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OPENSEQ.org
LPLT - Lysophospholipid transporter LplT
UniProt: P39196 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12455
Length: 397 (377)
Sequences: 65926
Seq/Len: 174.87
LPLT
Paralog alert: 0.91 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
88_L 112_G 3.592 1.00
95_S 105_G 3.514 1.00
97_C 168_A 3.12 1.00
61_A 107_T 3.102 1.00
92_G 105_G 2.853 1.00
69_V 115_A 2.853 1.00
90_L 174_Y 2.803 1.00
128_T 136_A 2.716 1.00
334_G 343_A 2.697 1.00
78_K 126_E 2.682 1.00
251_D 254_T 2.507 1.00
47_P 50_S 2.468 1.00
132_K 135_K 2.432 1.00
85_A 115_A 2.428 1.00
65_F 111_V 2.361 1.00
134_V 278_T 2.335 1.00
79_G 83_M 2.312 1.00
298_I 311_L 2.288 1.00
92_G 112_G 2.283 1.00
226_S 354_A 2.259 1.00
129_T 132_K 2.244 1.00
92_G 108_L 2.234 1.00
230_G 358_M 2.194 1.00
74_D 341_G 2.187 1.00
265_G 313_M 2.183 1.00
269_G 317_V 2.1 1.00
335_K 338_V 2.028 1.00
162_H 165_V 2.013 1.00
210_T 214_R 1.99 1.00
282_V 332_E 1.928 1.00
73_A 119_A 1.896 1.00
94_A 171_A 1.886 1.00
295_V 318_M 1.829 1.00
57_V 107_T 1.814 1.00
65_F 114_A 1.812 1.00
57_V 103_F 1.803 1.00
295_V 311_L 1.802 1.00
306_L 310_A 1.8 1.00
46_Y 101_N 1.774 1.00
50_S 101_N 1.765 1.00
71_Q 75_S 1.756 1.00
234_T 362_Y 1.756 1.00
92_G 109_V 1.747 1.00
61_A 65_F 1.728 1.00
77_A 80_R 1.728 1.00
90_L 178_V 1.722 1.00
83_M 178_V 1.705 1.00
46_Y 50_S 1.703 1.00
96_I 105_G 1.684 1.00
281_T 284_R 1.656 1.00
275_K 279_L 1.636 1.00
87_G 178_V 1.599 1.00
90_L 171_A 1.586 1.00
375_I 379_F 1.576 1.00
80_R 84_F 1.571 1.00
20_I 143_S 1.559 1.00
289_G 321_F 1.557 1.00
249_I 254_T 1.518 1.00
168_A 172_L 1.512 1.00
222_L 350_G 1.502 1.00
39_A 42_K 1.485 1.00
72_V 76_F 1.482 1.00
76_F 81_V 1.478 1.00
72_V 81_V 1.469 1.00
262_V 316_G 1.461 1.00
265_G 269_G 1.457 1.00
130_G 133_L 1.438 1.00
293_G 385_L 1.426 1.00
135_K 278_T 1.415 1.00
254_T 257_Y 1.412 1.00
97_C 171_A 1.409 1.00
274_A 278_T 1.395 0.99
60_G 356_L 1.387 0.99
65_F 68_F 1.379 0.99
84_F 88_L 1.376 0.99
244_P 252_N 1.364 0.99
304_E 307_P 1.361 0.99
244_P 255_P 1.348 0.99
276_L 280_E 1.343 0.99
80_R 83_M 1.337 0.99
160_D 253_A 1.337 0.99
70_G 74_D 1.328 0.99
76_F 80_R 1.327 0.99
94_A 98_F 1.323 0.99
125_G 133_L 1.314 0.99
179_V 182_I 1.31 0.99
211_S 338_V 1.31 0.99
124_L 140_M 1.306 0.99
165_V 168_A 1.301 0.99
272_A 275_K 1.298 0.99
88_L 92_G 1.286 0.99
85_A 112_G 1.285 0.99
153_V 260_A 1.279 0.99
306_L 309_Y 1.279 0.99
293_G 297_L 1.276 0.99
68_F 71_Q 1.27 0.99
90_L 175_G 1.269 0.99
74_D 342_N 1.256 0.99
104_L 108_L 1.254 0.99
213_W 219_R 1.249 0.99
242_W 247_L 1.248 0.99
