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OPENSEQ.org
YEAN - Inner membrane transport protein YeaN
UniProt: P76242 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13500
Length: 393 (376)
Sequences: 64025
Seq/Len: 170.28
YEAN
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_S 103_L 4.303 1.00
88_L 114_G 3.595 1.00
95_I 107_G 3.522 1.00
97_S 171_L 3.302 1.00
61_A 109_A 3.069 1.00
90_C 177_P 2.996 1.00
78_M 128_R 2.979 1.00
92_G 107_G 2.94 1.00
69_A 117_L 2.823 1.00
135_A 271_H 2.583 1.00
244_S 247_Q 2.538 1.00
85_A 117_L 2.485 1.00
133_S 136_R 2.441 1.00
130_F 137_L 2.418 1.00
47_T 50_Q 2.402 1.00
92_G 110_V 2.346 1.00
92_G 114_G 2.329 1.00
65_I 113_G 2.321 1.00
102_Y 105_F 2.198 1.00
258_A 306_L 2.164 1.00
225_L 351_G 2.075 1.00
79_E 83_F 2.071 1.00
65_I 116_A 2.062 1.00
99_P 103_L 2.052 1.00
205_R 209_R 2.043 1.00
262_P 310_F 2.038 1.00
99_P 107_G 1.984 1.00
94_A 174_M 1.96 1.00
187_Q 190_S 1.945 1.00
57_L 105_F 1.874 1.00
370_M 374_I 1.872 1.00
57_L 109_A 1.867 1.00
293_G 304_W 1.86 1.00
54_L 104_L 1.852 1.00
286_M 311_G 1.845 1.00
92_G 111_I 1.799 1.00
163_G 168_G 1.781 1.00
229_V 355_M 1.757 1.00
288_A 380_A 1.721 1.00
71_P 75_R 1.719 1.00
96_R 107_G 1.7 1.00
61_A 65_I 1.682 1.00
268_L 272_H 1.665 1.00
73_A 121_L 1.662 1.00
70_A 74_R 1.642 1.00
77_G 80_R 1.638 1.00
83_F 181_L 1.633 1.00
90_C 181_L 1.612 1.00
87_L 181_L 1.581 1.00
103_L 107_G 1.574 1.00
290_G 304_W 1.566 1.00
328_S 331_H 1.561 1.00
206_G 209_R 1.556 1.00
46_L 50_Q 1.553 1.00
290_G 311_G 1.548 1.00
96_R 104_L 1.547 1.00
72_V 81_S 1.514 1.00
243_Y 247_Q 1.507 1.00
39_T 42_S 1.503 1.00
275_D 325_L 1.501 1.00
80_R 84_A 1.491 1.00
188_W 191_Q 1.487 1.00
46_L 102_Y 1.486 1.00
50_Q 102_Y 1.486 1.00
76_F 81_S 1.485 1.00
95_I 98_L 1.474 1.00
186_P 189_R 1.474 1.00
171_L 175_C 1.469 1.00
258_A 262_P 1.462 1.00
90_C 174_M 1.462 1.00
288_A 377_L 1.446 1.00
267_P 271_H 1.446 1.00
72_V 76_F 1.446 1.00
221_G 347_L 1.443 1.00
165_G 168_G 1.44 1.00
97_S 174_M 1.434 1.00
136_R 271_H 1.434 1.00
247_Q 250_S 1.43 1.00
84_A 88_L 1.424 1.00
187_Q 191_Q 1.407 0.99
255_L 309_G 1.402 0.99
283_V 314_A 1.392 0.99
65_I 68_L 1.392 0.99
239_I 248_A 1.39 0.99
88_L 92_G 1.372 0.99
94_A 98_L 1.369 0.99
239_I 245_E 1.368 0.99
106_G 110_V 1.347 0.99
269_F 273_V 1.344 0.99
334_A 338_G 1.34 0.99
80_R 83_F 1.327 0.99
36_L 160_A 1.324 0.99
76_F 80_R 1.309 0.99
357_K 361_A 1.299 0.99
154_A 253_G 1.294 0.99
265_L 268_L 1.286 0.99
85_A 114_G 1.281 0.99
159_L 168_G 1.272 0.99
68_L 71_P 1.271 0.99
