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YEGT - Putative nucleoside transporter YegT
UniProt: P76417 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14063
Length: 425 (375)
Sequences: 62161
Seq/Len: 165.76
YEGT
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_T 93_G 4.217 1.00
84_F 97_L 3.539 1.00
77_A 104_T 3.52 1.00
49_A 99_L 2.988 1.00
81_L 97_L 2.933 1.00
57_V 107_P 2.914 1.00
92_A 96_P 2.89 1.00
86_A 165_L 2.767 1.00
329_A 337_A 2.693 1.00
90_T 93_G 2.691 1.00
67_A 118_A 2.675 1.00
79_A 171_S 2.59 1.00
120_V 126_D 2.576 1.00
91_F 95_F 2.501 1.00
74_L 107_P 2.472 1.00
35_S 38_E 2.425 1.00
124_E 267_K 2.35 1.00
281_T 313_S 2.322 1.00
154_Y 160_T 2.322 1.00
288_F 306_G 2.316 1.00
68_Q 72_A 2.279 1.00
53_S 103_L 2.256 1.00
81_L 100_A 2.243 1.00
258_F 312_V 2.236 1.00
81_L 104_T 2.235 1.00
62_D 335_T 2.228 1.00
122_D 125_R 2.157 1.00
254_S 308_L 2.141 1.00
219_F 349_G 2.126 1.00
223_M 353_G 2.09 1.00
285_R 306_G 2.049 1.00
88_Q 93_G 2.047 1.00
271_I 327_K 2.013 1.00
203_L 207_R 2.011 1.00
330_P 333_M 2.009 1.00
301_A 305_L 1.897 1.00
88_Q 97_L 1.883 1.00
383_T 387_V 1.86 1.00
38_E 91_F 1.852 1.00
283_A 393_A 1.844 1.00
227_F 357_G 1.817 1.00
61_T 111_L 1.778 1.00
285_R 313_S 1.773 1.00
81_L 101_Y 1.772 1.00
45_C 99_L 1.764 1.00
34_F 91_F 1.747 1.00
59_S 63_R 1.725 1.00
45_C 95_F 1.706 1.00
83_Y 168_A 1.704 1.00
42_S 94_F 1.676 1.00
152_L 161_N 1.675 1.00
270_G 273_K 1.671 1.00
85_A 97_L 1.666 1.00
53_S 106_M 1.658 1.00
49_A 53_S 1.647 1.00
65_F 69_K 1.619 1.00
278_G 316_F 1.588 1.00
165_L 169_G 1.585 1.00
283_A 390_A 1.562 1.00
34_F 38_E 1.538 1.00
72_A 178_A 1.535 1.00
264_F 268_R 1.535 1.00
69_K 73_V 1.514 1.00
241_M 244_A 1.512 1.00
251_G 311_G 1.51 1.00
85_A 94_F 1.507 1.00
93_G 97_L 1.501 1.00
204_I 207_R 1.476 1.00
204_I 333_M 1.458 1.00
290_I 383_T 1.454 1.00
263_P 267_K 1.442 1.00
79_A 168_A 1.438 1.00
60_I 64_F 1.432 1.00
83_Y 87_Q 1.408 1.00
244_A 247_W 1.393 0.99
254_S 258_F 1.375 0.99
84_F 87_Q 1.363 0.99
125_R 267_K 1.361 0.99
64_F 70_V 1.345 0.99
27_L 30_S 1.344 0.99
58_G 62_D 1.344 0.99
69_K 72_A 1.339 0.99
60_I 70_V 1.338 0.99
74_L 104_T 1.338 0.99
86_A 168_A 1.337 0.99
77_A 81_L 1.336 0.99
261_A 264_F 1.332 0.99
153_G 160_T 1.331 0.99
280_V 393_A 1.322 0.99
73_V 77_A 1.321 0.99
92_A 95_F 1.318 0.99
53_S 56_L 1.308 0.99
265_F 269_F 1.306 0.99
272_K 276_L 1.302 0.99
349_G 353_G 1.295 0.99
359_V 363_K 1.278 0.99
224_P 389_I 1.276 0.99
48_I 351_L 1.276 0.99
