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YJDL - Probable dipeptide and tripeptide permease YjdL
UniProt: P39276 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12469
Length: 485 (446)
Sequences: 41370
Seq/Len: 92.76
YJDL
Paralog alert: 0.88 [within 20: 0.53] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_T 101_S 4.956 1.00
100_F 104_L 3.715 1.00
93_G 171_A 3.649 1.00
84_L 112_G 3.629 1.00
86_T 177_M 3.362 1.00
91_V 105_A 3.328 1.00
74_N 126_E 2.968 1.00
213_S 216_V 2.945 1.00
403_K 408_L 2.85 1.00
98_S 101_S 2.845 1.00
56_L 107_A 2.844 1.00
88_G 105_A 2.769 1.00
131_N 134_R 2.676 1.00
81_G 115_L 2.555 1.00
64_G 115_L 2.539 1.00
99_T 103_Y 2.501 1.00
42_D 45_H 2.409 1.00
128_Y 138_G 2.404 1.00
358_L 380_G 2.384 1.00
200_K 207_F 2.378 1.00
69_D 406_G 2.314 1.00
88_G 108_I 2.311 1.00
88_G 112_G 2.31 1.00
136_D 330_S 2.305 1.00
134_R 137_G 2.207 1.00
299_Q 306_P 2.174 1.00
449_S 453_E 2.165 1.00
351_L 387_A 2.152 1.00
95_D 101_S 2.129 1.00
353_A 459_V 2.117 1.00
317_A 382_A 2.083 1.00
355_G 380_G 2.073 1.00
129_D 134_R 2.069 1.00
79_I 181_L 2.068 1.00
52_A 107_A 2.066 1.00
321_A 386_F 2.058 1.00
249_I 253_M 2.047 1.00
353_A 456_L 2.002 1.00
60_T 111_C 1.96 1.00
182_L 186_S 1.9 1.00
355_G 387_A 1.883 1.00
90_V 94_I 1.877 1.00
75_R 79_I 1.86 1.00
90_V 174_G 1.858 1.00
164_Y 168_V 1.85 1.00
60_T 114_G 1.839 1.00
79_I 185_L 1.828 1.00
86_T 181_L 1.821 1.00
95_D 105_A 1.82 1.00
279_V 424_A 1.79 1.00
92_L 105_A 1.77 1.00
348_G 390_F 1.753 1.00
350_L 459_V 1.751 1.00
66_W 70_R 1.746 1.00
83_L 181_L 1.714 1.00
52_A 103_Y 1.701 1.00
73_G 76_T 1.69 1.00
68_A 119_N 1.689 1.00
45_H 99_T 1.671 1.00
67_L 77_A 1.662 1.00
55_S 422_W 1.634 1.00
165_G 168_V 1.628 1.00
375_G 379_S 1.628 1.00
88_G 109_I 1.625 1.00
212_W 216_V 1.62 1.00
360_A 449_S 1.609 1.00
160_A 168_V 1.607 1.00
275_T 420_A 1.605 1.00
41_F 99_T 1.602 1.00
326_A 330_S 1.585 1.00
357_M 452_G 1.576 1.00
49_L 102_L 1.545 1.00
101_S 105_A 1.533 1.00
41_F 45_H 1.522 1.00
86_T 174_G 1.513 1.00
184_F 188_H 1.497 1.00
92_L 102_L 1.493 1.00
453_E 457_A 1.481 1.00
346_A 459_V 1.473 1.00
353_A 357_M 1.47 1.00
14_V 145_A 1.467 1.00
334_R 401_R 1.441 1.00
56_L 60_T 1.433 1.00
283_Q 428_A 1.432 1.00
317_A 321_A 1.431 1.00
93_G 174_G 1.425 1.00
60_T 63_L 1.417 1.00
327_W 331_P 1.417 1.00
76_T 80_A 1.417 1.00
162_Q 305_V 1.409 1.00
84_L 88_G 1.404 0.99
68_A 74_N 1.404 0.99
353_A 452_G 1.383 0.99
306_P 309_L 1.359 0.99
91_V 94_I 1.346 0.99
350_L 354_C 1.342 0.99
69_D 74_N 1.341 0.99
435_Q 443_A 1.34 0.99
280_L 455_T 1.335 0.99
155_I 312_S 1.321 0.99
373_S 376_V 1.318 0.99
71_L 77_A 1.316 0.99
56_L 110_I 1.311 0.99
343_L 347_F 1.297 0.99
65_G 406_G 1.296 0.99
79_I 184_F 1.295 0.99
333_S 343_L 1.292 0.99
314_N 385_G 1.282 0.99
237_Y 241_I 1.282 0.99
137_G 330_S 1.28 0.99
69_D 407_V 1.277 0.99
104_L 108_I 1.276 0.99
355_G 384_M 1.274 0.99
53_Y 113_Y 1.272 0.99
67_L 71_L 1.271 0.99
250_I 253_M 1.269 0.99
