.99
96_A 100_W 1.325 0.99
87_T 117_A 1.321 0.99
294_L 297_R 1.319 0.99
203_Q 206_F 1.311 0.99
298_Y 302_T 1.31 0.99
295_I 344_A 1.294 0.99
317_G 321_G 1.293 0.99
67_L 70_P 1.292 0.99
105_A 108_L 1.29 0.99
109_I 113_L 1.289 0.99
276_T 279_V 1.287 0.99
29_F 149_A 1.286 0.99
92_G 187_V 1.283 0.99
158_P 282_A 1.283 0.99
233_D 361_A 1.28 0.99
386_K 390_L 1.278 0.99
41_T 44_I 1.273 0.99
165_E 275_F 1.271 0.99
129_T 145_F 1.269 0.99
14_R 137_N 1.258 0.99
255_Y 377_G 1.251 0.99
317_G 402_A 1.248 0.99
130_S 138_R 1.243 0.98
311_L 315_A 1.233 0.98
82_T 85_G 1.229 0.98
314_L 318_I 1.225 0.98
321_G 402_A 1.224 0.98
266_A 274_G 1.223 0.98
76_R 364_A 1.218 0.98
184_L 188_G 1.217 0.98
131_Q 362_L 1.207 0.98
63_V 115_R 1.205 0.98
177_W 180_V 1.2 0.98
291_G 294_L 1.199 0.98
58_G 378_F 1.199 0.98
163_L 177_W 1.195 0.98
70_P 73_L 1.193 0.98
162_A 166_M 1.193 0.98
50_N 389_T 1.19 0.98
303_G 307_N 1.19 0.98
264_Q 269_L 1.188 0.98
312_T 341_G 1.188 0.98
82_T 199_D 1.182 0.98
138_R 355_Q 1.178 0.98
99_A 176_F 1.177 0.98
385_V 389_T 1.162 0.97
240_V 244_A 1.161 0.97
319_G 338_A 1.16 0.97
324_G 402_A 1.151 0.97
128_L 197_L 1.149 0.97
193_T 197_L 1.147 0.97
78_L 82_T 1.146 0.97
376_G 380_A 1.144 0.97
65_A 371_L 1.139 0.97
93_F 97_A 1.138 0.97
314_L 409_S 1.138 0.97
167_H 174_G 1.136 0.97
319_G 337_V 1.128 0.97
38_A 164_L 1.126 0.97
235_L 241_W 1.126 0.97
72_N 363_A 1.124 0.97
97_A 106_K 1.121 0.97
43_Q 53_Y 1.12 0.96
75_M 80_A 1.12 0.96
324_G 399_L 1.119 0.96
83_W 86_T 1.117 0.96
60_F 64_Y 1.111 0.96
51_E 389_T 1.11 0.96
329_V 332_I 1.109 0.96
286_V 290_F 1.106 0.96
403_A 407_I 1.103 0.96
140_S 144_L 1.099 0.96
60_F 118_E 1.096 0.96
45_D 176_F 1.091 0.96
321_G 325_L 1.09 0.96
79_G 83_W 1.088 0.96
158_P 162_A 1.078 0.95
76_R 80_A 1.074 0.95
55_L 382_I 1.072 0.95
297_R 300_D 1.067 0.95
299_S 348_V 1.059 0.95
333_V 337_V 1.058 0.95
55_L 59_I 1.058 0.95
31_D 34_N 1.056 0.95
253_A 405_A 1.05 0.94
26_V 152_A 1.049 0.94
353_P 369_V 1.048 0.94
100_W 180_V 1.036 0.94
250_I 345_V 1.035 0.94
88_T 190_G 1.033 0.94
106_K 109_I 1.033 0.94
153_L 285_W 1.028 0.94
79_G 199_D 1.028 0.94
30_L 156_G 1.026 0.94
279_V 283_I 1.025 0.93
24_L 121_F 1.023 0.93
264_Q 268_L 1.02 0.93
41_T 45_D 1.019 0.93
406_V 410_L 1.018 0.93
241_W 245_I 1.017 0.93
395_A 399_L 1.016 0.93
85_G 89_L 1.015 0.93
333_V 336_C 1.011 0.93
213_T 217_N 1.011 0.93
58_G 382_I 1.01 0.93
159_L 162_A 1.01 0.93
26_V 155_L 1.009 0.93
312_T 345_V 1.009 0.93
65_A 378_F 1.006 0.93
187_V 191_V 1.004 0.93
387_A 391_F 1.003 0.93
102_D 176_F 1.003 0.93
212_K 216_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.97671000.143Contact Map0.507
3wdoA10.92541000.19Contact Map0.631
4j05A20.98831000.195Contact Map0.611
3o7qA10.93711000.228Contact Map0.629
2gfpA20.86481000.236Contact Map0.176
2cfqA10.93011000.249Contact Map0.507
4gc0A10.9791000.259Contact Map0.712
4ldsA20.95341000.264Contact Map0.629
2xutA30.96971000.277Contact Map0.535
4apsA20.96971000.289Contact Map0.547
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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