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MDTH - Multidrug resistance protein MdtH
UniProt: P69367 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13878
Length: 402 (375)
Sequences: 66722
Seq/Len: 177.93
MDTH
Paralog alert: 0.90 [within 20: 0.68] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
97_H 101_L 4.052 1.00
85_M 112_G 3.465 1.00
92_T 105_S 3.412 1.00
94_G 168_A 3.227 1.00
58_I 107_L 3.101 1.00
100_W 104_F 2.957 1.00
75_A 126_K 2.883 1.00
89_G 105_S 2.874 1.00
87_A 174_F 2.849 1.00
66_G 115_L 2.702 1.00
98_E 101_L 2.689 1.00
326_A 334_Y 2.607 1.00
128_I 136_F 2.534 1.00
82_G 115_L 2.531 1.00
241_A 244_A 2.51 1.00
99_P 103_W 2.509 1.00
44_A 47_M 2.474 1.00
89_G 112_G 2.328 1.00
89_G 108_L 2.315 1.00
132_Q 135_R 2.299 1.00
290_P 303_L 2.282 1.00
62_L 111_L 2.238 1.00
134_G 269_K 2.204 1.00
71_D 332_G 2.192 1.00
273_L 324_S 2.152 1.00
283_I 310_G 2.095 1.00
129_R 132_Q 2.06 1.00
202_T 206_R 2.005 1.00
222_M 349_G 1.99 1.00
287_S 303_L 1.972 1.00
161_Y 165_L 1.949 1.00
76_K 80_V 1.947 1.00
218_A 345_G 1.947 1.00
96_A 101_L 1.936 1.00
91_A 171_A 1.933 1.00
327_D 330_A 1.917 1.00
80_V 182_A 1.91 1.00
96_A 105_S 1.889 1.00
255_L 305_C 1.885 1.00
62_L 114_T 1.883 1.00
298_Q 302_T 1.877 1.00
47_M 99_P 1.847 1.00
89_G 109_S 1.788 1.00
179_A 183_W 1.784 1.00
54_L 107_L 1.767 1.00
80_V 178_A 1.765 1.00
51_A 102_L 1.764 1.00
272_R 275_H 1.753 1.00
87_A 178_A 1.75 1.00
54_L 103_W 1.743 1.00
43_W 99_P 1.718 1.00
70_A 119_P 1.695 1.00
68_A 72_R 1.691 1.00
255_L 259_L 1.678 1.00
74_G 77_P 1.667 1.00
265_R 269_K 1.666 1.00
280_G 313_I 1.654 1.00
84_L 178_A 1.629 1.00
285_S 381_F 1.629 1.00
93_M 105_S 1.618 1.00
287_S 310_G 1.613 1.00
259_L 309_I 1.611 1.00
371_M 375_I 1.587 1.00
43_W 47_M 1.56 1.00
87_A 171_A 1.551 1.00
58_I 62_L 1.527 1.00
101_L 105_S 1.507 1.00
94_G 171_A 1.501 1.00
240_G 244_A 1.492 1.00
168_A 172_V 1.49 1.00
93_M 102_L 1.472 1.00
226_Q 353_G 1.454 1.00
77_P 81_T 1.454 1.00
214_V 341_G 1.454 1.00
92_T 95_I 1.444 1.00
203_R 206_R 1.441 1.00
203_R 330_A 1.44 1.00
69_I 78_M 1.424 1.00
69_I 73_F 1.417 1.00
73_F 78_M 1.412 1.00
285_S 378_I 1.406 0.99
162_D 165_L 1.394 0.99
62_L 65_F 1.393 0.99
67_G 71_D 1.39 0.99
180_F 184_L 1.389 0.99
104_F 108_L 1.363 0.99
81_T 85_M 1.36 0.99
296_G 299_Q 1.357 0.99
244_A 247_W 1.342 0.99
45_A 358_D 1.329 0.99
130_P 133_R 1.32 0.99
82_G 112_G 1.314 0.99
85_M 89_G 1.314 0.99
91_A 95_I 1.31 0.99
57_F 347_A 1.307 0.99
275_H 278_M 1.303 0.99
282_L 286_L 1.289 0.99
