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MDTM - Multidrug resistance protein MdtM
UniProt: P39386 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12576
Length: 410 (384)
Sequences: 67029
Seq/Len: 174.55
MDTM
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_T 103_Q 4.001 1.00
87_I 114_S 3.583 1.00
94_A 107_A 3.525 1.00
96_M 171_A 3.221 1.00
60_G 109_A 2.933 1.00
91_A 107_A 2.914 1.00
68_L 117_F 2.85 1.00
77_R 128_E 2.825 1.00
89_T 177_G 2.813 1.00
102_T 106_I 2.778 1.00
100_S 103_Q 2.7 1.00
84_G 117_F 2.59 1.00
249_T 252_Q 2.572 1.00
130_F 138_L 2.561 1.00
101_M 105_L 2.528 1.00
136_I 276_K 2.507 1.00
338_N 345_V 2.485 1.00
46_D 49_L 2.45 1.00
134_K 137_K 2.396 1.00
91_A 114_S 2.325 1.00
267_A 321_F 2.307 1.00
64_L 113_T 2.299 1.00
91_A 110_I 2.276 1.00
290_I 322_G 2.271 1.00
73_D 343_G 2.249 1.00
225_S 356_V 2.182 1.00
131_G 134_K 2.166 1.00
263_A 317_S 2.094 1.00
78_R 82_I 2.091 1.00
164_M 168_V 2.073 1.00
209_R 213_C 2.069 1.00
229_I 360_S 2.063 1.00
280_E 336_F 1.975 1.00
98_T 103_Q 1.973 1.00
93_A 174_A 1.911 1.00
98_T 107_A 1.906 1.00
49_L 101_M 1.879 1.00
82_I 181_F 1.874 1.00
64_L 116_C 1.868 1.00
72_S 121_V 1.837 1.00
89_T 181_F 1.834 1.00
45_A 101_M 1.818 1.00
82_I 185_L 1.789 1.00
91_A 111_Q 1.779 1.00
60_G 64_L 1.747 1.00
182_V 186_L 1.734 1.00
310_L 314_L 1.732 1.00
70_P 74_R 1.731 1.00
53_A 104_F 1.724 1.00
233_S 364_G 1.718 1.00
95_T 107_A 1.716 1.00
279_T 282_R 1.695 1.00
56_L 105_L 1.665 1.00
297_L 315_G 1.639 1.00
76_G 79_P 1.634 1.00
294_G 315_G 1.633 1.00
56_L 109_A 1.615 1.00
273_R 277_D 1.6 1.00
86_L 181_F 1.587 1.00
45_A 49_L 1.541 1.00
95_T 104_F 1.533 1.00
248_L 252_Q 1.517 1.00
260_V 320_A 1.516 1.00
171_A 175_V 1.51 1.00
272_A 276_K 1.491 1.00
221_A 352_V 1.489 1.00
89_T 174_A 1.481 1.00
96_M 174_A 1.462 1.00
69_G 73_D 1.459 1.00
210_N 213_C 1.455 1.00
263_A 267_A 1.452 1.00
79_P 83_T 1.436 1.00
137_K 276_K 1.428 1.00
132_Q 135_G 1.428 1.00
71_L 80_V 1.424 1.00
38_N 41_R 1.421 1.00
308_V 311_W 1.413 1.00
103_Q 107_A 1.411 1.00
71_L 75_I 1.409 1.00
93_A 97_F 1.403 0.99
210_N 341_P 1.402 0.99
75_I 80_V 1.398 0.99
83_T 87_I 1.389 0.99
59_A 358_S 1.384 0.99
183_G 187_A 1.378 0.99
87_I 91_A 1.367 0.99
64_L 67_L 1.361 0.99
243_I 253_F 1.356 0.99
94_A 97_F 1.353 0.99
243_I 250_T 1.338 0.99
102_T 105_L 1.335 0.99
89_T 178_F 1.335 0.99
270_I 273_R 1.331 0.99
47_V 369_F 1.326 0.99
274_F 278_P 1.325 0.99
84_G 114_S 1.32 0.99
267_A 270_I 1.315 0.99
165_H 168_V 1.312 0.99
19_I 145_I 1.307 0.99
252_Q 255_W 1.304 0.99
126_V 142_I 1.301 0.99
