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YGCS - Inner membrane metabolite transport protein YgcS
UniProt: Q46909 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13126
Length: 445 (415)
Sequences: 61590
Seq/Len: 148.41
YGCS
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_T 109_H 4.311 1.00
93_L 120_G 3.684 1.00
100_L 113_L 3.493 1.00
102_F 179_A 3.336 1.00
66_G 115_I 3.141 1.00
97_A 113_L 3.011 1.00
108_E 112_G 2.992 1.00
95_T 185_A 2.937 1.00
83_R 134_E 2.854 1.00
74_L 123_G 2.788 1.00
106_T 109_H 2.778 1.00
107_P 111_I 2.671 1.00
142_G 305_H 2.607 1.00
363_F 371_G 2.53 1.00
136_S 144_L 2.495 1.00
52_T 55_M 2.465 1.00
140_H 143_I 2.403 1.00
90_S 123_G 2.367 1.00
319_L 347_T 2.366 1.00
70_G 119_I 2.346 1.00
97_A 120_G 2.332 1.00
79_D 369_S 2.31 1.00
97_A 116_L 2.296 1.00
326_V 340_L 2.225 1.00
292_L 342_V 2.16 1.00
137_P 140_H 2.137 1.00
296_G 346_T 2.098 1.00
84_Q 88_T 2.095 1.00
207_R 210_E 2.082 1.00
104_A 109_H 2.019 1.00
309_H 361_E 2.001 1.00
364_P 367_I 1.998 1.00
238_K 242_S 1.971 1.00
257_V 382_G 1.957 1.00
404_L 408_T 1.953 1.00
104_A 113_L 1.932 1.00
70_G 122_G 1.92 1.00
99_F 182_A 1.917 1.00
55_M 107_P 1.908 1.00
78_S 127_V 1.878 1.00
62_S 111_I 1.875 1.00
172_E 176_W 1.868 1.00
62_S 115_I 1.855 1.00
323_T 347_T 1.834 1.00
321_A 414_F 1.827 1.00
323_T 340_L 1.813 1.00
97_A 117_I 1.789 1.00
261_I 386_S 1.778 1.00
76_W 80_H 1.777 1.00
25_F 151_V 1.767 1.00
321_A 411_L 1.751 1.00
101_Q 113_L 1.747 1.00
51_L 107_P 1.745 1.00
59_I 110_L 1.741 1.00
66_G 70_G 1.702 1.00
335_S 339_L 1.691 1.00
101_Q 110_L 1.682 1.00
82_G 85_K 1.646 1.00
88_T 189_T 1.631 1.00
316_S 350_A 1.62 1.00
51_L 55_M 1.619 1.00
280_E 283_L 1.607 1.00
265_V 390_L 1.596 1.00
77_I 86_I 1.593 1.00
302_V 306_L 1.573 1.00
308_A 311_K 1.563 1.00
88_T 192_R 1.555 1.00
95_T 189_T 1.542 1.00
85_K 89_F 1.531 1.00
318_L 414_F 1.519 1.00
65_L 384_A 1.508 1.00
75_G 79_D 1.49 1.00
102_F 182_A 1.476 1.00
81_I 86_I 1.464 1.00
301_L 305_H 1.459 1.00
99_F 103_F 1.459 1.00
100_L 103_F 1.441 1.00
109_H 113_L 1.423 1.00
173_A 176_W 1.415 1.00
44_Q 47_P 1.411 1.00
323_T 344_F 1.41 1.00
70_G 73_V 1.408 1.00
179_A 183_L 1.405 0.99
138_R 141_R 1.404 0.99
95_T 182_A 1.396 0.99
92_L 189_T 1.396 0.99
289_L 345_S 1.388 0.99
112_G 116_L 1.385 0.99
209_A 212_H 1.385 0.99
143_I 305_H 1.378 0.99
314_L 414_F 1.372 0.99
89_F 93_L 1.369 0.99
292_L 296_G 1.366 0.99
93_L 97_A 1.366 0.99
77_I 81_I 1.355 0.99
61_G 384_A 1.337 0.99
166_F 176_W 1.317 0.99
32_G 152_W 1.314 0.99
108_E 111_I 1.309 0.99
325_V 407_A 1.306 0.99
321_A 407_A 1.304 0.99
328_A 404_L 1.303 0.99
303_L 307_L 1.303 0.99
