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OPENSEQ.org
XAPB - Xanthosine permease
UniProt: P45562 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13159
Length: 418 (379)
Sequences: 65848
Seq/Len: 173.74
XAPB
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_T 94_M 4.08 1.00
78_V 105_A 3.505 1.00
85_Y 98_V 3.468 1.00
87_A 163_Y 3.228 1.00
50_A 100_L 2.978 1.00
82_V 98_V 2.835 1.00
58_M 108_P 2.788 1.00
80_A 169_S 2.748 1.00
93_D 97_W 2.742 1.00
91_D 94_M 2.672 1.00
337_V 345_A 2.628 1.00
75_C 108_P 2.509 1.00
92_P 96_F 2.48 1.00
36_T 39_N 2.368 1.00
127_D 130_T 2.366 1.00
121_L 131_A 2.361 1.00
297_F 314_S 2.304 1.00
290_A 321_A 2.293 1.00
82_V 101_V 2.251 1.00
54_M 104_M 2.238 1.00
67_R 119_S 2.224 1.00
82_V 105_A 2.222 1.00
129_V 276_K 2.204 1.00
63_D 343_A 2.153 1.00
267_F 320_C 2.111 1.00
263_A 316_I 2.105 1.00
218_M 357_G 2.053 1.00
222_A 361_G 2.017 1.00
280_I 335_Q 2.012 1.00
156_E 160_L 1.983 1.00
89_V 94_M 1.975 1.00
338_D 341_I 1.935 1.00
202_F 206_K 1.932 1.00
294_R 314_S 1.925 1.00
292_T 395_A 1.884 1.00
84_F 166_S 1.882 1.00
39_N 92_P 1.866 1.00
385_L 389_G 1.855 1.00
309_I 313_L 1.848 1.00
68_A 73_M 1.838 1.00
89_V 98_V 1.836 1.00
73_M 173_S 1.788 1.00
122_A 127_D 1.781 1.00
54_M 107_M 1.761 1.00
35_F 92_P 1.745 1.00
226_I 365_S 1.745 1.00
43_V 95_M 1.736 1.00
46_S 100_L 1.725 1.00
82_V 102_N 1.721 1.00
294_R 321_A 1.715 1.00
60_I 64_K 1.694 1.00
80_A 173_S 1.689 1.00
86_A 98_V 1.673 1.00
292_T 392_L 1.66 1.00
46_S 96_F 1.65 1.00
279_G 282_T 1.629 1.00
122_A 126_L 1.612 1.00
62_A 112_L 1.592 1.00
77_L 173_S 1.589 1.00
273_F 277_R 1.585 1.00
35_F 39_N 1.577 1.00
50_A 54_M 1.574 1.00
287_S 324_F 1.547 1.00
66_L 70_R 1.517 1.00
203_V 206_K 1.516 1.00
174_A 177_L 1.513 1.00
87_A 166_S 1.497 1.00
70_R 74_L 1.486 1.00
86_A 95_M 1.476 1.00
94_M 98_V 1.476 1.00
163_Y 167_G 1.464 1.00
260_S 319_G 1.463 1.00
61_I 65_W 1.443 1.00
80_A 166_S 1.442 1.00
203_V 341_I 1.43 1.00
272_P 276_K 1.422 1.00
299_A 385_L 1.418 1.00
214_F 353_V 1.412 1.00
289_V 395_A 1.389 0.99
130_T 276_K 1.375 0.99
263_A 267_F 1.368 0.99
61_I 71_A 1.365 0.99
74_L 78_V 1.353 0.99
84_F 88_S 1.352 0.99
27_S 30_I 1.334 0.99
78_V 82_V 1.33 0.99
296_G 388_A 1.328 0.99
270_T 273_F 1.321 0.99
65_W 71_A 1.32 0.99
59_G 63_D 1.315 0.99
157_L 160_L 1.314 0.99
85_Y 88_S 1.311 0.99
54_M 57_I 1.31 0.99
281_K 285_L 1.307 0.99
93_D 96_F 1.306 0.99
49_I 359_W 1.304 0.99
274_F 278_F 1.298 0.99
75_C 105_A 1.295 0.99
160_L 163_Y 1.289 0.99
357_G 361_G 1.288 0.99
80_A 170_L 1.286 0.99
367_M 371_Y 1.283 0.99
285_L 395_A 1.276 0.99
