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EMRB - Multidrug resistance protein B
UniProt: P0AEJ0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11439
Length: 512 (491)
Sequences: 15120
Seq/Len: 30.79
EMRB
Paralog alert: 0.84 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_S 104_M 5.39 1.00
90_A 178_G 4.503 1.00
88_A 115_V 3.923 1.00
97_G 172_F 3.87 1.00
390_L 398_A 3.31 1.00
212_G 245_I 3.246 1.00
208_L 251_W 3.226 1.00
103_N 107_F 3.206 1.00
95_A 108_F 3.092 1.00
101_S 104_M 2.868 1.00
263_S 394_R 2.802 1.00
211_I 244_A 2.726 1.00
302_T 305_W 2.61 1.00
320_L 373_F 2.596 1.00
78_E 129_N 2.585 1.00
57_S 110_V 2.527 1.00
216_L 241_A 2.419 1.00
316_I 369_F 2.408 1.00
92_A 115_V 2.398 1.00
83_L 182_V 2.377 1.00
61_A 110_V 2.322 1.00
202_D 205_G 2.322 1.00
350_W 367_P 2.312 1.00
204_V 251_W 2.291 1.00
278_S 409_A 2.266 1.00
65_S 114_I 2.219 1.00
94_W 98_V 2.214 1.00
92_A 111_I 2.172 1.00
347_C 371_Q 2.16 1.00
223_G 228_W 2.131 1.00
104_M 108_F 2.122 1.00
391_P 394_R 2.111 1.00
161_I 169_W 2.101 1.00
46_S 102_L 2.101 1.00
83_L 186_L 2.076 1.00
235_I 239_V 2.069 1.00
282_M 413_G 2.061 1.00
137_S 329_H 2.06 1.00
183_L 187_Q 2.049 1.00
261_D 394_R 2.011 1.00
135_K 138_I 1.998 1.00
296_Q 306_A 1.997 1.00
219_M 238_T 1.985 1.00
246_C 250_V 1.983 1.00
92_A 108_F 1.941 1.00
185_T 189_L 1.929 1.00
85_S 118_P 1.92 1.00
165_Y 169_W 1.905 1.00
69_T 118_P 1.897 1.00
345_A 489_L 1.853 1.00
96_C 108_F 1.851 1.00
47_S 50_Q 1.845 1.00
212_G 241_A 1.838 1.00
102_L 106_I 1.795 1.00
347_C 374_A 1.758 1.00
99_S 104_M 1.744 1.00
22_A 82_F 1.741 1.00
36_A 162_S 1.731 1.00
340_S 377_C 1.724 1.00
131_Y 139_A 1.718 1.00
215_S 237_L 1.712 1.00
24_F 150_A 1.704 1.00
93_S 174_N 1.694 1.00
294_L 299_Y 1.694 1.00
286_G 417_T 1.693 1.00
482_W 486_G 1.691 1.00
57_S 106_I 1.684 1.00
74_K 396_A 1.679 1.00
253_L 263_S 1.665 1.00
163_D 304_T 1.665 1.00
166_H 169_W 1.662 1.00
347_C 367_P 1.655 1.00
132_P 135_K 1.654 1.00
236_I 240_V 1.65 1.00
72_L 81_L 1.648 1.00
248_L 252_E 1.646 1.00
65_S 117_G 1.634 1.00
133_P 136_R 1.63 1.00
255_D 258_P 1.623 1.00
241_A 245_I 1.603 1.00
58_F 116_A 1.6 1.00
349_Y 485_A 1.599 1.00
96_C 105_L 1.595 1.00
11_Q 135_K 1.588 1.00
265_F 271_T 1.585 1.00
79_V 83_L 1.584 1.00
215_S 240_V 1.584 1.00
342_I 346_V 1.574 1.00
99_S 108_F 1.566 1.00
343_M 374_A 1.56 1.00
36_A 170_I 1.548 1.00
305_W 308_L 1.545 1.00
64_I 210_V 1.542 1.00
46_S 50_Q 1.54 1.00
61_A 113_G 1.529 1.00
179_V 183_L 1.509 1.00
83_L 185_T 1.506 1.00
29_D 32_I 1.503 1.00
87_I 182_V 1.492 1.00
301_Y 309_A 1.49 1.00
325_G 329_H 1.478 1.00
285_F 410_G 1.466 1.00
84_W 88_A 1.463 1.00
219_M 241_A 1.46 1.00
54_V 105_L 1.458 1.00
157_L 160_Y 1.448 1.00
340_S 378_F 1.443 1.00
94_W 175_V 1.442 1.00
215_S 244_A 1.436 1.00
271_T 275_L 1.432 1.00
212_G 244_A 1.421 1.00
339_F 377_C 1.418 1.00
200_R 257_N 1.41 1.00
90_A 182_V 1.405 0.99
71_W 75_R 1.391 0.99
73_A 78_E 1.387 0.99
362_G 366_W 1.382 0.99
240_V 244_A 1.378 0.99
83_L 87_I 1.374 0.99
352_A 482_W 1.362 0.99
50_Q 102_L 1.352 0.99
95_A 104_M 1.339 0.99
163_D 303_A 1.333 0.99
160_Y 164_N 1.332 0.99
205_G 251_W 1.331 0.99