280_V 284_I 1.269 0.99
287_G 386_A 1.268 0.99
161_N 165_L 1.249 0.99
283_A 287_G 1.248 0.99
276_L 393_A 1.246 0.98
143_L 249_T 1.245 0.98
387_V 391_I 1.234 0.98
285_R 310_H 1.233 0.98
226_A 350_S 1.231 0.98
116_A 130_I 1.229 0.98
29_L 39_I 1.227 0.98
36_A 362_E 1.226 0.98
96_P 100_A 1.223 0.98
325_V 341_I 1.218 0.98
70_V 73_V 1.218 0.98
56_L 59_S 1.216 0.98
62_D 336_A 1.204 0.98
215_F 345_C 1.202 0.98
237_T 245_T 1.202 0.98
285_R 309_L 1.196 0.98
79_A 172_A 1.194 0.98
278_G 317_Y 1.19 0.98
283_A 386_A 1.189 0.98
51_I 343_L 1.178 0.98
301_A 304_F 1.176 0.98
211_F 215_F 1.174 0.98
84_F 93_G 1.171 0.98
258_F 261_A 1.168 0.97
273_K 276_L 1.167 0.97
278_G 313_S 1.167 0.97
58_G 335_T 1.164 0.97
206_L 212_L 1.161 0.97
237_T 243_N 1.155 0.97
118_A 334_R 1.149 0.97
273_K 277_L 1.147 0.97
176_V 180_F 1.146 0.97
117_F 123_V 1.144 0.97
37_G 362_E 1.139 0.97
49_A 102_S 1.138 0.97
64_F 69_K 1.134 0.97
44_A 355_R 1.129 0.97
376_F 380_G 1.126 0.97
212_L 216_F 1.121 0.97
287_G 291_Y 1.112 0.96
80_L 84_F 1.109 0.96
61_T 67_A 1.107 0.96
44_A 351_L 1.107 0.96
41_W 45_C 1.105 0.96
296_E 301_A 1.103 0.96
115_I 181_L 1.103 0.96
46_T 105_Y 1.101 0.96
281_T 285_R 1.1 0.96
262_L 316_F 1.095 0.96
290_I 386_A 1.091 0.96
147_F 151_I 1.086 0.96
236_L 241_M 1.086 0.96
277_L 281_T 1.085 0.96
166_I 169_G 1.085 0.96
93_G 96_P 1.08 0.95
125_R 129_R 1.071 0.95
292_G 306_G 1.069 0.95
72_A 175_G 1.06 0.95
41_W 355_R 1.06 0.95
253_F 257_F 1.059 0.95
146_G 246_G 1.058 0.95
379_S 383_T 1.057 0.95
168_A 172_A 1.057 0.95
218_S 341_I 1.057 0.95
209_K 212_L 1.056 0.95
143_L 147_F 1.053 0.95
358_G 362_E 1.05 0.94
264_F 267_K 1.047 0.94
269_F 274_V 1.041 0.94
123_V 327_K 1.032 0.94
86_A 160_T 1.03 0.94
284_I 288_F 1.029 0.94
282_A 389_I 1.026 0.94
144_A 147_F 1.025 0.93
266_T 320_T 1.022 0.93
333_M 336_A 1.017 0.93
27_L 31_K 1.014 0.93
148_L 161_N 1.012 0.93
270_G 274_V 1.009 0.93
384_F 388_M 1.007 0.93
69_K 183_D 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.93411000.202Contact Map0.631
4j05A20.94821000.223Contact Map0.63
1pw4A10.92241000.223Contact Map0.496
2cfqA10.91761000.243Contact Map0.517
2gfpA20.86121000.256Contact Map0.187
3o7qA10.88471000.261Contact Map0.664
4ldsA20.94121000.27Contact Map0.637
4gc0A10.96241000.274Contact Map0.706
2xutA30.96241000.296Contact Map0.548
4apsA20.92941000.301Contact Map0.54
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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