309_I 312_L 1.26 0.99
292_T 388_A 1.257 0.99
289_V 293_L 1.256 0.99
148_W 258_S 1.253 0.99
70_R 73_M 1.251 0.99
37_G 370_D 1.249 0.99
292_T 296_G 1.234 0.98
63_D 344_S 1.231 0.98
267_F 270_T 1.223 0.98
97_W 101_V 1.222 0.98
57_I 60_I 1.22 0.98
368_A 372_F 1.218 0.98
287_S 321_A 1.208 0.98
73_M 176_A 1.202 0.98
236_H 252_Y 1.201 0.98
294_R 318_Y 1.197 0.98
175_Y 178_T 1.188 0.98
223_V 391_A 1.185 0.98
29_M 40_V 1.175 0.98
71_A 74_L 1.172 0.98
282_T 285_L 1.171 0.98
389_G 393_F 1.168 0.97
299_A 388_A 1.161 0.97
294_R 317_V 1.161 0.97
333_V 349_F 1.159 0.97
38_A 370_D 1.157 0.97
153_L 160_L 1.154 0.97
271_I 324_F 1.153 0.97
81_G 85_Y 1.149 0.97
167_G 171_L 1.148 0.97
211_A 215_L 1.147 0.97
225_Q 358_A 1.146 0.97
118_Y 128_P 1.145 0.97
282_T 286_M 1.138 0.97
205_F 211_A 1.136 0.97
27_S 31_N 1.135 0.97
286_M 290_A 1.133 0.97
87_A 159_S 1.133 0.97
287_S 325_F 1.124 0.97
85_Y 94_M 1.121 0.97
42_M 46_S 1.12 0.96
273_F 276_K 1.115 0.96
65_W 70_R 1.112 0.96
296_G 300_Y 1.108 0.96
210_M 214_F 1.105 0.96
45_S 359_W 1.103 0.96
372_F 382_T 1.1 0.96
59_G 343_A 1.099 0.96
45_S 363_I 1.096 0.96
76_H 173_S 1.093 0.96
236_H 253_P 1.086 0.96
234_F 239_A 1.086 0.96
50_A 103_A 1.084 0.96
262_M 266_G 1.083 0.96
278_F 283_V 1.082 0.96
130_T 134_P 1.081 0.95
88_S 163_Y 1.071 0.95
94_M 97_W 1.071 0.95
366_G 370_D 1.07 0.95
62_A 67_R 1.069 0.95
288_M 394_L 1.066 0.95
290_A 294_R 1.066 0.95
148_W 152_L 1.065 0.95
170_L 174_A 1.063 0.95
70_R 181_K 1.059 0.95
47_K 106_F 1.057 0.95
381_Q 385_L 1.046 0.94
128_P 335_Q 1.046 0.94
117_S 135_I 1.045 0.94
382_T 386_V 1.042 0.94
208_P 212_I 1.041 0.94
63_D 67_R 1.038 0.94
235_L 250_V 1.034 0.94
116_V 179_L 1.034 0.94
119_S 342_R 1.03 0.94
208_P 211_A 1.027 0.94
313_L 316_I 1.025 0.93
301_G 314_S 1.023 0.93
382_T 385_L 1.022 0.93
292_T 391_A 1.02 0.93
341_I 344_S 1.019 0.93
313_L 317_V 1.017 0.93
266_G 269_L 1.016 0.93
42_M 363_I 1.016 0.93
285_L 399_F 1.013 0.93
152_L 155_L 1.012 0.93
149_A 152_L 1.011 0.93
12_F 142_G 1.008 0.93
77_L 81_G 1.005 0.93
266_G 270_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.9451000.161Contact Map0.497
3wdoA10.93061000.164Contact Map0.644
2cfqA10.9451000.178Contact Map0.52
2gfpA20.88521000.192Contact Map0.168
4j05A20.94741000.196Contact Map0.632
3o7qA10.90671000.202Contact Map0.654
2xutA30.97371000.228Contact Map0.524
4ldsA20.94981000.246Contact Map0.663
4apsA20.95221000.254Contact Map0.549
4gc0A10.94741000.262Contact Map0.73
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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