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OPENSEQ.org
GALP - Galactose-proton symporter
UniProt: P0AEP1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12148
Length: 464 (428)
Sequences: 56500
Seq/Len: 132.01
GALP
Paralog alert: 0.90 [within 20: 0.62] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
103_P 107_V 4.578 1.00
91_L 118_A 3.66 1.00
100_A 175_G 3.483 1.00
98_F 111_S 3.442 1.00
106_E 110_L 3.193 1.00
93_V 181_A 3.151 1.00
64_G 113_V 3.144 1.00
95_G 111_S 2.93 1.00
104_N 107_V 2.873 1.00
72_S 121_V 2.79 1.00
105_V 109_I 2.71 1.00
81_R 132_E 2.631 1.00
140_G 312_D 2.523 1.00
134_A 142_M 2.493 1.00
50_T 53_T 2.426 1.00
88_G 121_V 2.424 1.00
284_T 288_E 2.41 1.00
138_I 141_S 2.405 1.00
333_V 354_M 2.347 1.00
95_G 114_L 2.345 1.00
326_V 361_G 2.315 1.00
68_G 117_L 2.304 1.00
203_R 206_D 2.285 1.00
77_F 384_D 2.26 1.00
95_G 118_A 2.258 1.00
135_P 138_I 2.186 1.00
378_Q 386_G 2.183 1.00
419_W 423_A 2.144 1.00
82_K 86_M 2.125 1.00
240_A 244_E 2.119 1.00
303_A 360_V 2.049 1.00
102_A 107_V 2.045 1.00
97_L 178_I 2.038 1.00
379_P 382_G 1.984 1.00
60_S 113_V 1.953 1.00
328_A 429_I 1.949 1.00
330_G 354_M 1.938 1.00
299_T 356_L 1.931 1.00
102_A 111_S 1.93 1.00
60_S 109_I 1.904 1.00
328_A 426_V 1.848 1.00
349_Y 353_A 1.839 1.00
68_G 120_G 1.823 1.00
265_T 401_V 1.816 1.00
316_R 376_E 1.813 1.00
53_T 105_V 1.799 1.00
76_S 125_T 1.797 1.00
99_S 111_S 1.777 1.00
86_M 185_L 1.77 1.00
95_G 115_L 1.768 1.00
74_W 78_K 1.76 1.00
49_I 105_V 1.751 1.00
168_G 172_W 1.748 1.00
57_V 108_L 1.729 1.00
99_S 108_L 1.685 1.00
64_G 68_G 1.684 1.00
86_M 188_V 1.67 1.00
325_L 429_I 1.665 1.00
23_A 149_M 1.662 1.00
93_V 185_L 1.651 1.00
80_G 83_K 1.638 1.00
63_F 399_M 1.628 1.00
309_G 313_R 1.625 1.00
75_L 84_S 1.618 1.00
315_G 318_P 1.61 1.00
49_I 53_T 1.606 1.00
90_I 185_L 1.577 1.00
97_L 101_A 1.543 1.00
107_V 111_S 1.522 1.00
269_V 405_F 1.498 1.00
83_K 87_I 1.496 1.00
211_L 230_E 1.496 1.00
308_I 312_D 1.487 1.00
93_V 178_I 1.484 1.00
91_L 95_G 1.481 1.00
98_F 101_A 1.473 1.00
330_G 361_G 1.462 1.00
100_A 178_I 1.461 1.00
79_L 84_S 1.454 1.00
42_F 45_D 1.453 1.00
169_A 172_W 1.45 1.00
68_G 71_G 1.449 1.00
87_I 91_L 1.441 1.00
321_T 429_I 1.44 1.00
73_G 77_F 1.422 1.00
299_T 303_A 1.415 1.00
110_L 114_L 1.411 1.00
175_G 179_I 1.402 0.99
328_A 422_A 1.393 0.99
75_L 79_L 1.392 0.99
136_E 139_R 1.389 0.99
330_G 358_F 1.378 0.99
261_M 397_A 1.366 0.99
332_G 422_A 1.362 0.99
335_G 419_W 1.358 0.99
328_A 332_G 1.356 0.99
59_S 399_M 1.341 0.99
141_S 312_D 1.335 0.99
106_E 109_I 1.334 0.99
79_L 83_K 1.313 0.99
325_L 329_A 1.306 0.99
288_E 291_W 1.302 0.99
83_K 86_M 1.297 0.99
159_L 294_V 1.293 0.99
306_I 309_G 1.292 0.99
310_L 314_W 1.291 0.99
332_G 336_T 1.289 0.99
279_E 289_Q 1.282 0.99
30_G 150_I 1.281 0.99
423_A 427_L 1.277 0.99
77_F 385_F 1.268 0.99
130_L 146_Y 1.265 0.99
44_A 54_Q 1.261 0.99