74_R 334_A 1.27 0.99
61_A 112_G 1.267 0.99
48_T 360_D 1.26 0.99
73_A 78_M 1.259 0.99
285_L 289_V 1.257 0.99
335_A 338_G 1.257 0.99
327_A 336_L 1.255 0.99
83_F 185_L 1.255 0.99
126_I 141_Y 1.252 0.99
274_K 277_R 1.248 0.99
288_A 292_V 1.244 0.98
127_K 134_V 1.24 0.98
60_L 349_A 1.239 0.98
339_M 342_S 1.236 0.98
168_G 171_L 1.233 0.98
91_A 95_I 1.227 0.98
74_R 78_M 1.225 0.98
81_S 84_A 1.222 0.98
341_Q 344_G 1.219 0.98
90_C 178_L 1.216 0.98
358_I 362_N 1.207 0.98
295_C 370_M 1.194 0.98
292_V 373_A 1.193 0.98
186_P 190_S 1.191 0.98
262_P 265_L 1.191 0.98
97_S 167_Q 1.185 0.98
288_A 373_A 1.18 0.98
374_I 378_L 1.172 0.98
281_A 380_A 1.163 0.97
56_T 349_A 1.158 0.97
154_A 158_P 1.158 0.97
161_L 246_A 1.155 0.97
58_P 62_F 1.153 0.97
342_S 345_Y 1.152 0.97
213_A 217_T 1.151 0.97
58_P 115_I 1.149 0.97
49_A 360_D 1.148 0.97
332_Q 335_A 1.147 0.97
238_L 243_Y 1.145 0.97
182_F 186_P 1.142 0.97
41_R 51_T 1.139 0.97
292_V 296_F 1.139 0.97
103_L 106_G 1.135 0.97
77_G 81_S 1.13 0.97
158_P 162_N 1.129 0.97
175_C 179_L 1.129 0.97
157_V 249_G 1.122 0.97
95_I 103_L 1.12 0.96
187_Q 192_Q 1.114 0.96
192_Q 195_N 1.113 0.96
268_L 271_H 1.111 0.96
24_T 148_A 1.109 0.96
285_L 380_A 1.109 0.96
214_W 218_L 1.102 0.96
283_V 311_G 1.099 0.96
39_T 43_A 1.098 0.96
337_S 341_Q 1.093 0.96
12_R 133_S 1.092 0.96
98_L 171_L 1.089 0.96
136_R 140_A 1.081 0.95
53_L 57_L 1.079 0.95
257_L 261_A 1.078 0.95
149_A 256_Q 1.076 0.95
178_L 182_F 1.07 0.95
86_L 181_L 1.065 0.95
43_A 167_Q 1.06 0.95
211_P 214_W 1.059 0.95
83_F 87_L 1.057 0.95
327_A 333_A 1.056 0.95
356_G 360_D 1.056 0.95
208_W 214_W 1.055 0.95
40_I 166_W 1.05 0.94
266_I 314_A 1.041 0.94
53_L 353_P 1.035 0.94
20_L 144_T 1.031 0.94
366_S 370_M 1.029 0.94
246_A 250_S 1.028 0.94
134_V 325_L 1.023 0.93
52_G 56_T 1.022 0.93
100_S 167_Q 1.018 0.93
228_Y 348_A 1.016 0.93
136_R 268_L 1.014 0.93
58_P 112_G 1.014 0.93
226_V 376_S 1.009 0.93
290_G 308_F 1.007 0.93
261_A 264_L 1.003 0.93
43_A 166_W 1.003 0.93
261_A 265_L 1.001 0.92
41_R 48_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98981000.139Contact Map0.464
3wdoA10.97711000.161Contact Map0.616
3o7qA10.98471000.185Contact Map0.618
4j05A20.98981000.19Contact Map0.616
2gfpA20.92621000.198Contact Map0.198
2cfqA10.96691000.22Contact Map0.488
4gc0A10.98221000.247Contact Map0.69
4ldsA20.96951000.252Contact Map0.606
2xutA30.98731000.254Contact Map0.571
4jr9A10.97461000.266Contact Map0.594
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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