392_W 396_Q 1.292 0.99
239_T 367_I 1.287 0.99
318_L 322_A 1.282 0.99
90_S 120_G 1.281 0.99
310_R 314_L 1.28 0.99
85_K 88_T 1.278 0.99
299_L 302_V 1.275 0.99
81_I 85_K 1.273 0.99
79_D 370_L 1.264 0.99
190_L 194_G 1.261 0.99
17_H 140_H 1.252 0.99
176_W 179_A 1.249 0.99
46_T 56_A 1.248 0.99
321_A 325_V 1.245 0.98
132_L 148_F 1.241 0.98
82_G 86_I 1.236 0.98
79_D 83_R 1.229 0.98
133_A 141_R 1.226 0.98
134_E 368_R 1.224 0.98
239_T 242_S 1.223 0.98
264_F 383_A 1.22 0.98
102_F 175_R 1.22 0.98
253_S 378_M 1.213 0.98
27_A 124_D 1.212 0.98
53_P 395_A 1.204 0.98
316_S 347_T 1.202 0.98
63_A 121_L 1.194 0.98
68_F 377_A 1.194 0.98
325_V 329_C 1.193 0.98
244_R 247_R 1.188 0.98
391_P 395_A 1.187 0.98
66_G 118_G 1.184 0.98
161_I 165_H 1.184 0.98
339_L 343_L 1.18 0.98
296_G 299_L 1.175 0.98
408_T 412_V 1.173 0.98
319_L 323_T 1.172 0.98
393_V 397_W 1.172 0.98
78_S 83_R 1.168 0.97
86_I 89_F 1.164 0.97
236_H 239_T 1.157 0.97
311_K 315_G 1.155 0.97
311_K 314_L 1.154 0.97
73_V 76_W 1.149 0.97
29_L 155_G 1.147 0.97
58_M 388_G 1.138 0.97
382_G 386_S 1.137 0.97
44_Q 48_A 1.134 0.97
96_L 100_L 1.132 0.97
320_L 410_L 1.126 0.97
335_S 338_L 1.12 0.96
100_L 109_H 1.119 0.96
75_G 369_S 1.117 0.96
183_L 187_L 1.115 0.96
323_T 343_L 1.109 0.96
328_A 407_A 1.108 0.96
85_K 197_E 1.107 0.96
95_T 186_L 1.107 0.96
291_A 295_V 1.103 0.96
54_F 395_A 1.101 0.96
58_M 62_S 1.095 0.96
350_A 354_L 1.086 0.96
401_V 405_L 1.085 0.96
274_A 279_L 1.074 0.95
317_F 413_G 1.071 0.95
62_S 66_G 1.069 0.95
103_F 179_A 1.068 0.95
45_L 174_W 1.065 0.95
273_I 277_I 1.064 0.95
315_G 319_L 1.061 0.95
339_L 342_V 1.06 0.95
275_Q 281_D 1.06 0.95
143_I 147_A 1.056 0.95
397_W 401_V 1.054 0.95
262_P 410_L 1.053 0.95
109_H 112_G 1.053 0.95
300_G 350_A 1.051 0.94
48_A 175_R 1.045 0.94
401_V 404_L 1.039 0.94
61_G 388_G 1.032 0.94
321_A 410_L 1.029 0.94
68_F 384_A 1.027 0.94
27_A 87_F 1.024 0.93
143_I 302_V 1.024 0.93
41_A 167_I 1.023 0.93
105_T 175_R 1.021 0.93
244_R 248_R 1.02 0.93
302_V 305_H 1.02 0.93
41_A 177_L 1.018 0.93
212_H 216_H 1.015 0.93
63_A 118_G 1.007 0.93
322_A 326_V 1.005 0.93
182_A 186_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j05A20.99781000.229Contact Map0.623
4gc0A10.97751000.259Contact Map0.723
1pw4A10.94831000.264Contact Map0.475
4ldsA20.96631000.271Contact Map0.638
3wdoA10.91011000.296Contact Map0.653
3o7qA10.88991000.32Contact Map0.631
2cfqA10.89891000.336Contact Map0.492
2gfpA20.82921000.341Contact Map0.167
2xutA30.96851000.341Contact Map0.525
4lepA20.97531000.374Contact Map0.622
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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