100_A 171_R 1.261 0.99
283_Y 288_E 1.257 0.99
77_F 81_R 1.25 0.99
318_P 322_L 1.247 0.99
66_A 392_A 1.236 0.98
164_F 172_W 1.232 0.98
279_E 285_N 1.23 0.98
407_T 411_T 1.224 0.98
296_V 359_I 1.222 0.98
88_G 118_A 1.221 0.98
284_T 287_T 1.22 0.98
397_A 401_V 1.219 0.98
323_G 365_S 1.216 0.98
51_S 410_N 1.213 0.98
172_W 175_G 1.206 0.98
27_L 153_G 1.202 0.98
220_E 225_L 1.201 0.98
84_S 87_I 1.2 0.98
408_M 412_L 1.2 0.98
317_K 321_T 1.197 0.98
76_S 81_R 1.191 0.98
83_K 193_D 1.19 0.98
166_Y 287_T 1.188 0.98
412_L 416_N 1.188 0.98
327_M 425_N 1.188 0.98
303_A 306_I 1.183 0.98
132_E 383_R 1.18 0.98
25_A 122_A 1.177 0.98
240_A 243_K 1.177 0.98
205_V 208_E 1.176 0.98
73_G 384_D 1.17 0.97
61_M 119_V 1.167 0.97
64_G 116_G 1.163 0.97
93_V 182_I 1.16 0.97
326_V 330_G 1.154 0.97
318_P 321_T 1.151 0.97
335_G 422_A 1.15 0.97
330_G 357_M 1.149 0.97
107_V 110_L 1.141 0.97
94_A 98_F 1.14 0.97
80_G 84_S 1.135 0.97
298_L 302_L 1.135 0.97
103_P 171_R 1.134 0.97
179_I 183_L 1.133 0.97
42_F 46_E 1.125 0.97
141_S 145_M 1.121 0.97
277_I 281_A 1.12 0.96
324_F 428_F 1.119 0.96
131_S 139_R 1.117 0.96
266_G 425_N 1.11 0.96
98_F 107_V 1.107 0.96
18_V 133_I 1.107 0.96
46_E 171_R 1.107 0.96
322_L 326_V 1.096 0.96
246_S 249_R 1.094 0.96
353_A 356_L 1.091 0.96
349_Y 352_I 1.09 0.96
159_L 163_A 1.089 0.96
406_L 410_N 1.089 0.96
416_N 420_V 1.088 0.96
163_A 167_T 1.086 0.96
329_A 333_V 1.082 0.96
328_A 425_N 1.079 0.95
59_S 403_A 1.072 0.95
340_I 343_H 1.068 0.95
141_S 309_G 1.067 0.95
204_F 229_R 1.066 0.95
101_A 175_G 1.065 0.95
426_V 430_L 1.064 0.95
86_M 90_I 1.059 0.95
40_L 54_Q 1.058 0.95
291_W 295_I 1.058 0.95
52_H 410_N 1.057 0.95
55_E 59_S 1.053 0.95
238_G 241_L 1.052 0.95
56_W 60_S 1.051 0.94
25_A 85_L 1.048 0.94
416_N 419_W 1.045 0.94
80_G 193_D 1.044 0.94
60_S 64_G 1.044 0.94
404_T 407_T 1.043 0.94
21_L 187_G 1.042 0.94
186_I 189_F 1.041 0.94
71_G 74_W 1.038 0.94
314_W 319_T 1.038 0.94
57_V 105_V 1.035 0.94
278_F 283_Y 1.03 0.94
27_L 156_G 1.028 0.94
324_F 429_I 1.026 0.94
246_S 250_R 1.026 0.94
130_L 142_M 1.024 0.93
178_I 182_I 1.021 0.93
39_A 173_M 1.02 0.93
89_A 185_L 1.02 0.93
333_V 336_T 1.019 0.93
129_Y 133_I 1.017 0.93
353_A 357_M 1.017 0.93
420_V 424_L 1.012 0.93
208_E 222_K 1.01 0.93
160_S 163_A 1.009 0.93
241_L 244_E 1.009 0.93
305_F 309_G 1.007 0.93
268_N 398_N 1.006 0.93
155_L 298_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gc0A10.96771000.252Contact Map0.71
4j05A20.97841000.255Contact Map0.643
4ldsA20.95691000.267Contact Map0.64
1pw4A10.91161000.294Contact Map0.49
3wdoA10.88581000.314Contact Map0.634
3o7qA10.84911000.351Contact Map0.614
2gfpA20.80391000.363Contact Map0.18
2xutA30.95691000.371Contact Map0.528
2cfqA10.86641000.373Contact Map0.486
4apsA20.94181000.396Contact Map0.517
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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