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YAJR - Inner membrane transport protein YajR
UniProt: P77726 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13614
Length: 454 (379)
Sequences: 52521
Seq/Len: 138.58
YAJR
Paralog alert: 0.90 [within 20: 0.60] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_D 103_G 4.164 1.00
94_I 107_G 3.375 1.00
96_A 169_W 3.238 1.00
102_W 106_L 2.888 1.00
60_T 109_A 2.855 1.00
89_A 175_A 2.837 1.00
91_G 107_G 2.832 1.00
331_S 339_A 2.712 1.00
100_S 103_G 2.676 1.00
77_R 126_D 2.627 1.00
87_V 114_G 2.51 1.00
101_I 105_I 2.463 1.00
245_P 248_E 2.368 1.00
287_L 315_A 2.36 1.00
46_S 49_L 2.35 1.00
128_T 136_A 2.341 1.00
222_M 350_G 2.336 1.00
134_T 272_E 2.323 1.00
132_N 135_K 2.313 1.00
226_I 354_G 2.3 1.00
294_V 308_G 2.292 1.00
64_F 113_S 2.268 1.00
73_D 337_G 2.266 1.00
91_G 110_L 2.16 1.00
129_R 132_N 2.11 1.00
162_L 166_A 2.082 1.00
78_K 82_V 2.062 1.00
332_P 335_Y 1.999 1.00
98_S 103_G 1.995 1.00
93_V 172_A 1.987 1.00
263_S 314_V 1.97 1.00
291_A 308_G 1.964 1.00
98_S 107_G 1.955 1.00
82_V 179_I 1.92 1.00
259_I 310_Q 1.915 1.00
206_S 210_A 1.894 1.00
49_L 101_I 1.889 1.00
82_V 183_I 1.864 1.00
89_A 179_I 1.842 1.00
372_L 376_M 1.831 1.00
56_I 109_A 1.818 1.00
86_A 179_I 1.771 1.00
230_S 358_G 1.725 1.00
303_W 307_V 1.719 1.00
56_I 105_I 1.709 1.00
180_A 184_W 1.708 1.00
289_V 382_L 1.702 1.00
53_A 104_I 1.687 1.00
60_T 64_F 1.681 1.00
91_G 111_Q 1.675 1.00
76_G 79_P 1.669 1.00
45_A 101_I 1.667 1.00
291_A 315_A 1.666 1.00
72_S 119_A 1.665 1.00
70_L 74_R 1.648 1.00
95_A 107_G 1.647 1.00
289_V 379_A 1.591 1.00
95_A 104_I 1.544 1.00
45_A 49_L 1.533 1.00
79_P 83_G 1.533 1.00
269_I 273_V 1.533 1.00
91_G 114_G 1.53 1.00
18_G 143_S 1.522 1.00
244_F 248_E 1.504 1.00
89_A 172_A 1.499 1.00
207_K 210_A 1.495 1.00
37_T 40_M 1.488 1.00
169_W 173_I 1.464 1.00
268_I 272_E 1.456 1.00
207_K 335_Y 1.455 1.00
71_L 75_I 1.444 1.00
71_L 80_L 1.439 1.00
96_A 172_A 1.438 1.00
93_V 97_L 1.43 1.00
240_A 249_H 1.429 1.00
103_G 107_G 1.413 1.00
284_C 318_L 1.397 0.99
278_K 282_V 1.397 0.99
277_M 329_K 1.394 0.99
218_N 346_S 1.394 0.99
130_E 133_R 1.391 0.99
59_L 352_A 1.384 0.99
75_I 80_L 1.381 0.99
64_F 67_P 1.372 0.99
83_G 87_V 1.37 0.99
256_T 313_F 1.365 0.99
259_I 263_S 1.363 0.99
296_W 372_L 1.363 0.99
163_G 166_A 1.339 0.99
60_T 112_G 1.328 0.99
94_I 97_L 1.323 0.99
87_V 91_G 1.32 0.99
240_A 246_A 1.318 0.99
286_G 382_L 1.316 0.99
89_A 176_T 1.305 0.99
286_G 290_V 1.304 0.99
75_I 79_P 1.302 0.99
73_D 338_T 1.292 0.99
360_W 364_M 1.289 0.99
69_G 73_D 1.288 0.99
