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YNFM - Inner membrane transport protein YnfM
UniProt: P43531 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12951
Length: 417 (371)
Sequences: 62684
Seq/Len: 168.96
YNFM
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
122_T 126_G 4.193 1.00
110_L 137_S 3.59 1.00
117_L 130_M 3.44 1.00
119_T 194_A 3.205 1.00
125_H 129_I 3.029 1.00
83_M 132_A 2.951 1.00
114_C 130_M 2.849 1.00
112_S 200_A 2.822 1.00
91_T 140_G 2.81 1.00
100_R 151_E 2.723 1.00
123_S 126_G 2.702 1.00
273_S 276_V 2.494 1.00
124_W 128_L 2.478 1.00
153_I 161_S 2.469 1.00
159_A 299_T 2.455 1.00
107_A 140_G 2.448 1.00
69_T 72_N 2.446 1.00
157_F 160_F 2.396 1.00
248_F 373_G 2.335 1.00
114_C 133_L 2.308 1.00
87_G 136_L 2.293 1.00
114_C 137_S 2.289 1.00
320_M 332_G 2.236 1.00
252_G 377_A 2.225 1.00
96_D 360_G 2.137 1.00
154_H 157_F 2.119 1.00
232_R 236_R 2.101 1.00
101_K 105_V 2.019 1.00
187_F 191_I 2 1.00
121_M 126_G 1.973 1.00
116_L 197_G 1.915 1.00
121_M 130_M 1.906 1.00
105_V 204_A 1.875 1.00
313_V 339_G 1.869 1.00
72_N 124_W 1.862 1.00
205_L 209_K 1.854 1.00
317_G 332_G 1.841 1.00
327_W 331_A 1.82 1.00
105_V 208_W 1.812 1.00
79_I 132_A 1.804 1.00
114_C 134_I 1.792 1.00
79_I 128_L 1.779 1.00
87_G 139_S 1.778 1.00
68_L 124_W 1.764 1.00
109_L 204_A 1.757 1.00
76_S 127_I 1.757 1.00
256_T 381_G 1.757 1.00
290_S 338_A 1.747 1.00
112_S 204_A 1.746 1.00
302_G 305_P 1.713 1.00
95_S 144_V 1.699 1.00
93_P 97_A 1.681 1.00
118_S 130_M 1.679 1.00
83_M 87_G 1.664 1.00
395_A 399_L 1.634 1.00
99_G 102_P 1.622 1.00
296_T 300_R 1.614 1.00
303_R 353_P 1.609 1.00
68_L 72_N 1.568 1.00
118_S 127_I 1.564 1.00
233_L 236_R 1.56 1.00
206_M 210_I 1.534 1.00
61_V 64_Q 1.534 1.00
112_S 197_G 1.527 1.00
126_G 130_M 1.504 1.00
233_L 358_A 1.503 1.00
102_P 106_T 1.498 1.00
194_A 198_C 1.492 1.00
272_V 276_V 1.491 1.00
244_F 369_S 1.473 1.00
355_A 358_A 1.457 1.00
119_T 197_G 1.446 1.00
94_L 103_V 1.441 1.00
98_I 103_V 1.435 1.00
160_F 299_T 1.422 1.00
117_L 120_M 1.418 1.00
94_L 98_I 1.41 1.00
295_G 299_T 1.408 1.00
317_G 339_G 1.4 0.99
350_W 353_P 1.399 0.99
106_T 110_L 1.399 0.99
116_L 120_M 1.386 0.99
155_P 158_V 1.381 0.99
383_V 387_N 1.38 0.99
315_L 405_L 1.375 0.99
276_V 279_L 1.374 0.99
110_L 114_C 1.361 0.99
129_I 133_L 1.355 0.99
87_G 90_F 1.352 0.99
297_M 301_Y 1.344 0.99
125_H 128_L 1.338 0.99
82_A 375_S 1.33 0.99
293_K 296_T 1.326 0.99
310_S 342_A 1.317 0.99
