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ARAJ - Protein AraJ
UniProt: P23910 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10060
Length: 394 (369)
Sequences: 65177
Seq/Len: 176.63
ARAJ
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_S 93_M 4.058 1.00
77_L 104_P 3.453 1.00
84_M 97_G 3.354 1.00
86_T 161_L 3.166 1.00
50_G 99_L 2.876 1.00
81_G 97_G 2.806 1.00
92_L 96_I 2.782 1.00
79_V 167_N 2.776 1.00
58_I 107_A 2.661 1.00
90_S 93_M 2.655 1.00
67_L 118_K 2.611 1.00
120_I 128_A 2.463 1.00
91_Y 95_A 2.459 1.00
233_S 236_A 2.45 1.00
36_S 39_A 2.409 1.00
126_T 260_G 2.384 1.00
74_L 107_A 2.356 1.00
81_G 104_P 2.309 1.00
124_K 127_A 2.309 1.00
54_G 103_F 2.242 1.00
81_G 100_V 2.217 1.00
274_I 302_G 2.208 1.00
281_M 295_F 2.199 1.00
63_S 323_L 2.152 1.00
251_G 301_A 2.104 1.00
209_M 336_G 2.064 1.00
247_G 297_F 2.042 1.00
121_K 124_K 2.027 1.00
213_A 340_G 1.997 1.00
68_K 72_L 1.982 1.00
88_S 93_M 1.954 1.00
154_F 158_Y 1.946 1.00
290_T 294_I 1.9 1.00
72_L 175_Y 1.889 1.00
88_S 97_G 1.859 1.00
278_A 295_F 1.835 1.00
172_A 176_F 1.827 1.00
193_F 197_R 1.817 1.00
83_A 164_A 1.812 1.00
39_A 91_Y 1.808 1.00
264_P 316_Q 1.773 1.00
72_L 171_M 1.773 1.00
46_Y 99_L 1.77 1.00
35_I 91_Y 1.735 1.00
43_M 94_L 1.73 1.00
359_L 363_L 1.723 1.00
46_Y 95_A 1.721 1.00
81_G 101_S 1.718 1.00
79_V 171_M 1.69 1.00
76_A 171_M 1.672 1.00
60_L 64_R 1.671 1.00
278_A 302_G 1.667 1.00
54_G 106_G 1.666 1.00
263_S 266_R 1.648 1.00
194_H 197_R 1.623 1.00
62_S 111_V 1.605 1.00
217_A 344_G 1.602 1.00
66_S 69_H 1.596 1.00
271_T 305_A 1.59 1.00
318_A 325_G 1.59 1.00
85_F 97_G 1.58 1.00
257_R 261_R 1.562 1.00
50_G 54_G 1.553 1.00
35_I 39_A 1.533 1.00
276_V 366_F 1.53 1.00
276_V 369_M 1.513 1.00
85_F 94_L 1.505 1.00
79_V 164_A 1.502 1.00
161_L 165_V 1.463 1.00
205_F 332_A 1.457 1.00
93_M 97_G 1.452 1.00
173_S 177_W 1.429 1.00
232_F 236_A 1.425 1.00
65_Y 70_I 1.423 1.00
28_E 31_H 1.421 1.00
69_H 73_F 1.411 1.00
127_A 260_G 1.401 0.99
194_H 321_G 1.396 0.99
84_M 87_L 1.389 0.99
83_A 87_L 1.387 0.99
244_V 300_C 1.384 0.99
61_F 70_I 1.376 0.99
247_G 251_G 1.375 0.99
86_T 164_A 1.356 0.99
61_F 65_Y 1.351 0.99
59_A 63_S 1.345 0.99
73_F 77_L 1.338 0.99
256_G 260_G 1.338 0.99
122_P 125_V 1.335 0.99
236_A 239_F 1.329 0.99
92_L 95_A 1.322 0.99
155_S 158_Y 1.319 0.99
227_M 237_M 1.315 0.99
288_M 291_T 1.315 0.99
77_L 81_G 1.312 0.99
346_M 350_L 1.303 0.99
54_G 57_I 1.297 0.99
258_I 262_Y 1.295 0.99
9_A 135_G 1.281 0.99
