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MDTL - Multidrug resistance protein MdtL
UniProt: P31462 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11720
Length: 391 (366)
Sequences: 61486
Seq/Len: 167.99
MDTL
Paralog alert: 0.90 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_E 93_L 4.183 1.00
77_L 104_G 3.592 1.00
84_F 97_G 3.44 1.00
86_S 161_W 3.238 1.00
50_G 99_F 3.031 1.00
92_T 96_A 2.934 1.00
79_I 167_G 2.9 1.00
81_A 97_G 2.859 1.00
58_A 107_C 2.849 1.00
67_R 118_D 2.835 1.00
90_T 93_L 2.78 1.00
236_E 239_E 2.557 1.00
91_S 95_L 2.546 1.00
74_G 107_C 2.515 1.00
120_L 128_V 2.492 1.00
126_A 263_G 2.487 1.00
36_S 39_Q 2.483 1.00
212_T 338_G 2.419 1.00
124_R 127_K 2.382 1.00
81_A 104_G 2.37 1.00
54_A 103_L 2.321 1.00
63_D 325_G 2.248 1.00
81_A 100_L 2.241 1.00
216_S 342_W 2.143 1.00
196_S 200_L 2.103 1.00
277_L 308_G 2.097 1.00
254_V 307_V 2.033 1.00
154_F 158_S 2.029 1.00
121_D 124_R 2.025 1.00
284_T 301_I 1.994 1.00
88_A 93_L 1.992 1.00
88_A 97_G 1.987 1.00
68_K 72_I 1.968 1.00
54_A 106_G 1.924 1.00
39_Q 91_S 1.91 1.00
250_V 303_A 1.89 1.00
72_I 175_L 1.887 1.00
83_V 164_A 1.886 1.00
46_V 99_F 1.879 1.00
172_M 176_F 1.858 1.00
81_A 101_Q 1.855 1.00
72_I 171_L 1.847 1.00
43_A 94_F 1.825 1.00
266_K 269_T 1.809 1.00
46_V 95_L 1.787 1.00
35_A 91_S 1.777 1.00
296_F 300_L 1.747 1.00
320_F 323_R 1.743 1.00
79_I 171_L 1.717 1.00
50_G 54_A 1.712 1.00
220_T 346_A 1.692 1.00
76_A 171_L 1.689 1.00
62_A 111_V 1.688 1.00
85_C 97_G 1.663 1.00
60_K 64_R 1.661 1.00
66_G 69_P 1.615 1.00
281_A 301_I 1.614 1.00
79_I 164_A 1.586 1.00
208_V 334_A 1.586 1.00
235_F 239_E 1.578 1.00
35_A 39_Q 1.575 1.00
260_F 264_I 1.564 1.00
93_L 97_G 1.513 1.00
197_E 200_L 1.512 1.00
85_C 94_F 1.495 1.00
65_S 70_V 1.473 1.00
259_P 263_G 1.472 1.00
61_V 70_V 1.464 1.00
61_V 65_S 1.461 1.00
28_R 31_A 1.46 1.00
86_S 164_A 1.455 1.00
197_E 323_R 1.45 1.00
69_P 73_P 1.443 1.00
59_G 63_D 1.439 1.00
161_W 165_M 1.436 1.00
155_P 158_S 1.418 1.00
127_K 263_G 1.412 1.00
83_V 87_L 1.404 0.99
74_G 104_G 1.396 0.99
239_E 242_T 1.394 0.99
122_D 125_R 1.39 0.99
54_A 57_F 1.39 0.99
73_P 77_L 1.385 0.99
84_F 87_L 1.384 0.99
281_A 308_G 1.383 0.99
250_V 254_V 1.38 0.99
267_P 318_G 1.365 0.99
247_T 306_S 1.364 0.99
77_L 81_A 1.358 0.99
230_M 240_Y 1.342 0.99
25_G 151_M 1.328 0.99
173_L 177_I 1.326 0.99
116_L 132_L 1.322 0.99
