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OPENSEQ.org
ARAE - Arabinose-proton symporter
UniProt: P0AE24 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10056
Length: 472 (434)
Sequences: 48963
Seq/Len: 112.82
ARAE
Paralog alert: 0.89 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_T 114_M 4.891 1.00
98_L 125_A 3.819 1.00
107_A 182_G 3.502 1.00
113_E 117_A 3.429 1.00
105_G 118_A 3.399 1.00
100_V 188_A 3.305 1.00
71_G 120_V 3.239 1.00
102_G 118_A 2.943 1.00
111_S 114_M 2.833 1.00
79_N 128_I 2.792 1.00
147_G 319_D 2.745 1.00
210_R 213_E 2.712 1.00
112_V 116_I 2.71 1.00
388_Q 396_G 2.62 1.00
88_R 139_E 2.55 1.00
57_T 60_L 2.486 1.00
102_G 121_V 2.409 1.00
84_F 394_D 2.38 1.00
141_A 149_M 2.366 1.00
145_V 148_K 2.345 1.00
102_G 125_A 2.342 1.00
95_G 128_I 2.33 1.00
429_W 433_A 2.328 1.00
75_G 124_I 2.307 1.00
291_T 294_E 2.294 1.00
142_S 145_V 2.196 1.00
335_A 436_I 2.119 1.00
67_S 120_V 2.115 1.00
109_A 114_M 2.105 1.00
75_G 127_G 2.089 1.00
340_V 364_M 2.072 1.00
333_V 371_G 2.061 1.00
389_P 392_C 2.053 1.00
335_A 439_V 1.99 1.00
67_S 116_I 1.969 1.00
89_K 93_M 1.952 1.00
109_A 118_A 1.949 1.00
81_W 85_R 1.915 1.00
323_R 386_E 1.913 1.00
247_A 250_K 1.908 1.00
60_L 112_V 1.892 1.00
104_I 185_A 1.88 1.00
64_V 115_L 1.879 1.00
102_G 122_L 1.875 1.00
332_S 439_V 1.859 1.00
106_S 118_A 1.821 1.00
93_M 195_V 1.801 1.00
310_A 370_A 1.78 1.00
93_M 192_I 1.762 1.00
337_G 364_M 1.746 1.00
322_G 325_P 1.744 1.00
82_L 91_S 1.719 1.00
175_G 179_A 1.701 1.00
83_S 132_T 1.698 1.00
30_A 156_M 1.698 1.00
316_F 320_K 1.662 1.00
328_K 439_V 1.641 1.00
56_L 112_V 1.629 1.00
306_T 310_A 1.601 1.00
104_I 108_F 1.6 1.00
56_L 60_L 1.598 1.00
114_M 118_A 1.597 1.00
306_T 366_M 1.594 1.00
106_S 115_L 1.594 1.00
87_G 90_Y 1.593 1.00
97_I 192_I 1.582 1.00
71_G 75_G 1.58 1.00
90_Y 94_A 1.561 1.00
100_V 192_I 1.554 1.00
335_A 432_T 1.542 1.00
98_L 102_G 1.542 1.00
105_G 108_F 1.526 1.00
359_W 363_G 1.519 1.00
117_A 121_V 1.502 1.00
86_L 91_S 1.467 1.00
339_L 432_T 1.465 1.00
212_I 215_E 1.456 1.00
80_G 84_F 1.452 1.00
70_L 409_M 1.447 1.00
335_A 339_L 1.443 1.00
342_G 429_W 1.43 1.00
94_A 98_L 1.426 1.00
49_F 52_D 1.424 1.00
369_I 375_S 1.423 1.00
315_V 319_D 1.418 1.00
107_A 185_A 1.417 1.00
100_V 185_A 1.416 1.00
171_F 179_A 1.415 1.00
82_L 86_L 1.409 1.00
90_Y 200_N 1.401 0.99
75_G 78_F 1.394 0.99
37_G 157_V 1.388 0.99
253_R 256_R 1.38 0.99
148_K 319_D 1.366 0.99
86_L 90_Y 1.363 0.99
272_T 411_I 1.359 0.99
176_N 179_A 1.357 0.99
433_A 437_A 1.355 0.99
90_Y 93_M 1.348 0.99
22_N 145_V 1.337 0.99
182_G 186_L 1.33 0.99
107_A 178_R 1.328 0.99
332_S 336_L 1.314 0.99
73_A 402_T 1.314 0.99
325_P 329_I 1.314 0.99
143_E 146_R 1.308 0.99
80_G 394_D 1.306 0.99
113_E 116_I 1.292 0.99
66_S 409_M 1.291 0.99
313_I 316_F 1.287 0.99
211_H 236_R 1.287 0.99
71_G 123_G 1.283 0.99
166_L 301_L 1.275 0.99
407_S 411_I 1.275 0.99
