| UniProt: | P41036 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG20145 | ||
| Length: | 496 (442) | ||
| Sequences: | 27477 | ||
| Seq/Len: | 62.17 |
| NANT
Paralog alert: 0.82 [within 20: 0.37] - ratio of genomes with paralogs Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 106_P | 110_T | 6.02 | 1.00 | |
| 206_G | 209_P | 4.146 | 1.00 | |
| 109_I | 113_I | 4.012 | 1.00 | |
| 103_G | 178_F | 3.815 | 1.00 | |
| 94_L | 121_G | 3.508 | 1.00 | |
| 96_S | 184_I | 3.477 | 1.00 | |
| 107_G | 110_T | 3.461 | 1.00 | |
| 101_A | 114_A | 3.409 | 1.00 | |
| 395_F | 403_G | 3.031 | 1.00 | |
| 67_S | 116_L | 2.844 | 1.00 | |
| 309_N | 312_T | 2.518 | 1.00 | |
| 100_L | 104_F | 2.477 | 1.00 | |
| 63_A | 116_L | 2.412 | 1.00 | |
| 53_T | 56_Q | 2.386 | 1.00 | |
| 98_G | 114_A | 2.363 | 1.00 | |
| 98_G | 117_V | 2.354 | 1.00 | |
| 208_A | 211_R | 2.337 | 1.00 | |
| 108_Y | 112_F | 2.328 | 1.00 | |
| 75_L | 124_G | 2.286 | 1.00 | |
| 105_A | 110_T | 2.275 | 1.00 | |
| 84_R | 135_E | 2.248 | 1.00 | |
| 143_N | 336_D | 2.155 | 1.00 | |
| 171_W | 175_A | 2.126 | 1.00 | |
| 63_A | 112_F | 2.098 | 1.00 | |
| 273_R | 277_G | 2.064 | 1.00 | |
| 141_L | 144_K | 2.043 | 1.00 | |
| 80_D | 401_A | 2.04 | 1.00 | |
| 78_M | 87_A | 2.037 | 1.00 | |
| 396_D | 399_Q | 2.035 | 1.00 | |
| 98_G | 121_G | 2.024 | 1.00 | |
| 91_S | 124_G | 1.986 | 1.00 | |
| 89_V | 191_R | 1.932 | 1.00 | |
| 347_S | 382_G | 1.932 | 1.00 | |
| 137_W | 145_A | 1.907 | 1.00 | |
| 85_R | 89_V | 1.902 | 1.00 | |
| 167_V | 175_A | 1.88 | 1.00 | |
| 110_T | 114_A | 1.836 | 1.00 | |
| 102_C | 114_A | 1.805 | 1.00 | |
| 71_G | 120_M | 1.798 | 1.00 | |
| 350_A | 378_M | 1.786 | 1.00 | |
| 285_L | 414_G | 1.767 | 1.00 | |
| 105_A | 114_A | 1.764 | 1.00 | |
| 77_A | 81_R | 1.759 | 1.00 | |
| 327_G | 378_M | 1.755 | 1.00 | |
| 52_L | 108_Y | 1.726 | 1.00 | |
| 138_P | 141_L | 1.723 | 1.00 | |
| 323_G | 374_F | 1.665 | 1.00 | |
| 71_G | 123_A | 1.633 | 1.00 | |
| 207_K | 211_R | 1.615 | 1.00 | |
| 234_A | 238_W | 1.59 | 1.00 | |
| 28_G | 88_M | 1.584 | 1.00 | |
| 66_I | 416_A | 1.567 | 1.00 | |
| 102_C | 111_M | 1.565 | 1.00 | |
| 60_L | 111_M | 1.56 | 1.00 | |
| 18_Q | 141_L | 1.556 | 1.00 | |
| 354_L | 372_L | 1.551 | 1.00 | |
| 339_G | 342_K | 1.532 | 1.00 | |
