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OPENSEQ.org
FSR - Fosmidomycin resistance protein
UniProt: P52067 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13268
Length: 406 (380)
Sequences: 64392
Seq/Len: 169.45
FSR
Paralog alert: 0.90 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_G 115_A 4.294 1.00
106_L 119_A 3.646 1.00
99_F 126_G 3.644 1.00
108_A 182_W 3.104 1.00
103_G 119_A 3.047 1.00
72_A 121_A 2.989 1.00
89_M 139_R 2.892 1.00
114_G 118_L 2.857 1.00
112_S 115_A 2.839 1.00
80_V 129_V 2.64 1.00
344_L 351_V 2.638 1.00
113_F 117_L 2.631 1.00
147_G 288_D 2.534 1.00
261_S 264_N 2.459 1.00
141_A 149_A 2.448 1.00
58_T 61_Q 2.434 1.00
145_R 148_L 2.413 1.00
103_G 126_G 2.381 1.00
103_G 122_L 2.347 1.00
96_G 129_V 2.345 1.00
85_D 349_G 2.263 1.00
90_P 94_P 2.248 1.00
309_I 321_L 2.22 1.00
76_L 125_T 2.213 1.00
142_S 145_R 2.201 1.00
275_A 323_V 2.193 1.00
302_G 328_I 2.091 1.00
279_G 327_F 2.036 1.00
175_Y 179_N 2.028 1.00
110_A 119_A 2.01 1.00
110_A 115_A 1.986 1.00
292_R 342_E 1.967 1.00
61_Q 113_F 1.907 1.00
68_T 121_A 1.881 1.00
101_L 188_L 1.877 1.00
76_L 128_S 1.87 1.00
57_L 113_F 1.851 1.00
384_K 388_F 1.851 1.00
306_F 321_L 1.843 1.00
65_I 116_V 1.818 1.00
103_G 123_V 1.794 1.00
68_T 117_L 1.787 1.00
72_A 76_L 1.779 1.00
82_Y 86_K 1.771 1.00
306_F 328_I 1.768 1.00
107_L 119_A 1.756 1.00
218_N 222_R 1.742 1.00
88_P 91_W 1.74 1.00
31_S 156_G 1.681 1.00
245_S 370_L 1.662 1.00
57_L 61_Q 1.654 1.00
285_P 289_K 1.631 1.00
291_G 294_Y 1.63 1.00
299_S 331_S 1.599 1.00
241_F 366_G 1.594 1.00
107_L 116_V 1.578 1.00
304_A 394_M 1.578 1.00
91_W 95_I 1.559 1.00
50_L 53_S 1.511 1.00
219_P 347_R 1.506 1.00
272_F 326_G 1.479 1.00
115_A 119_A 1.477 1.00
81_G 85_D 1.476 1.00
84_T 133_E 1.474 1.00
260_L 264_N 1.464 1.00
83_W 92_S 1.459 1.00
83_W 87_Y 1.456 1.00
304_A 391_L 1.456 1.00
148_L 288_D 1.448 1.00
94_P 195_A 1.448 1.00
105_V 109_L 1.446 1.00
275_A 279_G 1.442 1.00
87_Y 92_S 1.439 1.00
284_G 288_D 1.437 1.00
176_G 179_N 1.419 1.00
143_G 146_H 1.418 1.00
106_L 109_L 1.413 1.00
76_L 79_V 1.399 0.99
95_I 99_F 1.399 0.99
192_V 196_Q 1.394 0.99
264_N 267_L 1.371 0.99
118_L 122_L 1.369 0.99
255_M 265_A 1.365 0.99
101_L 187_A 1.36 0.99
99_F 103_G 1.346 0.99
47_I 172_I 1.343 0.99
286_V 290_I 1.323 0.99
114_G 117_L 1.313 0.99
96_G 126_G 1.31 0.99
255_M 262_I 1.301 0.99
85_D 350_M 1.296 0.99
84_T 89_M 1.282 0.99
87_Y 91_W 1.281 0.99
282_I 285_P 1.274 0.99
301_L 305_P 1.273 0.99
79_V 82_Y 1.272 0.99
166_L 270_F 1.269 0.99
293_K 297_W 1.267 0.99
306_F 325_I 1.265 0.99
294_Y 297_W 1.263 0.99
137_V 153_F 1.261 0.99
139_R 348_I 1.259 0.99
