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OPENSEQ.org
SETA - Sugar efflux transporter A
UniProt: P31675 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11754
Length: 392 (370)
Sequences: 64971
Seq/Len: 175.60
SETA
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_R 105_T 4.055 1.00
89_M 117_A 3.308 1.00
98_A 175_S 3.199 1.00
96_L 110_G 3.173 1.00
61_A 112_L 3.007 1.00
91_I 181_F 2.834 1.00
102_H 105_T 2.63 1.00
93_N 110_G 2.585 1.00
78_D 130_E 2.506 1.00
135_S 138_E 2.493 1.00
47_Q 50_W 2.484 1.00
140_V 276_K 2.48 1.00
249_P 252_L 2.45 1.00
132_A 142_F 2.384 1.00
290_A 317_F 2.34 1.00
138_E 141_M 2.32 1.00
333_M 340_A 2.308 1.00
297_G 310_L 2.27 1.00
93_N 117_A 2.257 1.00
65_V 116_L 2.238 1.00
103_Y 107_I 2.237 1.00
225_T 351_G 2.197 1.00
267_A 316_V 2.191 1.00
74_D 338_G 2.138 1.00
263_L 312_L 2.119 1.00
93_N 113_L 2.117 1.00
229_T 355_A 2.081 1.00
104_L 109_C 2.015 1.00
168_Y 172_V 2.008 1.00
209_Q 213_Q 1.974 1.00
133_D 138_E 1.919 1.00
95_L 178_A 1.9 1.00
50_W 103_Y 1.852 1.00
46_A 103_Y 1.847 1.00
233_M 359_Q 1.828 1.00
100_N 105_T 1.822 1.00
186_V 190_F 1.818 1.00
294_F 310_L 1.812 1.00
280_K 331_D 1.808 1.00
84_I 185_L 1.802 1.00
305_M 309_T 1.795 1.00
57_V 112_L 1.76 1.00
54_F 106_L 1.742 1.00
91_I 185_L 1.717 1.00
93_N 114_A 1.716 1.00
88_L 185_L 1.694 1.00
373_W 377_V 1.692 1.00
84_I 189_A 1.685 1.00
73_S 123_Q 1.679 1.00
100_N 110_G 1.67 1.00
71_K 75_S 1.669 1.00
294_F 317_F 1.66 1.00
61_A 65_V 1.636 1.00
210_G 336_R 1.623 1.00
279_G 282_R 1.608 1.00
79_R 84_I 1.606 1.00
292_V 383_L 1.597 1.00
273_Y 277_R 1.589 1.00
46_A 50_W 1.572 1.00
57_V 107_I 1.543 1.00
210_G 213_Q 1.539 1.00
287_A 320_I 1.5 1.00
97_F 110_G 1.492 1.00
70_A 74_D 1.474 1.00
91_I 178_A 1.459 1.00
248_L 252_L 1.456 1.00
221_F 347_S 1.433 1.00
292_V 380_V 1.42 1.00
72_R 76_Q 1.418 1.00
65_V 119_T 1.396 0.99
263_L 267_A 1.396 0.99
175_S 179_G 1.395 0.99
272_G 276_K 1.392 0.99
96_L 99_F 1.388 0.99
19_M 149_Q 1.386 0.99
77_G 80_R 1.374 0.99
187_L 191_M 1.372 0.99
299_I 373_W 1.361 0.99
69_L 120_A 1.36 0.99
38_L 42_R 1.359 0.99
252_L 255_F 1.358 0.99
361_A 365_S 1.357 0.99
65_V 68_W 1.356 0.99
89_M 93_N 1.35 0.99
141_M 276_K 1.35 0.99
169_G 172_V 1.345 0.99
60_I 353_I 1.338 0.99
97_F 106_L 1.336 0.99
85_F 89_M 1.333 0.99
274_Y 278_Y 1.322 0.99
98_A 178_A 1.319 0.99
243_S 250_D 1.317 0.99
111_V 115_S 1.316 0.99
105_T 110_G 1.311 0.99
95_L 99_F 1.311 0.99
260_A 315_A 1.305 0.99
303_S 306_A 1.302 0.99
48_P 364_Q 1.296 0.99
289_A 293_L 1.289 0.99
270_L 273_Y 1.281 0.99