95_S 98_F 1.243 0.98
269_G 272_A 1.242 0.98
295_V 315_I 1.241 0.98
126_E 340_A 1.237 0.98
273_A 321_F 1.228 0.98
379_F 383_F 1.228 0.98
291_L 294_V 1.227 0.98
83_M 181_N 1.225 0.98
73_A 78_K 1.225 0.98
36_A 159_A 1.214 0.98
153_V 157_V 1.21 0.98
284_R 287_P 1.205 0.98
61_A 110_G 1.198 0.98
41_L 51_Q 1.197 0.98
330_L 347_Q 1.19 0.98
81_V 84_F 1.187 0.98
158_L 165_V 1.186 0.98
180_A 183_Y 1.185 0.98
253_A 257_Y 1.182 0.98
243_V 249_I 1.173 0.98
211_S 214_R 1.169 0.97
27_A 144_T 1.165 0.97
216_G 219_R 1.164 0.97
233_V 355_M 1.164 0.97
157_V 161_W 1.153 0.97
70_G 341_G 1.151 0.97
53_I 57_V 1.148 0.97
284_R 288_A 1.148 0.97
77_A 81_V 1.14 0.97
310_A 314_L 1.14 0.97
295_V 314_L 1.137 0.97
135_K 139_L 1.129 0.97
216_G 220_F 1.126 0.97
293_G 382_L 1.124 0.97
283_S 287_P 1.123 0.97
56_M 356_L 1.116 0.96
338_V 342_N 1.116 0.96
80_R 186_K 1.115 0.96
91_L 95_S 1.115 0.96
368_I 372_V 1.108 0.96
365_A 368_I 1.108 0.96
289_G 318_M 1.104 0.96
39_A 43_A 1.097 0.96
264_I 268_V 1.096 0.96
106_Y 110_G 1.095 0.96
354_A 358_M 1.093 0.96
56_M 360_G 1.093 0.96
280_E 285_C 1.09 0.96
172_L 176_G 1.086 0.96
218_T 222_L 1.08 0.95
206_L 210_T 1.078 0.95
289_G 322_F 1.073 0.95
57_V 61_A 1.07 0.95
133_L 332_E 1.067 0.95
208_A 211_S 1.066 0.95
275_K 278_T 1.065 0.95
175_G 179_V 1.065 0.95
297_L 378_G 1.06 0.95
215_N 219_R 1.059 0.95
257_Y 261_M 1.058 0.95
86_N 178_V 1.057 0.95
78_K 122_G 1.057 0.95
123_I 184_I 1.056 0.95
300_S 375_I 1.055 0.95
63_I 349_L 1.054 0.95
266_I 320_G 1.048 0.94
58_F 113_A 1.048 0.94
53_I 360_G 1.043 0.94
268_V 272_A 1.042 0.94
268_V 271_G 1.041 0.94
171_A 175_G 1.038 0.94
291_L 385_L 1.038 0.94
24_F 147_A 1.038 0.94
93_A 171_A 1.033 0.94
297_L 301_L 1.032 0.94
125_G 340_A 1.028 0.94
22_A 116_Y 1.023 0.93
98_F 168_A 1.023 0.93
242_W 246_A 1.019 0.93
156_G 256_T 1.016 0.93
40_L 164_L 1.014 0.93
374_P 378_G 1.014 0.93
219_R 223_V 1.009 0.93
280_E 284_R 1.008 0.93
58_F 110_G 1.006 0.93
310_A 313_M 1.005 0.93
305_L 309_Y 1.005 0.93
148_I 263_A 1.005 0.93
74_D 78_K 1.002 0.92
371_P 375_I 1.002 0.92
83_M 87_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.96221000.149Contact Map0.66
1pw4A10.99241000.154Contact Map0.495
4j05A20.99241000.156Contact Map0.597
2gfpA20.91941000.168Contact Map0.19
3o7qA10.97481000.172Contact Map0.639
2cfqA10.96981000.179Contact Map0.537
2xutA30.98991000.222Contact Map0.568
4gc0A10.98741000.234Contact Map0.748
4apsA20.99241000.237Contact Map0.577
4ldsA20.97481000.238Contact Map0.61
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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