83_S 88_R 1.272 0.99
317_T 321_A 1.271 0.99
324_K 328_K 1.268 0.99
32_A 129_A 1.259 0.99
84_F 88_R 1.249 0.99
333_V 337_G 1.248 0.99
179_A 182_G 1.241 0.98
276_I 415_F 1.239 0.98
34_L 160_G 1.239 0.98
139_E 393_R 1.234 0.98
137_L 153_Y 1.232 0.98
114_M 117_A 1.228 0.98
84_F 395_F 1.225 0.98
426_G 429_W 1.22 0.98
51_T 61_Q 1.216 0.98
215_E 229_R 1.211 0.98
252_N 256_R 1.21 0.98
426_G 430_L 1.203 0.98
417_T 421_S 1.201 0.98
110_T 178_R 1.198 0.98
34_L 163_L 1.18 0.98
105_G 114_M 1.177 0.98
101_L 105_G 1.174 0.98
95_G 125_A 1.174 0.98
342_G 432_T 1.169 0.97
193_I 196_V 1.161 0.97
305_L 309_F 1.159 0.97
418_L 422_I 1.156 0.97
310_A 313_I 1.153 0.97
53_H 178_R 1.153 0.97
58_S 420_D 1.153 0.97
138_S 146_R 1.153 0.97
92_L 136_Y 1.148 0.97
330_G 375_S 1.148 0.97
68_M 126_V 1.148 0.97
32_A 92_L 1.145 0.97
339_L 343_Y 1.144 0.97
38_L 184_L 1.142 0.97
284_I 288_A 1.141 0.97
290_F 294_E 1.141 0.97
46_A 180_M 1.136 0.97
329_I 333_V 1.136 0.97
237_E 240_K 1.135 0.97
312_F 316_F 1.132 0.97
91_S 94_A 1.128 0.97
334_M 435_N 1.124 0.97
87_G 91_S 1.124 0.97
275_N 408_N 1.117 0.96
167_S 170_A 1.112 0.96
49_F 53_H 1.11 0.96
422_I 426_G 1.11 0.96
336_L 340_V 1.1 0.96
215_E 219_R 1.1 0.96
303_V 369_I 1.097 0.96
148_K 152_M 1.097 0.96
331_F 438_F 1.096 0.96
25_V 140_M 1.094 0.96
50_I 177_W 1.09 0.96
47_L 61_Q 1.09 0.96
247_A 392_C 1.089 0.96
430_L 434_L 1.086 0.96
436_I 440_G 1.085 0.96
68_M 119_R 1.083 0.96
87_G 200_N 1.082 0.96
100_V 189_V 1.08 0.95
88_R 200_N 1.08 0.95
147_G 315_V 1.079 0.95
64_V 112_V 1.078 0.95
331_F 439_V 1.077 0.95
325_P 328_K 1.076 0.95
253_R 257_R 1.075 0.95
63_W 413_A 1.074 0.95
211_H 215_E 1.074 0.95
286_K 292_T 1.073 0.95
337_G 368_C 1.073 0.95
148_K 316_F 1.072 0.95
96_A 192_I 1.067 0.95
430_L 433_A 1.066 0.95
414_T 417_T 1.065 0.95
38_L 164_A 1.063 0.95
416_L 420_D 1.062 0.95
137_L 149_M 1.059 0.95
335_A 435_N 1.059 0.95
62_E 66_S 1.056 0.95
186_L 190_L 1.056 0.95
166_L 170_A 1.055 0.95
321_A 326_A 1.054 0.95
26_S 141_A 1.054 0.95
298_I 302_V 1.05 0.94
294_E 298_I 1.048 0.94
72_A 405_W 1.04 0.94
63_W 67_S 1.04 0.94
179_A 183_V 1.04 0.94
46_A 172_S 1.029 0.94
161_I 304_G 1.027 0.94
452_V 456_H 1.026 0.94
93_M 97_I 1.018 0.93
425_A 429_W 1.015 0.93
189_V 193_I 1.013 0.93
432_T 436_I 1.01 0.93
99_F 125_A 1.007 0.93
340_V 343_Y 1.006 0.93
108_F 182_G 1.004 0.93
28_A 194_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gc0A10.94491000.248Contact Map0.725
4ldsA20.94491000.254Contact Map0.646
4j05A20.97251000.285Contact Map0.652
1pw4A10.9111000.321Contact Map0.488
3wdoA10.86441000.352Contact Map0.625
3o7qA10.84961000.378Contact Map0.609
2gfpA20.78811000.388Contact Map0.171
2xutA30.95131000.39Contact Map0.518
2cfqA10.85171000.398Contact Map0.461
4apsA20.94491000.423Contact Map0.521
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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