72_R 81_K 1.274 0.99
80_R 194_S 1.26 0.99
243_S 253_A 1.256 0.99
172_V 175_S 1.245 0.98
86_C 117_A 1.241 0.98
91_I 182_T 1.239 0.98
68_W 71_K 1.229 0.98
281_R 285_V 1.227 0.98
282_R 286_I 1.226 0.98
159_P 258_G 1.223 0.98
80_R 85_F 1.223 0.98
76_Q 80_R 1.222 0.98
351_G 355_A 1.222 0.98
134_N 139_V 1.217 0.98
76_Q 81_K 1.216 0.98
294_F 313_F 1.209 0.98
362_I 366_W 1.201 0.98
128_A 146_M 1.197 0.98
366_W 370_A 1.195 0.98
292_V 296_T 1.192 0.98
129_R 139_V 1.189 0.98
289_A 383_L 1.187 0.98
267_A 270_L 1.186 0.98
377_V 381_V 1.185 0.98
87_C 185_L 1.179 0.98
285_V 383_L 1.179 0.98
232_T 352_V 1.172 0.98
164_L 172_V 1.17 0.97
282_R 285_V 1.166 0.97
305_M 308_M 1.166 0.97
77_G 81_K 1.164 0.97
127_L 192_L 1.163 0.97
49_F 364_Q 1.156 0.97
74_D 339_A 1.154 0.97
218_R 222_V 1.15 0.97
92_G 96_L 1.149 0.97
287_A 317_F 1.137 0.97
104_L 107_I 1.136 0.97
294_F 314_N 1.134 0.97
61_A 115_S 1.129 0.97
41_S 51_I 1.126 0.97
80_R 84_I 1.126 0.97
242_I 248_L 1.126 0.97
179_G 183_L 1.125 0.97
70_A 338_G 1.123 0.97
56_T 353_I 1.121 0.97
159_P 163_M 1.121 0.97
212_W 218_R 1.121 0.97
130_E 337_A 1.117 0.96
99_F 175_S 1.115 0.96
296_T 300_F 1.114 0.96
271_A 320_I 1.114 0.96
296_T 376_A 1.112 0.96
53_L 57_V 1.11 0.96
241_W 246_L 1.109 0.96
217_V 221_F 1.107 0.96
23_F 153_A 1.097 0.96
166_L 251_K 1.094 0.96
287_A 321_V 1.093 0.96
98_A 171_T 1.09 0.96
273_Y 276_K 1.086 0.96
215_S 218_R 1.085 0.96
35_T 165_A 1.085 0.96
360_G 364_Q 1.081 0.95
63_I 346_N 1.069 0.95
292_V 376_A 1.068 0.95
73_S 78_D 1.067 0.95
230_C 379_S 1.065 0.95
329_F 344_F 1.059 0.95
251_K 255_F 1.057 0.95
286_I 290_A 1.056 0.95
53_L 357_V 1.05 0.94
109_C 113_L 1.05 0.94
26_G 150_L 1.044 0.94
262_G 266_P 1.042 0.94
278_Y 283_M 1.038 0.94
188_I 192_L 1.035 0.94
41_S 48_P 1.034 0.94
96_L 105_T 1.029 0.94
154_W 261_A 1.028 0.94
163_M 167_N 1.028 0.94
309_T 313_F 1.025 0.93
56_T 357_V 1.021 0.93
104_L 108_T 1.019 0.93
266_P 269_I 1.019 0.93
111_V 114_A 1.01 0.93
269_I 273_Y 1.009 0.93
309_T 312_L 1.002 0.92
264_E 319_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.97451000.2Contact Map0.657
1pw4A10.98471000.201Contact Map0.486
2gfpA20.94391000.204Contact Map0.182
2cfqA10.96681000.218Contact Map0.546
3o7qA10.97191000.229Contact Map0.638
4j05A20.98211000.25Contact Map0.621
2xutA30.98721000.268Contact Map0.534
4apsA20.99231000.287Contact Map0.566
4jr9A10.97191000.293Contact Map0.63
4lepA20.97961000.298Contact Map0.634
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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