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DTPB - Dipeptide and tripeptide permease B
UniProt: P36837 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12232
Length: 489 (442)
Sequences: 41154
Seq/Len: 93.11
DTPB
Paralog alert: 0.87 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_L 107_L 5.087 1.00
99_G 177_N 3.622 1.00
106_D 110_I 3.616 1.00
90_V 118_G 3.587 1.00
92_A 183_L 3.308 1.00
97_M 111_A 3.255 1.00
207_R 210_S 3.076 1.00
80_T 132_K 2.999 1.00
104_K 107_L 2.921 1.00
408_V 416_I 2.875 1.00
62_L 113_G 2.819 1.00
137_K 140_R 2.704 1.00
94_G 111_A 2.696 1.00
48_S 51_Q 2.542 1.00
87_G 121_L 2.507 1.00
70_G 121_L 2.489 1.00
363_A 385_V 2.442 1.00
94_G 114_T 2.433 1.00
105_P 109_F 2.406 1.00
94_G 118_G 2.358 1.00
134_Y 144_A 2.284 1.00
459_G 463_L 2.259 1.00
140_R 143_G 2.231 1.00
75_D 414_G 2.213 1.00
325_A 391_L 2.166 1.00
303_E 310_N 2.162 1.00
58_A 113_G 2.156 1.00
216_Y 219_L 2.123 1.00
355_M 392_G 2.118 1.00
357_S 466_L 2.087 1.00
85_V 187_L 2.085 1.00
357_S 469_A 2.08 1.00
142_D 334_T 2.072 1.00
101_S 107_L 2.055 1.00
85_V 191_I 2.006 1.00
409_P 412_L 2 1.00
188_L 192_A 1.996 1.00
210_S 213_K 1.98 1.00
359_G 385_V 1.977 1.00
135_P 140_R 1.976 1.00
321_W 387_L 1.926 1.00
359_G 392_G 1.924 1.00
66_L 117_V 1.907 1.00
96_F 180_G 1.897 1.00
213_K 216_Y 1.895 1.00
101_S 111_A 1.876 1.00
279_V 427_A 1.875 1.00
354_F 469_A 1.847 1.00
89_L 187_L 1.835 1.00
170_F 174_V 1.828 1.00
98_T 111_A 1.827 1.00
92_A 187_L 1.813 1.00
96_F 100_M 1.778 1.00
66_L 120_G 1.752 1.00
352_G 395_F 1.752 1.00
72_Y 76_H 1.745 1.00
361_L 462_G 1.739 1.00
380_W 384_L 1.736 1.00
81_K 85_V 1.73 1.00
47_F 105_P 1.726 1.00
283_I 431_G 1.724 1.00
58_A 109_F 1.72 1.00
94_G 115_I 1.707 1.00
365_A 459_G 1.699 1.00
107_L 111_A 1.698 1.00
79_G 82_R 1.664 1.00
55_T 108_I 1.631 1.00
51_Q 105_P 1.624 1.00
330_A 334_T 1.61 1.00
73_V 83_T 1.586 1.00
350_T 469_A 1.585 1.00
74_G 125_N 1.585 1.00
61_A 429_L 1.583 1.00
47_F 51_Q 1.57 1.00
357_S 462_G 1.565 1.00
166_I 174_V 1.526 1.00
357_S 361_L 1.524 1.00
98_T 108_I 1.517 1.00
171_G 174_V 1.509 1.00
331_G 335_H 1.493 1.00
82_R 86_L 1.478 1.00
190_Y 194_R 1.467 1.00
463_L 467_G 1.458 1.00
310_N 313_S 1.428 1.00
20_F 151_S 1.4 0.99
90_V 94_G 1.391 0.99
66_L 69_I 1.389 0.99
347_M 351_L 1.383 0.99
321_W 325_A 1.381 0.99
287_Q 435_A 1.377 0.99
92_A 180_G 1.369 0.99
136_P 141_L 1.355 0.99
62_L 66_L 1.354 0.99
77_L 83_T 1.35 0.99
262_K 412_L 1.339 0.99
284_L 465_T 1.336 0.99
110_I 114_T 1.33 0.99
73_V 77_L 1.329 0.99
86_L 90_V 1.324 0.99
97_M 100_M 1.31 0.99
318_N 390_S 1.306 0.99
354_F 358_L 1.305 0.99
378_S 381_F 1.303 0.99
71_G 414_G 1.294 0.99
246_S 250_T 1.292 0.99
261_D 265_R 1.281 0.99
99_G 180_G 1.276 0.99
337_G 347_M 1.269 0.99
74_G 80_T 1.263 0.99
59_F 119_N 1.262 0.99
57_G 429_L 1.254 0.99
