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OPENSEQ.org
HSRA - Probable transport protein HsrA
UniProt: P31474 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11732
Length: 475 (438)
Sequences: 46656
Seq/Len: 106.52
HSRA
Paralog alert: 0.88 [within 20: 0.55] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
97_N 101_Q 4.833 1.00
85_L 112_G 3.734 1.00
94_A 169_L 3.481 1.00
100_P 104_V 3.396 1.00
92_A 105_F 3.248 1.00
87_T 175_G 3.137 1.00
98_S 101_Q 2.874 1.00
58_T 107_V 2.849 1.00
383_L 391_G 2.73 1.00
89_G 105_F 2.677 1.00
99_L 103_V 2.618 1.00
66_S 115_M 2.599 1.00
75_T 126_R 2.591 1.00
195_R 198_I 2.514 1.00
296_Q 299_I 2.478 1.00
128_Y 136_V 2.43 1.00
314_A 366_M 2.412 1.00
44_S 47_A 2.407 1.00
134_L 323_R 2.396 1.00
71_D 389_S 2.382 1.00
89_G 112_G 2.351 1.00
82_A 115_M 2.347 1.00
89_G 108_I 2.336 1.00
132_E 135_P 2.329 1.00
272_I 402_S 2.327 1.00
337_I 367_A 2.305 1.00
344_Q 360_P 2.238 1.00
310_G 362_F 2.159 1.00
62_L 111_I 2.116 1.00
96_S 101_Q 2.107 1.00
434_I 438_I 2.063 1.00
54_S 107_V 2.014 1.00
80_T 179_L 2.009 1.00
276_L 406_G 2.008 1.00
341_M 360_P 2 1.00
384_T 387_N 1.999 1.00
129_P 132_E 1.991 1.00
207_S 239_L 1.975 1.00
339_G 444_A 1.959 1.00
87_T 179_L 1.931 1.00
80_T 183_R 1.912 1.00
96_S 105_F 1.902 1.00
62_L 114_A 1.874 1.00
355_W 359_L 1.846 1.00
76_R 80_T 1.834 1.00
162_A 166_W 1.831 1.00
339_G 441_V 1.822 1.00
91_L 172_I 1.809 1.00
47_A 99_L 1.798 1.00
54_S 103_V 1.794 1.00
256_L 260_K 1.778 1.00
180_L 184_K 1.761 1.00
341_M 367_A 1.757 1.00
91_L 95_L 1.728 1.00
130_R 133_L 1.725 1.00
84_S 179_L 1.723 1.00
17_A 143_P 1.702 1.00
93_C 105_F 1.695 1.00
68_W 72_R 1.683 1.00
203_L 245_H 1.679 1.00
89_G 109_Q 1.672 1.00
51_A 102_L 1.67 1.00
93_C 102_L 1.669 1.00
70_A 119_V 1.664 1.00
43_R 99_L 1.632 1.00
268_I 398_T 1.59 1.00
257_D 387_N 1.582 1.00
69_L 78_I 1.58 1.00
43_R 47_A 1.578 1.00
206_L 238_L 1.574 1.00
327_Y 381_A 1.567 1.00
58_T 62_L 1.563 1.00
280_C 410_S 1.556 1.00
74_G 77_R 1.545 1.00
346_S 434_I 1.545 1.00
341_M 364_L 1.529 1.00
101_Q 105_F 1.513 1.00
326_G 329_H 1.497 1.00
277_G 440_T 1.484 1.00
343_A 437_G 1.476 1.00
307_T 365_G 1.475 1.00
257_D 260_K 1.473 1.00
69_L 73_F 1.453 1.00
211_F 235_S 1.45 1.00
163_T 166_W 1.449 1.00
87_T 172_I 1.447 1.00
310_G 314_A 1.446 1.00
319_T 323_R 1.442 1.00
334_I 370_T 1.424 1.00
81_L 85_L 1.423 1.00
438_I 442_A 1.421 1.00
77_R 81_L 1.414 1.00
339_G 343_A 1.409 1.00
320_Q 324_R 1.409 1.00
336_V 444_A 1.393 0.99
92_A 95_L 1.391 0.99
279_G 403_I 1.375 0.99
197_D 200_G 1.372 0.99
57_L 404_S 1.371 0.99
85_L 89_G 1.361 0.99
100_P 103_V 1.353 0.99
295_Y 299_I 1.352 0.99
158_L 166_W 1.348 0.99
67_G 71_D 1.347 0.99
299_I 302_C 1.336 0.99
334_I 371_Q 1.327 0.99
229_L 233_V 1.313 0.99
153_V 305_A 1.305 0.99
36_A 39_H 1.305 0.99
290_Q 300_A 1.301 0.99
