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OPENSEQ.org
HCAT - Probable 3-phenylpropionic acid transporter
UniProt: Q47142 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13454
Length: 379 (362)
Sequences: 65169
Seq/Len: 180.02
HCAT
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_A 95_W 4.182 1.00
86_A 99_V 3.496 1.00
79_L 106_F 3.469 1.00
88_W 161_A 3.213 1.00
51_A 101_I 3.102 1.00
59_I 109_P 2.888 1.00
94_A 98_L 2.852 1.00
83_F 99_V 2.846 1.00
81_L 166_G 2.817 1.00
92_H 95_W 2.715 1.00
68_R 120_T 2.571 1.00
122_Q 128_D 2.493 1.00
37_T 40_T 2.484 1.00
235_S 238_A 2.475 1.00
93_V 97_M 2.432 1.00
76_L 109_P 2.36 1.00
126_P 262_R 2.347 1.00
276_C 303_T 2.33 1.00
55_G 105_L 2.27 1.00
83_F 102_G 2.268 1.00
83_F 106_F 2.248 1.00
283_I 296_V 2.239 1.00
253_I 302_G 2.138 1.00
212_C 338_S 2.122 1.00
64_S 324_I 2.077 1.00
195_S 199_A 2.015 1.00
249_A 298_I 1.995 1.00
124_Q 127_L 1.994 1.00
154_F 158_V 1.973 1.00
90_G 95_W 1.967 1.00
216_G 342_M 1.957 1.00
319_Q 322_E 1.936 1.00
90_G 99_V 1.915 1.00
40_T 93_V 1.897 1.00
266_A 317_A 1.883 1.00
359_W 363_L 1.864 1.00
280_R 296_V 1.859 1.00
47_A 101_I 1.857 1.00
69_L 74_R 1.829 1.00
36_L 93_V 1.813 1.00
220_A 346_A 1.807 1.00
291_P 295_V 1.775 1.00
47_A 97_M 1.772 1.00
83_F 103_F 1.746 1.00
44_L 96_L 1.744 1.00
63_V 113_L 1.724 1.00
265_S 268_D 1.703 1.00
55_G 108_S 1.695 1.00
200_L 203_Q 1.678 1.00
278_V 369_M 1.658 1.00
280_R 303_T 1.656 1.00
87_F 99_V 1.619 1.00
259_K 263_R 1.604 1.00
61_P 65_D 1.592 1.00
278_V 366_L 1.581 1.00
273_S 306_V 1.569 1.00
51_A 55_G 1.555 1.00
95_W 99_V 1.545 1.00
36_L 40_T 1.54 1.00
196_A 199_A 1.526 1.00
87_F 96_L 1.521 1.00
196_A 322_E 1.489 1.00
234_Y 238_A 1.479 1.00
29_V 32_K 1.446 1.00
62_R 66_P 1.435 1.00
230_Q 236_A 1.414 1.00
258_N 262_R 1.414 1.00
348_F 352_Y 1.412 1.00
86_A 89_A 1.402 0.99
285_G 359_W 1.384 0.99
75_V 79_L 1.383 0.99
60_A 64_S 1.382 0.99
127_L 262_R 1.377 0.99
246_G 301_C 1.368 0.99
85_V 89_A 1.364 0.99
79_L 83_F 1.353 0.99
238_A 241_Y 1.349 0.99
260_L 264_C 1.345 0.99
271_L 369_M 1.337 0.99
55_G 58_L 1.326 0.99
249_A 253_I 1.315 0.99
74_R 173_G 1.31 0.99
208_L 334_A 1.307 0.99
155_D 158_V 1.307 0.99
275_I 369_M 1.302 0.99
158_V 161_A 1.301 0.99
26_F 151_V 1.298 0.99
275_I 279_V 1.296 0.99
94_A 97_M 1.293 0.99
256_L 259_K 1.279 0.99
289_A 292_W 1.272 0.99
120_T 323_V 1.262 0.99
50_V 340_A 1.261 0.99
118_A 132_V 1.255 0.99
98_L 102_G 1.25 0.99
278_V 282_G 1.247 0.99