96_A 100_L 1.294 0.99
49_A 340_S 1.293 0.99
92_T 95_L 1.286 0.99
66_G 70_V 1.286 0.99
219_L 339_S 1.275 0.99
117_R 125_R 1.275 0.99
230_M 237_R 1.274 0.99
69_P 72_I 1.264 0.99
79_I 168_I 1.262 0.99
261_A 265_F 1.26 0.99
158_S 161_W 1.26 0.99
150_I 158_S 1.249 0.99
257_S 260_F 1.248 0.99
118_D 324_A 1.244 0.98
279_L 283_I 1.238 0.98
152_L 238_G 1.235 0.98
276_V 280_A 1.23 0.98
63_D 326_V 1.227 0.98
269_T 273_T 1.227 0.98
47_Y 105_A 1.205 0.98
80_I 84_F 1.204 0.98
57_F 60_K 1.202 0.98
69_P 180_E 1.198 0.98
145_V 245_A 1.196 0.98
62_A 67_R 1.195 0.98
268_R 272_I 1.187 0.98
174_S 178_L 1.183 0.98
65_S 69_P 1.176 0.98
50_G 102_G 1.173 0.98
70_V 73_P 1.167 0.97
228_L 233_M 1.167 0.97
30_A 40_L 1.163 0.97
254_V 257_S 1.159 0.97
204_F 208_V 1.151 0.97
86_S 157_Q 1.151 0.97
84_F 93_L 1.151 0.97
59_G 325_G 1.144 0.97
45_S 340_S 1.142 0.97
269_T 272_I 1.129 0.97
75_A 171_L 1.128 0.97
87_L 161_W 1.128 0.97
260_F 263_G 1.117 0.96
274_S 311_V 1.113 0.96
115_I 178_L 1.112 0.96
18_G 21_M 1.112 0.96
323_R 326_V 1.108 0.96
211_T 331_L 1.107 0.96
28_R 32_D 1.106 0.96
338_G 342_W 1.106 0.96
205_L 209_V 1.106 0.96
229_L 235_F 1.097 0.96
300_L 304_G 1.096 0.96
63_D 67_R 1.093 0.96
42_I 46_V 1.091 0.96
165_M 169_A 1.089 0.96
199_L 205_L 1.087 0.96
296_F 299_T 1.083 0.96
93_L 96_A 1.081 0.95
297_G 300_L 1.068 0.95
249_G 253_T 1.068 0.95
32_D 157_Q 1.064 0.95
283_I 287_V 1.062 0.95
149_L 153_K 1.061 0.95
47_Y 102_G 1.053 0.95
171_L 175_L 1.052 0.95
148_H 241_A 1.052 0.95
52_A 333_I 1.051 0.94
145_V 149_L 1.047 0.94
127_K 131_L 1.041 0.94
281_A 305_F 1.035 0.94
30_A 37_E 1.033 0.94
72_I 76_A 1.031 0.94
168_I 172_M 1.029 0.94
321_S 324_A 1.023 0.93
202_R 205_L 1.02 0.93
76_A 80_I 1.019 0.93
265_F 270_L 1.011 0.93
202_R 206_S 1.009 0.93
238_G 242_T 1.009 0.93
16_P 136_T 1.007 0.93
52_A 340_S 1.007 0.93
294_S 297_G 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.98721000.148Contact Map0.476
2gfpA20.94121000.163Contact Map0.19
3wdoA10.98211000.166Contact Map0.632
4j05A20.99231000.191Contact Map0.616
3o7qA10.9541000.202Contact Map0.626
2cfqA10.97951000.208Contact Map0.493
2xutA30.99741000.249Contact Map0.559
4apsA20.99231000.256Contact Map0.541
4gc0A10.99231000.257Contact Map0.724
4ldsA20.99231000.268Contact Map0.636
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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