188_N 191_I 1.316 0.99
107_A 137_S 1.313 0.99
312_G 316_F 1.294 0.99
92_G 96_D 1.293 0.99
315_L 402_V 1.286 0.99
112_S 201_L 1.279 0.99
325_S 328_L 1.269 0.99
317_G 336_F 1.265 0.99
42_F 168_G 1.255 0.99
149_L 165_Y 1.248 0.99
102_P 105_V 1.242 0.98
70_P 386_H 1.239 0.98
305_P 308_L 1.239 0.98
58_I 184_T 1.239 0.98
98_I 102_P 1.233 0.98
304_G 308_L 1.217 0.98
384_F 388_Y 1.215 0.98
90_F 93_P 1.212 0.98
191_I 194_A 1.207 0.98
327_W 330_F 1.202 0.98
150_S 158_V 1.201 0.98
315_L 319_L 1.198 0.98
113_I 117_L 1.197 0.98
80_S 84_L 1.175 0.98
305_P 309_F 1.174 0.98
102_P 213_E 1.173 0.98
151_E 359_K 1.168 0.97
198_C 202_A 1.165 0.97
96_D 361_Q 1.164 0.97
183_F 191_I 1.161 0.97
207_F 211_L 1.16 0.97
119_T 190_R 1.158 0.97
49_F 169_N 1.152 0.97
63_S 73_S 1.152 0.97
148_Y 211_L 1.149 0.97
99_G 103_V 1.147 0.97
290_S 293_K 1.146 0.97
266_M 274_Q 1.14 0.97
185_D 275_A 1.13 0.97
71_A 386_H 1.129 0.97
373_G 377_A 1.129 0.97
126_G 129_I 1.128 0.97
61_V 65_E 1.125 0.97
83_M 135_G 1.121 0.97
103_V 106_T 1.12 0.96
95_S 100_R 1.114 0.96
255_V 374_S 1.113 0.96
266_M 277_V 1.113 0.96
178_L 182_V 1.105 0.96
117_L 126_G 1.105 0.96
241_P 245_A 1.104 0.96
78_S 375_S 1.096 0.96
313_V 317_G 1.086 0.96
296_T 299_T 1.085 0.96
235_W 241_P 1.082 0.96
44_A 141_V 1.081 0.95
160_F 164_L 1.081 0.95
388_Y 392_G 1.079 0.95
77_L 259_N 1.074 0.95
309_F 313_V 1.071 0.95
75_I 379_T 1.069 0.95
75_I 79_I 1.067 0.95
120_M 194_A 1.064 0.95
78_S 379_T 1.058 0.95
308_L 405_L 1.057 0.95
382_G 386_H 1.05 0.94
331_A 335_L 1.048 0.94
351_I 366_Y 1.044 0.94
275_A 279_L 1.044 0.94
238_R 241_P 1.043 0.94
85_A 368_F 1.043 0.94
301_Y 306_V 1.04 0.94
319_L 323_F 1.032 0.94
92_G 360_G 1.026 0.94
317_G 335_L 1.019 0.93
240_L 244_F 1.018 0.93
105_V 109_L 1.013 0.93
312_G 405_L 1.011 0.93
201_L 205_L 1.01 0.93
247_G 366_Y 1.01 0.93
122_T 190_R 1.007 0.93
80_S 138_L 1.005 0.93
349_S 353_P 1.001 0.92
65_E 190_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.97361000.257Contact Map0.478
3o7qA10.9641000.278Contact Map0.632
3wdoA10.92331000.281Contact Map0.638
4j05A20.98081000.292Contact Map0.638
2gfpA20.88731000.295Contact Map0.201
2cfqA10.92331000.335Contact Map0.515
4jr9A10.97121000.346Contact Map0.611
2xutA30.941000.347Contact Map0.536
4ldsA20.92091000.364Contact Map0.632
4gc0A10.93291000.364Contact Map0.703
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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