278_M 381_F 1.283 0.99
73_F 77_P 1.283 0.99
87_A 175_V 1.282 0.99
100_W 103_W 1.281 0.99
124_V 140_L 1.276 0.99
345_G 349_G 1.269 0.99
285_S 289_M 1.269 0.99
16_L 143_Q 1.267 0.99
77_P 80_V 1.263 0.99
165_L 168_A 1.258 0.99
77_P 187_A 1.254 0.99
298_Q 301_F 1.24 0.98
252_E 308_Y 1.239 0.98
275_H 279_A 1.227 0.98
274_E 278_M 1.202 0.98
282_L 381_F 1.201 0.98
259_L 262_P 1.198 0.98
65_F 68_A 1.198 0.98
126_K 331_R 1.192 0.98
289_M 374_G 1.186 0.98
88_A 92_T 1.176 0.98
35_I 39_D 1.173 0.98
125_V 133_R 1.168 0.97
71_D 333_S 1.166 0.97
158_L 165_L 1.165 0.97
58_I 110_G 1.161 0.97
94_G 164_R 1.159 0.97
266_W 270_H 1.155 0.97
287_S 307_F 1.153 0.97
78_M 81_T 1.151 0.97
46_V 358_D 1.148 0.97
53_G 347_A 1.144 0.97
70_A 75_A 1.142 0.97
181_N 185_L 1.141 0.97
123_L 185_L 1.137 0.97
67_G 332_G 1.135 0.97
292_G 371_M 1.131 0.97
322_S 338_S 1.131 0.97
287_S 306_L 1.122 0.97
279_A 283_I 1.12 0.96
101_L 104_F 1.117 0.96
153_L 157_W 1.115 0.96
74_G 78_M 1.11 0.96
236_N 242_P 1.109 0.96
286_L 290_P 1.106 0.96
225_V 346_G 1.103 0.96
92_T 101_L 1.1 0.96
205_M 211_V 1.099 0.96
172_V 176_L 1.096 0.96
133_R 324_S 1.095 0.96
53_G 351_I 1.09 0.96
135_R 269_K 1.084 0.96
280_G 310_G 1.084 0.96
375_I 379_F 1.082 0.96
153_L 250_A 1.079 0.95
302_T 306_L 1.074 0.95
106_C 110_G 1.07 0.95
55_R 113_G 1.069 0.95
243_S 247_W 1.068 0.95
60_Q 340_L 1.068 0.95
83_M 178_A 1.062 0.95
38_V 45_A 1.059 0.95
80_V 84_L 1.056 0.95
50_I 54_L 1.054 0.95
20_M 147_G 1.052 0.95
355_W 359_L 1.048 0.94
271_F 275_H 1.047 0.94
95_I 168_A 1.045 0.94
271_F 276_R 1.045 0.94
135_R 139_L 1.044 0.94
272_R 276_R 1.041 0.94
38_V 48_V 1.04 0.94
32_L 159_L 1.039 0.94
378_I 382_L 1.036 0.94
289_M 293_M 1.031 0.94
283_I 287_S 1.029 0.94
211_V 215_L 1.028 0.94
175_V 179_A 1.025 0.93
50_I 351_I 1.025 0.93
263_I 266_W 1.019 0.93
330_A 333_S 1.017 0.93
354_G 358_D 1.012 0.93
236_N 245_V 1.008 0.93
84_L 88_A 1.005 0.93
60_Q 347_A 1.005 0.93
154_L 157_W 1.003 0.93
285_S 374_G 1.003 0.93
254_C 258_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98261000.194Contact Map0.477
3wdoA10.98011000.201Contact Map0.629
2cfqA10.97511000.224Contact Map0.513
2gfpA20.91791000.233Contact Map0.176
4j05A20.98261000.239Contact Map0.628
3o7qA10.95771000.244Contact Map0.625
2xutA30.99751000.272Contact Map0.534
4apsA20.98511000.301Contact Map0.55
4jr9A10.95021000.303Contact Map0.62
4ldsA20.97511000.307Contact Map0.636
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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