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YAAU - Putative metabolite transport protein YaaU
UniProt: P31679 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11566
Length: 443 (416)
Sequences: 61474
Seq/Len: 147.77
YAAU
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_S 108_E 4.385 1.00
92_A 119_V 3.652 1.00
99_A 112_M 3.357 1.00
101_M 177_G 3.254 1.00
65_G 114_V 3.068 1.00
107_V 111_V 3.057 1.00
94_G 183_C 2.941 1.00
96_I 112_M 2.91 1.00
73_F 122_A 2.892 1.00
82_R 133_E 2.817 1.00
106_P 110_L 2.764 1.00
105_S 108_E 2.76 1.00
141_A 304_N 2.691 1.00
363_F 371_A 2.599 1.00
135_S 143_S 2.539 1.00
139_Q 142_F 2.488 1.00
51_D 54_W 2.48 1.00
89_D 122_A 2.399 1.00
78_D 369_A 2.394 1.00
69_G 118_I 2.391 1.00
136_S 139_Q 2.264 1.00
205_R 208_E 2.2 1.00
83_R 87_L 2.193 1.00
96_I 115_L 2.124 1.00
364_P 367_I 2.105 1.00
308_R 361_E 2.088 1.00
291_F 342_A 2.083 1.00
103_V 108_E 2.056 1.00
96_I 119_V 2.052 1.00
69_G 121_G 2.052 1.00
54_W 106_P 1.993 1.00
325_V 340_A 1.988 1.00
98_V 180_A 1.95 1.00
257_I 386_S 1.932 1.00
234_R 238_N 1.917 1.00
77_S 126_I 1.907 1.00
404_L 408_G 1.882 1.00
103_V 112_M 1.881 1.00
61_G 114_V 1.88 1.00
253_T 382_G 1.87 1.00
276_G 279_K 1.861 1.00
61_G 110_L 1.85 1.00
75_Y 79_K 1.826 1.00
322_A 340_A 1.801 1.00
320_T 414_L 1.77 1.00
58_L 109_L 1.755 1.00
50_L 106_P 1.749 1.00
96_I 116_I 1.743 1.00
170_G 174_W 1.727 1.00
320_T 411_L 1.726 1.00
50_L 54_W 1.724 1.00
65_G 69_G 1.718 1.00
100_T 112_M 1.715 1.00
81_G 84_K 1.696 1.00
87_L 190_R 1.666 1.00
24_S 150_M 1.66 1.00
76_I 85_M 1.648 1.00
307_G 310_P 1.64 1.00
315_S 350_G 1.636 1.00
74_G 78_D 1.604 1.00
295_G 346_F 1.591 1.00
100_T 109_L 1.586 1.00
64_A 384_I 1.563 1.00
300_M 304_N 1.517 1.00
301_L 305_T 1.504 1.00
84_K 88_I 1.5 1.00
317_A 414_L 1.483 1.00
69_G 72_L 1.48 1.00
171_G 174_W 1.473 1.00
291_F 295_G 1.473 1.00
80_V 85_M 1.47 1.00
318_M 347_F 1.469 1.00
335_W 339_M 1.468 1.00
99_A 102_F 1.467 1.00
92_A 96_I 1.463 1.00
108_E 112_M 1.461 1.00
177_G 181_I 1.459 1.00
43_Q 46_P 1.454 1.00
76_I 80_V 1.444 1.00
261_A 390_L 1.431 1.00
320_T 324_A 1.421 1.00
313_I 414_L 1.412 1.00
235_D 367_I 1.403 0.99
142_F 304_N 1.397 0.99
207_K 210_E 1.385 0.99
111_V 115_L 1.371 0.99
137_T 140_R 1.366 0.99
322_A 347_F 1.365 0.99
235_D 238_N 1.36 0.99
88_I 92_A 1.357 0.99
295_G 298_P 1.352 0.99
240_R 243_P 1.35 0.99
324_A 407_A 1.349 0.99
80_V 84_K 1.343 0.99
89_D 119_V 1.326 0.99
174_W 177_G 1.324 0.99
94_G 180_A 1.322 0.99
87_L 187_L 1.32 0.99
107_V 110_L 1.317 0.99
188_I 192_E 1.31 0.99
101_M 180_A 1.305 0.99
131_I 147_I 1.305 0.99
84_K 87_L 1.305 0.99
31_G 151_W 1.302 0.99
81_G 85_M 1.302 0.99
78_D 370_S 1.301 0.99
133_E 368_R 1.298 0.99