361_I 365_F 1.286 0.99
124_L 140_I 1.28 0.99
248_E 251_K 1.277 0.99
279_Q 282_V 1.272 0.99
301_Q 304_Q 1.271 0.99
279_Q 283_F 1.261 0.99
270_Y 274_K 1.26 0.99
102_W 105_I 1.254 0.99
39_G 50_I 1.252 0.99
291_A 312_F 1.243 0.98
284_C 319_M 1.24 0.98
303_W 306_V 1.239 0.98
293_I 375_A 1.232 0.98
291_A 311_L 1.229 0.98
85_L 179_I 1.225 0.98
376_M 380_V 1.222 0.98
263_S 266_P 1.218 0.98
135_K 272_E 1.216 0.98
181_L 185_V 1.213 0.98
106_L 110_L 1.213 0.98
239_L 244_F 1.204 0.98
229_M 351_V 1.203 0.98
158_I 166_A 1.189 0.98
289_V 293_I 1.188 0.98
289_V 375_A 1.188 0.98
34_V 159_T 1.186 0.98
182_T 186_V 1.184 0.98
79_P 82_V 1.178 0.98
238_Q 242_A 1.177 0.98
282_V 382_L 1.17 0.97
283_F 287_L 1.163 0.97
166_A 169_W 1.158 0.97
153_V 254_L 1.157 0.97
55_G 352_A 1.154 0.97
96_A 165_H 1.153 0.97
94_I 103_G 1.153 0.97
266_P 269_I 1.152 0.97
160_H 247_A 1.148 0.97
125_S 133_R 1.143 0.97
365_F 369_G 1.142 0.97
350_G 354_G 1.14 0.97
209_L 215_L 1.138 0.97
97_L 169_W 1.137 0.97
25_M 144_F 1.137 0.97
123_L 186_V 1.133 0.97
20_V 116_I 1.132 0.97
221_I 343_Y 1.13 0.97
73_D 77_R 1.12 0.96
275_R 279_Q 1.113 0.96
47_E 363_G 1.112 0.96
227_L 378_A 1.11 0.96
214_L 218_N 1.109 0.96
90_A 94_I 1.108 0.96
126_D 336_K 1.105 0.96
176_T 180_A 1.102 0.96
153_V 157_I 1.101 0.96
373_A 377_L 1.101 0.96
327_I 343_Y 1.094 0.96
293_I 297_N 1.092 0.96
67_P 70_L 1.091 0.96
37_T 41_A 1.091 0.96
72_S 77_R 1.087 0.96
103_G 106_L 1.083 0.96
79_P 188_N 1.079 0.95
296_W 375_A 1.069 0.95
76_G 80_L 1.068 0.95
154_L 157_I 1.067 0.95
157_I 161_K 1.059 0.95
359_G 363_G 1.053 0.95
80_L 83_G 1.052 0.95
57_Y 112_G 1.045 0.94
258_L 262_G 1.038 0.94
215_L 219_F 1.036 0.94
52_I 356_S 1.032 0.94
135_K 139_F 1.029 0.94
290_V 294_V 1.027 0.94
48_A 363_G 1.025 0.93
22_S 147_T 1.018 0.93
86_A 90_A 1.015 0.93
269_I 272_E 1.013 0.93
267_F 318_L 1.01 0.93
307_V 311_L 1.009 0.93
239_L 305_L 1.009 0.93
173_I 177_T 1.009 0.93
20_V 81_I 1.007 0.93
212_P 215_L 1.005 0.93
54_I 233_V 1.005 0.93
133_R 329_K 1.003 0.93
373_A 376_M 1.002 0.92
156_P 250_W 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.99561000.226Contact Map0.656
1pw4A10.88771000.369Contact Map0.499
4j05A20.91411000.396Contact Map0.615
2gfpA20.81061000.399Contact Map0.178
2cfqA10.86781000.402Contact Map0.522
3o7qA10.85461000.41Contact Map0.638
2xutA30.90091000.422Contact Map0.529
4ldsA20.88991000.444Contact Map0.645
4gc0A10.90971000.445Contact Map0.723
4lepA20.93831000.447Contact Map0.643
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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