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OPENSEQ.org
PROP - Proline/betaine transporter
UniProt: P0C0L7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11612
Length: 500 (429)
Sequences: 18908
Seq/Len: 44.07
PROP
Paralog alert: 0.79 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
233_K 236_Q 5.276 1.00
117_P 121_T 3.598 1.00
120_D 132_I 3.274 1.00
114_G 205_F 3.209 1.00
334_A 364_I 3.046 1.00
112_C 133_C 2.798 1.00
78_I 135_M 2.63 1.00
162_G 320_D 2.548 1.00
35_A 178_L 2.502 1.00
118_S 121_T 2.502 1.00
105_I 140_S 2.466 1.00
324_R 378_A 2.444 1.00
251_K 255_T 2.442 1.00
109_S 133_C 2.253 1.00
86_F 143_G 2.25 1.00
102_T 143_G 2.238 1.00
404_P 408_A 2.235 1.00
293_S 296_H 2.227 1.00
107_S 211_G 2.206 1.00
380_F 388_A 2.197 1.00
336_F 429_V 2.159 1.00
252_E 383_H 2.104 1.00
89_L 98_I 2.088 1.00
109_S 136_A 2.061 1.00
181_G 302_I 2.033 1.00
191_G 194_N 2.028 1.00
329_L 432_L 2.01 1.00
311_V 363_V 2.01 1.00
111_F 115_L 2.01 1.00
91_D 386_Y 2.008 1.00
124_I 128_I 1.988 1.00
264_C 392_A 1.957 1.00
90_G 147_G 1.952 1.00
216_Y 220_A 1.937 1.00
352_G 356_A 1.931 1.00
122_I 125_W 1.889 1.00
270_A 431_G 1.885 1.00
111_F 208_L 1.875 1.00
399_V 403_T 1.814 1.00
93_Y 97_K 1.808 1.00
269_I 399_V 1.762 1.00
234_L 238_D 1.75 1.00
156_S 164_M 1.749 1.00
74_V 131_L 1.747 1.00
112_C 115_L 1.742 1.00
336_F 432_L 1.737 1.00
29_A 217_L 1.736 1.00
409_W 413_S 1.731 1.00
119_Y 131_L 1.679 1.00
88_M 92_K 1.677 1.00
100_A 218_R 1.674 1.00
77_L 401_G 1.657 1.00
157_P 160_K 1.654 1.00
160_K 163_F 1.614 1.00
184_V 299_L 1.612 1.00
375_T 438_M 1.607 1.00
202_I 206_I 1.592 1.00
229_Q 234_L 1.59 1.00
333_V 432_L 1.589 1.00
330_L 334_A 1.582 1.00
331_G 368_F 1.577 1.00
198_W 202_I 1.567 1.00
46_F 183_V 1.54 1.00
265_I 391_A 1.531 1.00
381_P 384_I 1.527 1.00
181_G 185_L 1.524 1.00
228_Q 233_K 1.523 1.00
85_F 139_F 1.514 1.00
109_S 140_S 1.513 1.00
402_L 406_L 1.504 1.00
116_I 133_C 1.499 1.00
189_I 196_L 1.474 1.00
109_S 137_Q 1.473 1.00
74_V 135_M 1.468 1.00
313_P 317_L 1.466 1.00
162_G 319_S 1.462 1.00
421_A 425_M 1.46 1.00
54_V 118_S 1.46 1.00
80_P 394_N 1.452 1.00
229_Q 237_G 1.451 1.00
47_V 204_F 1.44 1.00
177_V 306_I 1.431 1.00
96_Q 100_A 1.414 1.00
429_V 433_I 1.412 1.00
132_I 136_A 1.41 1.00
444_R 448_G 1.404 0.99
89_L 93_Y 1.395 0.99
100_A 215_L 1.393 0.99
170_F 309_L 1.392 0.99
325_R 329_L 1.376 0.99
87_G 386_Y 1.369 0.99
95_R 154_E 1.368 0.99
47_V 203_P 1.368 0.99
116_I 121_T 1.367 0.99
420_P 424_L 1.366 0.99
93_Y 98_I 1.351 0.99
318_L 322_F 1.345 0.99
332_S 432_L 1.345 0.99
27_I 164_M 1.33 0.99
151_F 155_Y 1.324 0.99
269_I 273_V 1.324 0.99
403_T 407_A 1.324 0.99
144_E 218_R 1.323 0.99
235_E 239_R 1.323 0.99
252_E 255_T 1.317 0.99
326_P 330_L 1.311 0.99
445_P 448_G 1.309 0.99
186_I 202_I 1.296 0.99
152_V 164_M 1.295 0.99
113_I 133_C 1.295 0.99