| 352_Q | 356_I | 1.529 | 1.00 | |
| 289_L | 418_A | 1.505 | 1.00 | |
| 33_G | 153_F | 1.504 | 1.00 | |
| 303_K | 313_V | 1.499 | 1.00 | |
| 349_L | 353_L | 1.498 | 1.00 | |
| 323_G | 327_G | 1.494 | 1.00 | |
| 79_G | 128_S | 1.493 | 1.00 | |
| 169_P | 311_H | 1.467 | 1.00 | |
| 246_Q | 249_A | 1.465 | 1.00 | |
| 242_A | 245_L | 1.46 | 1.00 | |
| 47_Q | 57_A | 1.439 | 1.00 | |
| 101_A | 104_F | 1.434 | 1.00 | |
| 273_R | 276_T | 1.425 | 1.00 | |
| 228_V | 232_A | 1.417 | 1.00 | |
| 113_I | 117_V | 1.401 | 0.99 | |
| 69_W | 409_N | 1.399 | 0.99 | |
| 243_G | 249_A | 1.39 | 0.99 | |
| 94_L | 98_G | 1.386 | 0.99 | |
| 26_W | 152_G | 1.379 | 0.99 | |
| 274_W | 278_V | 1.378 | 0.99 | |
| 242_A | 246_Q | 1.376 | 0.99 | |
| 67_S | 119_G | 1.372 | 0.99 | |
| 30_L | 156_G | 1.372 | 0.99 | |
| 101_A | 110_T | 1.372 | 0.99 | |
| 56_Q | 108_Y | 1.37 | 0.99 | |
| 52_L | 56_Q | 1.363 | 0.99 | |
| 42_V | 176_L | 1.359 | 0.99 | |
| 301_Y | 306_L | 1.353 | 0.99 | |
| 333_F | 337_W | 1.351 | 0.99 | |
| 30_L | 159_V | 1.349 | 0.99 | |
| 224_I | 227_I | 1.344 | 0.99 | |
| 80_D | 84_R | 1.344 | 0.99 | |
| 357_P | 372_L | 1.343 | 0.99 | |
| 78_M | 82_Y | 1.341 | 0.99 | |
| 273_R | 278_V | 1.34 | 0.99 | |
| 354_L | 379_L | 1.337 | 0.99 | |
| 86_L | 196_E | 1.334 | 0.99 | |
| 250_I | 253_V | 1.333 | 0.99 | |
| 45_E | 48_G | 1.333 | 0.99 | |
| 332_G | 336_D | 1.33 | 0.99 | |
| 233_A | 237_L | 1.328 | 0.99 | |
| 162_Q | 318_F | 1.328 | 0.99 | |
| 238_W | 242_A | 1.328 | 0.99 | |
| 262_F | 272_K | 1.309 | 0.99 | |
| 86_L | 90_T | 1.296 | 0.99 | |
| 98_G | 118_I | 1.294 | 0.99 | |
| 293_P | 422_G | 1.292 | 0.99 | |
| 89_V | 188_L | 1.291 | 0.99 | |
| 354_L | 376_Q | 1.29 | 0.99 | |
| 100_L | 181_I | 1.289 | 0.99 | |
| 340_T | 393_G | 1.287 | 0.99 | |
| 82_Y | 87_A | 1.287 | 0.99 | |
| 90_T | 94_L | 1.272 | 0.99 | |
| 104_F | 110_T | 1.272 | 0.99 | |
| 202_E | 207_K | 1.27 | 0.99 | |
| 341_R | 345_V | 1.263 | 0.99 | |
| 350_A | 379_L | 1.261 | 0.99 | |
| 38_L | 176_L | 1.258 | 0.99 | |
| 211_R | 215_D | 1.258 | 0.99 | |
| 41_L | 164_Y | 1.253 | 0.99 | |
| 281_M | 410_V | 1.252 | 0.99 | |
| 260_A | 399_Q | 1.252 | 0.99 | |
| 64_A | 122_M | 1.247 | 0.99 | |
| 84_R | 196_E | 1.239 | 0.98 | |
| 109_I | 112_F | 1.237 | 0.98 | |