332_V 444_A 1.296 0.99
104_V 108_I 1.294 0.99
73_F 78_I 1.294 0.99
53_I 404_S 1.286 0.99
55_Y 113_G 1.276 0.99
94_A 172_I 1.276 0.99
259_F 265_S 1.267 0.99
288_M 293_F 1.266 0.99
339_G 437_G 1.264 0.99
182_A 186_M 1.262 0.99
214_G 232_I 1.262 0.99
62_L 65_V 1.26 0.99
218_F 223_V 1.26 0.99
77_R 188_N 1.253 0.99
336_V 340_L 1.244 0.98
317_M 320_Q 1.244 0.98
160_T 298_F 1.239 0.98
135_P 323_R 1.231 0.98
82_A 112_G 1.23 0.98
92_A 101_Q 1.222 0.98
353_A 356_M 1.222 0.98
33_A 159_V 1.22 0.98
154_L 157_V 1.211 0.98
60_A 397_V 1.2 0.98
77_R 80_T 1.196 0.98
321_V 325_L 1.195 0.98
124_L 140_V 1.193 0.98
402_S 406_G 1.192 0.98
273_A 443_S 1.188 0.98
94_A 165_H 1.18 0.98
346_S 437_G 1.178 0.98
207_S 235_S 1.177 0.98
58_T 110_G 1.174 0.98
210_L 231_V 1.174 0.98
199_T 245_H 1.174 0.98
329_H 333_G 1.171 0.98
71_D 390_S 1.168 0.97
181_Y 185_H 1.161 0.97
46_L 415_R 1.158 0.97
255_S 387_N 1.157 0.97
97_N 165_H 1.153 0.97
355_W 358_I 1.149 0.97
38_A 48_M 1.146 0.97
70_A 75_T 1.142 0.97
135_P 139_F 1.14 0.97
87_T 176_I 1.139 0.97
24_A 144_G 1.139 0.97
169_L 173_P 1.139 0.97
166_W 169_L 1.138 0.97
45_P 415_R 1.133 0.97
71_D 75_T 1.132 0.97
73_F 77_R 1.13 0.97
268_I 394_V 1.129 0.97
67_G 389_S 1.129 0.97
101_Q 104_V 1.126 0.97
78_I 81_L 1.12 0.96
83_V 179_L 1.118 0.96
51_A 99_L 1.114 0.96
290_Q 297_A 1.104 0.96
341_M 363_I 1.093 0.96
311_S 369_S 1.091 0.96
80_T 84_S 1.087 0.96
435_T 439_I 1.085 0.96
359_L 363_I 1.085 0.96
265_S 269_V 1.081 0.95
88_L 92_A 1.081 0.95
309_L 313_I 1.078 0.95
60_A 404_S 1.073 0.95
328_R 332_V 1.065 0.95
240_L 244_L 1.064 0.95
295_Y 303_M 1.063 0.95
21_F 147_G 1.061 0.95
196_F 200_G 1.057 0.95
333_G 337_I 1.056 0.95
334_I 367_A 1.055 0.95
431_Y 434_I 1.053 0.95
126_R 388_A 1.052 0.95
271_N 395_L 1.05 0.94
19_A 116_M 1.046 0.94
338_I 440_T 1.046 0.94
50_S 408_A 1.039 0.94
337_I 341_M 1.037 0.94
412_A 416_V 1.033 0.94
95_L 169_L 1.031 0.94
173_P 177_A 1.028 0.94
157_V 161_W 1.028 0.94
329_H 332_V 1.027 0.94
33_A 167_I 1.027 0.94
379_T 395_L 1.027 0.94
125_L 133_L 1.027 0.94
332_V 448_M 1.026 0.94
230_T 234_T 1.022 0.93
435_T 438_I 1.022 0.93
19_A 79_F 1.021 0.93
122_L 125_L 1.015 0.93
158_L 162_A 1.014 0.93
210_L 234_T 1.012 0.93
411_A 415_R 1.009 0.93
441_V 445_A 1.008 0.93
343_A 347_L 1.008 0.93
29_I 167_I 1.007 0.93
322_L 374_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.89471000.315Contact Map0.503
3wdoA10.86111000.325Contact Map0.662
4j05A20.95581000.331Contact Map0.636
4gc0A10.93681000.363Contact Map0.728
2gfpA20.78951000.365Contact Map0.166
3o7qA10.82321000.368Contact Map0.645
4ldsA20.90741000.372Contact Map0.64
2cfqA10.84841000.379Contact Map0.52
2xutA30.99161000.395Contact Map0.535
4apsA20.95581000.407Contact Map0.554
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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