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OPENSEQ.org
BCR - Bicyclomycin resistance protein
UniProt: P28246 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11419
Length: 396 (369)
Sequences: 67255
Seq/Len: 182.26
BCR
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_N 100_Q 4.105 1.00
84_V 111_A 3.494 1.00
91_A 104_M 3.464 1.00
93_A 168_W 3.225 1.00
57_G 106_F 2.872 1.00
99_D 103_V 2.805 1.00
86_A 174_A 2.794 1.00
65_Y 114_A 2.781 1.00
88_A 104_M 2.778 1.00
97_T 100_Q 2.691 1.00
74_R 125_D 2.627 1.00
247_A 250_N 2.545 1.00
335_F 342_A 2.535 1.00
127_Y 135_M 2.489 1.00
98_I 102_I 2.43 1.00
43_P 46_S 2.428 1.00
81_G 114_A 2.375 1.00
133_S 274_R 2.3 1.00
61_G 110_L 2.291 1.00
88_A 107_F 2.286 1.00
131_E 134_R 2.283 1.00
88_A 111_A 2.273 1.00
223_G 353_I 2.211 1.00
265_M 318_G 2.178 1.00
70_D 340_G 2.142 1.00
207_A 211_R 2.091 1.00
128_P 131_E 2.079 1.00
261_F 314_A 2.047 1.00
227_A 357_V 1.996 1.00
75_K 79_L 1.972 1.00
161_L 165_Y 1.959 1.00
90_V 171_A 1.929 1.00
95_A 100_Q 1.929 1.00
288_I 319_C 1.907 1.00
95_A 104_M 1.877 1.00
79_L 182_F 1.864 1.00
46_S 98_I 1.86 1.00
61_G 113_A 1.824 1.00
179_A 183_F 1.815 1.00
79_L 178_S 1.809 1.00
42_V 98_I 1.8 1.00
278_A 333_D 1.791 1.00
307_W 311_V 1.775 1.00
88_A 108_H 1.762 1.00
277_G 280_N 1.736 1.00
50_T 101_L 1.734 1.00
53_T 106_F 1.72 1.00
53_T 102_I 1.719 1.00
86_A 178_S 1.714 1.00
69_A 118_V 1.689 1.00
296_M 312_G 1.679 1.00
67_P 71_S 1.65 1.00
57_G 61_G 1.645 1.00
83_L 178_S 1.628 1.00
92_C 104_M 1.614 1.00
271_R 275_R 1.609 1.00
73_G 76_P 1.598 1.00
208_A 211_R 1.548 1.00
293_A 312_G 1.534 1.00
42_V 46_S 1.527 1.00
246_V 250_N 1.522 1.00
208_A 338_M 1.515 1.00
100_Q 104_M 1.501 1.00
305_G 308_S 1.501 1.00
261_F 265_M 1.491 1.00
168_W 172_L 1.489 1.00
219_M 349_F 1.466 1.00
92_C 101_L 1.466 1.00
35_V 38_A 1.46 1.00
86_A 171_A 1.454 1.00
231_S 361_L 1.452 1.00
72_F 77_V 1.446 1.00
68_M 77_V 1.439 1.00
76_P 80_G 1.436 1.00
180_M 184_L 1.426 1.00
91_A 94_L 1.415 1.00
270_S 274_R 1.415 1.00
241_I 248_P 1.403 0.99
68_M 72_F 1.399 0.99
84_V 88_A 1.382 0.99
93_A 171_A 1.379 0.99
268_F 271_R 1.378 0.99
80_G 84_V 1.37 0.99
250_N 253_Y 1.365 0.99
258_N 317_V 1.364 0.99
90_V 94_L 1.364 0.99
81_G 111_A 1.36 0.99
363_L 367_N 1.358 0.99
66_G 70_D 1.357 0.99
129_K 132_F 1.356 0.99
16_G 142_V 1.354 0.99
241_I 251_F 1.346 0.99
134_R 274_R 1.342 0.99
61_G 64_I 1.341 0.99
99_D 102_I 1.337 0.99
272_F 276_I 1.313 0.99
76_P 79_L 1.309 0.99
103_V 107_F 1.307 0.99
198_H 201_T 1.305 0.99
