Submit Sequence for Coevolution Analysis
Note, due to limited resources your submission may take forever to complete (Jobs Running: 0).
Email (Will only be used to send you notice of Completion/Error).
Job name
Starting alignment
Alignment must be in FASTA format. Alternatively, you may provide a single sequence in plain text or in FASTA format.

NOTE: We treat your input as a "starting alignment" which is then enriched using HHblits. If Jackhmmer is selected only the first (or query) sequence is used. [20 < query_length < 1000] contact us if you wish to submit a sequence larger than the limit.

NEW: We have a seperate submission page for protein-protein coevolution analysis.
Generate MSA using: Filter MSA GREMLIN
E-value: Iterations: Coverage: Remove gaps: Prior:
  • HHblits/Jackhmmer
    • HHblits and Jackhmmer are methods used to generate the Multiple Sequence Alignment (MSA).
    • <E-value/Iterations> options are used to control the diversity of MSA generation.
    • To use your own alignment, without MSA enrichment, set Iterations to 0.
  • Filter MSA
    • <Coverage> Filter MSA to remove sequences that don't cover at least (%) of query.
    • <Remove gaps> After coverage filter, remove positions in the alignment that have (%) gaps.
    • only Vanilia works right now, other options are under construction.
    • Vanilla - Pure sequence based analysis (no prior).
    • SS - Add Secondary Structure prior, based on PSIPRED predictions.
    • SVM - Add SVM-CON prior.
1 + 2 =
List results for others to see.

UniProt Database Update: (HHblits: 2016_02) (Jackhmmer: 2016_04)
PDB Update: (HHsearch: pdb70_06Aug15)