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OPENSEQ.org
UHPT - Hexose phosphate transport protein
UniProt: P0AGC0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11054
Length: 463 (404)
Sequences: 51082
Seq/Len: 126.44
UHPT
Paralog alert: 0.90 [within 20: 0.57] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_V 125_L 4.419 1.00
104_L 136_F 3.697 1.00
124_F 128_A 3.453 1.00
111_G 129_F 3.413 1.00
113_S 196_I 3.347 1.00
106_A 202_A 3.32 1.00
77_T 131_A 3.011 1.00
108_C 129_F 2.916 1.00
122_S 125_L 2.742 1.00
85_V 139_T 2.659 1.00
123_L 127_I 2.646 1.00
94_T 150_K 2.637 1.00
293_S 296_V 2.628 1.00
158_G 320_D 2.578 1.00
379_V 387_A 2.558 1.00
222_L 225_A 2.536 1.00
101_M 139_T 2.45 1.00
63_S 66_Q 2.424 1.00
152_T 160_F 2.391 1.00
269_I 399_G 2.337 1.00
108_C 132_L 2.308 1.00
90_D 385_G 2.237 1.00
81_G 135_F 2.222 1.00
156_K 159_T 2.21 1.00
108_C 136_F 2.191 1.00
153_P 156_K 2.141 1.00
273_V 403_A 2.081 1.00
95_K 99_P 2.075 1.00
110_L 199_S 2.014 1.00
99_P 206_G 2.002 1.00
380_P 383_A 1.996 1.00
73_G 131_A 1.95 1.00
89_A 143_C 1.923 1.00
66_Q 123_L 1.923 1.00
120_S 125_L 1.92 1.00
81_G 138_S 1.9 1.00
253_E 257_K 1.883 1.00
207_F 211_R 1.877 1.00
73_G 127_I 1.87 1.00
188_D 193_G 1.793 1.00
427_A 432_A 1.781 1.00
99_P 210_L 1.777 1.00
227_E 230_G 1.768 1.00
36_F 167_S 1.767 1.00
108_C 133_S 1.764 1.00
103_I 206_G 1.758 1.00
277_G 407_L 1.73 1.00
112_F 129_F 1.73 1.00
70_I 126_M 1.723 1.00
87_Y 91_G 1.717 1.00
106_A 206_G 1.709 1.00
120_S 129_F 1.697 1.00
62_L 123_L 1.688 1.00
356_S 359_A 1.656 1.00
110_L 114_A 1.645 1.00
88_Y 97_F 1.637 1.00
112_F 126_M 1.632 1.00
62_L 66_Q 1.619 1.00
28_F 156_K 1.59 1.00
223_G 226_E 1.564 1.00
77_T 81_G 1.552 1.00
254_Y 383_A 1.537 1.00
111_G 114_A 1.534 1.00
125_L 129_F 1.525 1.00
96_Q 100_F 1.525 1.00
93_N 96_Q 1.496 1.00
88_Y 92_K 1.463 1.00
355_A 359_A 1.452 1.00
76_I 401_S 1.447 1.00
316_G 320_D 1.444 1.00
307_G 311_G 1.441 1.00
324_G 377_G 1.432 1.00
100_F 104_L 1.428 1.00
323_N 326_R 1.427 1.00
55_D 58_S 1.417 1.00
338_I 342_G 1.415 1.00
154_R 157_R 1.407 0.99
189_G 193_G 1.405 0.99
128_A 132_L 1.397 0.99
178_V 302_T 1.396 0.99
106_A 199_S 1.392 0.99
409_M 413_G 1.383 0.99
159_T 320_D 1.381 0.99
189_G 192_I 1.373 0.99
265_C 394_F 1.368 0.99
124_F 127_I 1.357 0.99
317_W 321_L 1.356 0.99
86_S 90_D 1.347 0.99
314_L 317_W 1.346 0.99
287_F 297_A 1.344 0.99
92_K 97_F 1.339 0.99
90_D 386_A 1.337 0.99
104_L 108_C 1.332 0.99
296_V 299_Q 1.324 0.99
224_K 227_E 1.323 0.99
292_L 296_V 1.315 0.99
223_G 227_E 1.315 0.99
338_I 435_G 1.314 0.99
276_I 400_D 1.312 0.99
81_G 84_L 1.305 0.99
150_K 384_I 1.304 0.99
113_S 199_S 1.302 0.99
254_Y 257_K 1.295 0.99
72_L 401_S 1.288 0.99
307_G 358_F 1.288 0.99
96_Q 99_P 1.288 0.99