41_A 51_G 1.331 0.99
326_R 330_K 1.327 0.99
251_W 255_D 1.313 0.99
79_V 186_L 1.307 0.99
163_D 302_T 1.307 0.99
493_G 497_F 1.305 0.99
20_S 146_T 1.303 0.99
345_A 349_Y 1.292 0.99
81_L 84_W 1.285 0.99
73_A 122_L 1.284 0.99
218_I 222_R 1.284 0.99
184_M 188_T 1.282 0.99
424_R 479_E 1.279 0.99
91_I 95_A 1.276 0.99
208_L 244_A 1.273 0.99
211_I 215_S 1.269 0.99
86_T 181_V 1.268 0.99
107_F 111_I 1.264 0.99
29_D 174_N 1.261 0.99
332_D 335_R 1.26 0.99
80_K 191_G 1.256 0.99
88_A 92_A 1.254 0.99
27_V 147_V 1.241 0.98
342_I 492_L 1.241 0.98
238_T 242_V 1.24 0.98
295_L 309_A 1.238 0.98
203_A 207_A 1.231 0.98
70_G 74_K 1.22 0.98
409_A 413_G 1.211 0.98
103_N 106_I 1.211 0.98
128_L 136_R 1.207 0.98
32_I 170_I 1.207 0.98
16_T 131_Y 1.206 0.98
92_A 95_A 1.197 0.98
208_L 247_F 1.193 0.98
175_V 179_V 1.192 0.98
54_V 102_L 1.19 0.98
68_L 206_L 1.187 0.98
335_R 339_F 1.173 0.98
161_I 165_Y 1.172 0.98
98_V 172_F 1.172 0.98
249_I 253_L 1.172 0.98
159_G 303_A 1.172 0.98
224_K 227_D 1.168 0.97
340_S 374_A 1.164 0.97
77_G 80_K 1.159 0.97
334_R 338_T 1.157 0.97
301_Y 305_W 1.153 0.97
274_C 401_L 1.151 0.97
74_K 78_E 1.151 0.97
39_T 42_G 1.151 0.97
261_D 397_A 1.151 0.97
316_I 320_L 1.149 0.97
250_V 254_T 1.147 0.97
273_G 386_T 1.147 0.97
485_A 489_L 1.145 0.97
263_S 266_K 1.142 0.97
219_M 234_I 1.141 0.97
249_I 262_L 1.139 0.97
232_Q 236_I 1.136 0.97
274_C 405_T 1.132 0.97
315_I 319_I 1.126 0.97
296_Q 303_A 1.125 0.97
356_E 359_M 1.123 0.97
137_S 141_A 1.122 0.97
345_A 492_L 1.12 0.96
25_M 178_G 1.119 0.96
355_F 359_M 1.117 0.96
360_D 363_A 1.116 0.96
205_G 252_E 1.115 0.96
95_A 98_V 1.111 0.96
471_Q 475_I 1.11 0.96
222_R 226_L 1.109 0.96
137_S 325_G 1.105 0.96
270_F 274_C 1.1 0.96
78_E 191_G 1.099 0.96
363_A 366_W 1.097 0.96
344_Y 374_A 1.089 0.96
56_T 221_D 1.087 0.96
230_S 235_I 1.083 0.96
213_I 408_L 1.083 0.96
283_L 488_F 1.081 0.95
222_R 225_E 1.078 0.95
245_I 249_I 1.077 0.95
313_V 372_G 1.075 0.95
20_S 142_L 1.072 0.95
53_W 57_S 1.071 0.95
127_L 143_W 1.067 0.95
320_L 376_A 1.065 0.95
205_G 255_D 1.064 0.95
324_I 377_C 1.063 0.95
210_V 214_G 1.058 0.95
327_F 331_L 1.057 0.95
242_V 246_C 1.054 0.95
18_A 184_M 1.05 0.94
243_V 247_F 1.043 0.94
80_K 84_W 1.042 0.94
84_W 87_I 1.041 0.94
335_R 338_T 1.04 0.94
474_I 478_N 1.035 0.94
15_M 130_N 1.033 0.94
96_C 171_F 1.031 0.94
40_I 51_G 1.029 0.94
267_S 271_T 1.026 0.94
61_A 65_S 1.025 0.93
420_M 483_M 1.023 0.93
95_A 111_I 1.018 0.93
347_C 370_I 1.018 0.93
429_H 432_L 1.017 0.93
37_I 55_I 1.015 0.93
424_R 427_M 1.014 0.93
104_M 107_F 1.014 0.93
19_L 123_S 1.014 0.93
361_F 365_A 1.011 0.93
39_T 43_N 1.008 0.93
36_A 40_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.82421000.484Contact Map0.519
2xutA30.9161000.501Contact Map0.499
2gfpA20.73241000.514Contact Map0.154
4j05A20.87891000.514Contact Map0.623
3wdoA10.77731000.52Contact Map0.67
4lepA20.90231000.533Contact Map0.598
3o7qA10.76951000.54Contact Map0.605
4gc0A10.85551000.54Contact Map0.706
4apsA20.88481000.542Contact Map0.566
4ldsA20.82811000.549Contact Map0.634
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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