279_L 283_R 1.3 0.99
162_S 165_Y 1.298 0.99
72_F 76_P 1.277 0.99
56_L 355_A 1.27 0.99
123_M 139_V 1.26 0.99
230_F 354_G 1.253 0.99
285_G 322_M 1.243 0.98
44_A 366_F 1.234 0.98
307_W 310_V 1.233 0.98
64_I 67_P 1.23 0.98
280_N 284_S 1.226 0.98
86_A 175_I 1.217 0.98
76_P 187_E 1.215 0.98
239_V 244_N 1.214 0.98
165_Y 168_W 1.214 0.98
124_R 132_F 1.21 0.98
87_A 91_A 1.207 0.98
57_G 109_G 1.196 0.98
25_S 28_M 1.19 0.98
152_I 256_A 1.188 0.98
265_M 268_F 1.181 0.98
280_N 283_R 1.178 0.98
91_A 100_Q 1.176 0.98
216_L 220_L 1.175 0.98
290_F 295_W 1.169 0.97
159_V 249_E 1.164 0.97
45_G 366_F 1.16 0.97
331_I 346_A 1.153 0.97
125_D 339_A 1.147 0.97
66_G 340_G 1.144 0.97
70_D 341_T 1.142 0.97
122_L 185_I 1.141 0.97
73_G 77_V 1.14 0.97
157_V 165_Y 1.138 0.97
215_V 219_M 1.136 0.97
77_V 80_G 1.135 0.97
296_M 299_S 1.132 0.97
35_V 39_Q 1.131 0.97
100_Q 103_V 1.13 0.97
353_I 357_V 1.128 0.97
32_A 158_L 1.124 0.97
93_A 164_H 1.121 0.97
69_A 74_R 1.118 0.96
172_L 176_L 1.115 0.96
181_I 185_I 1.114 0.96
288_I 293_A 1.111 0.96
132_F 333_D 1.105 0.96
37_S 47_T 1.105 0.96
249_E 253_Y 1.103 0.96
269_N 322_M 1.102 0.96
293_A 319_C 1.099 0.96
54_Y 58_F 1.099 0.96
271_R 274_R 1.097 0.96
285_G 323_V 1.092 0.96
213_K 217_S 1.091 0.96
311_V 315_A 1.09 0.96
49_M 53_T 1.088 0.96
52_S 355_A 1.083 0.96
285_G 319_C 1.081 0.95
368_S 372_M 1.071 0.95
210_F 216_L 1.069 0.95
59_A 348_T 1.067 0.95
262_L 321_S 1.064 0.95
240_Y 246_V 1.061 0.95
152_I 156_W 1.06 0.95
292_M 296_M 1.059 0.95
49_M 359_A 1.055 0.95
94_L 168_W 1.051 0.94
253_Y 257_L 1.046 0.94
277_G 281_M 1.038 0.94
260_V 264_V 1.034 0.94
287_W 292_M 1.033 0.94
82_T 178_S 1.032 0.94
276_I 281_M 1.031 0.94
134_R 138_F 1.03 0.94
197_F 201_T 1.028 0.94
39_Q 164_H 1.027 0.94
156_W 160_W 1.018 0.93
79_L 83_L 1.018 0.93
52_S 359_A 1.017 0.93
364_A 368_S 1.016 0.93
338_M 341_T 1.013 0.93
37_S 44_A 1.013 0.93
83_L 87_A 1.006 0.93
284_S 288_I 1.003 0.93
294_A 298_I 1 0.92
175_I 179_A 1 0.92
54_Y 112_A 1 0.92
197_F 200_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99241000.146Contact Map0.486
2gfpA20.93941000.169Contact Map0.188
3wdoA10.97221000.17Contact Map0.625
3o7qA10.98231000.173Contact Map0.633
4j05A20.99241000.19Contact Map0.631
2cfqA10.97471000.213Contact Map0.498
2xutA30.99751000.248Contact Map0.541
4jr9A10.96721000.261Contact Map0.603
4ldsA20.98481000.263Contact Map0.629
4gc0A10.99241000.267Contact Map0.712
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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