| 144_K | 336_D | 1.237 | 0.98 | |
| 139_K | 142_R | 1.233 | 0.98 | |
| 281_M | 406_F | 1.231 | 0.98 | |
| 87_A | 90_T | 1.226 | 0.98 | |
| 79_G | 84_R | 1.225 | 0.98 | |
| 345_V | 349_L | 1.223 | 0.98 | |
| 86_L | 89_V | 1.223 | 0.98 | |
| 172_G | 175_A | 1.222 | 0.98 | |
| 367_W | 371_L | 1.219 | 0.98 | |
| 24_A | 190_L | 1.218 | 0.98 | |
| 83_G | 86_L | 1.216 | 0.98 | |
| 21_A | 136_S | 1.213 | 0.98 | |
| 429_L | 437_S | 1.211 | 0.98 | |
| 82_Y | 86_L | 1.204 | 0.98 | |
| 35_D | 38_L | 1.204 | 0.98 | |
| 42_V | 168_V | 1.202 | 0.98 | |
| 227_I | 231_L | 1.199 | 0.98 | |
| 414_G | 418_A | 1.196 | 0.98 | |
| 421_I | 424_L | 1.196 | 0.98 | |
| 245_L | 248_A | 1.191 | 0.98 | |
| 68_R | 412_A | 1.179 | 0.98 | |
| 22_F | 137_W | 1.177 | 0.98 | |
| 284_V | 288_F | 1.175 | 0.98 | |
| 30_L | 152_G | 1.175 | 0.98 | |
| 163_V | 166_L | 1.173 | 0.98 | |
| 341_R | 451_G | 1.172 | 0.98 | |
| 60_L | 108_Y | 1.166 | 0.97 | |
| 282_V | 286_F | 1.164 | 0.97 | |
| 330_V | 333_F | 1.162 | 0.97 | |
| 59_S | 63_A | 1.159 | 0.97 | |
| 283_V | 286_F | 1.151 | 0.97 | |
| 334_L | 338_L | 1.148 | 0.97 | |
| 425_I | 429_L | 1.146 | 0.97 | |
| 76_G | 80_D | 1.144 | 0.97 | |
| 274_W | 277_G | 1.142 | 0.97 | |
| 189_W | 192_K | 1.141 | 0.97 | |
| 271_G | 275_P | 1.139 | 0.97 | |
| 80_D | 402_A | 1.135 | 0.97 | |
| 71_G | 74_M | 1.133 | 0.97 | |
| 244_N | 247_N | 1.128 | 0.97 | |
| 342_K | 346_C | 1.128 | 0.97 | |
| 302_L | 316_V | 1.126 | 0.97 | |
| 338_L | 343_A | 1.126 | 0.97 | |
| 322_F | 326_V | 1.125 | 0.97 | |
| 312_T | 315_N | 1.125 | 0.97 | |
| 62_S | 416_A | 1.123 | 0.97 | |
| 99_T | 180_G | 1.123 | 0.97 | |
| 134_I | 142_R | 1.12 | 0.96 | |
| 271_G | 274_W | 1.118 | 0.96 | |
| 175_A | 179_I | 1.116 | 0.96 | |
| 329_C | 333_F | 1.112 | 0.96 | |
| 272_K | 277_G | 1.11 | 0.96 | |
| 335_G | 386_I | 1.109 | 0.96 | |
| 244_N | 250_I | 1.109 | 0.96 | |
| 89_V | 93_V | 1.108 | 0.96 | |
| 231_L | 234_A | 1.107 | 0.96 | |
| 26_W | 148_F | 1.106 | 0.96 | |
| 201_K | 206_G | 1.103 | 0.96 | |
| 49_E | 174_R | 1.102 | 0.96 | |
| 110_T | 113_I | 1.097 | 0.96 | |
| 345_V | 447_I | 1.097 | 0.96 | |
| 368_V | 371_L | 1.091 | 0.96 | |
| 349_L | 447_I | 1.091 | 0.96 | |
| 42_V | 177_F | 1.089 | 0.96 | |
| 436_A | 440_F | 1.086 | 0.96 | |