45_T 55_I 1.298 0.99
382_G 386_S 1.291 0.99
160_L 164_W 1.275 0.99
165_L 174_W 1.269 0.99
317_A 321_L 1.263 0.99
67_F 377_S 1.261 0.99
85_M 88_I 1.26 0.99
298_P 301_L 1.258 0.99
94_G 98_V 1.256 0.99
309_R 313_I 1.254 0.99
78_D 82_R 1.241 0.98
98_V 102_F 1.238 0.98
132_T 140_R 1.233 0.98
392_I 396_N 1.233 0.98
322_A 344_Y 1.225 0.98
77_S 82_R 1.218 0.98
391_P 395_N 1.215 0.98
53_D 395_N 1.213 0.98
40_A 166_Y 1.212 0.98
72_L 75_Y 1.212 0.98
310_P 313_I 1.207 0.98
310_P 314_G 1.197 0.98
60_A 384_I 1.193 0.98
74_G 369_A 1.186 0.98
52_A 395_N 1.185 0.98
84_K 195_E 1.179 0.98
327_G 404_L 1.174 0.98
288_I 345_A 1.172 0.98
294_L 298_P 1.17 0.97
26_G 123_D 1.168 0.97
275_L 279_K 1.167 0.97
181_I 185_L 1.165 0.97
101_M 173_R 1.164 0.97
62_T 120_I 1.164 0.97
318_M 322_A 1.161 0.97
393_F 397_Y 1.154 0.97
320_T 407_A 1.153 0.97
302_W 306_A 1.153 0.97
65_G 117_G 1.15 0.97
324_A 328_L 1.148 0.97
108_E 111_V 1.144 0.97
16_H 139_Q 1.134 0.97
339_M 343_V 1.133 0.97
269_I 273_L 1.119 0.96
43_Q 47_A 1.116 0.96
260_F 383_T 1.113 0.96
99_A 108_E 1.113 0.96
335_W 338_V 1.11 0.96
142_F 146_F 1.106 0.96
81_G 195_E 1.102 0.96
62_T 66_L 1.102 0.96
239_R 242_F 1.101 0.96
47_A 173_R 1.098 0.96
232_R 235_D 1.095 0.96
94_G 187_L 1.092 0.96
95_V 99_A 1.089 0.96
408_G 412_F 1.088 0.96
94_G 184_L 1.088 0.96
160_L 286_V 1.087 0.96
28_F 154_G 1.087 0.96
306_A 311_L 1.083 0.96
397_Y 401_N 1.08 0.95
290_L 294_L 1.078 0.95
271_G 277_V 1.075 0.95
339_M 342_A 1.073 0.95
167_D 278_G 1.073 0.95
26_G 86_F 1.071 0.95
161_V 164_W 1.066 0.95
57_L 61_G 1.065 0.95
314_G 318_M 1.047 0.94
270_V 275_L 1.046 0.94
102_F 177_G 1.045 0.94
82_R 195_E 1.043 0.94
33_V 36_M 1.042 0.94
60_A 388_W 1.041 0.94
130_M 193_L 1.04 0.94
249_A 378_L 1.038 0.94
67_F 384_I 1.037 0.94
57_L 388_W 1.036 0.94
44_L 172_W 1.033 0.94
91_I 187_L 1.023 0.93
71_S 75_Y 1.022 0.93
365_T 368_R 1.022 0.93
130_M 134_F 1.021 0.93
210_E 214_I 1.021 0.93
142_F 301_L 1.02 0.93
45_T 50_L 1.018 0.93
319_M 410_S 1.016 0.93
40_A 175_M 1.015 0.93
180_A 184_L 1.014 0.93
87_L 91_I 1.014 0.93
62_T 117_G 1.013 0.93
359_P 375_I 1.011 0.93
41_L 55_I 1.003 0.93
297_I 301_L 1.001 0.92
320_T 410_S 1 0.92
213_M 225_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j05A20.99321000.197Contact Map0.637
4gc0A10.97971000.205Contact Map0.717
1pw4A10.95941000.229Contact Map0.469
4ldsA20.97071000.229Contact Map0.63
3wdoA10.91421000.252Contact Map0.622
3o7qA10.89621000.295Contact Map0.62
2xutA30.97521000.303Contact Map0.51
2cfqA10.90741000.304Contact Map0.494
2gfpA20.83971000.306Contact Map0.177
4apsA20.97291000.335Contact Map0.518
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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