58_L 61_P 1.241 0.98
76_L 106_F 1.236 0.98
74_R 170_M 1.229 0.98
282_G 362_A 1.228 0.98
230_Q 239_V 1.227 0.98
38_P 351_Q 1.227 0.98
280_R 300_H 1.222 0.98
119_N 125_F 1.204 0.98
66_P 72_A 1.204 0.98
46_G 340_A 1.201 0.98
267_R 271_L 1.201 0.98
62_R 72_A 1.198 0.98
349_L 353_L 1.195 0.98
64_S 325_R 1.193 0.98
150_L 158_V 1.188 0.98
88_W 157_R 1.181 0.98
268_D 271_L 1.179 0.98
268_D 272_I 1.179 0.98
71_S 75_V 1.173 0.98
278_V 362_A 1.171 0.98
145_A 244_S 1.171 0.98
338_S 342_M 1.169 0.97
31_L 41_I 1.165 0.97
71_S 74_R 1.162 0.97
82_L 86_A 1.161 0.97
253_I 256_L 1.16 0.97
282_G 286_A 1.159 0.97
81_L 170_M 1.155 0.97
315_I 330_Y 1.15 0.97
363_L 367_P 1.15 0.97
291_P 294_I 1.148 0.97
86_A 95_W 1.145 0.97
78_L 170_M 1.143 0.97
280_R 299_L 1.141 0.97
219_A 339_I 1.136 0.97
117_L 176_I 1.134 0.97
72_A 75_V 1.126 0.97
193_G 196_A 1.125 0.97
152_T 237_S 1.123 0.97
272_I 276_C 1.119 0.96
273_S 303_T 1.117 0.96
53_F 332_A 1.116 0.96
145_A 149_K 1.114 0.96
259_K 262_R 1.107 0.96
347_G 351_Q 1.106 0.96
51_A 104_N 1.102 0.96
89_A 161_A 1.102 0.96
43_L 344_V 1.1 0.96
60_A 324_I 1.1 0.96
39_E 351_Q 1.096 0.96
217_A 365_A 1.086 0.96
229_W 234_Y 1.085 0.96
127_L 131_K 1.084 0.96
202_R 205_W 1.083 0.96
43_L 47_A 1.082 0.96
204_N 208_L 1.081 0.95
63_V 68_R 1.079 0.95
257_S 306_V 1.079 0.95
237_S 241_Y 1.07 0.95
248_V 252_I 1.068 0.95
14_F 139_A 1.067 0.95
85_V 164_T 1.066 0.95
29_V 33_G 1.065 0.95
46_G 344_V 1.065 0.95
95_W 98_L 1.062 0.95
198_L 205_W 1.06 0.95
322_E 325_R 1.052 0.95
125_F 317_A 1.047 0.94
213_L 368_A 1.039 0.94
205_W 209_A 1.038 0.94
252_I 255_A 1.037 0.94
285_G 362_A 1.037 0.94
273_S 307_C 1.035 0.94
17_F 136_G 1.034 0.94
229_W 293_L 1.034 0.94
295_V 298_I 1.034 0.94
264_C 269_M 1.031 0.94
67_S 71_S 1.029 0.94
279_V 283_I 1.027 0.94
171_L 174_F 1.023 0.93
48_G 107_F 1.02 0.93
140_F 247_V 1.016 0.93
167_V 171_L 1.009 0.93
42_G 46_G 1.009 0.93
78_L 82_L 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.98681000.135Contact Map0.652
1pw4A10.98941000.139Contact Map0.482
2gfpA20.96571000.14Contact Map0.184
2cfqA10.98941000.151Contact Map0.542
3o7qA10.98421000.161Contact Map0.645
4j05A20.99211000.172Contact Map0.623
2xutA30.99471000.232Contact Map0.55
4ldsA20.99211000.24Contact Map0.645
4jr9A10.96831000.249Contact Map0.605
4apsA20.99211000.251Contact Map0.547
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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