308_M 366_N 1.292 0.99
48_A 63_V 1.29 0.99
317_L 321_R 1.286 0.99
212_I 216_Y 1.285 0.99
82_G 139_F 1.281 0.99
334_A 338_L 1.281 0.99
262_L 266_G 1.28 0.99
95_R 223_E 1.279 0.99
151_F 221_L 1.276 0.99
422_Y 426_V 1.276 0.99
307_G 311_V 1.272 0.99
410_L 414_S 1.271 0.99
155_Y 225_P 1.27 0.99
99_L 148_A 1.246 0.98
97_K 100_A 1.242 0.98
365_L 368_F 1.24 0.98
31_S 171_G 1.239 0.98
35_A 171_G 1.233 0.98
90_G 386_Y 1.229 0.98
108_I 112_C 1.226 0.98
408_A 412_E 1.216 0.98
232_D 235_E 1.211 0.98
40_D 134_K 1.21 0.98
333_V 337_V 1.21 0.98
323_G 326_P 1.209 0.98
265_I 395_I 1.205 0.98
227_F 231_V 1.201 0.98
258_W 262_L 1.194 0.98
266_G 434_T 1.186 0.98
114_G 208_L 1.185 0.98
73_S 401_G 1.183 0.98
163_F 320_D 1.18 0.98
39_F 207_A 1.179 0.98
91_D 387_S 1.176 0.98
226_A 447_K 1.168 0.97
299_L 303_A 1.167 0.97
224_T 227_F 1.159 0.97
322_F 327_F 1.158 0.97
91_D 95_R 1.151 0.97
226_A 446_L 1.151 0.97
406_L 409_W 1.148 0.97
320_D 323_G 1.148 0.97
58_G 62_S 1.143 0.97
190_V 194_N 1.14 0.97
103_I 215_L 1.136 0.97
249_S 252_E 1.135 0.97
105_I 109_S 1.135 0.97
400_A 403_T 1.133 0.97
97_K 101_I 1.131 0.97
33_G 99_L 1.129 0.97
322_F 330_L 1.123 0.97
114_G 201_R 1.118 0.96
314_V 317_L 1.117 0.96
157_P 164_M 1.116 0.96
63_V 67_A 1.115 0.96
150_I 154_E 1.11 0.96
228_Q 232_D 1.11 0.96
49_Y 53_K 1.107 0.96
336_F 428_A 1.103 0.96
47_V 183_V 1.096 0.96
341_P 344_I 1.096 0.96
104_V 215_L 1.091 0.96
153_A 165_G 1.085 0.96
353_L 357_G 1.082 0.96
163_F 167_W 1.082 0.96
274_T 428_A 1.073 0.95
401_G 405_T 1.072 0.95
281_Y 408_A 1.071 0.95
180_A 301_I 1.069 0.95
266_G 270_A 1.065 0.95
257_Y 384_I 1.064 0.95
228_Q 236_Q 1.063 0.95
287_S 294_E 1.062 0.95
45_G 283_P 1.061 0.95
82_G 142_G 1.059 0.95
228_Q 231_V 1.058 0.95
306_I 310_F 1.056 0.95
337_V 341_P 1.054 0.95
332_S 431_G 1.052 0.95
340_I 344_I 1.051 0.94
255_T 258_W 1.049 0.94
98_I 101_I 1.048 0.94
356_A 360_M 1.047 0.94
51_L 55_F 1.046 0.94
106_M 140_S 1.04 0.94
364_I 368_F 1.039 0.94
100_A 219_H 1.036 0.94
73_S 405_T 1.03 0.94
59_A 412_E 1.027 0.94
118_S 122_I 1.027 0.94
310_F 314_V 1.026 0.94
310_F 313_P 1.025 0.93
64_Q 408_A 1.02 0.93
273_V 427_V 1.014 0.93
336_F 340_I 1.014 0.93
94_G 223_E 1.011 0.93
233_K 237_G 1.011 0.93
79_R 397_V 1.007 0.93
307_G 359_L 1.005 0.93
329_L 333_V 1.002 0.92
223_E 227_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gc0A10.871000.479Contact Map0.754
4j05A20.91000.508Contact Map0.647
4ldsA20.8381000.523Contact Map0.633
1pw4A10.8621000.532Contact Map0.456
3wdoA10.8861000.538Contact Map0.531
2gfpA20.7481000.574Contact Map0.133
3o7qA10.8241000.58Contact Map0.568
2cfqA10.8021000.602Contact Map0.433
2xutA30.8461000.605Contact Map0.517
4jr9A10.8041000.612Contact Map0.542
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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