57_I 67_L 1.284 0.99
246_T 250_I 1.278 0.99
208_I 212_Y 1.27 0.99
43_Y 168_H 1.265 0.99
285_Y 290_L 1.264 0.99
113_S 192_I 1.261 0.99
96_Q 215_D 1.254 0.99
125_L 128_A 1.249 0.99
335_A 339_A 1.244 0.98
40_L 171_G 1.242 0.98
318_L 322_A 1.238 0.98
196_I 200_I 1.233 0.98
38_G 98_L 1.233 0.98
184_N 193_G 1.233 0.98
311_G 362_F 1.227 0.98
92_K 96_Q 1.221 0.98
287_F 294_K 1.218 0.98
311_G 314_L 1.217 0.98
209_G 213_G 1.204 0.98
106_A 203_L 1.193 0.98
180_L 183_A 1.186 0.98
262_W 266_F 1.186 0.98
101_M 136_F 1.185 0.98
336_L 340_T 1.173 0.98
399_G 403_A 1.169 0.97
64_M 412_D 1.167 0.97
343_V 356_S 1.165 0.97
256_L 262_W 1.164 0.97
186_L 295_A 1.159 0.97
44_L 198_P 1.154 0.97
338_I 437_I 1.153 0.97
55_D 59_T 1.151 0.97
286_A 292_L 1.15 0.97
410_I 420_T 1.145 0.97
89_A 94_T 1.142 0.97
200_I 204_I 1.142 0.97
335_A 437_I 1.138 0.97
69_M 405_L 1.136 0.97
246_T 249_Q 1.13 0.97
148_I 164_W 1.127 0.97
159_T 163_F 1.125 0.97
31_S 151_W 1.124 0.97
111_G 125_L 1.124 0.97
79_G 393_T 1.12 0.96
52_A 194_M 1.116 0.96
149_T 157_R 1.112 0.96
261_I 265_C 1.107 0.96
323_N 327_G 1.105 0.96
77_T 134_G 1.101 0.96
102_L 206_G 1.098 0.96
44_L 175_A 1.096 0.96
408_G 412_D 1.095 0.96
86_S 385_G 1.09 0.96
183_A 187_F 1.088 0.96
332_I 336_L 1.085 0.96
107_I 111_G 1.082 0.96
40_L 174_G 1.079 0.95
90_D 94_T 1.077 0.95
325_R 329_V 1.076 0.95
420_T 424_G 1.066 0.95
147_T 213_G 1.066 0.95
74_F 137_Q 1.063 0.95
299_Q 303_L 1.063 0.95
72_L 405_L 1.061 0.95
193_G 196_I 1.058 0.95
65_T 412_D 1.055 0.95
99_P 103_I 1.051 0.94
38_G 140_G 1.049 0.94
306_A 310_V 1.049 0.94
428_A 433_A 1.048 0.94
222_L 226_E 1.047 0.94
178_V 183_A 1.046 0.94
339_A 343_V 1.046 0.94
158_G 316_G 1.046 0.94
52_A 185_Y 1.045 0.94
48_N 194_M 1.045 0.94
148_I 160_F 1.038 0.94
121_V 192_I 1.038 0.94
147_T 151_W 1.038 0.94
333_A 366_G 1.037 0.94
45_I 48_N 1.036 0.94
313_L 317_W 1.032 0.94
93_N 215_D 1.028 0.94
284_V 288_Q 1.018 0.93
336_L 363_L 1.018 0.93
310_V 313_L 1.018 0.93
105_S 136_F 1.017 0.93
97_F 100_F 1.016 0.93
74_F 78_Y 1.015 0.93
266_F 270_F 1.015 0.93
203_L 207_F 1.01 0.93
95_K 215_D 1.01 0.93
93_N 97_F 1.009 0.93
295_A 299_Q 1.005 0.93
342_G 430_D 1.003 0.93
79_G 401_S 1.003 0.93
281_W 408_G 1.002 0.92
53_Q 67_L 1 0.92
259_K 263_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.9591000.233Contact Map0.502
4j05A20.95251000.278Contact Map0.647
3wdoA10.86611000.286Contact Map0.63
3o7qA10.87691000.299Contact Map0.609
4gc0A10.93091000.328Contact Map0.728
2gfpA20.79911000.329Contact Map0.178
4ldsA20.9051000.335Contact Map0.625
2cfqA10.8791000.347Contact Map0.487
2xutA30.92221000.358Contact Map0.523
4apsA20.92221000.375Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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