80_A 84_L 1.266 0.99
360_A 452_G 1.261 0.99
348_G 391_I 1.261 0.99
156_A 159_L 1.261 0.99
100_F 103_Y 1.248 0.99
51_S 422_W 1.248 0.99
346_A 463_V 1.243 0.98
76_T 79_I 1.233 0.98
224_V 243_C 1.226 0.98
130_E 135_R 1.219 0.98
65_G 69_D 1.216 0.98
18_I 149_G 1.21 0.98
126_E 405_S 1.203 0.98
293_D 307_T 1.194 0.98
78_V 123_L 1.193 0.98
324_V 327_W 1.18 0.98
249_I 252_R 1.179 0.98
91_V 101_S 1.175 0.98
30_L 169_G 1.175 0.98
58_Y 414_L 1.171 0.98
101_S 104_L 1.17 0.97
420_A 424_A 1.17 0.97
355_G 383_L 1.168 0.97
216_V 220_C 1.166 0.97
282_Q 421_N 1.161 0.97
298_R 306_P 1.152 0.97
125_G 135_R 1.152 0.97
207_F 210_P 1.15 0.97
252_R 256_K 1.15 0.97
291_F 296_V 1.149 0.97
168_V 171_A 1.149 0.97
446_R 450_Q 1.148 0.97
299_Q 304_E 1.148 0.97
227_T 240_A 1.142 0.97
81_G 112_G 1.138 0.97
86_T 178_F 1.137 0.97
21_Y 146_G 1.135 0.97
77_A 80_A 1.134 0.97
82_A 181_L 1.131 0.97
171_A 175_G 1.13 0.97
271_M 416_T 1.129 0.97
343_L 346_A 1.126 0.97
352_M 455_T 1.126 0.97
375_G 378_I 1.125 0.97
49_L 99_T 1.124 0.97
87_L 91_V 1.113 0.96
26_G 169_G 1.112 0.96
30_L 161_A 1.098 0.96
94_I 171_A 1.096 0.96
93_G 167_H 1.093 0.96
273_V 276_L 1.093 0.96
124_L 142_L 1.09 0.96
347_F 351_L 1.089 0.96
427_V 430_Q 1.089 0.96
445_Q 449_S 1.089 0.96
33_L 37_H 1.088 0.96
73_G 77_A 1.085 0.96
353_A 455_T 1.083 0.96
23_S 26_G 1.08 0.95
178_F 182_L 1.08 0.95
456_L 460_A 1.078 0.95
79_I 83_L 1.078 0.95
349_L 458_C 1.076 0.95
240_A 244_L 1.075 0.95
329_A 394_V 1.073 0.95
89_H 173_A 1.073 0.95
431_T 435_Q 1.071 0.95
354_C 358_L 1.068 0.95
124_L 138_G 1.067 0.95
250_I 254_M 1.066 0.95
96_T 167_H 1.063 0.95
231_E 236_G 1.061 0.95
135_R 401_R 1.056 0.95
430_Q 434_S 1.055 0.95
348_G 387_A 1.055 0.95
16_I 78_V 1.054 0.95
71_L 76_T 1.051 0.94
238_L 242_V 1.05 0.94
349_L 391_I 1.048 0.94
346_A 350_L 1.047 0.94
328_L 332_E 1.043 0.94
325_L 390_F 1.04 0.94
243_C 247_A 1.04 0.94
48_S 52_A 1.039 0.94
18_I 145_A 1.039 0.94
159_L 163_W 1.035 0.94
74_N 122_C 1.035 0.94
357_M 361_F 1.032 0.94
446_R 449_S 1.031 0.94
183_I 187_G 1.031 0.94
58_Y 422_W 1.029 0.94
450_Q 453_E 1.028 0.94
321_A 324_V 1.024 0.93
252_R 255_I 1.021 0.93
271_M 411_I 1.019 0.93
209_L 213_S 1.018 0.93
188_H 191_F 1.011 0.93
94_I 101_S 1.01 0.93
291_F 295_F 1.009 0.93
48_S 426_V 1.008 0.93
89_H 174_G 1.007 0.93
292_I 298_R 1.007 0.93
174_G 178_F 1.004 0.93
379_S 383_L 1.004 0.93
186_S 189_R 1.003 0.93
23_S 173_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.86191000.245Contact Map0.51
3wdoA10.82471000.259Contact Map0.685
4j05A20.91751000.259Contact Map0.652
4gc0A10.90721000.272Contact Map0.742
2xutA30.97111000.281Contact Map0.545
4ldsA20.9011000.284Contact Map0.675
4lepA20.97531000.294Contact Map0.658
4apsA20.95881000.299Contact Map0.569
2gfpA20.76911000.301Contact Map0.164
2cfqA10.82891000.306Contact Map0.506
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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