294_G 322_G 1.296 0.99
281_P 285_W 1.281 0.99
79_P 82_I 1.274 0.99
67_L 70_P 1.263 0.99
127_Q 135_G 1.261 0.99
366_W 370_N 1.255 0.99
168_V 171_A 1.252 0.99
106_I 110_I 1.249 0.99
35_G 161_M 1.241 0.98
75_I 79_P 1.24 0.98
282_R 285_W 1.239 0.98
60_G 112_G 1.228 0.98
155_L 258_V 1.225 0.98
73_D 344_T 1.221 0.98
271_V 325_L 1.218 0.98
162_H 251_S 1.215 0.98
287_A 325_L 1.206 0.98
241_I 246_G 1.204 0.98
160_L 168_V 1.199 0.98
79_P 190_E 1.191 0.98
90_L 94_A 1.188 0.98
232_M 357_M 1.18 0.98
378_L 382_V 1.175 0.98
40_V 50_A 1.169 0.97
212_F 218_L 1.166 0.97
125_T 188_M 1.163 0.97
310_L 313_V 1.163 0.97
264_V 324_G 1.162 0.97
128_E 342_K 1.161 0.97
96_M 167_K 1.16 0.97
273_R 276_K 1.16 0.97
72_S 77_R 1.157 0.97
282_R 286_R 1.157 0.97
48_S 369_F 1.154 0.97
287_A 322_G 1.153 0.97
69_G 343_G 1.151 0.97
76_G 80_V 1.151 0.97
287_A 326_I 1.149 0.97
80_V 83_T 1.147 0.97
85_A 181_F 1.147 0.97
184_L 188_M 1.139 0.97
175_V 179_I 1.136 0.97
218_L 222_A 1.135 0.97
289_P 293_V 1.132 0.97
55_S 362_E 1.125 0.97
23_F 149_A 1.125 0.97
135_G 336_F 1.125 0.97
94_A 103_Q 1.11 0.96
57_Y 115_I 1.109 0.96
155_L 159_A 1.104 0.96
356_V 360_S 1.099 0.96
341_P 344_T 1.099 0.96
217_F 221_A 1.098 0.96
334_T 349_L 1.097 0.96
26_Y 146_V 1.094 0.96
55_S 358_S 1.089 0.96
52_A 56_L 1.087 0.96
292_L 296_S 1.086 0.96
137_K 141_I 1.082 0.96
38_N 42_D 1.08 0.95
255_W 259_P 1.079 0.95
97_F 171_A 1.079 0.95
159_A 163_F 1.075 0.95
52_A 362_E 1.073 0.95
365_R 369_F 1.072 0.95
242_L 248_L 1.066 0.95
279_T 283_F 1.066 0.95
262_G 266_V 1.064 0.95
40_V 47_V 1.061 0.95
62_M 351_M 1.058 0.95
278_P 283_F 1.054 0.95
103_Q 106_I 1.054 0.95
73_D 77_R 1.051 0.94
292_L 388_V 1.048 0.94
215_R 218_L 1.045 0.94
266_V 269_A 1.044 0.94
241_I 245_A 1.044 0.94
314_L 318_L 1.032 0.94
42_D 167_K 1.031 0.94
215_R 219_F 1.029 0.94
367_L 371_G 1.029 0.94
92_C 174_A 1.027 0.94
40_V 45_A 1.024 0.93
77_R 190_E 1.019 0.93
66_W 70_P 1.018 0.93
82_I 86_L 1.017 0.93
266_V 270_I 1.014 0.93
39_V 166_W 1.013 0.93
57_Y 112_G 1.011 0.93
178_F 182_V 1.006 0.93
158_A 254_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99021000.176Contact Map0.491
3wdoA10.97321000.207Contact Map0.626
4j05A20.99021000.207Contact Map0.628
3o7qA10.95851000.228Contact Map0.629
2gfpA20.91461000.23Contact Map0.18
2cfqA10.96591000.249Contact Map0.499
4ldsA20.98051000.267Contact Map0.622
2xutA30.99761000.27Contact Map0.539
4gc0A10.99021000.273Contact Map0.715
4apsA20.99761000.293Contact Map0.551
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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