| 241_F | 245_L | 1.084 | 0.96 | |
| 308_Y | 316_V | 1.082 | 0.96 | |
| 278_V | 282_V | 1.079 | 0.95 | |
| 43_L | 57_A | 1.077 | 0.95 | |
| 189_W | 193_N | 1.076 | 0.95 | |
| 292_W | 415_G | 1.076 | 0.95 | |
| 228_V | 231_L | 1.075 | 0.95 | |
| 346_C | 350_A | 1.069 | 0.95 | |
| 262_F | 269_S | 1.068 | 0.95 | |
| 35_D | 180_G | 1.062 | 0.95 | |
| 83_G | 196_E | 1.062 | 0.95 | |
| 247_N | 250_I | 1.058 | 0.95 | |
| 348_L | 383_I | 1.049 | 0.94 | |
| 135_E | 400_R | 1.045 | 0.94 | |
| 98_G | 101_A | 1.044 | 0.94 | |
| 244_N | 248_A | 1.044 | 0.94 | |
| 275_P | 278_V | 1.04 | 0.94 | |
| 154_S | 324_A | 1.036 | 0.94 | |
| 133_V | 149_L | 1.035 | 0.94 | |
| 308_Y | 312_T | 1.034 | 0.94 | |
| 225_A | 228_V | 1.034 | 0.94 | |
| 272_K | 275_P | 1.033 | 0.94 | |
| 88_M | 132_Y | 1.033 | 0.94 | |
| 103_G | 174_R | 1.028 | 0.94 | |
| 102_C | 177_F | 1.027 | 0.94 | |
| 97_A | 101_A | 1.027 | 0.94 | |
| 368_V | 372_L | 1.026 | 0.94 | |
| 248_A | 252_A | 1.022 | 0.93 | |
| 327_G | 377_Q | 1.021 | 0.93 | |
| 349_L | 352_Q | 1.021 | 0.93 | |
| 244_N | 249_A | 1.019 | 0.93 | |
| 208_A | 212_T | 1.017 | 0.93 | |
| 354_L | 375_F | 1.016 | 0.93 | |
| 42_V | 46_V | 1.015 | 0.93 | |
| 303_K | 310_P | 1.012 | 0.93 | |
| 92_I | 187_A | 1.011 | 0.93 | |
| 245_L | 249_A | 1.01 | 0.93 | |
| 302_L | 308_Y | 1.009 | 0.93 | |
| 379_L | 382_G | 1.009 | 0.93 | |
| 45_E | 49_E | 1.009 | 0.93 | |
| 67_S | 71_G | 1.008 | 0.93 | |
| 76_G | 401_A | 1.007 | 0.93 | |
| 246_Q | 250_I | 1.003 | 0.93 | |
| 417_L | 421_I | 1.002 | 0.92 | |
| 169_P | 310_P | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4gc0A | 1 | 0.9012 | 100 | 0.35 | Contact Map | 0.719 |
| 4j05A | 2 | 0.9476 | 100 | 0.378 | Contact Map | 0.649 |
| 4ldsA | 2 | 0.8851 | 100 | 0.384 | Contact Map | 0.655 |
| 1pw4A | 1 | 0.873 | 100 | 0.433 | Contact Map | 0.475 |
| 3wdoA | 1 | 0.8569 | 100 | 0.446 | Contact Map | 0.63 |
| 3o7qA | 1 | 0.8044 | 100 | 0.498 | Contact Map | 0.605 |
| 2gfpA | 2 | 0.752 | 100 | 0.498 | Contact Map | 0.154 |
| 2xutA | 3 | 0.9153 | 100 | 0.499 | Contact Map | 0.537 |
| 2cfqA | 1 | 0.8125 | 100 | 0.517 | Contact Map | 0.472 |
| 4lepA | 2 | 0.9254 | 100 | 0.522 | Contact Map | 0.612 |
Sequence Conservation (Image Generated using WebLogo v3)