227_M 234_E 1.281 0.99
74_L 104_P 1.274 0.99
49_L 338_A 1.268 0.99
273_F 277_L 1.261 0.99
96_I 100_V 1.258 0.99
79_V 168_I 1.258 0.99
145_P 242_M 1.252 0.99
37_I 349_T 1.239 0.98
254_L 257_R 1.238 0.98
276_V 280_L 1.232 0.98
65_Y 69_H 1.231 0.98
116_L 132_M 1.222 0.98
69_H 72_L 1.222 0.98
266_R 270_V 1.22 0.98
57_I 60_L 1.21 0.98
278_A 299_C 1.201 0.98
283_F 359_L 1.2 0.98
117_S 125_V 1.191 0.98
269_A 369_M 1.185 0.98
25_V 151_S 1.184 0.98
280_L 284_F 1.179 0.98
115_V 178_V 1.177 0.98
158_Y 161_L 1.173 0.98
280_L 362_A 1.166 0.97
290_T 293_L 1.161 0.97
69_H 180_D 1.16 0.97
273_F 369_M 1.158 0.97
201_P 205_F 1.158 0.97
265_L 269_A 1.154 0.97
336_G 340_G 1.146 0.97
47_Y 51_V 1.146 0.97
118_K 322_E 1.141 0.97
80_I 84_M 1.133 0.97
214_G 365_S 1.132 0.97
50_G 102_G 1.132 0.97
63_S 324_L 1.131 0.97
251_G 254_L 1.13 0.97
278_A 298_I 1.125 0.97
150_L 158_Y 1.124 0.97
86_T 157_R 1.122 0.97
225_Y 230_S 1.122 0.97
66_S 70_I 1.121 0.97
271_T 302_G 1.119 0.96
257_R 260_G 1.118 0.96
276_V 362_A 1.117 0.96
165_V 169_A 1.116 0.96
152_Q 235_T 1.115 0.96
202_W 206_A 1.114 0.96
266_R 269_A 1.111 0.96
70_I 73_F 1.11 0.96
38_P 349_T 1.11 0.96
30_A 40_A 1.102 0.96
84_M 93_M 1.099 0.96
93_M 96_I 1.08 0.95
75_V 171_M 1.079 0.95
16_G 136_M 1.079 0.95
62_S 67_L 1.078 0.95
246_L 250_L 1.075 0.95
352_L 356_Y 1.069 0.95
45_S 338_A 1.067 0.95
277_L 281_M 1.064 0.95
28_E 32_N 1.058 0.95
52_V 331_I 1.054 0.95
235_T 239_F 1.053 0.95
11_G 108_F 1.053 0.95
294_I 298_I 1.052 0.95
270_V 274_I 1.051 0.94
196_L 202_W 1.051 0.94
42_H 46_Y 1.046 0.94
59_A 323_L 1.045 0.94
271_T 306_L 1.042 0.94
226_M 232_F 1.04 0.94
314_L 329_G 1.039 0.94
255_S 305_A 1.034 0.94
145_P 149_Y 1.033 0.94
87_L 161_L 1.032 0.94
127_A 131_G 1.032 0.94
13_F 139_A 1.03 0.94
72_L 76_A 1.024 0.93
208_T 329_G 1.024 0.93
174_V 178_V 1.023 0.93
168_I 172_A 1.022 0.93
42_H 342_Y 1.021 0.93
274_I 278_A 1.02 0.93
363_L 367_A 1.014 0.93
312_I 316_Q 1.002 0.92
45_S 342_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98731000.18Contact Map0.49
3wdoA10.98981000.188Contact Map0.647
2gfpA20.9341000.216Contact Map0.187
4j05A20.99241000.222Contact Map0.631
2cfqA10.98481000.228Contact Map0.514
3o7qA10.95691000.231Contact Map0.647
2xutA30.99751000.264Contact Map0.538
4apsA20.99241000.28Contact Map0.552
4jr9A10.95431000.284Contact Map0.609
4lepA20.99751000.29Contact Map0.648
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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