85_V 190_Y 1.25 0.99
27_R 152_I 1.248 0.99
338_N 406_A 1.246 0.98
275_M 423_T 1.242 0.98
161_S 316_A 1.236 0.98
75_D 415_F 1.234 0.98
97_M 107_L 1.229 0.98
162_L 165_V 1.228 0.98
143_G 334_T 1.227 0.98
39_V 43_K 1.223 0.98
93_I 97_M 1.218 0.98
350_T 473_L 1.217 0.98
223_V 250_T 1.215 0.98
359_G 388_F 1.215 0.98
75_D 80_T 1.212 0.98
359_G 389_Q 1.21 0.98
328_I 331_G 1.209 0.98
295_F 300_V 1.207 0.98
168_D 309_I 1.203 0.98
442_D 452_P 1.202 0.98
427_A 431_G 1.192 0.98
365_A 462_G 1.191 0.98
184_I 188_L 1.191 0.98
455_T 459_G 1.184 0.98
82_R 85_V 1.175 0.98
24_L 155_G 1.172 0.98
106_D 109_F 1.163 0.97
132_K 413_M 1.163 0.97
352_G 396_I 1.162 0.97
71_G 75_D 1.157 0.97
107_L 110_I 1.155 0.97
88_A 187_L 1.15 0.97
99_G 173_S 1.14 0.97
87_G 118_G 1.138 0.97
380_W 383_V 1.136 0.97
347_M 350_T 1.136 0.97
466_L 470_V 1.135 0.97
286_A 428_F 1.134 0.97
456_N 459_G 1.134 0.97
456_N 460_K 1.132 0.97
62_L 116_A 1.132 0.97
303_E 308_S 1.131 0.97
92_A 184_I 1.131 0.97
280_V 468_V 1.129 0.97
131_S 141_L 1.127 0.97
437_F 441_P 1.124 0.97
332_I 336_L 1.123 0.97
297_I 311_P 1.122 0.97
358_L 363_A 1.119 0.96
130_L 144_A 1.116 0.96
77_L 82_R 1.112 0.96
32_G 175_T 1.112 0.96
55_T 105_P 1.108 0.96
302_H 310_N 1.107 0.96
130_L 148_F 1.103 0.96
460_K 463_L 1.099 0.96
351_L 355_M 1.097 0.96
438_T 442_D 1.093 0.96
177_N 181_A 1.092 0.96
434_V 437_F 1.092 0.96
361_L 366_A 1.087 0.96
272_F 276_L 1.085 0.96
303_E 309_I 1.083 0.96
29_G 179_C 1.083 0.96
64_Y 429_L 1.08 0.95
83_T 86_L 1.079 0.95
219_L 223_V 1.079 0.95
102_L 173_S 1.075 0.95
174_V 177_N 1.073 0.95
64_Y 422_L 1.069 0.95
333_Y 399_L 1.066 0.95
95_Y 179_C 1.063 0.95
384_L 388_F 1.062 0.95
36_V 175_T 1.062 0.95
295_F 299_N 1.059 0.95
53_F 57_G 1.058 0.95
194_R 197_V 1.058 0.95
276_L 280_V 1.056 0.95
470_V 474_L 1.049 0.94
22_V 84_I 1.048 0.94
85_V 89_L 1.048 0.94
327_P 331_G 1.044 0.94
49_Q 440_V 1.038 0.94
79_G 83_T 1.036 0.94
100_M 177_N 1.033 0.94
267_K 270_V 1.032 0.94
141_L 406_A 1.031 0.94
29_G 32_G 1.027 0.94
350_T 354_F 1.027 0.94
36_V 167_A 1.026 0.94
189_V 193_C 1.019 0.93
54_V 58_A 1.017 0.93
352_G 392_G 1.016 0.93
95_Y 180_G 1.016 0.93
366_A 459_G 1.015 0.93
56_F 290_T 1.015 0.93
98_T 176_Y 1.01 0.93
275_M 419_M 1.009 0.93
277_E 280_V 1.006 0.93
88_A 186_A 1.003 0.93
462_G 466_L 1.003 0.93
320_F 324_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.8631000.255Contact Map0.512
3wdoA10.8161000.266Contact Map0.674
4j05A20.92431000.272Contact Map0.656
4lepA20.98161000.281Contact Map0.643
2xutA30.96931000.287Contact Map0.552
2cfqA10.821000.293Contact Map0.509
4apsA20.9551000.295Contact Map0.568
3o7qA10.80981000.305Contact Map0.651
2gfpA20.76691000.308Contact Map0.162
4gc0A10.90181000.318Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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