301_L 394_M 1.258 0.99
52_Q 62_I 1.257 0.99
388_F 392_L 1.256 0.99
38_D 157_G 1.255 0.99
94_P 191_I 1.249 0.99
91_W 94_P 1.249 0.99
98_C 191_I 1.241 0.98
279_G 282_I 1.24 0.98
224_K 227_L 1.236 0.98
372_L 376_H 1.236 0.98
193_V 197_I 1.233 0.98
253_Y 258_F 1.231 0.98
85_D 89_M 1.221 0.98
92_S 95_I 1.217 0.98
138_A 146_H 1.215 0.98
50_L 54_E 1.197 0.98
304_A 387_A 1.191 0.98
171_I 179_N 1.191 0.98
179_N 182_W 1.189 0.98
254_L 260_L 1.181 0.98
102_S 106_L 1.174 0.98
72_A 124_G 1.169 0.97
294_Y 298_G 1.167 0.97
166_L 170_V 1.167 0.97
373_I 377_T 1.166 0.97
173_A 263_Q 1.165 0.97
108_A 178_G 1.162 0.97
101_L 191_I 1.158 0.97
69_F 127_S 1.153 0.97
106_L 115_A 1.152 0.97
33_S 130_F 1.152 0.97
377_T 381_L 1.15 0.97
311_P 384_K 1.149 0.97
283_G 331_S 1.148 0.97
297_W 394_M 1.145 0.97
219_P 222_R 1.142 0.97
59_F 375_D 1.137 0.97
304_A 308_L 1.128 0.97
285_P 288_D 1.121 0.97
88_P 92_S 1.121 0.97
39_M 164_G 1.12 0.96
302_G 306_F 1.115 0.96
69_F 124_G 1.114 0.96
148_L 152_I 1.114 0.96
40_I 43_L 1.113 0.96
35_L 160_G 1.113 0.96
170_V 174_P 1.11 0.96
306_F 324_I 1.108 0.96
81_G 349_G 1.107 0.96
267_L 271_A 1.104 0.96
274_F 278_A 1.101 0.96
63_G 67_L 1.097 0.96
64_M 68_T 1.094 0.96
54_E 178_G 1.083 0.96
115_A 118_L 1.083 0.96
242_Y 390_P 1.076 0.95
308_L 387_A 1.075 0.95
298_G 302_G 1.071 0.95
263_Q 267_L 1.068 0.95
357_G 361_G 1.061 0.95
381_L 384_K 1.055 0.95
299_S 332_A 1.055 0.95
290_I 295_V 1.055 0.95
109_L 182_W 1.05 0.94
303_V 390_P 1.05 0.94
148_L 285_P 1.049 0.94
308_L 312_Y 1.048 0.94
94_P 98_C 1.042 0.94
278_A 281_V 1.039 0.94
52_Q 59_F 1.037 0.94
299_S 328_I 1.036 0.94
33_S 93_L 1.035 0.94
64_M 368_A 1.033 0.94
66_T 248_S 1.032 0.94
361_G 364_G 1.027 0.94
27_L 141_A 1.026 0.94
201_Y 204_Q 1.024 0.93
380_E 384_K 1.022 0.93
371_G 375_D 1.019 0.93
120_A 124_G 1.018 0.93
52_Q 57_L 1.017 0.93
161_S 273_L 1.016 0.93
196_Q 199_R 1.013 0.93
47_I 180_V 1.01 0.93
300_I 393_G 1.009 0.93
278_A 282_I 1.009 0.93
237_F 363_G 1.004 0.93
169_A 266_Q 1.004 0.93
260_L 268_H 1.003 0.93
67_L 368_A 1.003 0.93
40_I 184_V 1.001 0.92
253_Y 257_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3o7qA10.98521000.224Contact Map0.636
1pw4A10.98521000.231Contact Map0.487
4j05A20.99511000.239Contact Map0.612
3wdoA10.94581000.245Contact Map0.628
2gfpA20.90391000.263Contact Map0.194
2cfqA10.94091000.285Contact Map0.506
4ldsA20.95071000.298Contact Map0.627
4gc0A10.96061000.304Contact Map0.711
2xutA30.96551000.307Contact Map0.552
4jr9A10.96311000.336Contact Map0.595
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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